.

Deeper Knowledge, Faster

  • Anticipate your formulary budget
  • Analyze global market entry opportunities
  • Uncover prior art in expired and abandoned patents

► See Plans and Pricing

Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

Serving 500+ biopharmaceutical companies globally:

Citi
Farmers Insurance
Medtronic
Deloitte
Julphar
Fuji
Accenture
Queensland Health
UBS
Boehringer Ingelheim

Generated: June 23, 2017

DrugPatentWatch Database Preview

Claims for Patent: 6,824,822

« Back to Dashboard

Claims for Patent: 6,824,822

Title: Residual solvent extraction method and microparticles produced thereby
Abstract:Methods for preparing microparticles having reduced residual solvent levels. Microparticles are contacted with a non-aqueous washing system to reduce the level of residual solvent in the microparticles. Preferred non-aqueous washing systems include 100% ethanol and a blend of ethanol and heptane. A solvent blend of a hardening solvent and a washing solvent can be used to harden and wash microparticles in a single step, thereby eliminating the need for a post-hardening wash step.
Inventor(s): Rickey; Michael E. (Loveland, OH), Ramstack; J. Michael (Lebanon, OH), Kumar; Rajesh (Loveland, OH)
Assignee: Alkermes Controlled Therapeutics Inc. II (Cambridge, MA)
Application Number:09/942,631
Patent Claims: 1. A method for preparing microparticles, comprising: preparing an emulsion comprising an active agent and a biodegradable, biocompatible polymer dissolved in a solvent; combining the emulsion with a coacervating agent that is free from solvents for the polymer to form a combined phase; and extracting the solvent from the combined phase with a solvent blend of a hardening solvent and a washing solvent, to thereby form hardened microparticles.

2. The method of claim 1, further comprising after the extracting step: rinsing the microparticles with the hardening solvent.

3. The method of claim 1, wherein the hardening solvent is a liquid alkane.

4. The method of claim 1, wherein the washing solvent is an alcohol.

5. The method of claim 3, wherein the washing solvent is an alcohol.

6. The method of claim 1, wherein the hardening solvent is selected from the group consisting of heptane, hexane, cyclohexane, diethyl ether, petroleum ether, mineral oil, fatty acid esters, and caprylate triglyceride.

7. The method of claim 1, wherein the washing solvent is selected from the group consisting of ethanol and isopropanol.

8. The method of claim 1, wherein the hardening solvent is heptane and the washing solvent is ethanol.

9. The method of claim 1, wherein the solvent is a halogenated solvent.

10. The method of claim 1, wherein the coacervating agent is silicone oil.

11. The method of claim 2, wherein the hardening solvent is heptane.

12. The method of claim 8, further comprising after the extracting step: rinsing the microparticles with heptane.

13. The method of claim 1, further comprising after the extracting step: rinsing the microparticles with a second hardening solvent different from the hardening solvent.

14. Microparticles prepared by the method of claim 1.
« Back to Dashboard

For more information try a trial or see the database preview and plans and pricing

Serving 500+ biopharmaceutical companies globally:

Johnson and Johnson
Medtronic
UBS
McKesson
Accenture
Fuji
McKinsey
Harvard Business School
Deloitte
US Department of Justice

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

Copyright 2002-2017 thinkBiotech LLC
ISSN: 2162-2639

Secure SSL Encrypted

Follow DrugPatentWatch:



Google
Twitter
Google Plus
botpot