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Serving 500+ biopharmaceutical companies globally:

Medtronic
Farmers Insurance
Fish and Richardson
Covington
Teva
Merck
Chinese Patent Office
Accenture
Colorcon
UBS

Generated: August 23, 2017

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Title:Treatment of respiratory disease
Abstract: A pharmaceutical composition for pulmonary delivery comprises glycopyrrolate in a controlled release formulation, wherein, on administration, the glycopyrrolate exerts its pharmacological effect over a period greater than 12 hours.
Inventor(s): Bannister; Robin Mark (Essex, GB), Richards; Andrew John McGlashan (Cambridge, GB), Gilbert; Julian Clive (Essex, GB), Morton; David A. V. (Bath, GB), Staniforth; John (Bath, GB)
Assignee: Sosei R&D Ltd (GB)
Application Number:10/266,717
Patent Claims: 1. A method for the treatment of chronic obstructive pulmonary disease (COPD) in a patient suffering from said disease, which comprises pulmonary delivery to said patient of a dry powder composition comprising microparticles of glycopyrrolate, wherein the composition is formulated so that one unit dose enables the glycopyrrolate to exert its pharmacological effect over a period of greater than 20 hours.

2. The method according to claim 1, wherein the microparticles have a mass median aerodynamic diameter of less than 30 .mu.m.

3. The method according to claim 1, wherein the composition additionally comprises large carrier particles.

4. The method according to claim 3, wherein the large carrier particles are lactose particles having a mass median aerodynamic diameter of greater than 90 .mu.m.

5. The method, according to claim 1, wherein the composition further comprises a hydrophobic material.

6. The method, according to claim 5, wherein the hydrophobic material is magnesium stearate.

7. The method, according to claim 1, wherein a dose of less than 1 mg is administered to the patient.
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Serving 500+ biopharmaceutical companies globally:

Cerilliant
Novartis
Medtronic
Covington
Cantor Fitzgerald
Chinese Patent Office
US Department of Justice
Harvard Business School
Dow
Johnson and Johnson

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