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Claims for Patent: 7,230,098

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Claims for Patent: 7,230,098

Title:Aminoheteroaryl compounds as protein kinase inhibitors
Abstract: Aminopyridine and aminopyrazine compounds of formula (1), compositions including these compounds, and methods of their use are provided. Preferred compounds of formula 1 have activity as protein kinase inhibitors, including as inhibitors of c-MET ##STR00001##
Inventor(s): Cui; Jingrong Jean (San Diego, CA), Bhumralkar; Dilip (San Diego, CA), Botrous; Iriny (San Diego, CA), Chu; Ji Yu (Fremont, CA), Funk; Lee A. (Oceanside, CA), Hanau; Cathleen Elizabeth (Chesterfield, MO), Harris; G. Davis (Chesterfield, MO), Jia; Lei (San Diego, CA), Johnson; Joanne (Guilderland, NY), Kolodziej; Stephen A. (Ballwin, MO), Kung; Pei-Pei (San Diego, CA), Li; Xiaoyuan (Sharon) (Los Altas, CA), Lin; Jason (Qishen) (San Diego, CA), Meng; Jerry Jialun (San Diego, CA), Nambu; Mitchell David (San Diego, CA), Nelson; Christopher G. (Fresno, CA), Pairish; Mason Alan (San Diego, CA), Shen; Hong (San Diego, CA), Tran-Dube; Michelle (La Jolla, CA), Walter; Allison (Rexford, NY), Zhang; Fang-Jie (Sunnyvale, CA), Zhang; Jennifer (Foster City, CA)
Assignee: Sugen, Inc. (South San Francisco, CA)
Application Number:10/786,610
Patent Claims: 1. A compound of formula 1 ##STR01602## wherein: Y is CR.sup.12; R.sup.1 is selected from C.sub.6-12 aryl, 5 12 membered heteroaryl, C.sub.3-12 cycloalkyl, 3 12 membered heteroalicyclic; and each hydrogen in R.sup.1 is optionally substituted by one or more R.sup.3 groups; R.sup.2 is hydrogen; R.sup.3 is halogen, C.sub.1-12 alkyl, C.sub.2-12 alkenyl, C.sub.2-12 alkynyl, C.sub.3-12 cycloalkyl, C.sub.6-12 aryl, 3 12 membered heteroalicyclic, 5 12 membered heteroaryl, --S(O).sub.mR.sup.4, --SO.sub.2NR.sup.4R.sup.5, --S(O).sub.2OR.sup.4, --NO.sub.2, --NR.sup.4R.sup.5, --(CR.sup.6R.sup.7).sub.nOR.sup.4, --CN, --C(O)R.sup.4, --OC(O)R.sup.4, --O(CR.sup.6R.sup.7).sub.nR.sup.4, --NR.sup.4C(O)R.sup.5, --(CR.sup.6R.sup.7).sub.nC(O)OR.sup.4, --(CR.sup.6R.sup.7).sub.nNCR.sup.4R.sup.5, --C(.dbd.NR.sup.6)NR.sup.4R.sup.5, --NR.sup.4C(O)NR.sup.5R.sup.6, --NR.sup.4S(O).sub.pR.sup.5 or --C(O)NR.sup.4R.sup.5, each hydrogen in R.sup.3 is optionally substituted by one or more R.sup.8 groups, and R.sup.3 groups on adjacent atoms may combine to form a C.sub.6-12 aryl, 5 12 membered heteroaryl, C.sub.3-12 cycloalkyl, or 3 12 membered heteroalicyclic group; each R.sup.4, R.sup.5, R.sup.6 and R.sup.7 is independently hydrogen, halogen, C.sub.1-12 alkyl, C.sub.2-12 alkenyl, C.sub.2-12 alkynyl, C.sub.3-12 cycloalkyl, C.sub.6-12 aryl, 3 12 membered heteroalicyclic, 5 12 membered heteroaryl; or any two of R.sup.4, R.sup.5, R.sup.6 and R.sup.7 bound to the same nitrogen atom may, together with the nitrogen to which they are bound, be combined to form a 3 to 12 membered heteroalicyclic or 5 12 membered heteroaryl group optionally containing 1 to 3 additional heteroatoms selected from N, O, and S; or any two of R.sup.4, R.sup.5, R.sup.6 and R.sup.7 bound to the same carbon atom may be combined to form a C.sub.3-12 cycloalkyl, C.sub.6-12 aryl, 3 12 membered heteroalicyclic or 5 12 membered heteroaryl group; and each hydrogen in R.sup.4, R.sup.5, R.sup.6 and R.sup.7 is optionally substituted by one or more R.sup.8 groups; each R.sup.8 is independently halogen, C.sub.1-12 alkyl, C.sub.2-12 alkenyl, C.sub.2-12 alkynyl, C.sub.3-12 cycloalkyl, C.sub.6-12 aryl, 3 12 membered heteroalicyclic, 5 12 membered heteroaryl, --CN, --O--C.sub.1-12 alkyl, --O--(CH.sub.2).sub.nC.sub.3-12 cycloalkyl, --O--(CH.sub.2).sub.nC.sub.6-12 aryl, --O--(CH.sub.2).sub.n(3 12 membered heteroalicyclic) or --O--(CH.sub.2).sub.n(5 12 membered heteroaryl); and each hydrogen in R.sup.8 is optionally substituted by one or more R.sup.11 groups; A.sup.1 is (CR.sup.9R.sup.10).sub.n-A.sup.2 each R.sup.9 and R.sup.10 is independently hydrogen, halogen, C.sub.1-12 alkyl, C.sub.3-12 cycloalkyl, C.sub.6-12 aryl, 3 12 membered heteroalicyclic, 5 12 membered heteroaryl, --S(O).sub.mR.sup.4, --SO.sub.2NR.sup.4R.sup.5, --S(O).sub.2OR.sup.4, --NO.sub.2, --NR.sup.4R.sup.5, --(CR.sup.6R.sup.7).sub.nOR.sup.4, --CN, --C(O)R.sup.4, --OC(O)R.sup.4, --NR.sup.4C(O)R.sup.5, --(CR.sup.6R.sup.7).sub.nC(O)OR.sup.4, --(CR.sup.6R.sup.7).sub.nNCR.sup.4R.sup.5, --NR.sup.4C(O)NR.sup.5R.sup.6, --NR.sup.4S(O).sub.pR.sup.5 or --C(O)NR.sup.4R.sup.5; R.sup.9 and R.sup.10 may combine to form a C.sub.3-12 cycloalkyl, 3 12 membered heteroalicyclic, C.sub.6-12 aryl or 5 12 membered heteroaryl ring; and each hydrogen in R.sup.9 and R.sup.10 is optionally substituted by one or more R.sup.3 groups; A.sup.2 is C.sub.6-12 aryl, 5 12 membered heteroaryl, C.sub.3-12 cycloalkyl or 3 12 membered heteroalicyclic, and A.sup.2 is optionally substituted by one or more R.sup.3 groups; each R.sup.11 is independently halogen, C.sub.1-12 alkyl, C.sub.1-12 alkoxy, C.sub.3-12 cycloalkyl, C.sub.6-12 aryl, 3 12 membered heteroalicyclic, 5 12 membered heteroaryl, --O--C.sub.1-12 alkyl, --O--(CH.sub.2).sub.nC.sub.3-12 cycloalkyl, --O--(CH.sub.2).sub.nC.sub.6-12 aryl, --O--(CH.sub.2).sub.n(3 12 membered heteroalicyclic), --O--(CH.sub.2).sub.n(5 12 membered heteroaryl) or --CN, and each hydrogen in R.sup.11 is optionally substituted by one or more groups selected from halogen, --OH, --CN, --C.sub.1-12 alkyl which may be partially or fully halogenated, --O--C.sub.1-12 alkyl which may be partially or fully halogenated, --CO, --SO and --SO.sub.2; R.sup.12 is hydrogen; m is 0, 1 or 2; n is 0, 1, 2, 3 or 4; and p is 1 or 2; wherein said 3 12 membered heteroalicyclic group is selected from pyrroline, pyrrolidine, dioxolane, imidazoline, imidazolidine, pyrazoline, pyrazolidine, pyran, piperidine, dioxane, morpholine, dithiane, thiomorpholine, piperazine and trithiane and said 5 12 membered heteroaryl group is selected from furan, thiophene, pyrrole, oxazole, thiazole, imidazole, pyrazole, isoxazole, isothiazole, oxadiazole, triazole, thiadiazole, pyridine, pyridazine, pyrimidine, pyrazine and triazine; or a pharmaceutically acceptable salt, or hydrate thereof.

2. The compound of claim 1, wherein the compound has formula 1a ##STR01603## wherein A.sup.2 is C.sub.6-12 aryl or 5 12 membered heteroaryl optionally substituted by one or more R.sup.3 groups.

3. The compound of claim 2, wherein R.sup.1 is selected from C.sub.6-12 aryl and 5 12 membered heteroaryl, and each hydrogen in R.sup.1 is optionally substituted by one or more R.sup.3 groups.

4. The compound of claim 2, wherein A.sup.2 is substituted by at least one halogen atom.

5. The compound of claim 1, wherein R.sup.1 is a furan, thiopene, pyrrole, pyrroline, pyrrolidine, dioxolane, oxazole, thiazole, imidazole, imidazoline, imidazolidine, pyrazole, pyrazoline, pyrazolidine, isoxazole, isothiazole, oxadiazole, triazole, thiadiazole, pyran, pyridine, piperidine, dioxane, morpholine, dithiane, thiomorpholine, pyridazine, pyrimidine, pyrazine, piperazine, triazine, trithiane or phenyl group, and each hydrogen in R.sup.1 is optionally substituted by one or more R.sup.3 groups.

6. A compound of formula 2 ##STR01604## wherein: R.sup.1 is selected from C.sub.6-12 aryl, 5 12 membered heteroaryl, C.sub.3-12 cycloalkyl, 3 12 membered heteroalicyclic; and each hydrogen in R.sup.1 is optionally substituted by one or more R.sup.3 groups; R.sup.2 is hydrogen; R.sup.3 is halogen, C.sub.1-12 alkyl, C.sub.2-12 alkenyl, C.sub.2-12 alkynyl, C.sub.3-12 cycloalkyl, C.sub.6-12-aryl, 3 12 membered heteroalicyclic, 5 12 membered heteroaryl, --S(O).sub.mR.sup.4, --SO.sub.2NR.sup.4R.sup.5, --S(O).sub.2OR.sup.4, --NO.sub.2, --NR.sup.4R.sup.5, --(CR.sup.6R.sup.7).sub.nOR.sup.4, --CN, --C(O)R.sup.4, --OC(O)R.sup.4, --O(CR.sup.6R.sup.7).sub.nR.sup.4, --NR.sup.4C(O)R.sup.5, --(CR.sup.6R.sup.7).sub.nC(O)OR.sup.4, --(CR.sup.6R.sup.7).sub.nNCR.sup.4R.sup.5, --C(.dbd.NR.sup.6)NR.sup.4R.sup.5, --NR.sup.4C(O)NR.sup.5R.sup.6, --NR.sup.4S(O).sub.pR.sup.5 or --C(O)NR.sup.4R.sup.5, each hydrogen in R.sup.3 is optionally substituted by one or more R.sup.8 groups, and R.sup.3 groups on adjacent atoms may combine to form a C.sub.6-12 aryl, 5 12 membered heteroaryl, C.sub.3-12 cycloalkyl or 3 12 membered heteroalicyclic group; each R.sup.4, R.sup.5, R.sup.6 and R.sup.7 is independently hydrogen, halogen, C.sub.1-12 alkyl, C.sub.2-12 alkenyl, C.sub.2-12 alkynyl, C.sub.3-12 cycloalkyl, C.sub.6-12 aryl, 3 12 membered heteroalicyclic, 5 12 membered heteroaryl; or any two of R.sup.4, R.sup.5, R.sup.6 and R.sup.7 bound to the same nitrogen atom may, together with the nitrogen to which they are bound, be combined to form a 3 to 12 membered heteroalicyclic or 5 12 membered heteroaryl group optionally containing 1 to 3 additional heteroatoms selected from N, O, and S; or any two of R.sup.4, R.sup.5, R.sup.6 and R.sup.7 bound to the same carbon atom may be combined to form a C.sub.3-12 cycloalkyl, C.sub.6-12 aryl, 3 12 membered heteroalicyclic or 5 12 membered heteroaryl group; and each hydrogen in R.sup.4, R.sup.5, R.sup.6 and R.sup.7 is optionally substituted by one or more R.sup.8 groups; each R.sup.8 is independently halogen, C.sub.1-12 alkyl, C.sub.2-12 alkenyl, C.sub.2-12 alkynyl, C.sub.3-12 cycloalkyl, C.sub.6-12 aryl, 3 12 membered heteroalicyclic, 5 12 membered heteroaryl, --CN, --O--C.sub.1-12 alkyl, --O--(CH.sub.2).sub.nC.sub.3-12 cycloalkyl, --O--(CH.sub.2).sub.nC.sub.6-12 aryl, --O--(CH.sub.2).sub.n(3 12 membered heteroalicyclic) or --O--(CH.sub.2).sub.n(5 12 membered heteroaryl); and each hydrogen in R.sup.8 is optionally substituted by one or more R.sup.11 groups; A.sup.1 is --(CR.sup.9R.sup.10).sub.n-A.sup.2; each R.sup.9 and R.sup.10 is independently hydrogen, halogen, C.sub.1-12 alkyl, C.sub.3-12 cycloalkyl, C.sub.6-12 aryl, 3 12 membered heteroalicyclic, 5 12 membered heteroaryl, --S(O).sub.mR.sup.4, --SO.sub.2NR.sup.4R.sup.5, --S(O).sub.2OR.sup.4, --NO.sub.2, --NR.sup.4R.sup.5, --(CR.sup.6R.sup.7).sub.nOR.sup.4, --CN, --C(O)R.sup.4, --OC(O)R.sup.4, --NR.sup.4C(O)R.sup.5, --(CR.sup.6R.sup.7).sub.nC(O)OR.sup.4, --(CR.sup.6R.sup.7).sub.nNCR.sup.4R.sup.5, --NR.sup.4C(O)NR.sup.5R.sup.6, --NR.sup.4S(O).sub.pR.sup.5 or --C(O)NR.sup.4R.sup.5; R.sup.9 and R.sup.10 may combine to form a C.sub.3-12 cycloalkyl, 3 12 membered heteroalicyclic, C.sub.6-12 aryl or 5 12 membered heteroaryl ring; and each hydrogen in R.sup.9 and R.sup.10 is optionally substituted by one or more R.sup.3 groups; A.sup.2 is C.sub.6-12 aryl, 5 12 membered heteroaryl, C.sub.3-12 cycloalkyl or 3 12 membered heteroalicyclic, and A.sup.2 is optionally substituted by one or more R.sup.3 groups; each R.sup.11 is independently halogen, C.sub.1-12 alkyl, C.sub.1-12 alkoxy, C.sub.3-12 cycloalkyl, C.sub.6-12 aryl, 3 12 membered heteroalicyclic, 5 12 membered heteroaryl, --O--C.sub.1-12 alkyl, --O--(CH.sub.2).sub.nC.sub.3-12 cycloalkyl, --O--(CH.sub.2).sub.nC.sub.6-12 aryl, --O--(CH.sub.2).sub.n(3 12 membered heteroalicyclic), --O--(CH.sub.2).sub.n(5 12 membered heteroaryl) or --CN, and each hydrogen in R.sup.11 is optionally substituted by one or more groups selected from halogen, --OH, --CN, --C.sub.1-12 alkyl which may be partially or fully halogenated, --O--C.sub.1-12 alkyl which may be partially or fully halogenated, --CO, --SO and --SO.sub.2; R.sup.12 is hydrogen; m is 0, 1 or 2; n is 0, 1, 2, 3 or 4; and p is 1 or 2; wherein said 3 12 membered heteroalicyclic group is selected from pyrroline, pyrrolidine, dioxolane, imidazoline, imidazolidine, pyrazoline, pyrazolidine, pyran, piperidine, dioxane, morpholine, dithiane, thiomorpholine, piperazine and trithiane and said 5 12 membered heteroaryl group is selected from furan, thiophene, pyrrole, oxazole, thiazole, imidazole, pyrazole, isoxazole, isothiazole, oxadiazole, triazole, thiadiazole, pyridine, pyridazine, pyrimidine, pyrazine and triazine; or a pharmaceutically acceptable salt, or hydrate thereof.

7. The compound of claim 6, wherein the compound has formula 2a ##STR01605## wherein A.sup.2 is C.sub.6-12 aryl or 5 12 membered heteroaryl optionally substituted by one or more R.sup.3 groups.

8. The compound of claim 7, wherein R.sup.1 is selected from C.sub.6-12 aryl and 5 12 membered heteroaryl, and each hydrogen in R.sup.1 is optionally substituted by one or more R.sup.3 groups.

9. The compound of claim 7, wherein A.sup.2 is substituted by at least one halogen atom.

10. The compound of claim 6, wherein R.sup.1 is a furan, thiopene, pyrrole, pyrroline, pyrrolidine, dioxolane, oxazole, thiazole, imidazole, imidazoline, imidazolidine, pyrazole, pyrazoline, pyrazolidine, isoxazole, isothiazole, oxadiazole, triazole, thiadiazole, pyran, pyridine, piperidine, dioxane, morpholine, dithiane, thiomorpholine, pyridazine, pyrimidine, pyrazine, piperazine, triazine, trithiane or phenyl group, and each hydrogen in R.sup.1 is optionally substituted by one or more R.sup.3 groups.

11. A compound of formula 4 ##STR01606## wherein: R.sup.1 is selected from C.sub.6-12 aryl, 5 12 membered heteroaryl, C.sub.3-12 cycloalkyl, 3 12 membered heteroalicyclic; and each hydrogen in R.sup.1 is optionally substituted by one or more R.sup.3 groups; R.sup.3 is halogen, C.sub.1-12 alkyl, C.sub.2-12 alkenyl, C.sub.2-12 alkynyl, C.sub.3-12 cycloalkyl, C.sub.6-12 aryl, 3 12 membered heteroalicyclic, 5 12 membered heteroaryl, --S(O).sub.mR.sup.4, --SO.sub.2NR.sup.4R.sup.5, --S(O).sub.2OR.sup.4, --NO.sub.2, --NR.sup.4R.sup.5, --(CR.sup.6R.sup.7).sub.nOR.sup.4, --CN, --C(O)R.sup.4, --OC(O)R.sup.4, --O(CR.sup.6R.sup.7).sub.nR.sup.4, --NR.sup.4C(O)R.sup.5, --(CR.sup.6R.sup.7).sub.nC(O)OR.sup.4, --(CR.sup.6R.sup.7).sub.nNCR.sup.4R.sup.5, --C(.dbd.NR.sup.6)NR.sup.4R.sup.5, --NR.sup.4C(O)NR.sup.5R.sup.6, --NR.sup.4S(O).sub.pR.sup.5 or --C(O)NR.sup.4R.sup.5, each hydrogen in R.sup.3 is optionally substituted by one or more R.sup.8 groups, and R.sup.3 groups on adjacent atoms may combine to form a C.sub.6-12 aryl, 5 12 membered heteroaryl, C.sub.3-12 cycloalkyl or 3 12 membered heteroalicyclic group; each R.sup.4, R.sup.5, R.sup.6 and R.sup.7 is independently hydrogen, halogen, C.sub.1-12 alkyl, C.sub.2-12 alkenyl, C.sub.2-12 alkynyl, C.sub.3-12 cycloalkyl, C.sub.6-12 aryl, 3 12 membered heteroalicyclic, 5 12 membered heteroaryl; or any two of R.sup.4, R.sup.5, R.sup.6 and R.sup.7 bound to the same nitrogen atom may, together with the nitrogen to which they are bound, be combined to form a 3 to 12 membered heteroalicyclic or 5 12 membered heteroaryl group optionally containing 1 to 3 additional heteroatoms selected from N, O, and S; or any two of R.sup.4, R.sup.5, R.sup.6 and R.sup.7 bound to the same carbon atom may be combined to form a C.sub.3-12 cycloalkyl, C.sub.6-12 aryl, 3 12 membered heteroalicyclic or 5 12 membered heteroaryl group; and each hydrogen in R.sup.4, R.sup.5, R.sup.6 and R.sup.7 is optionally substituted by one or more R.sup.8 groups; each R.sup.8 is independently halogen, C.sub.1-12 alkyl, C.sub.2-12 alkenyl, C.sub.2-12 alkynyl, C.sub.3-12 cycloalkyl, C.sub.6-12 aryl, 3 12 membered heteroalicyclic, 5 12 membered heteroaryl, --CN, --O--C.sub.1-12 alkyl, --O--(CH.sub.2).sub.nC.sub.3-12 cycloalkyl, --O--(CH.sub.2).sub.nC.sub.6-12 aryl, --O--(CH.sub.2).sub.n(3 12 membered heteroalicyclic) or --O--(CH.sub.2).sub.n(5 12 membered heteroaryl); and each hydrogen in R.sup.8 is optionally substituted by one or more R.sup.11 groups; each R.sup.9 and R.sup.10 is independently hydrogen, halogen, C.sub.1-12 alkyl, C.sub.3-12 cycloalkyl, C.sub.6-12 aryl, 3 12 membered heteroalicyclic, 5 12 membered heteroaryl, --S(O).sub.mR.sup.4, --SO.sub.2NR.sup.4R.sup.5, --S(O).sub.2OR.sup.4, --NO.sub.2, --NR.sup.4R.sup.5, --(CR.sup.6R.sup.7).sub.nOR.sup.4, --CN, --C(O)R.sup.4, --OC(O)R.sup.4, --NR.sup.4C(O)R.sup.5, --(CR.sup.6R.sup.7).sub.nC(O)OR.sup.4, --(CR.sup.6R.sup.7).sub.nNCR.sup.4R.sup.5, --NR.sup.4C(O)NR.sup.5R.sup.6, --NR.sup.4S(O).sub.pR.sup.5 or --C(O)NR.sup.4R.sup.5; R.sup.9 and R.sup.10 may combine to form a C.sub.3-12 cycloalkyl, 3 12 membered heteroalicyclic, C.sub.6-12 aryl or 5 12 membered heteroaryl ring; and each hydrogen in R.sup.9 and R.sup.10 is optionally substituted by one or more R.sup.3 groups; A.sup.2 is C.sub.6-12 aryl, 5 12 membered heteroaryl, C.sub.3-12 cycloalkyl or 3 12 membered heteroalicyclic, and A.sup.2 is optionally substituted by one or more R.sup.3 groups; each R.sup.11 is independently halogen, C.sub.1-12 alkyl, C.sub.1-12 alkoxy, C.sub.3-12 cycloalkyl, C.sub.6-12 aryl, 3 12 membered heteroalicyclic, 5 12 membered heteroaryl, --O--C.sub.1-12 alkyl, --O--(CH.sub.2).sub.nC.sub.3-12 cycloalkyl, --O--(CH.sub.2).sub.nC.sub.6-12 aryl, --O--(CH.sub.2).sub.n(3 12 membered heteroalicyclic), --O--(CH.sub.2).sub.n(5 12 membered heteroaryl) or --CN, and each hydrogen in R.sup.11 is optionally substituted by one or more groups selected from halogen, --OH, --CN, --C.sub.1-12 alkyl which may be partially or fully halogenated, --O--C.sub.1-12 alkyl which may be partially or fully halogenated, --CO, --SO and --SO.sub.2; m is 0, 1 or 2; n is 0, 1, 2, 3 or 4; and p is 1 or 2; wherein said 3 12 membered heteroalicyclic group is selected from pyrroline, pyrrolidine, dioxolane, imidazoline, imidazolidine, pyrazoline, pyrazolidine, pyran, piperidine, dioxane, morpholine, dithiane, thiomorpholine, piperazine and trithiane and said 5 12 membered heteroaryl group is selected from furan, thiophene, pyrrole, oxazole, thiazole, imidazole, pyrazole, isoxazole, isothiazole, oxadiazole, triazole, thiadiazole, pyridine, pyridazine, pyrimidine, pyrazine and triazine; or a pharmaceutically acceptable salt, or hydrate thereof.

12. The compound of claim 11, wherein A.sup.2 is C.sub.6-12 aryl or 5 12 membered heteroaryl optionally substituted by one or more R.sup.3 groups.

13. A compound of formula 6 ##STR01607## wherein, Z is CR or N; Aryl is an optionally fused aryl or an optionally fused heteroaryl group which is optionally substituted by one or more substituents selected from the group consisting of a halogen, --OR.sup.24, COR.sup.24, --COOR.sup.24, --CONR.sup.24R.sup.25, --CN, --NO.sub.2, --S(O).sub.mR.sup.24, --SO.sub.2NR.sup.24R.sup.25, perfluoroalkyl, lower alkyl, cycloalkyl, heterocycle, alkenyl, alkynyl, aryl, --NR.sup.24R.sup.25, --NR.sup.24C(O)R.sup.25 and --NR.sup.24S(O).sub.pR.sup.25; R.sup.21 and R.sup.22 are independently selected from the group consisting of hydrogen, halogen, --COR.sup.24, --COOR.sup.24, --CONR.sup.24R.sup.25, --CN, perfluoroalkyl, lower alkyl, cycloalkyl, heterocycle, alkenyl, alkynyl, and aryl; R.sup.23 is selected from the group consisting of: an optionally fused aryl, heteroaryl, alicyclic or heterocyclic group, optionally substituted by one or more substituents selected from the group consisting of a halogen, --(CH.sub.2).sub.n--OR.sup.24, COR.sup.24, --COOR.sup.24, --CONR.sup.24R.sup.25, --CN, --NO.sub.2, --S(O).sub.mR.sup.24, --SO.sub.2NR.sup.24R.sup.25, perfluoroalkyl, --O-perfluoroalkyl, lower alkyl, cycloalkyl, heterocycle, heteroaryl, alkenyl, alkynyl, aryl, --(CH.sub.2).sub.n--NR.sup.24R.sup.25, --NR.sup.24C(O)R.sup.25 and --NR.sup.24S(O).sub.pR.sup.25, wherein said heterocycle, heteroaryl and aryl substituents may be optionally substituted by a group selected from the group consisting of lower alkyl, halogen, --C(O)NR.sup.24R.sup.25, NR.sup.24R.sup.25, NR.sup.24C(O)R.sup.25 and NR.sup.24S(O).sub.pR.sup.25; --OR.sup.24, --COR.sup.24, --COOR.sup.24, --CN, --NO.sub.2, --S(O).sub.mR.sup.24, --SO.sub.2NR.sup.24R.sup.25, perfluoroalkyl, cycloalkyl, heterocycle, alkenyl, and alkynyl; R.sup.24 and R.sup.25 are independently selected from the group consisting of hydrogen, lower alkyl, cycloalkyl, alkenyl, alkynyl, aryl, aminoalkyl, alkylaminoalkyl, alkylaminocycloalkyl, dialkylaminoalkyl and --(CH.sub.2).sub.n-heterocycle, wherein said --(CH.sub.2).sub.n-heterocycle may be further substituted by one or more of lower alkyl, --(CH.sub.2).sub.n-hydroxy, heterocycle and --C(O)R.sup.26, or R.sup.24 and R.sup.25 can combine to form a 5- to 6-membered heterocyclic ring having one or more heteroatoms selected from the group consisting of N, O, S, S(O) and SO.sub.2, said 5- to 6-membered heterocyclic ring may be optionally substituted by lower alkyl, --(CH.sub.2).sub.n-heterocycle, cycloalkyl, halo, --(CH.sub.2).sub.n--NR.sup.26R.sup.27, amino, --C(O)R.sup.26, --NR.sup.26--(O)OR.sup.27 and --NR.sup.26--C(O)R.sup.27; wherein R.sup.26 and R.sup.27 are independently selected from the group consisting of hydrogen, lower alkyl, --(CH.sub.2).sub.n-cycloalkyl and --C(O)--(CH.sub.2).sub.n--OH; except that when Z is N and R.sup.21 and R.sup.22 are H and Aryl is m-chlorophenyl, R.sup.23 is not piperazine; m is 0, 1 or 2; n is 0, 1, 2 or 3; p is 1 or 2; wherein said heterocyclic group is selected from pyrroline, pyrrolidine, dioxolane, imidazoline, imidazolidine, pyrazoline, pyrazolidine, pyran, piperidine, dioxane, morpholine, dithiane, thiomorpholine, piperazine and trithiane and said heteroaryl group is selected from furan, thiophene, pyrrole, oxazole, thiazole, imidazole, pyrazole, isoxazole, isothiazole, oxadiazole, triazole, thiadiazole, pyridine, pyridazine, pyrimidine, pyrazine and triazine; or a pharmaceutically acceptable salt thereof.

14. The compound of claim 13, wherein R.sup.23 is aryl or heteroaryl.

15. A compound selected from the group consisting of: (4-{6-amino-5-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridin-3-yl}-phe- nyl)-(4-methyl-piperazin-1-yl)-methanone; N-[2-(4-acetyl-piperazin-1-yl)-ethyl]-4-{6-amino-5-[1-(2,6-dichloro-3-flu- oro-phenyl)-ethoxy]-pyridin-3-yl}-benzamide; 4-{6-amino-5-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridin-3-yl}--N-(- 3-pyrrolidin-1-yl-propyl)-benzamide; 4-{6-amino-5-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridin-3-yl}-N-(2- -morpholin-4-yl-ethyl)-benzamide; (4-{6-amino-5-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridin-3-yl}-phe- nyl)-((S)-3-amino-pyrrolidin-1-yl)-methanone; (4-{6-amino-5-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridin-3-yl}-phe- nyl)-((R)-3-amino-pyrrolidin-1-yl)-methanone; (4-{6-amino-5-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridin-3-yl}-phe- nyl)-(4-amino-piperidin-1-yl)-methanone; (4-{6-amino-5-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridin-3-yl}-phe- nyl)-((S)-3-hydroxy-pyrrolidin-1-yl)-methanone; (4-{6-amino-5-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridin-3-yl}-phe- nyl)-((R)-3-hydroxy-pyrrolidin-1-yl)-methanone; (4-(6-amino-5-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridin-3-yl}-phe- nyl)-((R)-2-hydroxymethyl-pyrrolidin-1-yl)-methanone; 4-{6-amino-5-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridin-3-yl}-N-(2- -diethylamino-ethyl)-benzamide; 4-{6-amino-5-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridin-3-yl}-N-(2- -pyrrolidin-1-yl-ethyl)-benzamide; 3-{6-amino-5-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridin-3-yl}-benz- oic acid; (3-{6-amino-5-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridin-- 3-yl}-phenyl)-(4-methyl-piperazin-1-yl)-methanone; 3-{6-amino-5-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridin-3-yl}-N-(1- -methyl-piperidin-4-yl)-benzamide; (3-{6-amino-5-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridin-3-yl}-phe- nyl)-((S)-2-pyrrolidin-1-ylmethyl-pyrrolidin-1-yl)-methanone; N-[2-(4-acetyl-piperazin-1-yl)-ethyl]-3-{6-amino-5-[1-(2,6-dichloro-3-flu- oro-phenyl)-ethoxy]-pyridin-3-yl}-benzamide; (3-{6-amino-5-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridin-3-yl}-phe- nyl)-((S)-3-amino-pyrrolidin-1-yl)-methanone; 3-{6-amino-5-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridin-3-yl}-N-(3- -morpholin-4-yl-propyl)-benzamide; (3-{6-amino-5-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridin-3-yl}-phe- nyl)-((R)-2-pyrrolidin-1-ylmethyl-pyrrolidin-1-yl)-methanone; 3-{6-amino-5-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridin-3-yl}-N-(2- -pyrrolidin-1-yl-ethyl)-benzamide; 3-{6-amino-5-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridin-3-yl}-N-(3- -pyrrolidin-1-yl-propyl)-benzamide; 3-{6-amino-5-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridin-3-yl}-N-(2- -morpholin-4-yl-ethyl)-benzamide; (3-{6-amino-5-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridin-3-yl}-phe- nyl)-(4-pyrrolidin-1-yl-piperidin-1-yl)-methanone; 2-diethylamino-ethanesulfonic acid (4-{6-amino-5-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridin-3-yl}-phe- nyl)-amide; 2-(4-Hydroxy-piperidin-1-yl)-ethanesulfonic acid (4-{6-amino-5-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridin-3-yl}-phe- nyl)-amide; 2-piperidin-1-yl-ethanesulfonic acid (4-{6-amino-5-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridin-3-yl}-phe- nyl)-amide; 2-(cyclopropylmethyl-amino)-ethanesulfonic acid (4-{6-amino-5-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridin-3-yl}-phe- nyl)-amide; 2-((R)-3-Hydroxy-pyrrolidin-1-yl)-ethanesulfonic acid (4-{6-amino-5-[1-(2-chloro-3,6-difluoro-phenyl)-ethoxy]-pyridin-3-yl}-phe- nyl)-amide; 2-cyclopropylamino-ethanesulfonic acid (4-{6-amino-5-[1-(2-chloro-3,6-difluoro-phenyl)-ethoxy]-pyridin-3-yl}-phe- nyl)-amide; 2-diethylamino-ethanesulfonic acid (4-{6-amino-5-[1-(2-chloro-3,6-difluoro-phenyl)-ethoxy]-pyridin-3-yl}-phe- nyl)-amide; 4-{6-amino-5-[1-(2-chloro-3,6-difluoro-phenyl)-ethoxy]-pyridin-3-yl}-benz- oic acid; 4-{6-amino-5-[1-(2-chloro-3,6-difluoro-phenyl)-ethoxy]-pyridin-3- -yl}-N-(2-morpholin-4-yl-ethyl)-benzamide; 4-{6-amino-5-[1-(2-chloro-3,6-difluoro-phenyl)-ethoxy]-pyridin-3-yl}-N-(1- -methyl-piperidin-4-yl)-benzamide; (4-{6-amino-5-[1-(2-chloro-3,6-difluoro-phenyl)-ethoxy]-pyridin-3-yl}-phe- nyl)-((R)-2-pyrrolidin-1-ylmethyl-pyrrolidin-1-yl)-methanone; (4-{6-amino-5-[1-(2-chloro-3,6-difluoro-phenyl)-ethoxyl]-pyridin-3-yl}-ph- enyl)-((R)-3-amino-pyrrolidin-1-yl)-methanone; (4-{6-amino-5-[1-(2-chloro-3,6-difluoro-phenyl)-ethoxy]-pyridin-3-yl}-phe- nyl)-((3R,5S)-3,5-dimethyl-piperazin-1-yl)-methanone; 4-{6-amino-5-[1-(2-chloro-3,6-difluoro-phenyl)-ethoxy]-pyridin-3-yl}-N-(3- -pyrrolidin-1-yl-propyl)-benzamide; (4-{6-amino-5-[1-(2-chloro-3,6-difluoro-phenyl)-ethoxy]-pyridin-3-yl}-phe- nyl)-((S)-2-pyrrolidin-1-ylmethyl-pyrrolidin-1-yl)-methanone; (4-{6-amino-5-[1-(2-chloro-3,6-difluoro-phenyl)-ethoxy]-pyridin-3-yl}-phe- nyl)-(4-methyl-piperazin-1-yl)-methanone; (4-{6-amino-5-[1-(2-chloro-3,6-difluoro-phenyl)-ethoxy]-pyridin-3-yl}-phe- nyl)-(4-pyrrolidin-1-yl-piperidin-1-yl)-methanone; 4-{6-amino-5-[1-(2-chloro-3,6-difluoro-phenyl)-ethoxy]-pyridin-3-yl}-N-(2- -pyrrolidin-1-yl-ethyl)-benzamide; (4-{6-amino-5-[1-(2-chloro-3,6-difluoro-phenyl)-ethoxy]-pyridin-3-yl}-phe- nyl)-((S)-3-amino-pyrrolidin-1-yl)-methanone; 3-{6-amino-5-[1-(2-chloro-3,6-difluoro-phenyl)-ethoxy]-pyridin-3-yl}-benz- oic acid; (3-{6-amino-5-[1-(2-chloro-3,6-difluoro-phenyl)-ethoxy]-pyridin-- 3-yl}-phenyl)-((3R,5S)-3,5-dimethyl-piperazin-1-yl)-methanone; (3-{6-amino-5-[1-(2-chloro-3,6-difluoro-phenyl)-ethoxy]-pyridin-3-yl}-phe- nyl)-((R)-3-amino-pyrrolidin-1-yl)-methanone; 3-{6-amino-5-[1-(2-chloro-3,6-difluoro-phenyl)-ethoxy]-pyridin-3-yl}-N-(1- -methyl-piperidin-4-yl)-benzamide; (3-{6-amino-5-[1-(2-chloro-3,6-difluoro-phenyl)-ethoxy]-pyridin-3-yl}-phe- nyl)-(4-methyl-piperazin-1-yl)-methanone; 3-{6-amino-5-[1-(2-chloro-3,6-difluoro-phenyl)-ethoxy]-pyridin-3-yl}-N-(3- -pyrrolidin-1-yl-propyl)-benzamide; 3-{6-amino-5-[1-(2-chloro-3,6-difluoro-phenyl)-ethoxy]-pyridin-3-yl}-N-(2- -pyrrolidin-1-yl-ethyl)-benzamide; (3-{6-amino-5-[1-(2-chloro-3,6-difluoro-phenyl)-ethoxy]-pyridin-3-yl}-phe- nyl)-((S)-3-amino-pyrrolidin-1-yl)-methanone; 3-{6-amino-5-[1-(2-chloro-3,6-difluoro-phenyl)-ethoxy]-pyridin-3-yl}-N-(2- -morpholin-4-yl-ethyl)-benzamide; (3-{6-amino-5-[1-(2-chloro-3,6-difluoro-phenyl)-ethoxy]-pyridin-3-yl}-phe- nyl)-((R)-2-pyrrolidin-1-ylmethyl-pyrrolidin-1-yl)-methanone; (3-{6-amino-5-[1-(2-chloro-3,6-difluoro-phenyl)-ethoxy]-pyridin-3-yl}-phe- nyl)-((S)-2-pyrrolidin-1-ylmethyl-pyrrolidin-1-yl)-methanone; 3-[1-(2-chloro-3,6-difluoro-phenyl)-ethoxy]-5-[4-(2-morpholin-4-yl-ethoxy- )-phenyl]-pyridin-2-ylamine; 3-[1-(2-chloro-3,6-difluoro-phenyl)-ethoxy]-5-[3-(2-morpholin-4-yl-ethoxy- )-phenyl]-pyridin-2-ylamine; 3-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-5-[4-(2-pyrrolidin-1-yl-ethox- y)-phenyl]-pyridin-2-ylamine; 3-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-5-{4-[2-(1-methyl-pyrrolidin-- 2-yl)-ethoxy]-phenyl}-pyridin-2-ylamine; 3-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-5-[4-(2-morpholin-4-yl-ethoxy- )-phenyl]-pyridin-2-ylamine; 3-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-5-[3-(2-morpholin-4-yl-ethoxy- )-phenyl]-pyridin-2-ylamine; 1-(4-{6-amino-5-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridin-3-yl}-p- henoxy)-3-morpholin-4-yl-propan-2-ol; 3-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-5-[4-(2-diethylamino-ethoxy)-- phenyl]-pyridin-2-ylamine; 3-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-5-[4-(1-methyl-piperidin-3-yl- methoxy)-phenyl]-pyridin-2-ylamine; 3-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-5-[4-(2-diisopropylamino-etho- xy)-phenyl]-pyridin-2-ylamine; 3-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-5-[4-(1-methyl-piperidin-4-yl- oxy)-phenyl]-pyridin-2-ylamine; N-(4-{6-amino-5-[1-(2-chloro-3,6-difluoro-phenyl)-ethoxy]-pyridin-3-yl}-p- henyl)-methanesulfonamide; 3-[1-(2-chloro-3,6-difluoro-phenyl)-ethoxy]-5-[4-(1,1-dioxo-1lambda*6*-is- othiazolidin-2-yl)-phenyl]-pyridin-2-ylamine; N-(4-{6-amino-5-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridin-3-yl}-p- henyl)-methanesulfonamide; 3-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-5-phenyl-pyridin-2-ylamine; N-(4-{6-amino-5-[(R)-1-(2-chloro-3,6-difluoro-phenyl)-ethoxy]-pyridin-3-y- l}-phenyl)-methanesulfonamide; 3-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-5-thiophen-3-yl-pyridin-2-yla- mine; 5-benzo[b]thiophen-2-yl-3-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-- pyridin-2-ylamine; 4-methyl-piperazine-1-carboxylic acid (4-{6-amino-5-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridin-3-yl}-phe- nyl)-amide; 1-(4-{6-amino-5-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridin-3-yl}-p- henyl)-3-(2-pyrrolidin-1-yl-ethyl)-urea; 1-(4-{6-amino-5-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridin-3-yl}-p- henyl)-3-(2-hydroxy-ethyl)-urea; 1-(4-{6-amino-5-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridin-3-yl}-p- henyl)-3-(2-morpholin-4-yl-ethyl)-urea; (R)-3-amino-pyrrolidine-1-carboxylic acid (4-{6-amino-5-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridin-3-yl}-phe- nyl)-amide; (S)-3-amino-pyrrolidine-1-carboxylic acid (4-{6-amino-5-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridin-3-yl}-phe- nyl)-amide; 1-(4-{6-amino-5-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridin-3-yl}-p- henyl)-3-(1-methyl-piperidin-4-yl)-urea; 1-(4-{6-amino-5-[1-(2-chloro-3,6-difluoro-phenyl)-ethoxy]-pyridin-3-yl}-p- henyl)-3-(1-methyl-piperidin-4-yl)-urea; (R)-3-amino-pyrrolidine-1-carboxylic acid (4-{6-amino-5-[1-(2-chloro-3,6-difluoro-phenyl)-ethoxy]-pyridin-3-yl}-phe- nyl)-amide; (S)-3-amino-pyrrolidine-1-carboxylic acid (4-{6-amino-5-[1-(2-chloro-3,6-difluoro-phenyl)-ethoxy]-pyridin-3-yl}-phe- nyl)-amide; 1-(4-(6-amino-5-[1-(2-chloro-3,6-difluoro-phenyl)-ethoxy]-pyridin-3-yl}-p- henyl)-3-(2-hydroxy-ethyl)-urea; 4-methyl-piperazine-1-carboxylic acid (4-{6-amino-5-[1-(2-chloro-3,6-difluoro-phenyl)-ethoxy]-pyridin-3-yl}-phe- nyl)-amide; 1-(4-{6-amino-5-[1-(2-chloro-3,6-difluoro-phenyl)-ethoxy]-pyridin-3-yl}-p- henyl)-3-(2-pyrrolidin-1-yl-ethyl)-urea; 1-(4-{6-amino-5-[1-(2-chloro-3,6-difluoro-phenyl)-ethoxy]-pyridin-3-yl}-p- henyl)-3-(2-morpholin-4-yl-ethyl)-urea; (R)-2-pyrrolidin-1-ylmethyl-pyrrolidine-1-carboxylic acid (4-{6-amino-5-[1-(2-chloro-3,6-difluoro-phenyl)-ethoxy]-pyridin-3-yl}-phe- nyl)-amide; 3-{6-amino-5-[1-(2,6-dichloro-phenyl)-ethoxy]-pyridin-3-yl}-benzoic acid; (3-{6-amino-5-[1-(2,6-dichloro-phenyl)-ethoxy]-pyridin-3-yl}-phenyl)-((3R- ,5S)-3,5-dimethyl-piperazin-1-yl)-methanone; (3-{6-amino-5-[1-(2,6-dichloro-phenyl)-ethoxy]-pyridin-3-yl}-phenyl)-(4-p- yrrolidin-1-yl-piperidin-1-yl)-methanone; 3-{6-amino-5-[1-(2,6-dichloro-phenyl)-ethoxy]-pyridin-3-yl}-N-(2-pyrrolid- in-1-yl-ethyl)-benzamide; 3-{6-amino-5-[1-(2,6-dichloro-phenyl)-ethoxy]-pyridin-3-yl}-N-(2-morpholi- n-4-yl-ethyl)-benzamide; (3-{6-amino-5-[1-(2,6-dichloro-phenyl)-ethoxy]-pyridin-3-yl}-phenyl)-((S)- -2-pyrrolidin-1-ylmethyl-pyrrolidin-1-yl)-methanone; 3-{6-amino-5-[1-(2,6-dichloro-phenyl)-ethoxy]-pyridin-3-yl}-N-(3-pyrrolid- in-1-yl-propyl)-benzamide; N-[2-(4-acetyl-piperazin-1-yl)-ethyl]-3-{6-amino-5-[1-(2,6-dichloro-pheny- l)-ethoxy]-pyridin-3-yl}-benzamide; 3-{6-amino-5-[1-(2,6-dichloro-phenyl)-ethoxy]-pyridin-3-yl}-N-(1-methyl-p- iperidin-4-yl)-benzamide; (3-{6-amino-5-[1-(2,6-dichloro-phenyl)-ethoxy]-pyridin-3-yl}-phenyl)-(4-m- ethyl-piperazin-1-yl)-methanone; (3-{6-amino-5-[1-(2,6-dichloro-phenyl)-ethoxy]-pyridin-3-yl}-phenyl)-((R)- -2-pyrrolidin-1-ylmethyl-pyrrolidin-1-yl)-methanone; (3-{6-amino-5-[1-(2,6-dichloro-phenyl)-ethoxy]-pyridin-3-yl}-phenyl)-((S)- -3-amino-pyrrolidin-1-yl)-methanone; (3-{6-amino-5-[1-(2,6-dichloro-phenyl)-ethoxy]-pyridin-3-yl}-phenyl)-((R)- -3-amino-pyrrolidin-1-yl)-methanone; 4-{6-amino-5-[1-(2,6-dichloro-phenyl)-ethoxy]-pyridin-3-yl}-benzoic acid; 4-{6-amino-5-[1-(2,6-dichloro-phenyl)-ethoxy]-pyridin-3-yl}-N-(2-pyrrolid- in-1-yl-ethyl)-benzamide; 4-{6-amino-5-[1-(2,6-dichloro-phenyl)-ethoxy]-pyridin-3-yl}-N-(2-morpholi- n-4-yl-ethyl)-benzamide; (4-{6-amino-5-[1-(2,6-dichloro-phenyl)-ethoxy]-pyridin-3-yl}-phenyl)-((S)- -2-pyrrolidin-1-ylmethyl-pyrrolidin-1-yl)-methanone; 4-{6-amino-5-[1-(2,6-dichloro-phenyl)-ethoxy]-pyridin-3-yl}-N-(1-methyl-p- iperidin-4-yl)-benzamide; (4-{6-amino-5-[1-(2,6-dichloro-phenyl)-ethoxy]-pyridin-3-yl}-phenyl)-((3R- ,5S)-3,5-dimethyl-piperazin-1-yl)-methanone; N-[2-(4-acetyl-piperazin-1-yl)-ethyl]-4-{6-amino-5-[1-(2,6-dichloro-pheny- l)-ethoxy]-pyridin-3-yl}-benzamide; 4-{6-amino-5-[1-(2,6-dichloro-phenyl)-ethoxy]-pyridin-3-yl}-N-(3-pyrrolid- in-1-yl-propyl)-benzamide; (4-{6-amino-5-[1-(2,6-dichloro-phenyl)-ethoxy]-pyridin-3-yl}-phenyl)-((S)- -3-aminopyrrolidin-1-yl)-methanone; (4-{6-amino-5-[1-(2,6-dichloro-phenyl)-ethoxy]-pyridin-3-yl}-phenyl)-((R)- -3-amino-pyrrolidin-1-yl)-methanone; (4-{6-amino-5-[1-(2,6-dichloro-phenyl)-ethoxy]-pyridin-3-yl}-phenyl)-((R)- -2-pyrrolidin-1-ylmethyl-pyrrolidin-1-yl)-methanone; (4-{6-amino-5-[1-(2,6-dichloro-phenyl)-ethoxy]-pyridin-3-yl}-phenyl)-(4-p- yrrolidin-1-yl-piperidin-1-yl)-methanone; (4-{6-amino-5-[1-(2,6-dichloro-phenyl)-ethoxy]-pyridin-3-yl}-phenyl)-(4-m- ethyl-piperazin-1-yl)-methanone; (4-{6-amino-5-[1-(3-fluoro-2-trifluoromethyl-phenyl)-ethoxy]-pyridin-3-yl- }-phenyl)-(4-methyl-piperazin-1-yl)-methanone; (4-{6-amino-5-[1-(3-fluoro-2-trifluoromethyl-phenyl)-ethoxy]-pyridin-3-yl- }-phenyl)-(4-pyrrolidin-1-yl-piperidin-1yl)-methanone; (4-{6-amino-5-[1-(3-fluoro-2-trifluoromethyl-phenyl)-ethoxy]-pyridin-3-yl- }-phenyl)-((3R,5S)-3,5-dimethyl-piperazin-1-yl)-methanone; (4-{6-amino-5-[1-(3-fluoro-2-trifluoromethyl-phenyl)-ethoxy]-pyridin-3-yl- }-phenyl)-((S)-2-pyrrolidin-1-ylmethyl-pyrrolidin-1-yl)-methanone; (4-{6-amino-5-[1-(3-fluoro-2-trifluoromethyl-phenyl)-ethoxy]-pyridin-3-yl- }-phenyl)-((R)-2-pyrrolidin-1-ylmethyl-pyrrolidin-1-yl)-methanone; 4-{6-amino-5-[1-(3-fluoro-2-trifluoromethyl-phenyl)-ethoxy]-pyridin-3-yl}- -N-(1-methyl-piperidin-4-yl)-benzamide; 4-{6-amino-5-[1-(3-fluoro-2-trifluoromethyl-phenyl)-ethoxy]-pyridin-3-yl}- -N-(2-pyrrolidin-1-yl-ethyl)-benzamide; 4-{6-amino-5-[1-(3-fluoro-2-trifluoromethyl-phenyl)-ethoxy]-pyridin-3-yl}- -N-(2-morpholin-4-yl-ethyl)-benzamide; 4-{6-amino-5-[1-(3-fluoro-2-trifluoromethyl-phenyl)-ethoxy]-pyridin-3-yl}- -N-(3-pyrrolidin-1-yl-propyl)-benzamide; 4-{6-amino-5-[1-(3-fluoro-2-trifluoromethyl-phenyl)-ethoxy]-pyridin-3-yl}- -N-(3-morpholin-4-yl-propyl)-benzamide; 3-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-5-(1H-pyrazol-4-yl)-pyridin-2- -ylamine; 3-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-5-[1-(2-pyrrolidin-1- -yl-ethyl)-1H-pyrazol-4-yl]-pyridin-2-ylamine; 3-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-5-[1-(2-diisopropylamino-ethy- l)-1H-pyrazol-4-yl]-pyridin-2-ylamine; 3-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-5-[1-(2-morpholin-4-yl-ethyl)- -1H-pyrazol-4-yl]-pyridin-2-ylamine;

{4-[6-amino-5-(3-fluoro-2-methoxy-benzyloxy)-pyridin-3-yl]-phenyl}-((3R,5- S)-3,5-dimethyl-piperazin-1-yl)-methanone; (4-{6-amino-5-[1-(3-fluoro-2-methoxy-phenyl)-ethoxy]-pyridin-3-yl}-phenyl- )-((3R,5S)-3,5-dimethyl-piperazin-1-yl)-methanone; {4-[6-amino-5-(3-fluoro-2-isopropoxy-benzyloxy)-pyridin-3-yl]-phenyl}-((3- R,5S)-3,5-dimethyl-piperazin-1-yl)-methanone; 5-(4-amino-phenyl)-3-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridin-2-- ylamine; (4-{6-amino-5-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridin-3- -yl}-phenoxy)-acetic acid methyl ester; (4-{6-amino-5-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridin-3-yl}-phe- noxy)-acetic acid; 2-(4-{6-amino-5-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridin-3-yl}-p- henoxy)-1-((3R,5S)-3,5-dimethyl-piperazin-1-yl)-ethanone; 2-(4-{6-amino-5-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridin-3-yl}-p- henoxy)-1-((R)-3-hydroxy-pyrrolidin-1-yl)-ethanone; 4-[2-(4-{6-amino-5-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridin-3-yl- }-phenoxy)-acetyl]-piperazine-1-carboxylic acid tert-butyl ester; 2-(4-{6-amino-5-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridin-3-yl}-p- henoxy)-1-((R)-2-pyrrolidin-1-ylmethyl-pyrrolidin-1-yl)-ethanone; {4-[6-amino-5-(3-fluoro-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-yloxy)-p- yridin-3-yl]-phenyl}-((3R,5S)-3,5-dimethyl-piperazin-1-yl)-methanone; 3-(3-fluoro-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-yloxy)-5-[4-(2-pyrro- lidin-1-yl-ethoxy)-phenyl]-pyridin-2-ylamine; N-{4-[6-amino-5-(3-fluoro-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-yloxy)- -pyridin-3-yl]-phenyl}-methanesulfonamide; 3-(3-fluoro-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-yloxy)-5-(1H-pyrazol- -4-yl)-pyridin-2-ylamine; 3-[1-(2-chloro-3-fluoro-phenyl)-ethoxy]-5-[4-(2-pyrrolidin-1-yl-ethoxy)-p- henyl]-pyridin-2-ylamine; 5'-benzyloxy-[2,3']bipyridinyl-6'-ylamine; 5-benzyloxy-[3,3']bipyridinyl-6-ylamine; 3-benzyloxy-5-pyrimidin-5-yl-pyridin-2-ylamine; 5-benzyloxy-[3,3']bipyridinyl-6,6'-diamine; 5'-(2-chloro-benzyloxy)-[2,3']bipyridinyl-6'-ylamine; 5-(2-chloro-benzyloxy)-[3,3']bipyridinyl-6-ylamine; 3-(2-chloro-benzyloxy)-5-pyrimidin-5-yl-pyridin-2-ylamine; 5-(2-chloro-benzyloxy)-[3,3']bipyridinyl-6,6'-diamine; 5'-(4-chloro-benzyloxy)-[2,3']bipyridinyl-6'-ylamine; 5-(4-chloro-benzyloxy)-[3,3']bipyridinyl-6-ylamine; 3-(4-chloro-benzyloxy)-5-pyrimidin-5-yl-pyridin-2-ylamine; 5-(4-chloro-benzyloxy)-[3,3']bipyridinyl-6,6'-diamine; 5'-(2-chloro-3,6-difluoro-benzyloxy)-[2,3']bipyridinyl-6'-ylamine; 5-(2-chloro-3,6-difluoro-benzyloxy)-[3,3']bipyridinyl-6-ylamine; 5-(2-chloro-3,6-difluoro-benzyloxy)-[3,4']bipyridinyl-6-ylamine; 3-(2-chloro3,6-difluoro-benzyloxy)-5-pyrimidin-5-yl-pyridin-2-ylamine; 5-(2-chloro-3,6-difluoro-benzyloxy)-[3,3']bipyridinyl-6,6'-diamine; 5'-(2,6-dichloro-benzyloxy)-[2,3']bipyridinyl-6'-ylamine; 5-(2,6-dichloro-benzyloxy)-[3,3']bipyridinyl-6-ylamine; 5-(2,6-dichloro-benzyloxy)-[3,4']bipyridinyl-6-ylamine; 3-(2,6-dichloro-benzyloxy)-5-pyrimidin-5-yl-pyridin-2-ylamine; 5-(2,6-dichloro-benzyloxy)-[3,3']bipyridinyl-6,6'-diamine; 5-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-[3,3']bipyridinyl-6,6'-diamin- e; {6'-amino-5'-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-[2,3']bipyridiny- l-4-yl}-(4-methyl-piperazin-1-yl)-methanone; {6'-amino-5'-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-[2,3']bipyridinyl-- 6-yl}-(4-methyl-piperazin-1-yl)-methanone; {6'-amino-5'-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-[3,3']bipyridinyl-- 5-yl}-(4-methyl-piperazin-1-yl)-methanone; {6'-amino-5'-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-[3,3']bipyridinyl-- 6-yl}-(4-methyl-piperazin-1-yl)-methanone; {6-amino-5-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-[3,4']bipyridinyl-2'- -yl}-(4-methyl-piperazin-1-yl)-methanone; 5-[1-(2-chloro-3,6-difluoro-phenyl)-ethoxy]-[3,3']bipyridinyl-6,6'-diamin- e; {6'-amino-5'-[1-(2-chloro-3,6-difluoro-phenyl)-ethoxy]-[2,3']bipyridiny- l-5-yl}-(4-methyl-piperazin-1-yl)-methanone; {6'-amino-5'-[1-(2-chloro-3,6-difluoro-phenyl)-ethoxy]-[2,3']bipyridinyl-- 4-yl}-(4-methyl-piperazin-1-yl)-methanone; {6'-amino-5'-[1-(2-chloro-3,6-difluoro-phenyl)-ethoxy]-[2,3']bipyridinyl-- 6-yl}-(4-methyl-piperazin-1-yl)-methanone; {6'-amino-5'-[1-(2-chloro-3,6-difluoro-phenyl)-ethoxy]-[3,3']bipyridinyl-- 5-yl}-(4-methyl-piperazin-1-yl)-methanone; {6'-amino-5'-[1-(2-chloro-3,6-difluoro-phenyl)-ethoxy]-[3,3']bipyridinyl-- 6-yl}-(4-methyl-piperazin-1-yl)-methanone; {6-amino-5-[1-(2-chloro-3,6-difluoro-phenyl)-ethoxy]-[3,4']bipyridinyl-2'- -yl}-(4-methyl-piperazin-1-yl)-methanone; 5'-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-[2,3']bipyridinyl-6'-ylamine- ; 5'-[1-(2-chloro-3,6-difluoro-phenyl)-ethoxy]-[2,3']bipyridinyl-6'-ylamin- e; 5-[1-(2-chloro-3,6-difluoro-phenyl)-ethoxy]-[3,3']bipyridinyl-6-ylamine- ; 3-[1-(2-chloro-3,6-difluoro-phenyl)-ethoxy]-5-pyrimidin-5-yl-pyridin-2-y- lamine; {6'-amino-5'-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-[2,3']bipyr- idinyl-5-yl}-(4-methyl-piperazin-1-yl)-methanone; 5-[1-(2-chloro-3,6-difluoro-phenyl)-ethoxy]-[3,4]bipyridinyl-6-ylamine; (4-{6-amino-5-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridin-3-yl}-phe- nyl)-((3R,5S)-3,5-dimethyl-piperazin-1-yl)-methanone; (4-{6-amino-5-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridin-3-yl}-phe- nyl)-((3R,5S)-3,5-dimethyl-piperazin-1-yl)-methanone; 5-{6-amino-5-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridin-3-yl}-2-fl- uoro-benzonitrile; 4-(4-{6-amino-5-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridin-3-yl}-p- henyl)-piperidin-4-ol; (4-{6-amino-5-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridin-3-yl}-phe- nyl)-piperidin-1-yl-methanone; (4-{6-amino-5-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridin-3-yl}-phe- nyl)-pyrrolidin-1-yl-methanone; 4-{6-amino-5-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridin-3-yl}-3-me- thyl-benzoic acid methyl ester; 3-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-5-[4-(dimethyl-piperazin-1-yl- methyl)-phenyl]-pyridin-2-ylamine; (4-{6-amino-5-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridin-3-yl}-3,5- -dimethoxy-phenyl)-(dimethyl-piperazin-1-yl)-methanone; (4-{6-amino-5-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridin-3-yl}-2-f- luoro-phenyl)-(dimethyl-piperazin-1-yl)-methanone; (4-{6-amino-5-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridin-3-yl}-3-f- luoro-phenyl)-(dimethyl-piperazin-1-yl)-methanone; (4-{6-amino-5-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridin-3-yl}-3-m- ethyl-phenyl)-(dimethyl-piperazin-1-yl)-methanone; (4-{6-amino-5-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridin-3-yl}-phe- nyl)-(4-methyl-[1,4]diazepan-1-yl)-methanone; (4-{6-amino-5-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridin-3-yl}-phe- nyl)-[1,4]diazepan-1-yl-methanone; (4-{6-amino-5-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridin-3-yl}-phe- nyl)-piperazin-1-yl-methanone; 3-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-5-vinyl-pyridin-2-ylamine; (4-{6-amino-5-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridin-3-yl}-phe- nyl)-((3R,4S)-3,4-dihydroxy-pyrrolidin-1-yl)-methanone; 5-[(1-benzyl-pyrrolidin-3-ylamino)-methyl]-3-[1-(2,6-dichloro-3-fluoro-ph- enyl)-ethoxy]-pyridin-2-ylamine; 4-{6-amino-5-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridin-3-yl}-N-az- etidin-3-yl-benzamide; 4-{6-amino-5-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridin-3-yl}-N,N-- dimethyl-benzenesulfonamide; 3-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-5-(6-methoxy-1H-benzoimidazol- -2-yl)-pyridin-2-ylamine; 3-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-5-(6-methoxy-1-methyl-1H-benz- oimidazol-2-yl)-pyridin-2-ylamine; 3-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-5-[4-(4-methyl-[1,4]diazepane- -1-sulfonyl)-phenyl]-pyridin-2-ylamine; 6-{6-amino-5-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridin-3-yl}-1-me- thyl-1H-indazole-3-carboxylic acid amide; 3-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-5-(1-methyl-1H-pyrazol-4-yl)-- pyridin-2-ylamine; 5-(3-chloro-phenyl)-3-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridin-2- -ylamine; 3-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-5-(4-fluoro-3-methyl- -phenyl)-pyridin-2-ylamine; 3-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-5-(3-trifluoromethyl-phenyl)-- pyridin-2-ylamine; 3-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-5-(3-fluoro-phenyl)-pyridin-2- -ylamine; 3-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-5-(3-trifluoromethox- y-phenyl)-pyridin-2-ylamine; 5-benzo [1,3]dioxol-5-yl-3-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridin-2-yl- amine; 3-{6-amino-5-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridin-3-yl- }-phenol; (3-{6-amino-5-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridin-- 3-yl}-phenyl)-methanol; 3-{6-amino-5-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridin-3-yl}-benz- onitrile; 3-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-5-(3-methoxy-phenyl)- -pyridin-2-ylamine; 3-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-5-(3,5-dichloro-phenyl)-pyrid- in-2-ylamine; 3-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-5-(2,5-dimethyl-phenyl)-pyrid- in-2-ylamine; 5-(5-chloro-2-methoxy-phenyl)-3-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]- -pyridin-2-ylamine; 5-(3-chloro-4-fluoro-phenyl)-3-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-- pyridin-2-ylamine; 3-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-5-(5-fluoro-2-methoxy-phenyl)- -pyridin-2-ylamine; 3-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-5-(3-isopropyl-phenyl)-pyridi- n-2-ylamine; 3-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-5-(3,4-dichloro-phenyl)-pyrid- in-2-ylamine; 4-{6-amino-5-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridin-3-yl}-benz- onitrile; 3-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-5-(3,4-difluoro-phen- yl)-pyridin-2-ylamine; (4-{6-amino-5-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridin-3-yl}-phe- nyl)-((2R,6S)-2,6-dimethyl-morpholin-4-yl)-methanone; 3-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-5-(2-ethoxy-phenyl)-pyridin-2- -ylamine; 3-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-5-(2,5-dimethoxy-phe- nyl)-pyridin-2-ylamine; 3-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-5-(2,4-dimethoxy-phenyl)-pyri- din-2-ylamine; 3-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-5-(2,6-dimethoxy-phenyl)-pyri- din-2-ylamine; 3-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-5-(2-trifluoromethyl-phenyl)-- pyridin-2-ylamine; 5-(2-chloro-phenyl)-3-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridin-2- -ylamine; 3-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-5-(2-trifluoromethox- y-phenyl)-pyridin-2-ylamine; 1-(2-{6-amino-5-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridin-3-yl}-p- henyl)-ethanone; 3-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-5-(2-fluoro-phenyl)-pyridin-2- -ylamine;(2-{6-amino-5-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridin-3- -yl}-phenyl)-methanol; 3-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-5-o-tolyl-pyridin-2-ylamine; 3-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-5-(2-methoxy-phenyl)-pyridin-- 2-ylamine; 3-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-5-(2,6-dimethyl-phe- nyl)-pyridin-2-ylamine; (4-{6-amino-5-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridin-3-yl}-phe- nyl)-morpholin-4-yl-methanone; (4-{6-amino-5-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridin-3-yl}-2-c- hloro-phenyl)-((3R,5S)-dimethyl-piperazin-1-yl)-methanone; 4-{6-amino-5-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridin-3-yl}-2-me- thyl-phenyl)-((3R,5S)-dimethyl-piperazin-1-yl)-methanone; 3-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-5-[4-((2R,6S)-2,6-dimethyl-mo- rpholin-4-ylmethyl)-phenyl]-pyridin-2-ylamine; 3-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-5-(4-morpholin-4-ylmethyl-phe- nyl)-pyridin-2-ylamine; 3-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-5-(3,5-dimethyl-phenyl)-pyrid- in-2-ylamine; 3-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-5-m-tolyl-pyridin-2-ylamine; 3-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-5-(3,4-dimethoxy-phenyl)-pyri- din-2-ylamine; 5-biphenyl-3-yl-3-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridin-2-yla- mine; 5-(3,5-bis-trifluoromethyl-phenyl)-3-[1-(2,6-dichloro-3-fluoro-pheny- l)-ethoxy]-pyridin-2-ylamine; 3-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-5-(3,4-dichloro-phenyl)-pyrid- in-2-ylamine; 1-(3-{6-amino-5-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridin-3-yl}-p- henyl)-ethanone; 3-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-5-(3,5-difluoro-phenyl)-pyrid- in-2-ylamine; 3-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-5-(2,5-dichloro-phenyl)-pyrid- in-2-ylamine; (4-{6-amino-5-[1-(2,6-dichloro-4-trifluoromethyl-phenyl)-ethoxy]-pyridin-- 3-yl}-phenyl)-((3R,5S)-3,5-dimethyl-piperazin-1-yl)-methanone; 3-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-5-(3-ethoxy-phenyl)-pyridin-2- -ylamine; (4-{6-amino-5-[1-(2-trifluoromethyl-phenyl)-ethoxy]-pyridin-3-yl- }-phenyl)-(3,5-dimethyl-piperazin-1-yl)-methanone; (4-{6-amino-5-[1-(3-trifluoromethyl-phenyl)-ethoxy]-pyridin-3-yl}-phenyl)- -(3,5-dimethyl-piperazin-1-yl)-methanone; 7-[4-(3,5-dimethyl-piperazine-1-carbonyl)-phenyl]-2-phenyl-4H-pyrido[3,2-- b][1,4]oxazin-3-one; {4-[6-amino-5-(3-fluoro-2-trifluoromethyl-benzyloxy)-pyridin-3-yl]-phenyl- }-(3,5-dimethyl-piperazin-1-yl)-methanone; (4-[6-amino-5-(2,6-difluoro-benzyloxy)-pyridin-3-yl]-phenyl}-(3,5-dimethy- l-piperazin-1-yl)-methanone; [4-(6-amino-5-benzyloxy-pyridin-3-yl)-phenyl]-(3,5-dimethyl-piperazin-1-y- l)-methanone; (4-{6-amino-5-[1-(2-chloro-3,6-difluoro-phenyl)-ethoxy]-pyridin-3-yl}-phe- nyl)-(4-ethyl-piperazin-1-yl)-methanone; [4-(6-amino-5-benzyloxy-pyridin-3-yl)-phenyl]-(4-ethyl-piperazin-1-yl)-me- thanone; {4-[6-amino-5-(2-methyl-benzyloxy)-pyridin-3-yl]-phenyl}-(3,5-dim- ethyl-piperazin-1-yl)-methanone; 3-{2-amino-5-[4-(4-pyrrolidin-1-yl-piperidine-1-carbonyl)-phenyl]-pyridin- -3-yloxymethyl}-benzoic acid methyl ester; 3-{2-amino-5-[4-(3,5-dimethyl-piperazine-1-carbonyl)-phenyl]-pyridin-3-yl- oxymethyl}-benzoic acid methyl ester; (4-[6-amino-5-(2-methyl-benzyloxy)-pyridin-3-yl]-phenyl}-(4-pyrrolidin-1-- yl-piperidin-1-yl)-methanone; [4-(6-amino-5-cyclohexylmethoxy-pyridin-3-yl)-phenyl]-(4-pyrrolidin-1-yl-- piperidin-1-yl)-methanone; 4-(1-{2-amino-5-[4-(4-pyrrolidin-1-yl-piperidine-1-carbonyl)-phenyl]-pyri- din-3-yloxy}-ethyl)-[2-(3-hydroxy-phenyl)-ethyl]-benzamide; 4-(1-{2-amino-5-[4-(4-pyrrolidin-1-yl-piperidine-1-carbonyl)-phenyl]-pyri- din-3-yloxy}-ethyl)-[2-(2,6-dichloro-phenyl)-ethyl]-benzamide; 4-(1-{2-amino-5-[4-(4-pyrrolidin-1-yl-piperidine-1-carbonyl)-phenyl]-pyri- din-3-yloxy}-ethyl)-(1-benzyl-piperidin-4-yl)-benzamide; 4-(1-{2-amino-5-[4-(4-pyrrolidin-1-yl-piperidine-1-carbonyl)-phenyl]-pyri- din-3-yloxy}-ethyl)-[3-(2-oxo-pyrrolidin-1-yl)-propyl]-benzamide; (4-{6-amino-5-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridin-3-yl}-phe- nyl)-(4-ethyl-piperazin-1-yl)-methanone; {4-[6-amino-5-(2,6-dichloro-benzyloxy)-pyridin-3-yl]-phenyl}-(3,5-dimethy- l-piperazin-1-yl)-methanone; (6-amino-3-aza-bicyclo

[3.1.0]hex-3-yl)-(4-{6-amino-5-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-- pyridin-3-yl}-phenyl)-methanone; 5-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-6'-(2-morpholin-4-yl-ethoxy)-- [3,3']bipyridinyl-6-ylamine; 6'-amino-5'-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-1-(2-pyrrolidin-1-y- l-ethyl)-1H-[3,3']bipyridinyl-6-one; 5-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-6'-(2-pyrrolidin-1-yl-ethoxy)- -[3,3']bipyridinyl-6-ylamine; 6'-amino-5'-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-1-[2-(1-methyl-pyrr- olidin-2-yl)-ethyl]-1H-[3,3']bipyridinyl-6-one; (4-{6-amino-5-[1-(2,4,6-trimethyl-phenyl)-ethoxy]-pyridin-3-yl}-phenyl)-(- 4-pyrrolidin-1-yl-piperidin-1-yl)-methanone; (4-{6-amino-5-[1-(2-chloro-6-fluoro-phenyl)-ethoxy]-pyridin-3-yl}-phenyl)- -(4-pyrrolidin-1-yl-piperidin-1-yl)-methanone; 3-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-5-(4-fluoro-phenyl)-pyridin-2- -ylamine; 6'-amino-5'-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-1H-[3,3']b- ipyridinyl-6-one; 5'-bromo-5-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-[3,3']bipyridinyl-6-- ylamine; 3-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-5-(4-dimethylamino-ph- enyl)-pyridin-2-ylamine; 5-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-2'-methoxy-[3,3']bipyridinyl-- 6-ylamine; 3-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-5-(1H-indol-5-yl)-p- yridin-2-ylamine; (4-{6-amino-5-[1-(2,6-dichloro-phenyl)-propoxy]-pyridin-3-yl}-phenyl)-(3,- 5-dimethyl-piperazin-1-yl)-methanone; [4-(6-amino-5-benzyloxy-pyridin-3-yl)-phenyl]-(4-pyrrolidin-1-yl-piperidi- n-1-yl)-methanone; 3-(2,6-dichloro-3-fluoro-benzyloxy)-5-thiazol-2-yl-pyridin-2-ylamine; (4-{6-amino-5-[1-(2-fluoro-6-trifluoromethyl-phenyl)-ethoxy]-pyridin-3-yl- }-phenyl)-(4-pyrrolidin-1-yl-piperidin-1-yl)-methanone; 3-(2,6-dichloro-3-fluoro-benzyloxy)-5-(1-methyl-1H-imidazol-2-yl)-pyridin- -2-ylamine; {4-[6-amino-5-(2,4,6-trimethyl-benzyloxy)-pyridin-3-yl]-phenyl}-(4-pyrrol- idin-1-yl-piperidin-1-yl)-methanone; {4-[6-amino-5-(2,3,5,6-tetramethyl-benzyloxy)-pyridin-3-yl]-phenyl}-(4-py- rrolidin-1-yl-piperidin-1-yl)-methanone; {4-[6-amino-5-(2,4,6-trifluoro-benzyloxy)-pyridin-3-yl]-phenyl}-(4-pyrrol- idin-1-yl-piperidin-1-yl)-methanone; (4-{6-amino-5-[1-(2-fluoro-6-trifluoromethyl-phenyl)-ethoxy]-pyridin-3-yl- }-phenyl)-(4-pyrrolidin-1-yl-piperidin-1-yl)-methanone; 6-amino-5-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-N-methyl-nicotinamidi- ne; 6-amino-5-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-N-(2-morpholin-4-y- l-ethyl)-nicotinamidine; (4-{6-amino-5-[1-(2,4,5-trifluoro-phenyl)-propoxy]-pyridin-3-yl}-phenyl)-- (4-pyrrolidin-1-yl-piperidin-1-yl)-methanone; (4-{6-amino-5-[1-(6-chloro-2-fluoro-3-methyl-phenyl)-ethoxy]-pyridin-3-yl- }-phenyl)-(4-pyrrolidin-1-yl-piperidin-1-yl)-methanone; 3-(1-{2-amino-5-[4-(4-pyrrolidin-1-yl-piperidine-1-carbonyl)-phenyl]-pyri- din-3-yloxy}-ethyl)-benzoic acid; and pharmaceutically acceptable salts, and hydrates thereof.
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