|Title:||Method for treating onychomycosis|
|Abstract:|| A novel method for evaluating an effect of an antimicrobial agent which comprises removing the antimicrobial agent remaining in a biological sample or the like to thereby accurately evaluate the effect of the antimicrobial agent without being affected by the remaining antimicrobial agent. A therapeutic agent for onychomycosis which can be obtained according to the evaluation method of the drug effect.|
|Inventor(s):|| Tatsumi; Yoshiyuki (Otsu, JP), Yokoo; Mamoru (Otsu, JP), Nakamura; Kosho (Moriyama, JP), Arika; Tadashi (Suita, JP) |
|Assignee:|| Kaken Pharmaceutical Co., Ltd. (Bunkyo-ku, Tokyo, JP) |
1. A method for treating a subject having onychomycosis wherein the method comprises topically administering to a nail of said subject having onychomycosis a
therapeutically effective amount of an antifungal compound represented by the following formula: ##STR00003## wherein, Ar is a non-substituted phenyl group or a phenyl group substituted with 1 to 3 substituents selected from a halogen atom and
trifluoromethyl group, R.sup.1 and R.sup.2 are the same or different and are hydrogen atom, C.sub.1-6 alkyl group, a non-substituted aryl group, an aryl group substituted with 1 to 3 substituents selected from a halogen atom, trifluoromethyl group, nitro
group and C.sub.1-16 alkyl group, C.sub.2-8 alkenyl group, C.sub.2-6 alkynyl group, or C.sub.7-12 aralkyl group, m is 2 or 3, n is 1 or 2, X is nitrogen atom or CH, and *1 and *2 mean an asymmetric carbon atom.
2. The method of claim 1, in which the compound represented by the formula (II) is (2R, 3R)-2-(2,4-difluorophenyl)-3-(4-methylen piperidine-1-yl)-1-(1H-1,2,4-triazole-1-yl)butane-2-ol.