Claims for Patent: 7,300,935

Summary for Patent: 7,300,935

Title:	Thienopyrimidine compounds and use thereof
Abstract:	The present invention provides a compound represented by the formula: ##STR00001## wherein R.sup.1 is a C.sub.1-4alkyl; R.sup.2 is (1) a 5- to 7-membered nitrogen-containing heterocyclic group which may have a substituent selected from the group consisting of (1') a halogen, (2') a hydroxy group, (3') a C.sub.1-4alkyl and (4') a C.sub.1-4alkoxy, (2) a phenyl which may have a substituent selected from the group consisting of (1') a halogen, (2') a C.sub.1-4alkoxy-C.sub.1-4alkyl, (3') a mono-C.sub.1-4alkyl-carbamoyl-C.sub.1-4alkyl, (4') a C.sub.1-4alkoxy and (5') a mono-C.sub.1-4alkylcarbamoyl-C.sub.1-4alkoxy, or the like; R.sup.3 is a C.sub.1-4alkyl; R.sup.4 is a C.sub.1-4alkoxy, or the like; n is an integer of 1 to 4; or a salt thereof, as a thienopyrimidine compound having gonadotropin-releasing hormone antagonistic activity.
Inventor(s):	Cho; Nobuo (Osaka, JP), Imada; Takashi (Osaka, JP), Hitaka; Takenori (Osaka, JP), Miwa; Kazuhiro (Osaka, JP), Kusaka; Masami (Osaka, JP), Suzuki; Nobuhiro (Tsukuba, JP)
Assignee:	Takeda Pharmaceutical Company (Osaka, JP)
Application Number:	10/544,069
Patent Claims:	1. N-(4-(1-(2,6-difluorobenzyl)-5-(((2-ethoxyethyl)(methyl)amino)methyl)-- 2,4-dioxo-3-(2-pyridinyl)-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl)ph- enyl)-N'-methoxyurea or a salt thereof. 2. N-(4-(1-(2,6-difluorobenzyl)-5-((dimethylamino)methyl)-3-(6-methoxy-3-- pyridazinyl)-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl)pheny- l)-N'-methoxyurea or a salt thereof.