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|Title:||Topical brimonidine tartrate formulations that lack chlorine dioxide|
|Abstract:||Topical solution compositions of brimonidine tartrate are disclosed. The solution compositions lack an oxidative preservative.|
|Inventor(s):||Espino; Ramon L. (Cleburne, TX), Bhagat; Haresh G. (Fort Worth, TX)|
|Assignee:||Alcon, Inc. (Hunenberg, CH)|
|Patent Claims:||1. A topically administrable ophthalmic solution consisting essentially of a) 0.07-0.15% (w/v) brimonidine tartrate; b) 0.001% (w/v) polyquatermium-1; c) 0.3% (w/v) boric acid; d) 0.02% (w/v) sodium borate; e) 1.0-1.5% (w/v) polyvinylpyrrolidone; f) sodium chloride; g) potassium chloride; h) calcium chloride; i) magnesium chloride; j) mannitol; and k) water, wherein the composition has an osmolality of 270-315 mOsm and a pH from 7.0-7.5.|
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