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Claims for Patent: 7,157,466

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Claims for Patent: 7,157,466

Title:Quinazoline ditosylate salt compounds
Abstract:Ditosylate salts of 4-quinazolineamines are described as well as methods of using the same in the treatment of disorde4rs characterized by aberrant erbB family PTK activity.
Inventor(s): McClure; Michael Scott (Durham, NC), Osterhout; Martin Howard (Durham, NC), Roschangar; Frank (Glen Allen, VA), Sacchetti; Mark Joseph (Foster City, CA)
Assignee: SmithKline Beecham (Cork) Limited (IE)
Application Number:10/311,678
Patent Claims: 1. A compound of Formula (II), ##STR00018## or anhydrate or hydrate forms thereof.

2. The compound of claim 1, wherein the compound is characterized by a powder x-ray diffraction pattern, comprising the peaks: TABLE-US-00009 Two theta (deg) d-spacing (angstroms) 4.8 18 8.7 10 18.0 4.9 18.9 4.7 21.0 4.2 22.3 4.0.

3. The compound of claim 1, wherein the compound is characterized by a powder x-ray diffraction pattern, comprising the peaks: TABLE-US-00010 Two theta (deg) d-spacing (angstroms) 6.6 13 8.3 10 11.5 7.7 18.1 4.9 21.1 4.2.

4. A compound of Formula (II), ##STR00019## in anhydrate form.

5. A compound of Formula (II), ##STR00020## in monohydrate form.

6. A mixture of anhydrous and hydrate forms of a compound of Formula (II), ##STR00021##

7. A pharmaceutical composition, comprising: a therapeutically effective amount of a compound, or anhydrate or hydrate forms thereof, as claimed in claim 1 and one or m&re of pharmaceutically acceptable carriers, diluents and excipients.

8. A pharmaceutical composition, comprising: a therapeutically effective amount of a compound, or anhydrate or hydrate forms thereof, as claimed in claim 4 and one or more of phamaceutically acceptable carriers, diluents and excipients.

9. A pharmaceutical composition, comprising: a therapeutically effective amount of a compound, or anhydrate or hydrate forms thereof, as claimed in claim 5 and one or more of pharmaceutically acceptable carriers, diluents and excipients.

10. A pharmaceutical composition, comprising: a therapeutically effective amount of the mixture, as claimed in claim 6 and one or more of pharmaceutically acceptable carriers, diluents and excipients.
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