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Claims for Patent: 6,770,660

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Claims for Patent: 6,770,660

Title: Method for inhibiting platelet aggregation
Abstract:A method for inhibiting platelet aggregation in a patient in need thereof, comprising 1) administering to the patient a bolus injection of an active drug, in an amount of about 25 .mu.g/kg, and 2) administering to the patient, after the bolus injection, an intravenous infusion for a period of between about 12 hours and about 72 hours, of the active drug, in an amount of about 0.15 .mu.g/kg/min, wherein the active drug is tirofiban or a salt thereof.
Inventor(s): DiBattiste; Peter M. (Chalfont, PA), Schneider; David (Shelburne, VT)
Assignee: Artery LLC (Baltimore, MA)
Application Number:10/427,436
Patent Claims: 1. A method for inhibiting platelet aggregation in a patient in need thereof, comprising 1) administering to the patient a bolus injection of an active drug, in an amount of about 25 .mu.g/kg, and 2) administering to the patient, after the bolus injection, an intravenous infusion for a period of between about 12 hours and about 72 hours, of the active drug, in an amount of about 0.15 .mu.g/kg/min, wherein the active drug is tirofiban or a salt thereof.

2. A method of claim 1, wherein the salt is tirofiban hydrochloride.

3. A method of claim 2, wherein the amount of tirofiban hydrochloride in the bolus injection is 25 .mu.g/kg.

4. A method of claim 3 wherein the intravenous infusion is between 12 hours and 72 hours.

5. A method of claim 4 wherein the intravenous infusion is between 18 hours and 72 hours.

6. A method for reducing the risk of acute coronary syndrome in a patient at risk to acute coronary syndrome, comprising 1) administering to the patient a bolus injection of an active drug, in an amount of about 25 .mu.g/kg, and 2) administering to the patient, after the bolus injection, an intravenous infusion for a period of between about 12 hours and about 72 hours, of the active drug, in an amount of about 0.15 .mu.g/kg/min, wherein the active drug is tirofiban or a salt thereof.
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