.

Pharmaceutical Business Intelligence

  • Anticipate P&T budget requirements
  • Evaluate market entry opportunities
  • Find generic sources and suppliers
  • Predict branded drug patent expiration

► Plans and Pricing

Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

DrugPatentWatch Database Preview

Claims for Patent: 7,199,098

« Back to Dashboard

Claims for Patent: 7,199,098

Title:Copolymer-1 improvements in compositions of copolymers
Abstract:The present invention relates to an improved composition of copolymer-1 comprising copolymer-1 substantially free of species having a molecular weight of over 40 kilodaltons.
Inventor(s): Konfino; Eliezer (Ramat Gan, IL), Sela; Michael (Rehovot, IL), Teitelbaum; Dvora (Rehovot, IL), Arnon; Ruth (Rehovot, IL)
Assignee: Yeda Research and Development Co., Ltd. (Rehovot, IL)
Application Number:11/098,432
Patent Claims: 1. A copolymer-1 composition comprising a mixture of copolymers of alanine, glutamic acid, lysine and tyrosine, the copolymer species in the mixture being non-uniform with respect to molecular weight and sequence, wherein over 75% of the copolymers in the mixture, on a molar fraction basis, have a molecular weight in the range of 2 kDa to 20 kDa and less than 5% of the copolymers have a molecular weight above 40 kDa, and wherein the composition is suitable for treating multiple sclerosis.

2. The composition of claim 1, wherein the mixture has an average molecular weight of 7000 Da.+-.2000 Da.

3. The composition of claim 1, wherein the mixture has an average molecular weight of 4 to 8.6 kDa.

4. The composition of claim 1, wherein the mixture has an average molecular weight of 6.25 to 8.4 kDa.

5. The composition of claim 1, wherein the mixture has an average molecular weight of 4 to 8 kDa.

6. The composition of claim 1, wherein the mixture has an average molecular weight of 7 to 8 kDa.

7. The composition of claim 1, wherein the mixture has a molecular weight distribution as depicted in FIG. 1 for the mixture with an average molecular weight of 7.7 kDa.

8. The composition of claim 1, wherein less than 2.5% of the copolymers in the mixture have a molecular weight above 40 kDa.

9. The composition of claim 8, wherein the mixture has an average molecular weight of 7000 Da.+-.2000 Da.

10. The composition of claim 8, wherein the mixture has an average molecular weight of 4 to 8.6 kDa.

11. The composition of claim 8, wherein the mixture has an average molecular weight of 6.2 5 to 8.4 kDa.

12. The composition of claim 8, wherein the mixture has an average molecular weight of 4 to 8 kDa.

13. The composition of claim 8, wherein the mixture has an average molecular weight of 7 to 8 kDa.

14. The composition of claim 8, wherein the mixture has a molecular weight distribution as depicted in FIG. 1 for the mixture with an average molecular weight of 7.7 kDa.

15. A process for preparing a copolymer-1 composition having an average molecular weight of 4 to about 8.6 kDa comprising: polymerizing a mixture of an N-carboxyanhydride of tyrosine, an N-carboxyanhydride of alanine, .gamma.-benzyl glutamate and trifluoroacetyllysine in a molar ratio of 1:5:2:4 to form a mixture of protected polypeptides; deprotecting the protected polypeptides to form a mixture of unprotected polypeptides; and isolating a copolymer-1 composition of unprotected polypeptides composed of glutamic acid, lysine, alanine and tyrosine, wherein the copolymer-1 composition has an average molecular weight of 4 to 9 kDa.

16. The process of claim 15, wherein the copolymer-1 composition has an average molecular weight of 6.25 to 8.4 kilodaltons.

17. A copolymer-1 composition having an average molecular weight of about 4 to about 8.6 kDa preparable by a process comprising: polymerizing a mixture of an N-carboxyanhydride of tyrosine, an N-carboxyanhydride of alanine, .gamma.-benzyl glutamate and trifluoroacetyllysine in a molar ratio of 1:5:2:4 to form a mixture of protected polypeptides; deprotecting the protected polypeptides to form a mixture of unprotected polypeptides; and isolating a mixture of unprotected polypeptides composed of glutamic acid, lysine, alanine and tyrosine, wherein the mixture has an average molecular weight of 4 to 9 kDa.

18. The composition of claim 17, wherein the mixture has an average molecular weight of 6.25 to 8.4 kilodaltons.

19. A copolymer-1 composition comprising a mixture of polypeptides composed of glutamic acid, lysine, alanine and tyrosine, wherein the mixture has an average molecular weight of 4 to about 8.6 kilodaltons, wherein the mixture of polypeptides is non-uniform with respect to molecular weight and sequence, and wherein the composition exhibits lower toxicity than a copolymer-1 composition having an average molecular weight greater than about 8.6 kilodaltons.

20. The composition of claim 19, wherein the mixture has an average molecular weight of 6.25 to 8.4 kilodaltons.
« Back to Dashboard

For more information try a trial or see the database preview and plans and pricing

How are People Using DrugPatentWatch?

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

`abc