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Claims for Patent: 7,119,106

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Claims for Patent: 7,119,106

Title:Pharmaceutical compositions of 1-oxo-2-(2,6-dioxopiperidin-3-yl)-4-aminoisoindoline
Abstract:Substituted 2-(2,6-dioxopiperidin-3-yl)phthalimides and 1-oxo-2-(2,6-dioxopiperidin-3-yl)isoindolines reduce the levels of TNF.alpha. in a mammal. Typical embodiments are 1-oxo-2-(2,6-dioxo-3-methylpiperidin-3-yl)-4,5,6,7-tetrafuoroisoindoline and 1,3-dioxo-2-(2,6-dioxo-3 -methylpiperidin-3-yl)-4-aminoisoindoline.
Inventor(s): Muller; George W. (Bridgewater, NJ), Stirling; David I. (Branchburg, NJ), Chen; Roger Shen-Chu (Edison, NJ)
Assignee: Celgene Corporation (Summit, NJ)
Application Number:10/337,602
Patent Claims: 1. A pharmaceutical composition comprising an effective amount of a compound of the formula: ##STR00007## or an acid addition salt thereof, and a pharmaceutically acceptable carrier, diluent or excipient.

2. The pharmaceutical composition of claim 1, which is suitable for oral administration.

3. The pharmaceutical composition of claim 2, which is in the form of a tablet or a capsule.

4. The pharmaceutical composition of claim 2, wherein the compound is present in an amount of 1 to 100 mg.

5. The pharmaceutical composition of claim 1, which is suitable for parenteral administration.

6. The pharmaceutical composition of clalm 5, which comprises a sterile injectable solution.

7. The pharmaceutical composition of claim 5, wherein the compound is present in a concentration of 20 to 100 mg/mL.
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