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|Title:||Methods of administering levothyroxine pharmaceutical compositions|
|Abstract:||The present invention generally relates to stable pharmaceutical compositions, and methods of making and administering such compositions. In one aspect, the invention features stabilized pharmaceutical compositions that include pharmaceutically active ingredients such as levothyroxine (T4) sodium and liothyronine (T3) sodium (thyroid hormone drugs), preferably in an immediate release solid dosage form. Also provided are methods for making and using such immediate release and stabilized compositions.|
|Inventor(s):||Franz; G. Andrew (St. Louis, MO), Strauss; Elaine A. (Seminole, FL), DiMenna; Phillip A. (St. Petersburg, FL), Gemma; Rocco L. (Dover, OH)|
1. A method of administering a levothyroxine pharmaceutical composition to a patient, comprising placing an immediate release levothyroxine pharmaceutical tablet that loses less than
about 0.7% potency per month for up to 18 months in an aqueous medium, dispersing the levothyroxine composition in the aqueous medium for less than ten minutes, and administering the aqueous medium to the patient.
2. The method of claim 1, wherein the aqueous medium is selected from water, saline, soft drinks and milk.
3. The method of claim 2, wherein the dispersion step is conducted for less than five minutes.