.

Pharmaceutical Business Intelligence

  • Anticipate P&T budget requirements
  • Evaluate market entry opportunities
  • Find generic sources and suppliers
  • Predict branded drug patent expiration

► Plans and Pricing

Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

DrugPatentWatch Database Preview

Claims for Patent: 6,939,033

« Back to Dashboard

Claims for Patent: 6,939,033

Title: Method and apparatus for preparing microparticles using in-line solvent extraction
Abstract:Apparatus and method for preparing microparticles using in-line solvent extraction. An emulsion is formed by combining two phases in a static mixer. The emulsion is combined with an extraction liquid in a blending static mixer. The outflow of the blending static mixer is combined with additional extraction liquid. The additional extraction liquid and the outflow of the blending static mixer can be combined in a vessel, or through the use of a static mixer manifold that includes a plurality of static mixers.
Inventor(s): Lyons; Shawn L. (Cincinnati, OH), Wright; Steven G. (Madeira, OH)
Assignee: Alkermes Controlled Therapeutics, Inc. II (Cambridge, MA)
Application Number:10/729,909
Patent Claims: 1. A method of preparing microparticles, comprising: combining a first phase, comprising an active agent, a polymer, and a solvent, and a second phase in a first static mixer to form an emulsion, the emulsion forming an outflow of the first static mixer; combining the outflow of the first static mixer and a first portion of a starting volume of an extraction liquid for extracting solvent from the emulsion in a manifold, wherein the manifold comprises a plurality of individual static mixers configured to form a plurality of parallel flow streams, each of the plurality of parallel flow streams comprising at least one of the plurality of individual static mixers; and combining an outflow of the manifold with a second portion of the extraction liquid to extract solvent from the emulsion.

2. The method of claim 1, wherein the step of combining the outflow of the manifold with the second portion of the extraction liquid comprises: allowing the outflow of the manifold to flow into a vessel containing the second portion of the extraction liquid.

3. The method of claim 1, wherein the step of combining the outflow of the manifold with the second portion of the extraction liquid comprises: combining the outflow of the manifold and the second portion of the extraction liquid in a second static mixer.

4. The method of claim 3, further comprising: allowing an outflow of the second static mixer to flow into a vessel.

5. The method of claim 4, further comprising: continuing the step of combining the outflow of the manifold and the second portion of the extraction liquid in the second static mixer until the first phase is depleted; and transferring a remainder of the starting volume of the extraction liquid to the vessel.

6. The method of claim 1, wherein the step of combining the outflow of the manifold with the second portion of the extraction liquid comprises: combining the outflow of the manifold and the second portion of the extraction liquid in a second static mixer and repeating this combining step until the starting volume of the extraction liquid is depleted.

7. Microparticles prepared by the method of claim 1.

8. The microparticles of claim 7, wherein the polymer is a poly(lactide-co-glycolide).
« Back to Dashboard

For more information try a trial or see the database preview and plans and pricing

How are People Using DrugPatentWatch?

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

`abc