|Title:|| Water soluble prodrugs of hindered alcohols|
|Abstract:||The present invention is directed to novel water-soluble prodrugs of aliphatic or aromatic hindered hydroxyl group containing pharmaceuticals.|
|Inventor(s):|| Stella; Valentino J. (Lawrence, KS), Zygmunt; Jan J. (Longmont, CO), Georg; Ingrid Gunda (Lawrence, KS), Safadi; Muhammad S. (Nazareth, IL) |
|Assignee:|| University of Kansas (Lawrence, KS) |
1. A compound selected from the group consisting of O-phosphonoxymethylpropofol Dibenzy ester, O-phosphonoxymethyl-alpha-tocopherol Dibenzyl ester, and 4'-O-phosphonooxymethyletopside
2. A compound selected from the group consisting of O-phosphonoxymethylpropofol Disodium salt, O-phosphonoxymethyl-alpha-tocopherol Disodium salt, and 4'-O-phosphonoxymethyletoposide Disodium salt.