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Claims for Patent: 6,863,891

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Claims for Patent: 6,863,891

Title: Oligopeptide lyophilisate, their preparation and use
Abstract:A novel lyophilizate and method of preparation as well as the use of the lyophilizate to treat female infertility and for gonad protection. Cetrorelix is dissolved in acetic acid 30% v/v, the solution is transferred to water and freeze dried.
Inventor(s): Engel; Jurgen (Alzenau, DE), Wichert; Burkhard (Bielefeld, DE), Sauerbier; Dieter (Werter, DE), Reissmann; Thomas (Frankfurt am Main, DE)
Assignee: Zentaris AG (Frankfurt, DE)
Application Number:10/040,457
Patent Claims: 1. A method of treating female infertility which comprises administering, to a female undergoing controlled ovarian stimulation, an effective amount of pharmaceutical composition comprising a lyophilizate of a certrorelix solution containing 100-10,000 parts by weight of acetic acid per part of dissolved cetrorelix, thereby preventing premature ovulation.

2. The method according to claim 1, wherein the lyophilizate further comprises a bulking agent.
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