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Claims for Patent: 7,265,221

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Claims for Patent: 7,265,221

Title:Pyrrolo[2,3-d]pyrimidine compounds
Abstract: A compound of the formula ##STR00001## wherein R.sup.1, R.sup.2 and R.sup.3 are as defined above, which are inhibitors of the enzyme protein kinases such as Janus Kinase 3 and as such are useful therapy as immunosuppressive agents for organ transplants, xeno transplation, lupus, multiple sclerosis, rheumatoid arthritis, psoriasis, Type I diabetes and complications from diabetes, cancer, asthma, atopic dermatitis, autoimmune thyroid disorders, ulcerative colitis, Crohn's disease, Alzheimer's disease, Leukemia and other autoimmune diseases.
Inventor(s): Blumenkopf; Todd A. (Old Lyme, CT), Flanagan; Mark E. (Gales Ferry, CT), Munchhof; Michael J. (Salem, CT)
Assignee: Pfizer, Inc. (New York, NY)
Application Number:11/474,233
Patent Claims: 1. A compound of the Formula I; ##STR00010## or a pharmaceutically acceptable salt thereof; wherein R.sup.1 is a group of the formula ##STR00011## wherein y is 0, 1 or 2; R.sup.4 is selected from the group consisting of hydrogen, (C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkylsulfonyl, (C.sub.2-C.sub.6)alkenyl, (C.sub.2-C.sub.6)alkynyl wherein the alkyl, alkenyl and alkynyl groups are optionally substituted by deuterium, hydroxy, amino, trifluoromethyl, (C.sub.1-C.sub.4)alkoxy, (C.sub.1-C.sub.6)acyloxy, (C.sub.1-C.sub.6)alkylamino, ((C.sub.1-C.sub.6)alkyl).sub.2amino, cyano, nitro, (C.sub.2-C.sub.6)alkenyl, (C.sub.2-C.sub.6)alkynyl or (C.sub.1-C.sub.6)acylamino; or R.sup.4 is (C.sub.3-C.sub.10)cycloalkyl wherein the cycloalkyl group is optionally substituted by deuterium, hydroxy, amino, trifluoromethyl, (C.sub.1-C.sub.6)acyloxy, (C.sub.1-C.sub.6)acylamino, (C.sub.1-C.sub.6)alkylamino, ((C.sub.1-C.sub.6)alkyl).sub.2amino, cyano, cyano(C.sub.1-C.sub.6)alkyl, trifluoromethyl(C.sub.1-C.sub.6)alkyl, nitro, nitro(C.sub.1-C.sub.6)alkyl or (C.sub.1-C.sub.6)acylamino; R.sup.5 is a piperidinyl substituted by one to five carboxy, cyano, amino, deuterium, hydroxy, (C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy, halo, (C.sub.1-C.sub.6)acyl, (C.sub.1-C.sub.6)alkylamino, amino(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy-CO--NH, (C.sub.1-C.sub.6)alkylamino-CO--, (C.sub.2-C.sub.6)alkenyl, (C.sub.2-C.sub.6)alkynyl, (C.sub.1-C.sub.6)alkylamino, amino(C.sub.1-C.sub.6)alkyl, hydroxy(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)acyloxy(C.sub.1-C.sub.6)alkyl, nitro, cyano(C.sub.1-C.sub.6)alkyl, halo(C.sub.1-C.sub.6)alkyl, nitro(C.sub.1-C.sub.6)alkyl, trifluoromethyl, trifluoromethyl(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)acylamino, (C.sub.1-C.sub.6)acylamino(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy(C.sub.1-C.sub.6)acylamino, amino(C.sub.1-C.sub.6)acyl, amino(C.sub.1-C.sub.6)acyl(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkylamino(C.sub.1-C.sub.6)acyl, ((C.sub.1-C.sub.6)alkyl).sub.2amino(C.sub.1-C.sub.6)acyl, R.sup.15R.sup.16N--CO--O--, R.sup.15R.sup.16N--CO--(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkyl-S(O).sub.m, R.sup.15R.sup.16NS(O).sub.m, R.sup.15R.sup.16NS(O).sub.m(C.sub.1-C.sub.6)alkyl, R.sup.15S(O).sub.mR.sup.16N, R.sup.15S(O).sub.mR.sup.16N(C.sub.1-C.sub.6)alkyl wherein m is 0, 1 or 2 and R.sup.15 and R.sup.16 are each independently selected from hydrogen or (C.sub.1-C.sub.6)alkyl; or a group of the formula ##STR00012## wherein R.sup.12 is carboxy, cyano, amino, oxo, deuterium, hydroxy, trifluoromethyl, (C.sub.1-C.sub.6)alkyl, trifluoromethyl(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy, halo, (C.sub.1-C.sub.6)acyl, (C.sub.1-C.sub.6)alkylamino, ((C.sub.1-C.sub.6)alkyl).sub.2 amino, amino(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy-CO--NH, (C.sub.1-C.sub.6)alkylamino-CO--, (C.sub.2-C.sub.6)alkenyl, (C.sub.2-C.sub.6)alkynyl, (C.sub.1-C.sub.6)alkylamino, hydroxy(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)acyloxy(C.sub.1-C.sub.6)alkyl, nitro, cyano(C.sub.1-C.sub.6)alkyl, halo(C.sub.1-C.sub.6)alkyl, nitro(C.sub.1-C.sub.6)alkyl, trifluoromethyl, trifluoromethyl(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)acylamino, (C.sub.1-C.sub.6)acylamino(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy(C.sub.1-C.sub.6)acylamino, amino(C.sub.1-C.sub.6)acyl, amino(C.sub.1-C.sub.6)acyl(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkylamino(C.sub.1-C.sub.6)acyl, ((C.sub.1-C.sub.6)alkyl).sub.2amino(C.sub.1-C.sub.6)acyl, R.sup.15R.sup.16N--CO--O--, R.sup.15R.sup.16N--CO--(C.sub.1-C.sub.6)alkyl, R.sup.15C(O)NH, R.sup.15OC(O)NH, R.sup.15NHC(O)NH, (C.sub.1-C.sub.6)alkyl-S(O).sub.m, (C.sub.1-C.sub.6)alkyl-S(O).sub.m(C.sub.1-C.sub.6)alkyl, R.sup.15R.sup.16NS(O).sub.m, R.sup.15R.sup.16NS(O).sub.m(C.sub.1-C.sub.6)alkyl, R.sup.15S(O).sub.mR.sup.16N, R.sup.15S(O).sub.mR.sup.16N(C.sub.1-C.sub.6)alkyl wherein m is 0, 1 or 2 and R.sup.15 and R.sup.16 are each independently selected from hydrogen or (C.sub.1-C.sub.6)alkyl; R.sup.2 and R.sup.3 are each hydrogen.

2. A compound of the Formula I; ##STR00013## or a pharmaceutically acceptable salt thereof; wherein R.sup.1 is a group of the formula ##STR00014## wherein y is 0, 1 or 2; R.sup.4 is selected from the group consisting of hydrogen; (C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkylsulfonyl, (C.sub.2-C.sub.6)alkenyl, (C.sub.2-C.sub.6)alkynyl wherein the alkyl, alkenyl and alkynyl groups are optionally substituted by deuterium, hydroxy, amino, trifluoromethyl, (C.sub.1-C.sub.4)alkoxy, (C.sub.1-C.sub.6)acyloxy, (C.sub.1-C.sub.6)alkylamino, ((C.sub.1-C.sub.6)alkyl).sub.2amino, cyano, nitro, (C.sub.2-C.sub.6)alkenyl, (C.sub.2-C.sub.6)alkynyl or (C.sub.1-C.sub.6)acylamino; or R.sup.4 is (C.sub.3-C.sub.10)cycloalkyl wherein the cycloalkyl group is optionally substituted by deuterium, hydroxy, amino, trifluoromethyl, (C.sub.1-C.sub.6)acyloxy, (C.sub.1-C.sub.6)acylamino, (C.sub.1-C.sub.6)alkylamino, ((C.sub.1-C.sub.6)alkyl).sub.2amino, cyano, cyano(C.sub.1-C.sub.6)alkyl, trifluoromethyl(C.sub.1-C.sub.6)alkyl, nitro, nitro(C.sub.1-C.sub.6)alkyl or (C.sub.1-C.sub.6)acylamino; R.sup.5 is a piperidinyl substituted by one to five carboxy, cyano, amino, deuterium, hydroxy, (C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy, halo, (C.sub.1-C.sub.6)acyl, (C.sub.1-C.sub.6)alkylamino, amino(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy-CO--NH, (C.sub.1-C.sub.6)alkylamino-CO--, (C.sub.2-C.sub.6)alkenyl, (C.sub.2-C.sub.6)alkynyl, (C.sub.1-C.sub.6)alkylamino, amino(C.sub.1-C.sub.6)alkyl, hydroxy(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)acyloxy(C.sub.1-C.sub.6)alkyl, nitro, cyano(C.sub.1-C.sub.6)alkyl, halo(C.sub.1-C.sub.6)alkyl, nitro(C.sub.1-C.sub.6)alkyl, trifluoromethyl, trifluoromethyl(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)acylamino, (C.sub.1-C.sub.6)acylamino(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy(C.sub.1-C.sub.6)acylamino, amino(C.sub.1-C.sub.6)acyl, amino(C.sub.1-C.sub.6)acyl(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkylamino(C.sub.1-C.sub.6)acyl, ((C.sub.1-C.sub.6)alkyl).sub.2amino(C.sub.1-C.sub.6)acyl, R.sup.15R.sup.16N--CO--O--, R.sup.15R.sup.16N--CO--(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkyl-S(O).sub.m, R.sup.15R.sup.16NS(O).sub.m, R.sup.15R.sup.16NS(O).sub.m(C.sub.1-C.sub.6)alkyl, R.sup.15S(O).sub.mR.sup.16N, R.sup.15S(O).sub.mR.sup.16N(C.sub.1-C.sub.6)alkyl wherein m is 0, 1 or 2 and R.sup.15 and R.sup.16 are each independently selected from hydrogen or (C.sub.1-C.sub.6)alkyl; or a group of the formula ##STR00015## wherein R.sup.8 is selected from the group consisting of hydrogen or (C.sub.1-C.sub.6)alkyl optionally substituted by deuterium, hydroxy, amino, trifluoromethyl, (C.sub.1-C.sub.6)acyloxy, (C.sub.1-C.sub.6)acylamino, (C.sub.1-C.sub.6)alkylamino, ((C.sub.1-C.sub.6)alkyl).sub.2amino, cyano, cyano(C.sub.1-C.sub.6)alkyl, trifluoromethyl(C.sub.1-C.sub.6)alkyl, nitro, nitro(C.sub.1-C.sub.6)alkyl or (C.sub.1-C.sub.6)acylamino; R.sup.12 is carboxy, cyano, amino, oxo, deuterium, hydroxy, trifluoromethyl, (C.sub.1-C.sub.6)alkyl, trifluoromethyl(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy, halo, (C.sub.1-C.sub.6)acyl, (C.sub.1-C.sub.6)alkylamino, ((C.sub.1-C.sub.6)alkyl).sub.2amino, amino(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy-CO--NH, (C.sub.1-C.sub.6)alkylamino-CO--, (C.sub.2-C.sub.6)alkenyl, (C.sub.2-C.sub.6)alkynyl, (C.sub.1-C.sub.6)alkylamino, hydroxy(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)acyloxy(C.sub.1-C.sub.6)alkyl, nitro, cyano(C.sub.1-C.sub.6)alkyl, halo(C.sub.1-C.sub.6)alkyl, nitro(C.sub.1-C.sub.6)alkyl, trifluoromethyl, trifluoromethyl(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)acylamino, (C.sub.1-C.sub.6)acylamino(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy(C.sub.1-C.sub.6)acylamino, amino(C.sub.1-C.sub.6)acyl, amino(C.sub.1-C.sub.6)acyl(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkylamino(C.sub.1-C.sub.6)acyl, ((C.sub.1-C.sub.6)alkyl).sub.2amino(C.sub.1-C.sub.6)acyl, R.sup.15R.sup.16N--CO--O--, R.sup.15R.sup.16N--CO--(C.sub.1-C.sub.6)alkyl, R.sup.15C(O)NH, R.sup.15OC(O)NH, R.sup.15NHC(O)NH, (C.sub.1-C.sub.6)alkyl-S(O).sub.m, (C.sub.1-C.sub.6)alkyl-S(O).sub.m--(C.sub.1-C.sub.6)alkyl, R.sup.15R.sup.16NS(O).sub.m, R.sup.15R.sup.16NS(O).sub.m(C.sub.1-C.sub.6)alkyl, R.sup.15S(O).sub.mR.sup.16N, R.sup.15S(O).sub.mR.sup.16N(C.sub.1-C.sub.6)alkyl wherein m is 0, 1 or 2 and R.sup.15 and R.sup.16 are each independently selected from hydrogen or (C.sub.1-C.sub.6)alkyl R.sup.2 and R.sup.3 are each hydrogen.

3. A compound of the Formula I; ##STR00016## or a pharmaceutically acceptable salt thereof; wherein R.sup.1 is a group of the formula ##STR00017## wherein y is 0, 1 br 2; R.sup.4 selected from the group consisting of hydrogen, (C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkylsulfonyl, (C.sub.2-C.sub.6)alkenyl, (C.sub.2-C.sub.6)alkynyl wherein the alkyl, alkenyl and alkynyl groups are optionally substituted by deuterium, hydroxy, amino, trifluoromethyl, (C.sub.1-C.sub.4)alkoxy, (C.sub.1-C.sub.6)acyloxy, (C.sub.1-C.sub.6)alkylamino, ((C.sub.1-C.sub.6)alkyl).sub.2amino, cyano, nitro, (C.sub.2-C.sub.6)alkenyl, (C.sub.2-C.sub.6)alkynyl or (C.sub.1-C.sub.6)acylamino; or R.sup.4 is (C.sub.3-C.sub.10)cycloalkyl wherein the cycloalkyl group is optionally substituted by deuterium, hydroxy, amino, trifluoromethyl, (C.sub.1-C.sub.6)acyloxy, (C.sub.1-C.sub.6)acylamino, (C.sub.1-C.sub.6)alkylamino, ((C.sub.1-C.sub.6)alkyl).sub.2amino, cyano, cyano(C.sub.1-C.sub.6)alkyl, trifluoromethyl(C.sub.1-C.sub.6)alkyl, nitro, nitro(C.sub.1-C.sub.6)alkyl or (C.sub.1-C.sub.6)acylamino; R.sup.5 is a piperidinyl substituted by one to five carboxy, cyano, amino, deuterium, hydroxy, (C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy, halo, (C.sub.1-C.sub.6)acyl, (C.sub.1-C.sub.6)alkylamino, amino(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy-CO--NH, (C.sub.1-C.sub.6)alkylamino-CO--, (C.sub.2-C.sub.6)alkenyl, (C.sub.2-C.sub.6)alkynyl, (C.sub.1-C.sub.6)alkylamino, amino(C.sub.1-C.sub.6)alkyl, hydroxy(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)acyloxy(C.sub.1-C.sub.6)alkyl, nitro, cyano(C.sub.1-C.sub.6)alkyl, halo(C.sub.1-C.sub.6)alkyl, nitro(C.sub.1-C.sub.6)alkyl, trifluoromethyl, trifluoromethyl(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)acylamino, (C.sub.1-C.sub.6)acylamino(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy(C.sub.1-C.sub.6)acylamino, amino(C.sub.1-C.sub.6)acyl, amino(C.sub.1-C.sub.6)acyl(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkylamino(C.sub.1-C.sub.6)acyl, ((C.sub.1-C.sub.6)alkyl).sub.2amino(C.sub.1-C.sub.6)acyl, R.sup.15R.sup.16N--CO--O--, R.sup.15R.sup.16N--CO--(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkyl-S(O).sub.m, R.sup.15R.sup.16NS(O).sub.m, R.sup.15R.sup.16NS(O).sub.m(C.sub.1-C.sub.6)alkyl, R.sup.15S(O).sub.mR.sup.16N, R.sup.15S(O).sub.mR.sup.16N(C.sub.1-C.sub.6)alkyl wherein m is 0, 1 or 2 and R.sup.15 and R.sup.16 are each independently selected from hydrogen or (C.sub.1-C.sub.6)alkyl; or a group of the formula ##STR00018## wherein R.sup.8 is independently selected from the group consisting of hydrogen or (C.sub.1-C.sub.6)alkyl optionally substituted by deuterium, hydroxy, amino, trifluoromethyl, (C.sub.1-C.sub.6)acyloxy, (C.sub.1-C.sub.6)acylamino, (C.sub.1-C.sub.6)alkylamino, ((C.sub.1-C.sub.6)alkyl).sub.2amino, cyano, cyano(C.sub.1-C.sub.6)alkyl, trifluoromethyl(C.sub.1-C.sub.6)alkyl, nitro, nitro(C.sub.1-C.sub.6)alkyl or (C.sub.1-C.sub.6)acylamino; R.sup.12 is carboxy, cyano, amino, oxo, deuterium, hydroxy, trifluoromethyl, (C.sub.1-C.sub.6)alkyl, trifluoromethyl(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy, halo, (C.sub.1-C.sub.6)acyl, (C.sub.1-C.sub.6)alkylamino, ((C.sub.1-C.sub.6)alkyl).sub.2amino, amino(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy-CO--NH, (C.sub.1-C.sub.6)alkylamino-CO--, (C.sub.2-C.sub.6)alkenyl, (C.sub.2-C.sub.6)alkynyl, (C.sub.1-C.sub.6)alkylamino, hydroxy(C.sub.1-C.sub.6)alkyl, (C.sub.2-C.sub.6)alkoxy(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)acyloxy(C.sub.1-C.sub.6)alkyl, nitro, cyano(C.sub.1-C.sub.6)alkyl, halo(C.sub.1-C.sub.6)alkyl, nitro(C.sub.1-C.sub.6)alkyl, trifluoromethyl, trifluoromethyl(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)acylamino, (C.sub.1-C.sub.6)acylamino(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy(C.sub.1-C.sub.6)acylamino, amino(C.sub.1-C.sub.6)acyl, amino(C.sub.1-C.sub.6)acyl(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkylamino(C.sub.1-C.sub.6)acyl, ((C.sub.1-C.sub.6)alkyl).sub.2amino(C.sub.1-C.sub.6)acyl, R.sup.15R.sup.16N--CO--O--, R.sup.15R.sup.16N--CO--(C.sub.1-C.sub.6)alkyl, R.sup.15C(O)NH, R.sup.15OC(O)NH, R.sup.15NHC(O)NH, (C.sub.1-C.sub.6)alkyl-S(O).sub.m, (C.sub.1-C.sub.6)alkyl-S(O).sub.m-(C.sub.1-C.sub.6)alkyl, R.sup.15R.sup.16NS(O).sub.m, R.sup.15R.sup.16NS(O).sub.m(C.sub.1-C.sub.6)alkyl, R.sup.15S(O).sub.mR.sup.16N, R.sup.15S(O).sub.mR.sup.16N(C.sub.1-C.sub.6)alkyl wherein m is 0, 1 or 2 and R.sup.15 and R.sup.16 are each independently selected from hydrogen or (C.sub.1-C.sub.6)alkyl; R.sup.2 and R.sup.3 are each hydrogen.

4. A compound of the Formula I; ##STR00019## or a pharmaceutically acceptable salt thereof; wherein R.sup.1 is a group of the formula ##STR00020## wherein y is 0, 1 or 2; R.sup.4 is selected from the group consisting of hydrogen, (C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkylsulfonyl, (C.sub.2-C.sub.6)alkenyl, (C.sub.2-C.sub.6)alkynyl wherein the alkyl, alkenyl and alkynyl groups are optionally substituted by deuterium, hydroxy, amino, trifluoromethyl, (C.sub.1-C.sub.4)alkoxy, (C.sub.1-C.sub.6)acyloxy, (C.sub.1-C.sub.6)alkylamino, ((C.sub.1-C.sub.6)alkylamino, cyano, nitro, (C.sub.2-C.sub.6)alkenyl, (C.sub.2-C.sub.6)alkynyl or (C.sub.1-C.sub.6)acylamino; or R.sup.4 is (C.sub.3-C.sub.10)cycloalkyl wherein the cycloalkyl group is optionally substituted by deuterium, hydroxy, amino, trifluoromethyl, (C.sub.1-C.sub.6)acyloxy, (C.sub.1-C.sub.6)acylamino, (C.sub.1-C.sub.6)alkylamino, ((C.sub.1-C.sub.6)alkyl).sub.2amino, cyano, cyano(C.sub.1-C.sub.6)alkyl, trifluoromethyl(C.sub.1-C.sub.6)alkyl, nitro, nitro(C.sub.1-C.sub.6)alkyl or (C.sub.1-C.sub.6)acylamino; R.sup.5 is a piperidinyl substituted by one to five carboxy, cyano, amino, deuterium, hydroxy, (C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy, halo, (C.sub.1-C.sub.6)acyl, (C.sub.1-C.sub.6)alkylamino, amino(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy-CO--NH, (C.sub.1-C.sub.6)alkylamino-CO--, (C.sub.2-C.sub.6)alkenyl, (C.sub.2-C.sub.6)alkynyl, (C.sub.1-C.sub.6)alkylamino, amino(C.sub.1-C.sub.6)alkyl, hydroxy(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)acyloxy(C.sub.1-C.sub.6)alkyl, nitro, cyano(C.sub.1-C.sub.6)alkyl, halo(C.sub.1-C.sub.6)alkyl, nitro(C.sub.1-C.sub.6)alkyl, trifluoromethyl, trifluoromethyl(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)acylamino, (C.sub.1-C.sub.6)acylamino(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy(C.sub.1-C.sub.6)acylamino, amino(C.sub.1-C.sub.6)acyl, amino(C.sub.1-C.sub.6)acyl(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkylamino(C.sub.1-C.sub.6)acyl, ((C.sub.1-C.sub.6)alkyl).sub.2amino(C.sub.1-C.sub.6)acyl, R.sup.15R.sup.16N--CO--O--, R.sup.15R.sup.16N--CO--(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkyl-S(O).sub.m, R.sup.15R.sup.16NS(O).sub.m, R.sup.15R.sup.16NS(O).sub.m(C.sub.1-C.sub.6)alkyl, R.sup.15S(O).sub.mR.sup.16N, R.sup.15S(O).sub.mR.sup.16N(C.sub.1-C.sub.6)alkyl wherein m is 0, 1 or 2 and R.sup.15 and R.sup.16 are each independently selected from hydrogen or (C.sub.1-C.sub.6)alkyl; or a group of the formula ##STR00021## wherein R.sup.12 is carboxy, cyano, amino, oxo, deuterium, hydroxy, trifluoromethyl, (C.sub.1-C.sub.6)alkyl, trifluoromethyl(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy, halo, (C.sub.1-C.sub.6)acyl, (C.sub.1-C.sub.6)alkylamino, ((C.sub.1-C.sub.6)alkyl).sub.2 amino, amino(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy-CO--NH, (C.sub.1-C.sub.6)alkylamino-CO--, (C.sub.2-C.sub.6)alkenyl, (C.sub.2-C.sub.6)alkynyl, (C.sub.1-C.sub.6)alkylamino, hydroxy(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)acyloxy(C.sub.1-C.sub.6)alkyl, nitro, cyano(C.sub.1-C.sub.6)alkyl, halo(C.sub.1-C.sub.6)alkyl, nitro(C.sub.1-C.sub.6)alkyl, trifluoromethyl, trifluoromethyl(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)acylamino, (C.sub.1-C.sub.6)acylamino(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy(C.sub.1-C.sub.6)acylamino, amino(C.sub.1-C.sub.6)acyl, amino(C.sub.1-C.sub.6)acyl(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkylamino(C.sub.1-C.sub.6)acyl, ((C.sub.1-C.sub.6)alkyl).sub.2amino(C.sub.1-C.sub.6)acyl, R.sup.15R.sup.16N--CO--O--, R.sup.15R.sup.16N--CO--(C.sub.1-C.sub.6)alkyl, R.sup.15C(O)NH, R.sup.15OC(O)NH, R.sup.15NHC(O)NH, (C.sub.1-C.sub.6)alkyl-S(O).sub.m, (C.sub.1-C.sub.6)alkyl-S(O).sub.m-(C.sub.1-C.sub.6)alkyl, R.sup.15R.sup.16NS(O).sub.m, R.sup.15R.sup.16NS(O).sub.m(C.sub.1-C.sub.6)alkyl, R.sup.15S(O).sub.mR.sup.16N, R.sup.15S(O).sub.mR.sup.16N(C.sub.1-C.sub.6)alkyl wherein m is 0, 1 or 2 and R.sup.15 and R.sup.16 are each independently selected from hydrogen or (C.sub.1-C.sub.6)alkyl; R.sup.2and R.sup.3 are each hydrogen.

5. A compound of the Formula I; ##STR00022## or a pharmaceutically acceptable salt thereof; wherein R.sup.1 is a group of the formula ##STR00023## wherein y is 0, 1 or 2; R.sup.4 is selected from the group consisting of hydrogen, (C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkylsulfonyl, (C.sub.2-C.sub.6)alkenyl, (C.sub.2-C.sub.6)alkynyl wherein the alkyl, alkenyl and alkynyl groups are optionally substituted by deuterium, hydroxy, amino, trifluoromethyl, (C.sub.1-C.sub.4)alkoxy, (C.sub.1-C.sub.6)acyloxy, (C.sub.1-C.sub.6)alkylamino, ((C.sub.1-C.sub.6)alkyl).sub.2amino, cyano, nitro, (C.sub.2-C.sub.6)alkenyl, (C.sub.2-C.sub.6)alkynyl or (C.sub.1-C.sub.6)acylamino; or R.sup.4 is (C.sub.3-C.sub.10)cycloalkyl wherein the cycloalkyl group is optionally substituted by deuterium, hydroxy, amino, trifluoromethyl, (C.sub.1-C.sub.6)acyloxy, (C.sub.1-C.sub.6)acylamino, (C.sub.1-C.sub.6)alkylamino, ((C.sub.1-C.sub.6)alkyl).sub.2amino, cyano, cyano(C.sub.1-C.sub.6)alkyl, trifluoromethyl(C.sub.1-C.sub.6)alkyl, nitro, nitro(C.sub.1-C.sub.6)alkyl or (C.sub.1-C.sub.6)acylamino; R.sup.5 is a piperidinyl substituted by one to five carboxy, cyano, amino, deuterium, hydroxy, (C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy, halo, (C.sub.1-C.sub.6)acyl, (C.sub.1-C.sub.6)alkylamino, amino(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy-CO--NH, (C.sub.1-C.sub.6)alkylamino-CO--, (C.sub.2-C.sub.6)alkenyl, (C.sub.2-C.sub.6)alkynyl, (C.sub.1-C.sub.6)alkylamino, amino(C.sub.1-C.sub.6)alkyl, hydroxy(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)acyloxy(C.sub.1-C.sub.6)alkyl, nitro, cyano(C.sub.1-C.sub.6)alkyl, halo(C.sub.1-C.sub.6)alkyl, nitro(C.sub.1-C.sub.6)alkyl, trifluoromethyl, trifluoromethyl(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)acylamino, (C.sub.1-C.sub.6)acylamino(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy(C.sub.1-C.sub.6)acylamino, amino(C.sub.1-C.sub.6)acyl, amino(C.sub.1-C.sub.6)acyl(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkylamino(C.sub.1-C.sub.6)acyl, ((C.sub.1-C.sub.6)alkyl).sub.2amino(C.sub.1-C.sub.6)acyl, R.sup.15R.sup.16N--CO--O--, R.sup.15R.sup.16N--CO--(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkyl-S(O).sub.m, R.sup.15R.sup.16NS(O).sub.m, R.sup.15R.sup.16NS(O).sub.m(C.sub.1-C.sub.6)alkyl, R.sup.15S(O).sub.mR.sup.16N, R.sup.15S(O).sub.mR.sup.16N(C.sub.1-C.sub.6)alkyl wherein m is 0, 1 or 2 and R.sup.15 and R.sup.16 are each independently selected from hydrogen or (C.sub.1-C.sub.6)alkyl; or a group of the formula ##STR00024## wherein R.sup.12 is carboxy, cyano, amino, oxo, deuterium, hydroxy, trifluoromethyl, (C.sub.1-C.sub.6)alkyl, trifluoromethyl(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy, halo, (C.sub.1-C.sub.6)acyl, (C.sub.1-C.sub.6)alkylamino, ((C.sub.1-C.sub.6)alkyl).sub.2 amino, amino(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy-CO--NH, (C.sub.1-C.sub.6)alkylamino-CO--, (C.sub.2-C.sub.6)alkenyl, (C.sub.2-C.sub.6)alkynyl, (C.sub.1-C.sub.6)alkylamino, hydroxy(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)acyloxy(C.sub.1-C.sub.6)alkyl, nitro, cyano(C.sub.1-C.sub.6)alkyl, halo(C.sub.1-C.sub.6)alkyl, nitro(C.sub.1-C.sub.6)alkyl, trifluoromethyl, trifluoromethyl(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)acylamino, (C.sub.1-C.sub.6)acylamino(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy(C.sub.1-C.sub.6)acylamino, amino(C.sub.1-C.sub.6)acyl, amino(C.sub.1-C.sub.6)acyl(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkylamino(C.sub.1-C.sub.6)acyl, ((C.sub.1-C.sub.6)alkyl).sub.2amino(C.sub.1-C.sub.6)acyl, R.sup.15R.sup.16N--CO--O--, R.sup.15R.sup.16N--CO--(C.sub.1-C.sub.6)alkyl, R.sup.15C(O)NH, R.sup.15OC(O)NH, R.sup.15NHC(O)NH, (C.sub.1-C.sub.6)alkyl-S(O).sub.m, (C.sub.1-C.sub.6)alkyl-S(O).sub.m--(C.sub.1-C.sub.6)alkyl, R.sup.15R.sup.16NS(O).sub.m, R.sup.15R.sup.16NS(O).sub.m(C.sub.1-C.sub.6)alkyl, R.sup.15S(O).sub.mR.sup.16N, R.sup.15S(O).sub.mR.sup.16N(C.sub.1-C.sub.6)alkyl wherein m is 0, 1 or 2 and R.sup.15 and R.sup.16 are each independently selected from hydrogen or (C.sub.1-C.sub.6)alkyl; R.sup.2 and R.sup.3 are each hydrogen.

6. A compound of the Formula I; ##STR00025## or a pharmaceutically acceptable salt thereof; wherein R.sup.1 is a group of the formula ##STR00026## wherein y is 0, 1 or 2; R.sup.4 is selected from the group consisting of hydrogen, (C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkylsulfonyl, (C.sub.2-C.sub.6)alkenyl, (C.sub.2-C.sub.6)alkynyl wherein the alkyl, alkenyl and alkynyl groups are, optionally substituted by deuterium, hydroxy, amino, trifluoromethyl, (C.sub.1-C.sub.4)alkoxy, (C.sub.1-C.sub.6)acyloxy, (C.sub.1-C.sub.6)alkylamino, ((C.sub.1-C.sub.6)alkyl).sub.2amino, cyano, nitro, (C.sub.2-C.sub.6)alkenyl, (C.sub.2-C.sub.6)alkynyl or (C.sub.1-C.sub.6)acylamino; or R.sup.4 is (C.sub.3-C.sub.10)cycloalkyl wherein the cycloalkyl group is optionally substituted by deuterium, hydroxy, amino, trifluoromethyl, (C.sub.1-C.sub.6)acyloxy, (C.sub.1-C.sub.6)acylamino, (C.sub.1-C.sub.6)alkylamino, ((C.sub.1-C.sub.6)alkyl).sub.2amino, cyano, cyano(C.sub.1-C.sub.6)alkyl, trifluoromethyl(C.sub.1-C.sub.6)alkyl, nitro, nitro(C.sub.1-C.sub.6)alkyl or (C.sub.1-C.sub.6)acylamino; R.sup.5 is a piperidinyl substituted by one to five carboxy, cyano, amino, deuterium, hydroxy, (C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy, halo, (C.sub.1-C.sub.6)acyl, (C.sub.1-C.sub.6)alkylamino, amino(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy-CO--NH, (C.sub.1-C.sub.6)alkylamino-CO--, (C.sub.2-C.sub.6)alkenyl, (C.sub.2-C.sub.6)alkynyl, (C.sub.1-C.sub.6)alkylamino, amino(C.sub.1-C.sub.6)alkyl, hydroxy(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)acyloxy(C.sub.1-C.sub.6)alkyl, nitro, cyano(C.sub.1-C.sub.6)alkyl, halo(C.sub.1-C.sub.6)alkyl, nitro(C.sub.1-C.sub.6)alkyl, trifluoromethyl, trifluoromethyl(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)acylamino, (C.sub.1-C.sub.6)acylamino(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy(C.sub.1-C.sub.6)acylamino, amino(C.sub.1-C.sub.6)acyl, amino(C.sub.1-C.sub.6)acyl(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkylamino(C.sub.1-C.sub.6)acyl, ((C.sub.1-C.sub.6)alkyl).sub.2amino(C.sub.1-C.sub.6)acyl, R.sup.15R.sup.16N--CO--O--, R.sup.15R.sup.16N--CO--(C.sub.1-C.sub.6)alkyl, C.sub.1-C.sub.6)alkyl-S(O).sub.m, R.sup.15R.sup.16NS(O).sub.m, R.sup.15R.sup.16NS(O).sub.m(C.sub.1-C.sub.6)alkyl, R.sup.15S(O).sub.mR.sup.16N, R.sup.15S(O).sub.mR.sup.16N(C.sub.1-C.sub.6)alkyl wherein m is 0, 1 or 2 and R.sup.15 and R.sup.16 are each independently selected from hydrogen or (C.sub.1-C.sub.6)alkyl; or a group of the formula ##STR00027## wherein d is 2; R.sup.9, R.sup.10, and R.sup.11 are each independently selected from the group consisting of hydrogen or (C.sub.1-C.sub.6)alkyl optionally substituted by deuterium, hydroxy, amino, trifluoromethyl, (C.sub.1-C.sub.6)acyloxy, (C.sub.1-C.sub.6)acylamino, (C.sub.1-C.sub.6)alkylamino, ((C.sub.1-C.sub.6)alkyl).sub.2amino, cyano, cyano(C.sub.1-C.sub.6)alkyl, trifluoromethyl(C.sub.1-C.sub.6)alkyl, nitro, nitro(C.sub.1-C.sub.6)alkyl or (C.sub.1-C.sub.6)acylamino; R.sup.12 is carboxy, cyano, amino, oxo, deuterium, hydroxy, trifluoromethyl, (C.sub.1-C.sub.6)alkyl, trifluoromethyl(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy, halo, (C.sub.1-C.sub.6)acyl, (C.sub.1-C.sub.6)alkylamino, ((C.sub.1-C.sub.6)alkyl).sub.2amino, amino(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy-CO--NH, (C.sub.1-C.sub.6)alkylamino-CO--, (C.sub.2-C.sub.6)alkenyl, (C.sub.2-C.sub.6)alkynyl, (C.sub.1-C.sub.6)alkylamino, hydroxy(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)acyloxy(C.sub.1-C.sub.6)alkyl, nitro, cyano(C.sub.1-C.sub.6)alkyl, halo(C.sub.1-C.sub.6)alkyl, nitro(C.sub.1-C.sub.6)alkyl, trifluoromethyl, trifluoromethyl(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)acylamino, (C.sub.1-C.sub.6)acylamino(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy(C.sub.1-C.sub.6)acylamino, amino(C.sub.1-C.sub.6)acyl, amino(C.sub.1-C.sub.6)acyl(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkylamino(C.sub.1-C.sub.6)acyl, ((C.sub.1-C.sub.6)alkyl).sub.2amino(C.sub.1-C.sub.6)acyl, R.sup.15R.sup.16N--CO--O--, R.sup.15R.sup.16N--CO--(C.sub.1-C.sub.6)alkyl, R.sup.15C(O)NH, R.sup.15OC(O)NH, R.sup.15NHC(O)NH, (C.sub.1-C.sub.6)alkyl-S(O).sub.m, (C.sub.1-C.sub.6)alkyl-S(O).sub.m-(C.sub.1-C.sub.6)alkyl, R.sup.15R.sup.16NS(O).sub.m, R.sup.15R.sup.16NS(O).sub.m(C.sub.1-C.sub.6)alkyl, R.sup.15S(O).sub.mR.sup.16N, R.sup.15S(O).sub.mR.sup.16N(C.sub.1-C.sub.6)alkyl wherein m is 0, 1 or 2 and R.sup.15 and R.sup.16 are each independently selected from hydrogen or (C.sub.1-C.sub.6)alkyl; R.sup.2 and R.sup.3 are each hydrogen.

7. A compound of the Formula I; ##STR00028## or a pharmaceutically acceptable salt thereof; wherein R.sup.1 is a group of the formula ##STR00029## wherein y is 0, 1 or 2; R.sup.4 is selected from the group consisting of hydrogen, (C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkylsulfonyl, (C.sub.2-C.sub.6)alkenyl, (C.sub.2-C.sub.6)alkynyl wherein the alkyl, alkenyl and alkynyl groups are optionally substituted by deuterium, hydroxy, amino, trifluoromethyl, (C.sub.1-C.sub.4)alkoxy, (C.sub.1-C.sub.6)acyloxy, (C.sub.1-C.sub.6)alkylamino, ((C.sub.1-C.sub.6)alkyl).sub.2amino, cyano, nitro, (C.sub.2-C.sub.6)alkenyl, (C.sub.2-C.sub.6)alkynyl or (C.sub.1-C.sub.6)acylamino; or R.sup.4 is (C.sub.3-C.sub.10)cycloalkyl wherein the cycloalkyl group is optionally substituted by deuterium, hydroxy, amino, trifluoromethyl, (C.sub.1-C.sub.6)acyloxy, (C.sub.1-C.sub.6)acylamino, (C.sub.1-C.sub.6)alkylamino, ((C.sub.1-C.sub.6)alkyl).sub.2amino, cyano, cyano(C.sub.1-C.sub.6)alkyl, trifluoromethyl(C.sub.1-C.sub.6)alkyl, nitro, nitro(C.sub.1-C.sub.6)alkyl or (C.sub.1-C.sub.6)acylamino; R.sup.5 is a piperidinyl substituted by one to five carboxy, cyano, amino, deuterium, hydroxy, (C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy, halo, (C.sub.1-C.sub.6)acyl, (C.sub.1-C.sub.6)alkylamino, amino(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy-CO--NH, (C.sub.1-C.sub.6)alkylamino-CO--, (C.sub.2-C.sub.6)alkenyl, (C.sub.2-C.sub.6)alkynyl, (C.sub.1-C.sub.6)alkylamino, amino(C.sub.1-C.sub.6)alkyl, hydroxy(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy(C.sub.1-C.sub.6)alkyl, C.sub.1-C.sub.6)acyloxy(C.sub.1-C.sub.6)alkyl, nitro, cyano(C.sub.1-C.sub.6)alkyl, halo(C.sub.1-C.sub.6)alkyl, nitro(C.sub.1-C.sub.6)alkyl, trifluoromethyl, trifluoromethyl(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)acylamino, (C.sub.1-C.sub.6)acylamino(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy(C.sub.1-C.sub.6)acylamino, amino(C.sub.1-C.sub.6)acyl, amino(C.sub.1-C.sub.6)acyl(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkylamino(C.sub.1-C.sub.6)acyl, ((C.sub.1-C.sub.6)alkyl).sub.2amino(C.sub.1-C.sub.6)acyl, R.sup.15R.sup.16N--CO--O--, R.sup.15R.sup.16N--CO--(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkyl-S(O).sub.m, R.sup.15R.sup.16NS(O).sub.m, R.sup.15R.sup.16NS(O).sub.m(C.sub.1-C.sub.6)alkyl, R.sup.15S(O).sub.mR.sup.16N, R.sup.15S(O).sub.mR.sup.16N(C.sub.1-C.sub.6)alkyl wherein m is 0, 1 or 2 and R.sup.15 and R.sup.16 are each independently selected from hydrogen or (C.sub.1-C.sub.6)alkyl; or a group of the formula ##STR00030## wherein d is 2; R.sup.9, R.sup.10, and R.sup.11 are each independently selected from the group consisting of hydrogen or (C.sub.1-C.sub.6)alkyl optionally substituted by deuterium, hydroxy, amino, trifluoromethyl, (C.sub.1-C.sub.6)acyloxy, (C.sub.1-C.sub.6)acylamino, (C.sub.1-C.sub.6)alkylamino, ((C.sub.1-C.sub.6)alkyl).sub.2amino, cyano, cyano(C.sub.1-C.sub.6)alkyl, trifluoromethyl(C.sub.1-C.sub.6)alkyl, nitro, nitro(C.sub.1-C.sub.6)alkyl or (C.sub.1-C.sub.6)acylamino; R.sup.12 is carboxy, cyano, amino, oxo, deuterium, hydroxy, trifluoromethyl, (C.sub.1-.sub.6)alkyl, trifluoromethyl(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy, halo, (C.sub.1-C.sub.6)acyl, (C.sub.1-C.sub.6)alkylamino, ((C.sub.1-C.sub.6)alkyl).sub.2amino, amino(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy-CO--NH, (C.sub.1-C.sub.6)alkylamino-CO--, (C.sub.2-C.sub.6)alkenyl, (C.sub.2-C.sub.6)alkynyl, (C.sub.1-C.sub.6)alkylamino, hydroxy(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)acyloxy(C.sub.1-C.sub.6)alkyl, nitro, cyano(C.sub.1-C.sub.6)alkyl, halo(C.sub.1-C.sub.6)alkyl, nitro(C.sub.1-C.sub.6)alkyl, trifluoromethyl, trifluoromethyl(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)acylamino, (C.sub.1-C.sub.6)acylamino(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy(C.sub.1-C.sub.6)acylamino, amino(C.sub.1-C.sub.6)acyl, amino(C.sub.1-C.sub.6)acyl(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkylamino(C.sub.1-C.sub.6)acyl, ((C.sub.1-C.sub.6)alkyl).sub.2amino(C.sub.1-C.sub.6)acyl, R.sup.15R.sup.16N--CO--O--, R.sup.15R.sup.16N--CO--(C.sub.1-C.sub.6)alkyl, R.sup.15C(O)NH, R.sup.15OC(O)NH, R.sup.15NHC(O)NH, (C.sub.1-C.sub.6)alkyl-S(O).sub.m, (C.sub.1-C.sub.6)alkyl-S(O).sub.m-(C.sub.1-C.sub.6)alkyl, R.sup.15R.sup.16NS(O).sub.m, R.sup.15R.sup.16NS(O).sub.m(C.sub.1-C.sub.6)alkyl, R.sup.15S(O).sub.mR.sup.16N, R.sup.15S(O).sub.mR.sup.16N(C.sub.1-C.sub.6)alkyl wherein m is 0, 1 or 2 and R.sup.15 and R.sup.16 are each independently selected from hydrogen or (C.sub.1-C.sub.6)alkyl; R.sup.2 and R.sup.3 are each hydrogen.

8. A compound of the Formula I; ##STR00031## or a pharmaceutically acceptable salt thereof; wherein R.sup.1 is a group of the formula ##STR00032## wherein y is 0, 1 or 2; R.sup.4 is selected from the group consisting of hydrogen, (C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkylsulfonyl, (C.sub.2-C.sub.6)alkenyl, (C.sub.2-C.sub.6)alkynyl wherein the alkyl, alkenyl and alkynyl groups are optionally substituted by deuterium, hydroxy, amino, trifluoromethyl, (C.sub.1-C.sub.4)alkoxy, (C.sub.1-C.sub.6)acyloxy, (C.sub.1-C.sub.6)alkylamino, ((C.sub.1-C.sub.6)alkyl).sub.2amino, cyano, nitro, (C.sub.2-C.sub.6)alkenyl, (C.sub.2-C.sub.6)alkynyl or (C.sub.1-C.sub.6)acylamino; or R.sup.4 is (C.sub.3-C.sub.10)cycloalkyl wherein the cycloalkyl group is optionally substituted by deuterium, hydroxy, amino, trifluoromethyl, (C.sub.1-C.sub.6)acyloxy, (C.sub.1-C.sub.6)acylamino, (C.sub.1-C.sub.6)alkylamino, ((C.sub.1-C.sub.6)alkyl).sub.2amino, cyano, cyano(C.sub.1-C.sub.6)alkyl, trifluoromethyl(C.sub.1-C.sub.6)alkyl, nitro, nitro(C.sub.1-C.sub.6)alkyl or (C.sub.1-C.sub.6)acylamino; R.sup.5 is a piperidinyl substituted by one to five carboxy, cyano, amino, deuterium, hydroxy, (C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy, halo, (C.sub.1-C.sub.6)acyl, (C.sub.1-C.sub.6)alkylamino, amino(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy-CO--NH, (C.sub.1-C.sub.6)alkylamino-CO--, (C.sub.2-C.sub.6)alkenyl, (C.sub.2-C.sub.6)alkynyl, (C.sub.1-C.sub.6)alkylamino, amino(C.sub.1-C.sub.6)alkyl, hydroxy(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)acyloxy(C.sub.1-C.sub.6)alkyl, nitro, cyano(C.sub.1-C.sub.6)alkyl, halo(C.sub.1-C.sub.6)alkyl, nitro(C.sub.1-C.sub.6)alkyl, trifluoromethyl, trifluoromethyl(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)acylamino, (C.sub.1-C.sub.6)acylamino(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy(C.sub.1-C.sub.6)acylamino, amino(C.sub.1-C.sub.6)acyl, amino(C.sub.1-C.sub.6)acyl(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkylamino(C.sub.1-C.sub.6)acyl, ((C.sub.1-C.sub.6)alkyl).sub.2amino(C.sub.1-C.sub.6)acyl, R.sup.15R.sup.16N--CO--O--, R.sup.15R.sup.16N--CO--(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkyl-S(O).sub.m, R.sup.15R.sup.16NS(O).sub.m, R.sup.15R.sup.16NS(O).sub.m(C.sub.1-C.sub.6)alkyl, R.sup.15S(O).sub.mR.sup.16N, R.sup.15S(O).sub.mR.sup.16N(C.sub.1-C.sub.6)alkyl wherein m is 0, 1 or 2 and R.sup.15 and R.sup.16 are each independently selected from hydrogen or (C.sub.1-C.sub.6)alkyl; or a group of the formula ##STR00033## wherein R.sup.8 is selected from the group consisting of hydrogen or (C.sub.1-C.sub.6)alkyl optionally substituted by deuterium, hydroxy, amino, trifluoromethyl, (C.sub.1-C.sub.6)acyloxy, (C.sub.1-C.sub.6)acylamino, (C.sub.1-C.sub.6)alkylamino, ((C.sub.1-C.sub.6)alkyl).sub.2amino, cyano, cyano(C.sub.1-C.sub.6)alkyl, trifluoromethyl(C.sub.1-C.sub.6)alkyl, nitro, nitro(C.sub.1-C.sub.6)alkyl or (C.sub.1-C.sub.6)acylamino; R.sup.12 is carboxy, cyano, amino, oxo, deuterium, hydroxy, trifluoromethyl, (C.sub.1-C.sub.6)alkyl, trifluoromethyl(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy, halo, (C.sub.1-C.sub.6)acyl, (C.sub.1-C.sub.6)alkylamino, ((C.sub.1-C.sub.6)alkyl).sub.2amino, amino(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy-CO--NH, (C.sub.1-C.sub.6)alkylamino-CO--, (C.sub.2-C.sub.6)alkenyl, (C.sub.2-C.sub.6)alkynyl, (C.sub.1-C.sub.6)alkylamino, hydroxy(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)acyloxy(C.sub.1-C.sub.6)alkyl, nitro, cyano(C.sub.1-C.sub.6)alkyl, halo(C.sub.1-C.sub.6)alkyl, nitro(C.sub.1-C.sub.6)alkyl, trifluoromethyl, trifluoromethyl(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)acylamino, (C.sub.1-C.sub.6)acylamino(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy(C.sub.1-C.sub.6)acylamino, amino(C.sub.1-C.sub.6)acyl, amino(C.sub.1-C.sub.6)acyl(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkylamino(C.sub.1-C.sub.6)acyl, ((C.sub.1-C.sub.6)alkyl).sub.2amino(C.sub.1-C.sub.6)acyl, R.sup.15R.sup.16N--CO--O--, R.sup.15R.sup.16N--CO--(C.sub.1-C.sub.6)alkyl, R.sup.15C(O)NH, R.sup.15OC(O)NH, R.sup.15NHC(O)NH, (C.sub.1-C.sub.6)alkyl-S(O).sub.m, (C.sub.1-C.sub.6)alkyl-S(O).sub.m-(C.sub.1-C.sub.6)alkyl, R.sup.15R.sup.16NS(O).sub.m, R.sup.15R.sup.16NS(O).sub.m(C.sub.1-C.sub.6)alkyl, R.sup.15S(O).sub.mR.sup.16N, R.sup.15S(O).sub.mR.sup.16N(C.sub.1-C.sub.6)alkyl wherein m is 0, 1 or 2 and R.sup.15 and R.sup.16 are each independently selected from hydrogen or (C.sub.1-C.sub.6)alkyl; R.sup.2 and R.sup.3 are each hydrogen.

9. A compound of the Formula I; ##STR00034## or a pharmaceutically acceptable salt thereof; wherein R.sup.1 is a group of the formula ##STR00035## wherein y is 0, 1 or 2; R.sup.4 is selected from the group consisting of hydrogen, (C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkylsulfonyl, (C.sub.2-C.sub.6)alkenyl, (C.sub.2-C.sub.6)alkynyl wherein the alkyl, alkenyl and alkynyl groups are optionally substituted by deuterium, hydroxy, amino, trifluoromethyl, (C.sub.1-C.sub.4)alkoxy, (C.sub.1-C.sub.6)acyloxy, (C.sub.1-C.sub.6)alkylamino, ((C.sub.1-C.sub.6)alkyl).sub.2amino, cyano, nitro, (C.sub.2-C.sub.6)alkenyl, (C.sub.2-C.sub.6)alkynyl or (C.sub.2-C.sub.6)acylamino; or R.sup.4 is (C.sub.3-C.sub.10)cycloalkyl wherein the cycloalkyl group is optionally substituted by deuterium, hydroxy, amino, trifluoromethyl, (C.sub.1-C.sub.6)acyloxy, (C.sub.1-C.sub.6)acylamino, (C.sub.1-C.sub.6)alkylamino, ((C.sub.1-C.sub.6)alkyl).sub.2amino, cyano, cyano(C.sub.1-C.sub.6)alkyl, trifluoromethyl(C.sub.1-C.sub.6)alkyl, nitro, nitro(C.sub.1-C.sub.6)alkyl or (C.sub.1-C.sub.6)acylamino; R.sup.5 is a piperidinyl substituted by one to five carboxy, cyano, amino, deuterium, hydroxy, (C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy, halo, (C.sub.1-C.sub.6)acyl, (C.sub.1-C.sub.6)alkylamino, amino(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy-CO--NH, (C.sub.1-C.sub.6)alkylamino-CO--, (C.sub.2-C.sub.6)alkenyl, (C.sub.2-C.sub.6)alkynyl, (C.sub.1-C.sub.6)alkylamino, amino(C.sub.1-C.sub.6)alkyl, hydroxy(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)acyloxy(C.sub.1-C.sub.6)alkyl, nitro, cyano(C.sub.1-C.sub.6)alkyl, halo(C.sub.1-C.sub.6)alkyl, nitro(C.sub.1-C.sub.6)alkyl, trifluoromethyl, trifluoromethyl(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)acylamino, (C.sub.1-C.sub.6)acylamino(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy(C.sub.1-C.sub.6)acylamino, amino(C.sub.1-C.sub.6)acyl, amino(C.sub.1-C.sub.6)acyl(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkylamino(C.sub.1-C.sub.6)acyl, ((C.sub.1-C.sub.6)alkyl).sub.2amino(C.sub.1-C.sub.6)acyl, R.sup.15R.sup.16N--CO--O--, R.sup.15R.sup.16N--CO--(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkyl-S(O).sub.m, R.sup.15R.sup.16NS(O).sub.m, R.sup.15R.sup.16NS(O).sub.m(C.sub.1-C.sub.6)alkyl, R.sup.15S(O).sub.mR.sup.16N, R.sup.15S(O).sub.mR.sup.16N(C.sub.1-C.sub.6)alkyl wherein m is 0, 1 or 2 and R.sup.15 and R.sup.16 are each independently selected from hydrogen or (C.sub.1-C.sub.6)alkyl; or a group of the formula ##STR00036## wherein R.sup.8 is selected from the group consisting of hydrogen or (C.sub.1-C.sub.6)alkyl optionally substituted by deuterium, hydroxy, amino, trifluoromethyl, (C.sub.1-C.sub.6)acyloxy, (C.sub.1-C.sub.6)acylamino, (C.sub.1-C.sub.6)alkylamino, ((C.sub.1-C.sub.6)alkyl).sub.2amino, cyano, cyano(C.sub.1-C.sub.6)alkyl, trifluoromethyl(C.sub.1-C.sub.6)alkyl, nitro, nitro(C.sub.1-C.sub.6)alkyl or (C.sub.1-C.sub.6)acylamino; R.sup.12 is carboxy, cyano, amino, oxo, deuterium, hydroxy, trifluoromethyl, (C.sub.1-C.sub.6)alkyl, trifluoromethyl(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy, halo, (C.sub.1-C.sub.6)acyl, (C.sub.1-C.sub.6)alkylamino, ((C.sub.1-C.sub.6)alkyl).sub.2amino, amino(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy-CO--NH, (C.sub.1-C.sub.6)alkylamino-CO--, (C.sub.2-C.sub.6)alkenyl, (C.sub.2-C.sub.6)alkynyl, (C.sub.1-C.sub.6)alkylamino, hydroxy(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)acyloxy(C.sub.1-C.sub.6)alkyl, nitro, cyano(C.sub.1-C.sub.6)alkyl, halo(C.sub.1-C.sub.6)alkyl, nitro(C.sub.1-C.sub.6)alkyl, trifluoromethyl, trifluoromethyl(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)acylamino, (C.sub.1-C.sub.6)acylamino(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy(C.sub.1-C.sub.6)acylamino, amino(C.sub.1-C.sub.6)acyl, amino(C.sub.1-C.sub.6)acyl(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkylamino(C.sub.1-C.sub.6)acyl, ((C.sub.1-C.sub.6)alkyl).sub.2amino(C.sub.1-C.sub.6)acyl, R.sup.15R.sup.16N--CO--O--, R.sup.15R.sup.16N--CO--(C.sub.1-C.sub.6)alkyl, R.sup.15C(O)NH, R.sup.15OC(O)NH, R.sup.15NHC(O)NH, (C.sub.1-C.sub.6)alkyl-S(O).sub.m, (C.sub.1-C.sub.6)alkyl-S(O).sub.m--(C.sub.1-C.sub.6)alkyl, R.sup.15R.sup.16NS(O).sub.m, R.sup.15R.sup.16NS(O).sub.m(C.sub.1-C.sub.6)alkyl, R.sup.15S(O).sub.mR.sup.16N, R.sup.15S(O).sub.mR.sup.16N(C.sub.1-C.sub.6)alkyl wherein m is 0, 1 or 2 and R.sup.15 and R.sup.16 are each independently selected from hydrogen or (C.sub.1-C.sub.6)alkyl; R.sup.2 and R.sup.3 are each hydrogen.

10. A compound of the Formula I; ##STR00037## or a pharmaceutically acceptable salt thereof; wherein R.sup.1 is a group of the formula ##STR00038## wherein y is 0, 1 or 2; R.sup.4 is selected from the group consisting of hydrogen, (C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkylsulfonyl, (C.sub.2-C.sub.6)alkenyl, (C.sub.2-C.sub.6)alkynyl wherein the alkyl, alkenyl and alkynyl groups are optionally substituted by deuterium, hydroxy, amino, trifluoromethyl, (C.sub.1-C.sub.4)alkoxy, (C.sub.1-C.sub.6)acyloxy, (C.sub.1-C.sub.6)alkylamino, ((C.sub.1-C.sub.6)alkyl).sub.2amino, cyano, nitro, (C.sub.2-C.sub.6)alkenyl, (C.sub.2-C.sub.6)alkynyl or (C.sub.1-C.sub.6)acylamino; or R.sup.4 is (C.sub.3-C.sub.10)cycloalkyl wherein the cycloalkyl group is optionally substituted by deuterium, hydroxy, amino, trifluoromethyl, (C.sub.1-C.sub.6)acyloxy, (C.sub.1-C.sub.6)acylamino, (C.sub.1-C.sub.6)alkylamino, ((C.sub.1-C.sub.6)alkyl).sub.2amino, cyano, cyano(C.sub.1-C.sub.6)alkyl, trifluoromethyl(C.sub.1-C.sub.6)alkyl, nitro, nitro(C.sub.1-C.sub.6)alkyl or (C.sub.1-C.sub.6)acylamino; R.sup.5 is a piperidinyl substituted by one to five carboxy, cyano, amino, deuterium, hydroxy, (C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy, halo, (C.sub.1-C.sub.6)acyl, (C.sub.1-C.sub.6)alkylamino, amino(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy-CO--NH, (C.sub.1-C.sub.6)alkylamino-CO--, (C.sub.2-C.sub.6)alkenyl, (C.sub.2-C.sub.6)alkynyl, (C.sub.1-C.sub.6)alkylamino, amino(C.sub.1-C.sub.6)alkyl, hydroxy(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)acyloxy(C.sub.1-C.sub.6)alkyl, nitro, cyano(C.sub.1-C.sub.6)alkyl, halo(C.sub.1-C.sub.6)alkyl, nitro(C.sub.1-C.sub.6)alkyl, trifluoromethyl, trifluoromethyl(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)acylamino, (C.sub.1-C.sub.6)acylamino(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy(C.sub.1-C.sub.6)acylamino, amino(C.sub.1-C.sub.6)acyl, amino(C.sub.1-C.sub.6)acyl(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkylamino(C.sub.1-C.sub.6)acyl, ((C.sub.1-C.sub.6)alkyl).sub.2amino(C.sub.1-C.sub.6)acyl, R.sup.15R.sup.16N--CO--O--, R.sup.15R.sup.16N--CO--(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkyl-S(O).sub.m, R.sup.15R.sup.16NS(O).sub.m, R.sup.15R.sup.16NS(O).sub.m(C.sub.1-C.sub.6)alkyl, R.sup.15S(O).sub.mR.sup.16N, R.sup.15S(O).sub.mR.sup.16N(C.sub.1-C.sub.6)alkyl wherein m is 0, 1 or 2 and R.sup.15 and R.sup.16 are each independently selected from hydrogen or (C.sub.1-C.sub.6)alkyl; or a group of the formula ##STR00039## wherein R.sup.6, R.sup.7, and R.sup.8 are each independently selected from the group consisting of hydrogen or (C.sub.1-C.sub.6)alkyl optionally substituted by deuterium, hydroxy, amino, trifluoromethyl, (C.sub.1-C.sub.6)acyloxy, (C.sub.1-C.sub.6)acylamino, (C.sub.1-C.sub.6)alkylamino, ((C.sub.1-C.sub.6)alkyl).sub.2amino, cyano, cyano(C.sub.1-C.sub.6)alkyl, trifluoromethyl(C.sub.1-C.sub.6)alkyl, nitro, nitro(C.sub.1-C.sub.6)alkyl or (C.sub.1-C.sub.6)acylamino; R.sup.12 is carboxy, cyano, amino, oxo, deuterium, hydroxy, trifluoromethyl, (C.sub.1-C.sub.6)alkyl, trifluoromethyl(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy, halo, (C.sub.1-C.sub.6)acyl, (C.sub.1-C.sub.6)alkylamino, ((C.sub.1-C.sub.6)alkyl).sub.2 amino, amino(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy-CO--NH, (C.sub.1-C.sub.6)alkylamino-CO--, (C.sub.2-C.sub.6)alkenyl, (C.sub.2-C.sub.6)alkynyl, (C.sub.1-C.sub.6)alkylamino, hydroxy(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)acyloxy(C.sub.1-C.sub.6)alkyl, nitro, cyano(C.sub.1-C.sub.6)alkyl, halo(C.sub.1-C.sub.6)alkyl, nitro(C.sub.1-C.sub.6)alkyl, trifluoromethyl, trifluoromethyl(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)acylamino, (C.sub.1-C.sub.6)acylamino(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy(C.sub.1-C.sub.6)acylamino, amino(C.sub.1-C.sub.6)acyl, amino(C.sub.1-C.sub.6)acyl(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkylamino(C.sub.1-C.sub.6)acyl, ((C.sub.1-C.sub.6)alkyl).sub.2amino(C.sub.1-C.sub.6)acyl, R.sup.15R.sup.16N--CO--O--, R.sup.15R.sup.16N--CO--(C.sub.1-C.sub.6)alkyl, R.sup.15C(O)NH, R.sup.15OC(O)NH, R.sup.15NHC(O)NH, (C.sub.1-C.sub.6)alkyl-S(O).sub.m, (C.sub.1-C.sub.6)alkyl-S(O).sub.m-(C.sub.1-C.sub.6)alkyl, R.sup.15R.sup.16NS(O).sub.m, R.sup.15R.sup.16NS(O).sub.m(C.sub.1-C.sub.6)alkyl, R.sup.15S(O).sub.mR.sup.16N, R.sup.15S(O).sub.mR.sup.16N(C.sub.1-C.sub.6)alkyl wherein m is 0, 1 or 2 and R.sup.15 and R.sup.16 are each independently selected from hydrogen or (C.sub.1-C.sub.6)alkyl; R.sup.2 and R.sup.3 are each hydrogen.

11. A compound of the Formula I; ##STR00040## or a pharmaceutically acceptable salt thereof; wherein R.sup.1 is a group of the formula ##STR00041## wherein y is 0, 1 or 2; R.sup.4 is selected from the group consisting of hydrogen, (C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkylsulfonyl, (C.sub.2-C.sub.6)alkenyl, (C.sub.2-C.sub.6)alkynyl wherein the alkyl, alkenyl and alkynyl groups are optionally substituted by deuterium, hydroxy, amino, trifluoromethyl, (C.sub.1-C.sub.4)alkoxy, (C.sub.1-C.sub.6)acyloxy, (C.sub.1-C.sub.6)alkylamino, ((C.sub.1-C.sub.6)alkyl).sub.2amino, cyano, nitro, (C.sub.2-C.sub.6)alkenyl, (C.sub.2-C.sub.6)alkynyl or C.sub.1-C.sub.6)acylamino; or R.sup.4 is (C.sub.3-C.sub.10)cycloalkyl wherein the cycloalkyl group is optionally substituted by deuterium, hydroxy, amino, trifluoromethyl, (C.sub.1-C.sub.6)acyloxy, (C.sub.1-C.sub.6)acylamino, (C.sub.1-C.sub.6)alkylamino, ((C.sub.1-C.sub.6)alkyl).sub.2amino, cyano, cyano(C.sub.1-C.sub.6)alkyl, trifluoromethyl(C.sub.1-C.sub.6)alkyl, nitro, nitro(C.sub.1-C.sub.6)alkyl or (C.sub.1-C.sub.6)acylamino; R.sup.5 is a piperidinyl substituted by one to five carboxy, cyano, amino, deuterium, hydroxy, (C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy, halo, (C.sub.1-C.sub.6)acyl, (C.sub.1-C.sub.6)alkylamino, amino(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy-CO--NH, (C.sub.1-C.sub.6)alkylamino-CO--, (C.sub.2-C.sub.6)alkenyl, (C.sub.2-C.sub.6)alkynyl, (C.sub.1-C.sub.6)alkylamino, amino(C.sub.1-C.sub.6)alkyl, hydroxy(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)acyloxy(C.sub.1-C.sub.6)alkyl, nitro, cyano(C.sub.1-C.sub.6)alkyl, halo(C.sub.1-C.sub.6)alkyl, nitro(C.sub.1-C.sub.6)alkyl, trifluoromethyl, trifluoromethyl(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)acylamino, (C.sub.1-C.sub.6)acylamino(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy(C.sub.1-C.sub.6)acylamino, amino(C.sub.1-C.sub.6)acyl, amino(C.sub.1-C.sub.6)acyl(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkylamino(C.sub.1-C.sub.6)acyl, ((C.sub.1-C.sub.6)alkyl).sub.2amino(C.sub.1-C.sub.6)acyl, R.sup.15R.sup.16N--CO--O--, R.sup.15R.sup.16N--CO--(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkyl-S(O).sub.m, R.sup.15R.sup.16NS(O).sub.m, R.sup.15R.sup.16NS(O).sub.m(C.sub.1-C.sub.6)alkyl, R.sup.15S(O).sub.mR.sup.16N, R.sup.15S(O).sub.mR.sup.16N(C.sub.1-C.sub.6)alkyl wherein m is 0, 1 or 2 and R.sup.15 and R.sup.16 are each independently selected from hydrogen or (C.sub.1-C.sub.6)alkyl; or a group of the formula ##STR00042## wherein X is S(O).sub.n wherein n is 0, 1 or 2; R.sup.9 and R.sup.10 are each independently selected from the group consisting of hydrogen or (C.sub.1-C.sub.6)alkyl optionally substituted by deuterium, hydroxy, amino, trifluoromethyl, (C.sub.1-C.sub.6)acyloxy, (C.sub.1-C.sub.6)acylamino, (C.sub.1-C.sub.6)alkylamino, ((C.sub.1-C.sub.6)alkyl).sub.2amino, cyano, cyano(C.sub.1-C.sub.6)alkyl, trifluoromethyl(C.sub.1-C.sub.6)alkyl, nitro, nitro(C.sub.1-C.sub.6)alkyl or (C.sub.1-C.sub.6)acylamino; R.sup.12 is carboxy, cyano, amino, oxo, deuterium, hydroxy, trifluoromethyl, (C.sub.1-C.sub.6)alkyl, trifluoromethyl (C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy, halo, (C.sub.1-C.sub.6)acyl, (C.sub.1-C.sub.6)alkylamino, ((C.sub.1-C.sub.6)alkyl).sub.2amino, amino(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy-CO--NH, (C.sub.1-C.sub.6)alkylamino-CO--, (C.sub.2-C.sub.6)alkenyl, (C.sub.2-C.sub.6)alkynyl, (C.sub.1-C.sub.6)alkylamino, hydroxy(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)acyloxy(C.sub.1-C.sub.6)alkyl, nitro, cyano(C.sub.1-C.sub.6)alkyl, halo(C.sub.1-C.sub.6)alkyl, nitro(C.sub.1-C.sub.6)alkyl, trifluoromethyl, trifluoromethyl(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)acylamino, (C.sub.1-C.sub.6)acylamino(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy(C.sub.1-C.sub.6)acylamino, amino(C.sub.1-C.sub.6)acyl, amino(C.sub.1-C.sub.6)acyl(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkylamino(C.sub.1-C.sub.6)acyl, ((C.sub.1-C.sub.6)alkyl).sub.2amino(C.sub.1-C.sub.6)acyl, R.sup.15R.sup.16N--CO--O--, R.sup.15R.sup.16N--CO--(C.sub.1-C.sub.6)alkyl, R.sup.15C(O)NH, R.sup.15OC(O)NH, R.sup.15NHC(O)NH, (C.sub.1-C.sub.6)alkyl-S(O).sub.m, (C.sub.1-C.sub.6)alkyl-S(O).sub.m-(C.sub.1-C.sub.6)alkyl, R.sup.15R.sup.16NS(O).sub.m, R.sup.15R.sup.16NS(O).sub.m(C.sub.1-C.sub.6)alkyl, R.sup.15S(O).sub.mR.sup.16N, R.sup.15S(O).sub.mR.sup.16N(C.sub.1-C.sub.6)alkyl wherein m is 0, 1 or 2 and R.sup.15 and R.sup.16 are each independently selected from hydrogen or (C.sub.1-C.sub.6)alkyl; R.sup.2 and R.sup.3 are each hydrogen.

12. A compound of the Formula I; ##STR00043## or a pharmaceutically acceptable salt thereof; wherein R.sup.1 is a group of the formula ##STR00044## wherein y is 0, 1 or 2; R.sup.4 selected from the group consisting of hydrogen, (C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkylsulfonyl, (C.sub.2-C.sub.6)alkenyl, (C.sub.2-C.sub.6)alkynyl wherein the alkyl, alkenyl and alkynyl groups are optionally substituted by deuterium, hydroxy, amino, trifluoromethyl, (C.sub.1-C.sub.4)alkoxy, (C.sub.1-C.sub.6)acyloxy, (C.sub.1-C.sub.6)alkylamino, ((C.sub.1-C.sub.6)alkyl).sub.2amino, cyano, nitro, (C.sub.2-C.sub.6)alkenyl, (C.sub.2-C.sub.6)alkynyl or (C.sub.1-C.sub.6)acylamino; or R.sup.4 is (C.sub.3-C.sub.10)cycloalkyl wherein the cycloalkyl group is optionally substituted by deuterium, hydroxy, amino, trifluoromethyl, (C.sub.1-C.sub.6)acyloxy, (C.sub.1-C.sub.6)acylamino, (C.sub.1-C.sub.6)alkylamino, ((C.sub.1-C.sub.6)alkyl).sub.2amino, cyano, cyano(C.sub.1-C.sub.6)alkyl, trifluoromethyl(C.sub.1-C.sub.6)alkyl, nitro, nitro(C.sub.1-C.sub.6)alkyl or (C.sub.1-C.sub.6)acylamino; R.sup.5 is a piperidinyl substituted by one to five carboxy, cyano, amino, deuterium, hydroxy, (C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy, halo, (C.sub.1-C.sub.6)acyl, (C.sub.1-C.sub.6)alkylamino, amino(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy-CO--NH, (C.sub.1-C.sub.6)alkylamino-CO--, (C.sub.2-C.sub.6)alkenyl, (C.sub.2-C.sub.6)alkynyl, (C.sub.1-C.sub.6)alkylamino, amino(C.sub.1-C.sub.6)alkyl, hydroxy(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)acyloxy(C.sub.1-C.sub.6)alkyl, nitro, cyano(C.sub.1-C.sub.6)alkyl, halo(C.sub.1-C.sub.6)alkyl, nitro(C.sub.1-C.sub.6)alkyl, trifluoromethyl, trifluoromethyl(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)acylamino, C.sub.1-C.sub.6)acylamino(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy(C.sub.1-C.sub.6)acylamino, amino(C.sub.1-C.sub.6)acyl, amino(C.sub.1-C.sub.6)acyl(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkylamino(C.sub.1-C.sub.6)acyl, ((C.sub.1-C.sub.6)alkyl).sub.2amino(C.sub.1-C.sub.6)acyl, R.sup.15R.sup.16N--CO--O--, R.sup.15R.sup.16N--CO--(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkyl-S(O).sub.m, R.sup.15R.sup.16NS(O).sub.m, R.sup.15R.sup.16NS(O).sub.m(C.sub.1-C.sub.6)alkyl, R.sup.15S(O).sub.mR.sup.16N, R.sup.15S(O).sub.mR.sup.16N(C.sub.1-C.sub.6)alkyl wherein m is 0, 1 or 2 and R.sup.15 and R.sup.16 are each independently selected from hydrogen or (C.sub.1-C.sub.6)alkyl; or a group of the formula ##STR00045## wherein X is S(O).sub.n wherein n is 0, 1 or 2; R.sup.9, R.sup.10 and R.sup.11 are each independently selected from the group consisting of hydrogen or (C.sub.1-C.sub.6)alkyl optionally substituted by deuterium, hydroxy, amino, trifluoromethyl, (C.sub.1-C.sub.6)acyloxy, (C.sub.1-C.sub.6)acylamino, (C.sub.1-C.sub.6)alkylamino, ((C.sub.1-C.sub.6)alkyl).sub.2amino, cyano, cyano(C.sub.1-C.sub.6)alkyl, trifluoromethyl(C.sub.1-C.sub.6)alkyl, nitro, nitro(C.sub.1-C.sub.6)alkyl or (C.sub.1-C.sub.6)acylamino; R.sup.12 is carboxy, cyano, amino, oxo, deuterium, hydroxy, trifluoromethyl, (C.sub.1-C.sub.6)alkyl, trifluoromethyl(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy, halo, (C.sub.1-C.sub.6)acyl, (C.sub.1-C.sub.6)alkylamino, ((C.sub.1-C.sub.6)alkyl).sub.2amino, amino(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy-CO--NH, (C.sub.1-C.sub.6)alkylamino-CO--, (C.sub.2-C.sub.6)alkenyl, (C.sub.2-C.sub.6)alkynyl, (C.sub.1-C.sub.6)alkylamino, hydroxy(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)acyloxy(C.sub.1-C.sub.6)alkyl, nitro, cyano(C.sub.1-C.sub.6)alkyl, halo(C.sub.1-C.sub.6)alkyl, nitro(C.sub.1-C.sub.6)alkyl, trifluoromethyl, trifluoromethyl(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)acylamino, (C.sub.1-C.sub.6)acylamino(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy(C.sub.1-C.sub.6)acylamino, amino(C.sub.1-C.sub.6)acyl, amino(C.sub.1-C.sub.6)acyl(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkylamino(C.sub.1-C.sub.6)acyl, ((C.sub.1-C.sub.6)alkyl).sub.2amino(C.sub.1-C.sub.6)acyl, R.sup.15R.sup.16N--CO--O--, R.sup.15R.sup.16N--CO--(C.sub.1-C.sub.6)alkyl, R.sup.15C(O)NH, R.sup.15OC(O)NH, R.sup.15NHC(O)NH, (C.sub.1-C.sub.6)alkyl-S(O).sub.m, (C.sub.1-C.sub.6)alkyl-S(O).sub.m-(C.sub.1-C.sub.6)alkyl, R.sup.15R.sup.16NS(O).sub.m, R.sup.15R.sup.16NS(O).sub.m(C.sub.1-C.sub.6)alkyl, R.sup.15S(O).sub.mR.sup.16N, R.sup.15S(O).sub.mR.sup.16N(C.sub.1-C.sub.6)alkyl wherein m is 0, 1 or 2 and R.sup.15 and R.sup.16 are each independently selected from hydrogen or (C.sub.1-C.sub.6)alkyl; R.sup.2 and R.sup.3 are each hydrogen.

13. A compound of the Formula I; ##STR00046## or a pharmaceutically acceptable salt thereof; wherein R.sup.1 is a group of the formula ##STR00047## wherein y is 0, 1 or 2; R.sup.4 is selected from the group consisting of hydrogen, (C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkylsulfonyl, (C.sub.2-C.sub.6)alkenyl, (C.sub.2-C.sub.6)alkynyl wherein the alkyl, alkenyl and alkynyl groups are optionally substituted by deuterium, hydroxy, amino, trifluoromethyl, (C.sub.1-C.sub.4)alkoxy, (C.sub.1-C.sub.6)acyloxy, (C.sub.1-C.sub.6)alkylamino, ((C.sub.1-C.sub.6)alkyl).sub.2amino, cyano, nitro, (C.sub.2-C.sub.6)alkenyl, (C.sub.2-C.sub.6)alkynyl or (C.sub.1-C.sub.6)acylamino; or R.sup.4 is (C.sub.3-C.sub.10)cycloalkyl wherein the cycloalkyl group is optionally substituted by deuterium, hydroxy, amino, trifluoromethyl, (C.sub.1-C.sub.6)acyloxy, (C.sub.1-C.sub.6)acylamino, (C.sub.1-C.sub.6)alkylamino, ((C.sub.1-C.sub.6)alkyl).sub.2amino, cyano, cyano(C.sub.1-C.sub.6)alkyl, trifluoromethyl(C.sub.1-C.sub.6)alkyl, nitro, nitro(C.sub.1-C.sub.6)alkyl or (C.sub.1-C.sub.6)acylamino; R.sup.5 is a piperidinyl substituted by one to five carboxy, cyano, amino, deuterium, hydroxy, (C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy, halo, (C.sub.1-C.sub.6)acyl, (C.sub.1-C.sub.6)alkylamino, amino(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy-CO--NH, (C.sub.1-C.sub.6)alkylamino-CO--, (C.sub.2-C.sub.6)alkenyl, (C.sub.2-C.sub.6)alkynyl, (C.sub.2-C.sub.6)alkylamino, amino(C.sub.1-C.sub.6)alkyl, hydroxy(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)acyloxy(C.sub.1-C.sub.6)alkyl, nitro, cyano(C.sub.1-C.sub.6)alkyl, halo(C.sub.1-C.sub.6)alkyl, nitro(C.sub.1-C.sub.6)alkyl, trifluoromethyl, trifluoromethyl(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)acylamino, (C.sub.1-C.sub.6)acylamino(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy(C.sub.1-C.sub.6)acylamino, amino(C.sub.1-C.sub.6)acyl, amino(C.sub.1-C.sub.6)acyl(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkylamino(C.sub.1-C.sub.6)acyl, ((C.sub.1-C.sub.6)alkyl).sub.2amino(C.sub.1-C.sub.6)acyl, R.sup.15R.sup.16N--CO--O--, R.sup.15R.sup.16N--CO--(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkyl-S(O).sub.m, R.sup.15R.sup.16NS(O).sub.m, R.sup.15R.sup.16NS(O).sub.m(C.sub.1-C.sub.6)alkyl, R.sup.15S(O).sub.mR.sup.16N, R.sup.15S(O).sub.mR.sup.16N(C.sub.1-C.sub.6)alkyl wherein m is 0, 1 or 2 and R.sup.15 and R.sup.16 are each independently selected from hydrogen or (C.sub.1-C.sub.6)alkyl; or a group of the formula ##STR00048## wherein R.sup.9, R.sup.10 and R.sup.11 are each independently selected from the group consisting of hydrogen or (C.sub.1-C.sub.6)alkyl optionally substituted by deuterium, hydroxy, amino, trifluoromethyl, (C.sub.1-C.sub.6)acyloxy, (C.sub.1-C.sub.6)acylamino, (C.sub.1-C.sub.6)alkylamino, ((C.sub.1-C.sub.6)alkyl).sub.2amino, cyano, cyano(C.sub.1-C.sub.6)alkyl, trifluoromethyl(C.sub.1-C.sub.6)alkyl, nitro, nitro(C.sub.1-C.sub.6)alkyl or (C.sub.1-C.sub.6)acylamino; R.sup.12 is carboxy, cyano, amino, oxo, deuterium, hydroxy, trifluoromethyl, (C.sub.1-C.sub.6)alkyl, trifluoromethyl(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy, halo, (C.sub.1-C.sub.6)acyl, (C.sub.1-C.sub.6)alkylamino, ((C.sub.1-C.sub.6)alkyl).sub.2amino, amino(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy-CO--NH, (C.sub.1-C.sub.6)alkylamino-CO--, (C.sub.2-C.sub.6)alkenyl, (C.sub.2-C.sub.6)alkynyl, (C.sub.1-C.sub.6)alkylamino, hydroxy(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)acyloxy(C.sub.1-C.sub.6)alkyl, nitro, cyano(C.sub.1-C.sub.6)alkyl, halo(C.sub.1-C.sub.6)alkyl, nitro(C.sub.1-C.sub.6)alkyl, trifluoromethyl, trifluoromethyl(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)acylamino, (C.sub.1-C.sub.6)acylamino(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy(C.sub.1-C.sub.6)acylamino, amino(C.sub.1-C.sub.6)acyl, amino(C.sub.1-C.sub.6)acyl(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkylamino(C.sub.1-C.sub.6)acyl, ((C.sub.1-C.sub.6)alkyl).sub.2amino(C.sub.1-C.sub.6)acyl, R.sup.15R.sup.16N--CO--O--, R.sup.15R.sup.16N--CO--(C.sub.1-C.sub.6)alkyl, R.sup.15C(O)NH, R.sup.15OC(O)NH, R.sup.15NHC(O)NH, (C.sub.1-C.sub.6)alkyl-S(O).sub.m, (C.sub.1-C.sub.6)alkyl-S(O).sub.m-(C.sub.1-C.sub.6)alkyl, R.sup.15R.sup.16NS(O).sub.m, R.sup.15R.sup.16NS(O).sub.m(C.sub.1-C.sub.6)alkyl, R.sup.15S(O).sub.mR.sup.16N, R.sup.15S(O).sub.mR.sup.16N(C.sub.1-C.sub.6)alkyl wherein m is 0, 1 or 2 and R.sup.15 and R.sup.16 are each independently selected from hydrogen or (C.sub.1-C.sub.6)alkyl; R.sup.2 and R.sup.3 are each hydrogen.

14. A compound of the Formula I; ##STR00049## or a pharmaceutically acceptable salt thereof; wherein R.sup.1 is a group of the formula ##STR00050## wherein y is 0, 1 or 2; R.sup.4 is selected from the group consisting of hydrogen, (C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkylsulfonyl, (C.sub.2-C.sub.6)alkenyl, (C.sub.2-C.sub.6)alkynyl wherein the alkyl, alkenyl and alkynyl groups are optionally substituted by deuterium, hydroxy, amino, trifluoromethyl, (C.sub.1-C.sub.4)alkoxy, (C.sub.1-C.sub.6)acyloxy, (C.sub.1-C.sub.6)alkylamino, ((C.sub.1-C.sub.6)alkyl).sub.2amino, cyano, nitro, (C.sub.2-C.sub.6)alkenyl, (C.sub.2-C.sub.6)alkynyl or (C.sub.1-C.sub.6)acylamino; or R.sup.4 is (C.sub.3-C.sub.10)cycloalkyl wherein the cycloalkyl group is optionally substituted by deuterium, hydroxy, amino, trifluoromethyl, (C.sub.1-C.sub.6)acyloxy, (C.sub.1-C.sub.6)acylamino, (C.sub.1-C.sub.6)alkylamino, ((C.sub.1-C.sub.6)alkyl).sub.2amino, cyano, cyano(C.sub.1-C.sub.6)alkyl, trifluoromethyl(C.sub.1-C.sub.6)alkyl, nitro, nitro(C.sub.1-C.sub.6)alkyl or (C.sub.1-C.sub.6)acylamino; R.sup.5 is a piperidinyl substituted by one to five carboxy, cyano, amino, deuterium, hydroxy, (C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy, halo, (C.sub.1-C.sub.6)acyl, (C.sub.1-C.sub.6)alkylamino, amino(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy-CO--NH, (C.sub.1-C.sub.6)alkylamino-CO--, (C.sub.2-C.sub.6)alkenyl, (C.sub.2-C.sub.6)alkynyl, (C.sub.1-C.sub.6)alkylamino, amino(C.sub.1-C.sub.6)alkyl, hydroxy(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)acyloxy(C.sub.1-C.sub.6)alkyl, nitro, cyano(C.sub.1-C.sub.6)alkyl, halo(C.sub.1-C.sub.6)alkyl, nitro(C.sub.1-C.sub.6)alkyl, trifluoromethyl, trifluoromethyl(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)acylamino, (C.sub.1-C.sub.6)acylamino(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy(C.sub.1-C.sub.6)acylamino, amino(C.sub.1-C.sub.6)acyl, amino(C.sub.1-C.sub.6)acyl(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkylamino(C.sub.1-C.sub.6)acyl, ((C.sub.1-C.sub.6)alkyl).sub.2amino(C.sub.1-C.sub.6)acyl, R.sup.15R.sup.16N--CO--O--, R.sup.15R.sup.16N--CO--(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkyl-S(O).sub.m, R.sup.15R.sup.16NS(O).sub.m, R.sup.15R.sup.16NS(O).sub.m(C.sub.1-C.sub.6)alkyl, R.sup.15S(O).sub.mR.sup.16N, R.sup.15S(O).sub.mR.sup.16N(C.sub.1-C.sub.6)alkyl wherein m is 0, 1 or 2 and R.sup.15 and R.sup.16 are each independently selected from hydrogen or (C.sub.1-C.sub.6)alkyl; or a group of the formula ##STR00051## wherein R.sup.9 and R.sup.10 are each independently selected from the group consisting of hydrogen or (C.sub.1-C.sub.6)alkyl optionally substituted by deuterium, hydroxy, amino, trifluoromethyl, (C.sub.1-C.sub.6)acyloxy, (C.sub.1-C.sub.6)acylamino, (C.sub.1-C.sub.6)alkylamino, ((C.sub.1-C.sub.6)alkyl).sub.2amino, cyano, cyano(C.sub.1-C.sub.6)alkyl, trifluoromethyl(C.sub.1-C.sub.6)alkyl, nitro, nitro(C.sub.1-C.sub.6)alkyl or (C.sub.1-C.sub.6)acylamino; R.sup.12 is carboxy, cyano, amino, oxo, deuterium, hydroxy, trifluoromethyl, (C.sub.1-C.sub.6)alkyl, trifluoromethyl(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy, halo, (C.sub.1-C.sub.6)acyl, (C.sub.1-C.sub.6)alkylamino, ((C.sub.1-C.sub.6)alkyl).sub.2amino, amino(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy-CO--NH, (C.sub.1-C.sub.6)alkylamino-CO--, (C.sub.2-C.sub.6)alkenyl, (C.sub.2-C.sub.6)alkynyl, (C.sub.1-C.sub.6)alkylamino, hydroxy(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)acyloxy(C.sub.1-C.sub.6)alkyl, nitro, cyano(C.sub.1-C.sub.6)alkyl, halo(C.sub.1-C.sub.6)alkyl, nitro(C.sub.1-C.sub.6)alkyl, trifluoromethyl, trifluoromethyl(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)acylamino, (C.sub.1-C.sub.6)acylamino(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy(C.sub.1-C.sub.6)acylamino, amino(C.sub.1-C.sub.6)acyl, amino(C.sub.1-C.sub.6)acyl(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkylamino(C.sub.1-C.sub.6)acyl, ((C.sub.1-C.sub.6)alkyl).sub.2amino(C.sub.1-C.sub.6)acyl, R.sup.15R.sup.16N--CO--O--, R.sup.15R.sup.16N--CO--(C.sub.1-C.sub.6)alkyl, R.sup.15C(O)NH, R.sup.15OC(O)NH, R.sup.15NHC(O)NH, (C.sub.1-C.sub.6)alkyl-S(O).sub.m, (C.sub.1-C.sub.6)alkyl-S(O).sub.m-(C.sub.1-C.sub.6)alkyl, R.sup.15R.sup.16NS(O).sub.m, R.sup.15R.sup.16NS(O).sub.m(C.sub.1-C.sub.6)alkyl, R.sup.15S(O).sub.mR.sup.16N, R.sup.15S(O).sub.mR.sup.16N(C.sub.1-C.sub.6)alkyl wherein m is 0, 1 or 2 and R.sup.15 and R.sup.16 are each independently selected from hydrogen or (C.sub.1-C.sub.6)alkyl; R.sup.2 and R.sup.3 are each hydrogen.

15. A compound of the Formula I; ##STR00052## or a pharmaceutically acceptable salt thereof; wherein R.sup.1 is a group of the formula ##STR00053## wherein y is 0, 1 or 2; R.sup.4 is selected from the group consisting of hydrogen, (C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkylsulfonyl, (C.sub.2-C.sub.6)alkenyl, (C.sub.2-C.sub.6)alkynyl wherein the alkyl, alkenyl and alkynyl groups are optionally substituted by deuterium, hydroxy, amino, trifluoromethyl, (C.sub.1-C.sub.4)alkoxy, (C.sub.1-C.sub.6)acyloxy, (C.sub.1-C.sub.6)alkylamino, ((C.sub.1-C.sub.6)alkyl).sub.2amino, cyano, nitro, (C.sub.2-C.sub.6)alkenyl, (C.sub.2-C.sub.6)alkynyl or (C.sub.1-C.sub.6)acylamino; or R.sup.4 is (C.sub.3-C.sub.10)cycloalkyl wherein the cycloalkyl group is optionally substituted by deuterium, hydroxy, amino, trifluoromethyl, (C.sub.1-C.sub.6)acyloxy, (C.sub.1-C.sub.6)acylamino, (C.sub.1-C.sub.6)alkylamino, ((C.sub.1-C.sub.6)alkyl).sub.2amino, cyano, cyano(C.sub.1-C.sub.6)alkyl, trifluoromethyl(C.sub.1-C.sub.6)alkyl, nitro, nitro(C.sub.1-C.sub.6)alkyl or (C.sub.1-C.sub.6)acylamino; R.sup.5 is a piperidinyl substituted by one to five carboxy, cyano, amino, deuterium, hydroxy, (C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy, halo, (C.sub.1-C.sub.6)acyl, (C.sub.1-C.sub.6)alkylamino, amino(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy-CO--NH, (C.sub.1-C.sub.6)alkylamino-CO--, (C.sub.2-C.sub.6)alkenyl, (C.sub.2-C.sub.6)alkynyl, (C.sub.1-C.sub.6)alkylamino, amino(C.sub.1-C.sub.6)alkyl, hydroxy(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)acyloxy(C.sub.1-C.sub.6)alkyl, nitro, cyano(C.sub.1-C.sub.6)alkyl, halo(C.sub.1-C.sub.6)alkyl, nitro(C.sub.1-C.sub.6)alkyl, trifluoromethyl, trifluoromethyl(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)acylamino, (C.sub.1-C.sub.6)acylamino(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy(C.sub.1-C.sub.6)acylamino, amino(C.sub.1-C.sub.6)acyl, amino(C.sub.1-C.sub.6)acyl(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkylamino(C.sub.1-C.sub.6)acyl, ((C.sub.1-C.sub.6)alkyl).sub.2amino(C.sub.1-C.sub.6)acyl, R.sup.15R.sup.16N--CO--O--, R.sup.15R.sup.16N--CO--(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkyl-S(O).sub.m, R.sup.15R.sup.16NS(O).sub.m, R.sup.15R.sup.16NS(O).sub.m(C.sub.1C.sub.6)alkyl, R.sup.15S(O).sub.mR.sup.16N, R.sup.15S(O).sub.mR.sup.16N(C.sub.1-C.sub.6)alkyl wherein m is 0, 1 or 2 and R.sup.15 and R.sup.16 are each independently selected from hydrogen or (C.sub.1-C.sub.6)alkyl; or a group of the formula ##STR00054## wherein Y is S(O).sub.n wherein n is 0, 1 or 2; R.sup.8, R.sup.9, and R.sup.10 are each independently selected from the group consisting of hydrogen or (C.sub.1-C.sub.6)alkyl optionally substituted by deuterium, hydroxy, amino, trifluoromethyl, (C.sub.1-C.sub.6)acyloxy, (C.sub.1-C.sub.6)acylamino, (C.sub.1-C.sub.6)alkylamino, ((C.sub.1-C.sub.6)alkyl).sub.2amino, cyano, cyano(C.sub.1-C.sub.6)alkyl, trifluoromethyl(C.sub.1-C.sub.6)alkyl, nitro, nitro(C.sub.1-C.sub.6)alkyl or (C.sub.1-C.sub.6)acylamino; R.sup.12 is carboxy, cyano, amino, oxo, deuterium, hydroxy, trifluoromethyl, (C.sub.1-C.sub.6)alkyl, trifluoromethyl(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy, halo, (C.sub.1-C.sub.6)acyl, (C.sub.1-C.sub.6)alkylamino, ((C.sub.1-C.sub.6)alkyl).sub.2amino, amino(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy-CO--NH, (C.sub.1-C.sub.6)alkylamino-CO--, (C.sub.2-C.sub.6)alkenyl, (C.sub.2-C.sub.6)alkynyl, (C.sub.1-C.sub.6)alkylamino, hydroxy(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)acyloxy(C.sub.1-C.sub.6)alkyl, nitro, cyano(C.sub.1-C.sub.6)alkyl, halo(C.sub.1-C.sub.6)alkyl, nitro(C.sub.1-C.sub.6)alkyl, trifluoromethyl, trifluoromethyl(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)acylamino, (C.sub.1-C.sub.6)acylamino(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy(C.sub.1-C.sub.6)acylamino, amino(C.sub.1-C.sub.6)acyl, amino(C.sub.1-C.sub.6)acyl(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkylamino(C.sub.1-C.sub.6)acyl, ((C.sub.1-C.sub.6)alkyl).sub.2amino(C.sub.1-C.sub.6)acyl, R.sup.15R.sup.16N--CO--O--, R.sup.15R.sup.16N--CO--(C.sub.1-C.sub.6)alkyl, R.sup.15C(O)NH, R.sup.15OC(O)NH, R.sup.15NHC(O)NH, (C.sub.1-C.sub.6)alkyl-S(O).sub.m, (C.sub.1-C.sub.6)alkyl-S(O).sub.m--(C.sub.1-C.sub.6)alkyl, R.sup.15R.sup.16NS(O).sub.m, R.sup.15R.sup.16NS (O).sub.m(C.sub.1-C.sub.6)alkyl, R.sup.15S(O).sub.mR.sup.16N, R.sup.15S(O).sub.mR.sup.16N(C.sub.1-C.sub.6)alkyl wherein m is 0, 1 or 2 and R.sup.15 and R.sup.16 are each independently selected from hydrogen or (C.sub.1-C.sub.6)alkyl; R.sup.2 and R.sup.3 are each hydrogen.

16. A compound of the Formula I; ##STR00055## or a pharmaceutically acceptable salt thereof; wherein R.sup.1 is a group of the formula ##STR00056## wherein y is 0, 1 or 2; R.sup.4 is selected from the group consisting of hydrogen, (C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkylsulfonyl, (C.sub.2-C.sub.6)alkenyl, (C.sub.2-C.sub.6)alkynyl wherein the alkyl, alkenyl and alkynyl groups are optionally substituted by deuterium, hydroxy, amino, trifluoromethyl, (C.sub.1-C.sub.4)alkoxy, (C.sub.1-C.sub.6)acyloxy, (C.sub.1-C.sub.6)alkylamino, ((C.sub.1-C.sub.6)alkyl).sub.2amino, cyano, nitro, (C.sub.2-C.sub.6)alkenyl, (C.sub.2-C.sub.6)alkynyl or (C.sub.1-C.sub.6)acylamino; or R.sup.4 is (C.sub.3-C.sub.10)cycloalkyl wherein the cycloalkyl group is optionally substituted by deuterium, hydroxy, amino, trifluoromethyl, (C.sub.1-C.sub.6)acyloxy, (C.sub.1-C.sub.6)acylamino, (C.sub.1-C.sub.6)alkylamino, ((C.sub.1-C.sub.6)alkyl).sub.2amino, cyano, cyano(C.sub.1-C.sub.6)alkyl, trifluoromethyl(C.sub.1-C.sub.6)alkyl, nitro, nitro(C.sub.1-C.sub.6)alkyl or (C.sub.1-C.sub.6)acylamino; R.sup.5 is a piperidinyl substituted by one to five carboxy, cyano, amino, deuterium, hydroxy, (C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy, halo, (C.sub.1-C.sub.6)acyl, (C.sub.1-C.sub.6)alkylamino, amino(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy-CO--NH, (C.sub.1-C.sub.6)alkylamino-CO--, (C.sub.2-C.sub.6)alkenyl, (C.sub.2-C.sub.6)alkynyl, (C.sub.1-C.sub.6)alkylamino, amino(C.sub.1-C.sub.6)alkyl, hydroxy(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)acyloxy(C.sub.1-C.sub.6)alkyl, nitro, cyano(C.sub.1-C.sub.6)alkyl, halo(C.sub.1-C.sub.6)alkyl, nitro(C.sub.1-C.sub.6)alkyl, trifluoromethyl, trifluoromethyl(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)acylamino, (C.sub.1-C.sub.6)acylamino(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy(C.sub.1-C.sub.6)acylamino, amino(C.sub.1-C.sub.6)acyl, amino(C.sub.1-C.sub.6)acyl(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkylamino(C.sub.1-C.sub.6)acyl, ((C.sub.1-C.sub.6)alkyl).sub.2amino(C.sub.1-C.sub.6)acyl, R.sup.15R.sup.16N--CO--O--, R.sup.15R.sup.16N--CO--(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkyl-S(O).sub.m, R.sup.15R.sup.16NS (O).sub.m, R.sup.15R.sup.16NS(O).sub.m(C.sub.1-C.sub.6)alkyl, R.sup.15S(O).sub.mR.sup.16N, R.sup.15S(O).sub.mR.sup.16N(C.sub.1-C.sub.6)alkyl wherein m is 0, 1 or 2 and R.sup.15 and R.sup.16 are each independently selected from hydrogen or (C.sub.1-C.sub.6)alkyl; or a group of the formula ##STR00057## wherein R.sup.8, R.sup.9, R.sup.10 and R.sup.11 are each independently selected from the group consisting of hydrogen or (C.sub.1-C.sub.6)alkyl optionally substituted by deuterium, hydroxy, amino, trifluoromethyl, (C.sub.1-C.sub.6)acyloxy, (C.sub.1-C.sub.6)acylamino, (C.sub.1-C.sub.6)alkylamino, ((C.sub.1-C.sub.6)alkyl).sub.2amino, cyano, cyano(C.sub.1-C.sub.6)alkyl, trifluoromethyl(C.sub.1-C.sub.6)alkyl, nitro, nitro(C.sub.1-C.sub.6)alkyl or (C.sub.1-C.sub.6)acylamino; R.sup.12 is carboxy, cyano, amino, oxo, deuterium, hydroxy, trifluoromethyl, (C.sub.1-C.sub.6)alkyl, trifluoromethyl(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy, halo, (C.sub.1-C.sub.6)acyl, (C.sub.1-C.sub.6)alkylamino, ((C.sub.1-C.sub.6)alkyl).sub.2amino, amino(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy-CO--NH, (C.sub.1-C.sub.6)alkylamino-CO--, (C.sub.2-C.sub.6)alkenyl, (C.sub.2-C.sub.6)alkynyl, (C.sub.1-C.sub.6)alkylamino, hydroxy(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)acyloxy(C.sub.1-C.sub.6)alkyl, nitro, cyano(C.sub.1-C.sub.6)alkyl, halo(C.sub.1-C.sub.6)alkyl, nitro(C.sub.1-C.sub.6)alkyl, trifluoromethyl, trifluoromethyl(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)acylamino, (C.sub.1-C.sub.6)acylamino(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkoxy(C.sub.1-C.sub.6)acylamino, amino(C.sub.1-C.sub.6)acyl, amino(C.sub.1-C.sub.6)acyl(C.sub.1-C.sub.6)alkyl, (C.sub.1-C.sub.6)alkylamino(C.sub.1-C.sub.6)acyl, ((C.sub.1-C.sub.6)alkyl).sub.2amino(C.sub.1-C.sub.6)acyl, R.sup.15R.sup.16N--CO--O--, R.sup.15R.sup.16N--CO--(C.sub.1-C.sub.6)alkyl, R.sup.15C(O)NH, R.sup.15OC(O)NH, R.sup.15NHC(O)NH, (C.sub.1-C.sub.6)alkyl-S(O).sub.m, (C.sub.1-C.sub.6)alkyl-S(O).sub.m--(C.sub.1-C.sub.6)alkyl, R.sup.15R.sup.16NS(O).sub.m, R.sup.15R.sup.16NS(O).sub.m(C.sub.1-C.sub.6)alkyl, R.sup.15S(O).sub.mR.sup.16N, R.sup.15S(O).sub.mR.sup.16N(C.sub.1-C.sub.6)alkyl wherein m is 0, 1 or 2 and R.sup.15 and R.sup.16 are each independently selected from hydrogen or (C.sub.1-C.sub.6)alkyl; R.sup.2 and R.sup.3 are each hydrogen.

17. A compound selected from the group consisting of: ({4-Methyl-3-[methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-piperidine-- 1-carbonyl}-amino)-acetic acid ethyl ester; N-cyano-4-methyl-3-[methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-N'-pr- opyl-piperidine-1-carboxamidine; and N-cyano-4,N',N'-Trimethyl-3-[methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-ami- no]-piperidine-1-carboxamidine, or a pharmaceutically acceptable salt thereof.

18. A compound selected from the group consisting of: 1-{4-Methyl-3-[methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-piperidin-- 1-yl}-ethanone; [1-(2-Amino-ethanesulfonyl)-4-methyl-piperidin-3-yl]-methyl-(7H-pyrrolo[2- ,3-d]pyrimidin-4-yl)-amine; (1-Ethanesulfonyl-4-methyl-piperidin-3-yl)-methyl-(7H-pyrrolo[2,3-d]pyrim- idin-4-yl)-amine; [1-(Butane-1-sulfonyl)-4-methyl-piperidin-3-yl]-methyl-(7H-pyrrolo[2,3-d]- pyrimidin-4-yl)-amine; 4-Methyl-3-[methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-piperidine-1-- carboxylic acid isobutyl ester; N-(2-{4-Methyl-3-[methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-piperid- ine-1-sulfonyl}-ethyl)-propionamide; (2-{4-Methyl-3-[methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-piperidin- e-1-sulfonyl}-ethyl)-carbamic acid methyl ester; N-(2-{4-Methyl-3-[methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-piperid- ine-1-sulfonyl}-ethyl)-isobutyramide; (1-Methanesulfonyl-piperidin-3-yl)-methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-y- l)-amine; (1-Ethanesulfonyl-piperidin-3-yl)-methyl-(7H-pyrrolo[2,3-d]pyrim- idin-4-yl)-amine; Methyl-[1-(propane-1-sulfonyl)-piperidin-3-yl]-(7H-pyrrolo[2,3-d]pyrimidi- n-4-yl)-amine; [1-(Butane-1-sulfonyl)-piperidin-3-yl]-methyl-(7H-pyrrolo[2,3-d]pyrimidin- -4-yl)-amine; 2,2-Dimethyl-N-(2-{4-methyl-3-[methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-a- mino]-piperidine-1-sulfonyl}-ethyl)-propionamide; (3-{4-Methyl-3-[methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-piperidin- -1-yl}-3-oxo-propyl)-carbamic acid tert-butyl ester; 3-Amino-1-{4-methyl-3-[methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-pi- peridin-1-yl}-propan-1-one; 2-Methoxy-1-{4-methyl-3-[methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-- piperidin-1-yl}-ethanone; 2-Dimethylamino-1-{4-methyl-3-[methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-a- mino]-piperidin-1-yl}-ethanone; (3-{4-Methyl-3-[methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-piperidin- -1-yl}-3-oxo-propyl)-carbamic acid tert-butyl ester; N-(2-{4-Methyl-3-[methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-piperid- in-1-yl}-2-oxo-ethyl)-acetamide; 3-Ethoxy-1-{4-methyl-3-[methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-p- iperidin-1-yl}-propan-1-one; 4-Methyl-3-[methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-piperidine-1-- carboxylic acid methylamide; 4-Methyl-3-4methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-piperidine-1-- carboxylic acid diethylamide; Methyl-[4-methyl-1-(2-methylamino-ethanesulfonyl)-piperidin-3-yl]-(7H-pyr- rolo[2,3-d]pyrimidin-4-yl)-amine, or a pharmaceutically acceptable salt thereof.
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