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Serving leading biopharmaceutical companies globally:

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Generated: December 13, 2017

DrugPatentWatch Database Preview

Claims for Patent: 7,135,489

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Claims for Patent: 7,135,489

Title:Crystalline form of 4-[5-methyl-3-phenylisoxazol-4-yl] benzenesulfonamide
Abstract:A stable crystalline form of 4-[5-methyl-3-phenylisoxazol-4-yl]benzenesulfonamide is described. This crystal structure, designated Form B, is more stable, has favorable handling properties and is characterized by its melting point, x-ray and other physical characterizations.
Inventor(s): Talley; John J (Brentwood, MO), Medich; John R (Gurnee, IL), McLaughlin; Kathleen T (Arlington Heights, IL), Gaud; Henry T (Evanston, IL), Yonan; Edward E (Carol Stream, IL)
Assignee: G. D. Searle & Co. (Skokie, IL)
Application Number:10/205,732
Patent Claims: 1. A crystalline form of 4-[5-methyl-3-phenylisoxazol-4-yl]benzenesulfonamide having an infrared spectrum with the following peaks 3377, 1170, 1151, 925, 844, 745, 729, and 534 cm.sup.-1.

2. A crystalline form of 4-[5-methyl-3-phenylisoxazol-4-yl]benzenesulfonamide having an X-ray powder diffraction pattern with peaks at about 12.2, 15.4, 15.8, 17.1, 19.8, 22.0, 23.6, 23.9, and 24.6 degrees two theta.

3. A crystalline form of 4-[5-methyl-3-phenylisoxazol-4-yl]benzenesulfonamide having an x-ray powder diffraction pattern with the following peaks: 12.221, 15.447, 17.081, 19.798 and 23.861 degrees two theta.

4. A form of 4-[5-methyl-3-phenylisoxazol-4-yl]benzenesulfonamide according to claim 2, which has an infrared spectrum lacking a significant peak at 723 cm.sup.-1.

5. A pharmaceutical composition comprising a therapeutically-effective amount of the crystalline form of claim 2.

6. A pharmaceutical composition comprising a therapeutically-effective amount of the crystalline form of claim 2.

7. A crystalline form of 4-[5-methyl-3-phenylisoxazol-4-yl]benzenesulfonamide having an onset of melting of about 170.9.degree. C. with a peak at about 172.5.degree. C. as determined by differential scanning calorimetry.

8. A crystalline form of 4-[5-methyl-3-phenylisoxazol-4-yl]benzenesulfonamide having an IR spectrum comprising three peaks selected from 3377, 1170, 1151, 925, 844, 745, 729, and 534 cm.sup.-1.

9. A crystalline form of 4-[5-methyl-3-phenylisoxazol-4-yl]benzenesulfonamide having an x-ray powder diffraction pattern comprising threee peaks selected from 12.221, 15.447, 17.081, 19.798 and 23.861 degrees 2.theta..

10. A pharmaceutical composition comprising a therapeutically-effective amount of the crystalline form of claim 8 and at least one pharmaceutically acceptable carrier, adjuvant, or diluent.

11. A pharmaceutical composition comprising a therapeutically-effective amount of the crystalline form of claim 9 and at least one pharmaceutically acceptable carrier, adjutant, or diluent.
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Healthtrust
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Harvard Business School
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Fish and Richardson
Merck
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Daiichi Sankyo
Chinese Patent Office

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