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Claims for Patent: 6,774,137

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Claims for Patent: 6,774,137

Title: Ophthalmic composition
Abstract:The present invention is related to an ophthalmic composition comprising ketotifen as a pharmaceutically active agent.
Inventor(s): Adam; Marcia Johanna (Gisikon, CH), Fetz; Andrea (Wetzikon, CH), Kis; Gyorgy Lajos (Triboltingen, CH)
Assignee: Novartis AG (Basel, CH)
Application Number:10/134,795
Patent Claims: 1. A method for treating allergic conjunctivitis, comprising administering to a subject suffering from or susceptible to allergic conjunctivitis an effective amount of an ophthalmic composition comprising about 0.01 to about 0.04% by weight of a ketotifen salt, a non ionic tonicity agent in an amount such that the total tonicity of the composition has an osmolarity in the range of 210 to 290 milliosmoles, a preservative, and water, wherein the pH of the composition is between 4.4 and 5.8.

2. The method of claim 1, wherein the ketotifen salt is ketotifen fumarate.

3. The method of claim 1, wherein the concentration of the ketotifen salt is 0.03 to 0.04% by weight.

4. The method of claim 1, wherein the non-ionic tonicity agent is glycerol.

5. The method of claim 4, wherein said glycerol is present in an amount of 1.5 to 2.5% by weight.

6. The method of claim 1, wherein said preservative is benzalkonium chloride.

7. The method of claim 1, wherein said ophthalmic composition consists essentially of ketotifen fumarate in a concentration between 0.03 and 0.04% by weight, glycerol in a concentration of 2 to 2.5% by weight, benzalkonium chloride in a concentration between 0.005 and 0.02% by weight, and water.

8. The method of claim 1, wherein said ophthalmic composition is administered twice per day.

9. The method of claim 8, wherein one drop of said ophthalmic composition is administered twice per day.

10. The method of claim 3, wherein said ophthalmic composition is administered twice per day.

11. The method of claim 10, wherein one drop of said ophthalmic composition is administered twice per day.

12. The method of claim 7, wherein said ophthalmic composition is administered twice per day.

13. The method of claim 12, wherein one drop of said ophthalmic composition is administered twice per day.
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