|Title:||Device for producing high pressure in a fluid in miniature|
|Abstract:|| A miniaturized device for pressurizing fluid. The device includes a hollow piston that provides a fluid path and a valve member. The valve member is configured for axial movement so that the valve axis remains parallel to the piston axis. The valve member is arranged at one end of the hollow piston. The valve member may be partially or completely disposed within the hollow piston. The device is particularly adapted for use in a mechanically operated atomizer to produce an inhalable aerosol of a liquid medicament without the use of propellant gas.|
|Inventor(s):|| Jaeger; Joachim (Bruchsal, DE), Cirillo; Pasquale (Dortmund, DE), Eicher; Joachim (Dortmund, DE), Geser; Johannes (Dortmund, DE), Freund; Bernhard (Gau-Algesheim, DE), Zierenberg; Bernd (Bingen am Rhein, DE) |
|Assignee:|| Boehringer Ingelheim International GmbH (DE) |
1. A replaceable unit for use with an atomizer in combination with a device for producing high pressure in a fluid, wherein said device includes a hollow piston capable of
moving axially within the replaceable unit and within a housing of the atomizer, said replaceable unit comprising: a dimensionally stable outer portion with a collapsible portion disposed within said outer portion; and a stopper firmly coupled to both
the dimensionally stable outer portion and to the collapsible portion of the replaceable unit, said stopper defining a bore through which the hollow piston of the atomizer projects so that fluid to be atomized can be withdrawn from a storage container;
wherein the replaceable unit is arranged within the housing of the atomizer and is firmly disposed on the hollow piston in a way such that the replaceable unit moves to and fro together with the hollow piston within the housing when the atomizer is
operated, and wherein said replaceable unit is capable of holding a supply of fluid to be atomized, is substantially not pressurized, and is free from propellants.
2. The replaceable unit of claim 1, wherein said storage container comprises a pharmaceutical composition.
3. The replaceable unit of claim 1, wherein said storage container comprises a pharmaceutically acceptable solution of a medicament selected from the group consisting of berotec, berodual, flunisolide, atrovent, salbutamol, budesonide,
combivent, tiotropium, oxivent, and suitable peptides.