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Serving leading biopharmaceutical companies globally:

US Department of Justice
Daiichi Sankyo
Argus Health
Fuji
Healthtrust
Dow
AstraZeneca
QuintilesIMS
Harvard Business School
Johnson and Johnson

Generated: January 16, 2018

DrugPatentWatch Database Preview

Claims for Patent: 7,109,205

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Summary for Patent: 7,109,205
Title:Carboxylic acid derivatives, their preparation and use
Abstract:Carboxylic acid derivatives ##STR00001## where R R.sup.6, X, Y and Z have the meanings stated in the description, and the preparation thereof, are described. The novel compounds are suitable for controlling diseases.
Inventor(s): Riechers; Hartmut (Neustadt, DE), Klinge; Dagmar (Heidelberg, DE), Amberg; Wilhelm (Friedrichsdorf, DE), Kling; Andreas (Mannheim, DE), Muller; Stefan (Speyer, DE), Baumann; Ernst (Dudenhofen, DE), Rheinheimer; Joachim (Ludwigshafen, DE), Vogelbacher; Uwe Josef (Ludwigshafen, DE), Wernet; Wolfgang (Hassloch, DE), Unger; Liliane (Ludwigshafen, DE), Raschack; Manfred (Weisenheim, DE)
Assignee: Abbott GmbH & Co. KG (Wiesbaden, DE)
Application Number:10/602,275
Patent Claims: 1. A compound having the formula: ##STR00016## wherein: X is CH; Y is oxygen; Z is oxygen; R is CO.sub.2H; R.sup.2 is methyl; R.sup.3 is methyl; R.sup.4 is phenyl; R.sup.5 is phenyl; and R.sup.6 is methyl, or a pharmaceutically acceptable salt thereof.

2. The compound of claim 1, wherein said compound is an optically active enantiomer.

3. The compound of claim 2, wherein the enantiomer is the S enantiomer.

4. The compound of claim 3, wherein the enantiomer is the pure form of the S enantiomer.

5. The compound of claim 2, wherein the enantiomer is the R enantiomer.

6. The compound of claim 5, wherein the enantiomer is the pure form of the R enantiomer.

7. A pharmaceutical composition comprising a compound having the formula: ##STR00017## wherein: X is CH; Y is oxygen; Z is oxygen; R is CO.sub.2H; R.sup.2 is methyl; R.sup.3 is methyl; R.sup.4 is phenyl; R.sup.5 is phenyl; R.sup.6 is methyl; or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.

8. The composition of claim 7, wherein said composition is suitable for oral, parenteral, or nasopharyngeal delivery.

9. The composition of claim 7, wherein the composition is in a solid form.

10. The composition of claim 7, wherein the composition is in a liquid form.

11. The composition of claim 7, wherein the composition is in the form of a tablet, capsule, powder, granule, suppository, solution, colloid, ointment, cream, vapor or spray.

12. The composition of claim 7, wherein the carrier comprises a tablet binder, filler, preservative, tablet disintegrant, flow regulator, plasticizer, wetting agent, dispersant, emulsifier, solvent, release-slowing agent, antioxidant, or propellant gas.

13. The composition of claim 7, wherein the compound is an optically active enantiomer.

14. The composition of claim 13, wherein the enantiomer is the S enantiomer.

15. The composition of claim 14, wherein the enantiomer is the pure form of the S enantiomer.

16. The composition of claim 13, wherein the enantiomer is the R enantiomer.

17. The composition of claim 16, wherein the enantiomer is the pure form of the R enantiomer.

18. The compound ##STR00018##

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Serving leading biopharmaceutical companies globally:

Cerilliant
McKinsey
Cantor Fitzgerald
Covington
Argus Health
Novartis
US Department of Justice
Citi
Boehringer Ingelheim

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