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|Title:||2-phenyl-1-[4-(2-aminoethoxy)-benzyl]-indoles as estrogenic agents|
|Abstract:||The present invention relates to new 2-Phenyl-1-[4-(2-Aminoethoxy)-Benzyl]-Indole compounds having the general structures below: ##STR00001## or ##STR00002## which are useful in treating or preventing bone loss.|
|Inventor(s):||Miller; Chris P. (Strafford, PA), Collini; Michael D. (Clifton Heights, PA)|
1. A compound of formula 1-[4-(2-Azepan-1-yl-ethoxy)-benzyl-2-(4-hydroxy-phenyl])-3-methyl-1H-indo- l-5-ol, or a pharmaceutically acceptable salt thereof.
2. The compound according to claim 1, which is 1-[4-(2-Azepan-1-yl-ethoxy)-benzyl-2-(4-hydroxy-phenyl])-3-methyl-1H-indo- l-5-ol.
3. A pharmaceutical composition comprising the compound of claim 1 or a pharmaceutically acceptable salt thereof, and a pharmaceutical carrier or excipient.
4. A method of treating or preventing bone loss in a mammal, the method comprising administering to a mammal in need thereof an effective amount of the compound of claim 1 or a pharmaceutically acceptable salt thereof.
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