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Generated: July 26, 2017

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Title:Pharmaceutical formulations of modafinil
Abstract:The present invention is related to compositions of modafinil, including compositions of modafinil and one or more diluents, disintegrants, binders and lubricants, and the processes for their preparation thereof.
Inventor(s): Corvari; Vincent (Carmel, IN), Grandolfi; George (Millford, OH), Parikh; Alpa (Hockessin, DE)
Assignee: Cephalon Inc. (Frazer, PA)
Application Number:10/155,913
Patent Claims: 1. A composition comprising modafinil, from about 30-50% of the composition by weight; a lactose monohydrate from about 25-35% of the composition by weight; a microcrystalline cellulose from about 5-15% of the composition by weight; a pregelatinized starch from about 5-15% of the composition by weight; a cross-linked sodium carboxymethyl cellulose from about 1-10% of the composition by weight; a polyvinyl pyrrolidone from about 1-10% of the composition by weight; and magnesium stearate from about 0.2-2.0% of the composition by weight.

2. The composition of claim 1, wherein the modafinil is about 40.0%, the lactose monohydrate is about 28.7%; the microcrystalline cellulose is about 10.4%; the pregelatinized starch is about 10.9%, the cross-linked sodium carboxyrnethyl cellulose is about 4.0%; the polyvinyl pyrrolidone is about 5.2% and the magnesium stearate is about 0.8% of the composition by weight.

3. The composition of claim 1, wherein the composition is a tablet.

4. The composition of claim 3, wherein the tablet weight is about 250 mg.

5. The composition of claim 4, comprising about 100 mg of modafinil.

6. The composition of claim 3, wherein the tablet weight is about 500 mg.

7. The composition of claim 6, comprising about 200 mg of modafinil.

8. The composition of claim 1, wherein inodafinil is the levorotatory isomer of modafirtil.

9. The composition of claim 2, wherein modafinil is the levorotatory isomer of modatinil.

10. The composition of claim 3, wherein modafinil is the levorotatory isomer of modafinil.

11. The composition of claim 4, wherein modafmil is the levorotatory isomer of modafinil.

12. The composition of claim 5, wherein modafinil is the levorotatory isomer of modafinil.

13. The composition of claim 6, wherein modafinil is the levorotatory isomer of modafinil.

14. The composition of claim 7, wherein modafinil is the levorotatory isomer of modafinil.
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Serving 500+ biopharmaceutical companies globally:

Novartis
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Fish and Richardson
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Dow
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UBS

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