Claims for Patent: 6,756,393

Summary for Patent: 6,756,393

Title:	Azacyclic compounds
Abstract:	Compounds and methods are provided for the treatment of disease conditions in which modification of serotonergic receptor activity has a beneficial effect. In the method, an effective amount of a compound is adminstered to a patient in need of such treatment.
Inventor(s):	Carl-Magnus A. Andersson, Glenn Croston, Eva L. Hansen, Allan Kjaersgaard Uldam
Assignee:	Acadia Pharmaceuticals Inc
Application Number:	US10/409,782
Patent Litigation and PTAB cases:	See patent lawsuits and PTAB cases for patent 6,756,393
Patent Claims:	1. A compound of formula (I) wherein Z is wherein R is a lower alkyl group, wherein said lower alkyl group is a methyl; and n is 1; X1 is methylene, vinylene, or an NH or N(lower alkyl) group; and X2 is methylene; or, when X1 is methylene or vinylene, X2 is methylene or a bond; or when X1 is methylene, X2 is O, S, NH, or N(lower alkyl) or a bond; Y1 is methylene and Y2 is methylene, vinylene, ethylene, propylene, or a bond; or Y1 is a bond and Y2 is vinylene; or Y1 is ethylene and Y2 is O, S, NH, or N(lower alkyl); Ar1 and Ar2 independently are unsubstituted or substituted aryl or heteroaryl groups, provided that Ar1 and Ar2 are not simultaneously unsubstituted phenyl; and W is oxygen; or a pharmaceutically acceptable salt or prodrug thereof. 2. A compound of formula (I) wherein Z is wherein R is a hydrogen, a cyclic or straight-chained or branched acyclic organyl group, a lower hydroxyalkyl group, a lower aminoalkyl group, or an aralkyl or heteroaralkyl group; and n is 1; X1 is an NH, and X2 is methylene; Y1 is methylene and Y2 is methylene, vinylene, ethylene, propylene, or a bond; or Y1 is a bond and Y2 is vinylene; or Y1 is ethylene and Y2 is O, S, NH, or N(lower alkyl); Ar1 and Ar2 independently are unsubstituted or substituted aryl or heteroaryl groups, provided that Ar1 and Ar2 are not simultaneously unsubstituted phenyl; and W is oxygen; or a pharmaceutically acceptable salt or prodrug thereof. 3. A compound of formula (I) wherein Z is wherein R is a hydrogen, a cyclic or straight-chained or branched acyclic organyl group, a lower hydroxyalkyl group, a lower aminoalkyl group, or an aralkyl or heteroaralkyl group; and n is 1; X1 is methylene, vinylene, or an NH or N(lower alkyl) group; and X2 is methylene, or, when X1 is methylene or vinylene, X2 is methylene or a bond; or when X1 is methylene, X2 is O, S, NH, or N(lower alkyl) or a bond; Y1 is methylene and Y2 is a bond; Ar1 and Ar2 independently are unsubstituted or substituted aryl or heteroaryl groups, provided that Ar1 and Ar2 are not simultaneously unsubstituted phenyl; and W is oxygen; or a pharmaceutically acceptable salt or prodrug thereof. 4. A compound of formula (I) wherein Z is wherein R is a hydrogen, a cyclic or straight-chained or branched acyclic organyl group, a lower hydroxyalkyl group, a lower aminoalkyl group, or an aralkyl or heteroaralkyl group; and n is 1; X1 is methylene, vinylene, or an NH or N(lower alkyl) group; and X2 is methylene, or, when X1 is methylene or vinylene, X2 is methylene or a bond; or when X1 is methylene, X2 is O, S, NH, or N(lower alkyl) or a bond; Y1 is methylene and Y2 is methylene, vinylene, ethylene, propylene, or a bond; or Y1 is a bond and Y2 is vinylene; or Y1 is ethylene and Y2 is O, S, NH, or N(lower alkyl); Ar1 is a 4-haloaryl, wherein said aryl is phenyl and said halo is a fluoro; Ar2 is a 4-substituted aryl, wherein said aryl is phenyl, and said phenyl is substituted with a lower alkoxy group, wherein the alkyl group of said lower alkoxy group is an isobutyl; and W is oxygen; or a pharmaceutically acceptable salt or prodrug thereof. 5. A tartrate salt of a compound of formula (I) wherein Z is wherein R is a hydrogen, a cyclic or straight-chained or branched acyclic organyl group, a lower hydroxyalkyl group, a lower aminoalkyl group, or an aralkyl or heteroaralkyl group; and n is 1; X1 is methylene, vinylene, or an NH or N(lower alkyl) group; and X2 is methylene, or, when X1 is methylene or vinylene, X2 is methylene or a bond; or when X1 is methylene, X2 is O, S, NH, or N(lower alkyl) or a bond; Y1 is methylene and Y2 is methylene, vinylene, ethylene, propylene, or a bond; or Y1 is a bond and Y2 is vinylene; or Y1 is ethylene and Y2 is O, S, NH, or N(lower alkyl); Ar1 and Ar2 independently are unsubstituted or substituted aryl or heteroaryl groups, provided that Ar1 and Ar2 are not simultaneously unsubstituted phenyl; and W is oxygen.