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Claims for Patent: 7,252,839

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Claims for Patent: 7,252,839

Title:Delivery system and a manufacturing process of a delivery system
Abstract: A delivery system including a body construction (7) and at least one capsule (8) containing a pharmaceutical composition, the capsule having at least a first end and a second end. The body construction (7, 12, 34) has at least two locking parts (9, 10), each locking part (9, 10) having at least a first end and a second end, the first end of each locking part (9, 10) having a surface adapted to face and cover one of the at least first and second ends of the capsule (8). The diameter of at least one of the locking parts varies along its length between the first end and the second end, and the capsule (8) is mounted between the at least two locking parts. Also disclosed is a manufacturing process of a delivery system, the system including a body construction and at least one capsule containing a pharmaceutical composition.
Inventor(s): Hallinen; Esa (Lempaala{umlaut over ( )}, FI), Lyytikainen; Heikki (Naantali, FI), Jarvela; Pentti (Lahti, FI), Kivi; Ilkka (Pirkkala, FI)
Assignee: Schering Oy (Turku, FI)
Application Number:10/528,237
Patent Claims: 1. A delivery system comprising a body construction and at least one capsule containing a pharmaceutical composition, said capsule having at least a first end and a second end, wherein the body construction has at least two locking parts, each locking part having at least a first end and a second end, said first end of each locking part having a surface adapted to face and cover one of the at least first and second ends of the capsule, the diameter of at least one of the locking parts varying along its length between said first end and said second end, and wherein the capsule is mounted between said at least two locking parts, and wherein said locking parts have the shape of a truncated cone, wherein said capsule containing a pharmaceutical composition consists essentially of a biocompatible polymer and at least one pharmaceutically active agent.

2. The system of claim 1, wherein the cross-sectional profile of said at least first or second end of the capsule is essentially identical in size and shape to said surface of the locking part facing said end of the capsule.

3. The system of claim 1, wherein said body construction consists of one body part.

4. The system of claim 1, wherein said body construction consists of at least two body parts.

5. The system of claim 1, wherein the end of the truncated cone having a larger diameter is the end having the said surface facing said end of the capsule.

6. The system of claim 1, wherein the surface of the cross-section of said at least first or second end of the capsule is essentially smaller than said surface of the locking part facing said end.

7. The system of claim 1, wherein it has two or more capsules containing a pharmaceutical composition.

8. The system of claim 1, wherein said system is an intrauterine system.

9. A manufacturing process for a delivery system, said system comprising a body construction and at least one capsule containing a pharmaceutical composition, comprising injection molding said body construction, and then injection molding said capsule onto said construction body in a separate step, wherein said capsule has at least a first end and a second end, wherein the body construction has at least two locking parts, each locking part having at least a first end and a second end, said first end of each locking part having a surface adapted to face and cover one of the at least first and second ends of the capsule, the diameter of at least one of the locking parts varying along its length between said first end and said second end, wherein the capsule is mounted between said at least two locking parts, and wherein said locking parts have the shape of a truncated cone, wherein said capsule containing a pharmaceutical composition consists essentially of a biocompatible polymer and at least one pharmaceutically active agent.

10. The process of claim 9, wherein said body construction consists of one body part.
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