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Claims for Patent: 7,196,205

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Claims for Patent: 7,196,205

Title:Synthesis of UDP-glucose: N-acylsphingosine glucosyltransferase inhibitors
Abstract: Disclosed is a novel enantiomeric synthesis ceramide-like inhibitors of UDP-glucose: N-acylsphingosine glucosyltransferase. Also disclosed are novel intermediates formed during the synthesis.
Inventor(s): Siegel; Craig (Woburn, MA), Shayman; James A. (Ann Arbor, MI), Nelson; Carol A. (Westford, MA), Harris; David J. (Lexington, MA), Copeland; Diane P. (North Billerica, MA)
Assignee: The Regents of the University of Michigan (Ann Arbor, MI) Genzyme Corporation (Cambridge, MA)
Application Number:11/091,836
Patent Claims: 1. A compound represented by the following structural formula: ##STR00033## or a physiologically acceptable salt thereof.

2. A compound represented by the following structural formula: ##STR00034## or a physiologically acceptable salt thereof.

3. The compound of claim 1, wherein the compound has an enantiomeric excess of at least 10%.

4. The compound of claim 1, wherein the compound has an enantiomeric excess of at least 25%.

5. The compound of claim 1, wherein the compound has an enantiomeric excess of at least 50%.

6. The compound of claim 1, wherein the compound has an enantiomeric excess of at least 75%.

7. The compound of claim 1, wherein the compound has an enantiomeric excess of at least 90%.

8. The compound of claim 1, wherein the compound has an enantiomeric excess of at least 95%.

9. The compound of claim 1, wherein the compound has an enantiomeric excess of at least 99%.

10. The compound of claim 2, wherein the compound has an enantiomeric excess of at least 10%.

11. The compound of claim 2, wherein the compound has an enantiomeric excess of at least 25%.

12. The compound of claim 2, wherein the compound has an enantiomeric excess of at least 50%.

13. The compound of claim 2, wherein the compound has an enantiomeric excess of at least 75%.

14. The compound of claim 2, wherein the compound has an enantiomeric excess of at least 90%.

15. The compound of claim 2, wherein the compound has an enantiomeric excess of at least 95%.

16. The compound of claim 2, wherein the compound has an enantiomeric excess of at least 99%.
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