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Claims for Patent: 6,858,584

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Claims for Patent: 6,858,584

Title: Pharmaceutical compositions containing a glycopeptide antibiotic and a cyclodextrin
Abstract:Disclosed are pharmaceutical compositions containing a cyclodextrin and a therapeutically effective amount of a glycopeptide antibiotic or a salt thereof. Also disclosed are methods of treating a bacterial disease in a mammal by administering such pharmaceutical compositions.
Inventor(s): Judice; J. Kevin (El Granada, CA), Shaw; Jeng-Pyng (Saratoga, CA), Mu; YongQi (Los Altos, CA), Conner; Michael W. (Half Moon Bay, CA), Pace; John L. (San Anselma, CA)
Assignee: Theravance, Inc. (South San Francisco, CA)
Application Number:09/846,893
Patent Claims: 1. A pharmaceutical composition comprising: (a) a cyclodextrin; and (b) a lipidated glycopeptide antibiotic or a pharmaceutically acceptable salt thereof.

2. The pharmaceutical composition of claim 1 which further comprises water.

3. The pharmaceutical composition of claim 1 which is a powder.

4. The pharmaceutical composition of claim 1 which is a lyophilized powder.

5. A pharmaceutical composition comprising: (a) an aqueous cyclodextrin carrier and (b) a therapeutically effective amount of a lipidated glycopeptide antibiotic or a pharmaceutically acceptable salt thereof.

6. The pharmaceutical composition of claim 5, wherein the pharmaceutical composition comprises: (a) a therapeutically effective amount of a lipidated glycopeptide antibiotic or a pharmaceutically acceptable salt thereof; (b) 1 to 40 weight percent of a cyclodextrin; and (c) 60 to 99 weight percent of water based on 100 weight percent of the composition.

7. The pharmaceutical composition of claim 5, wherein the cyclodextrin is hydroxypropyl-.beta.-cyclodextrin or sulfobutyl ether .beta.-cyclodextrin.

8. The pharmaceutical composition of claim 7, wherein the cyclodextrin is hydroxypropyl-.beta.-cyclodextrin.

9. The pharmaceutical composition of claim 6, wherein the cyclodextrin comprises about 5 to 35 weight percent of the composition.

10. The pharmaceutical composition of claim 9, wherein the cyclodextrin comprises about 10 to 30 weight percent of the composition.
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