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Serving 500+ biopharmaceutical companies globally:

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Generated: July 24, 2017

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Title: Stabilized pharmaceutical composition
Abstract:The pharmaceutical composition of the invention, which comprises a benzimidazole compound of the formula ##STR1## wherein R.sup.1 is hydrogen, alkyl, halogen, cyano, carboxy, carboalkoxy, carboalkoxyalkyl, carbamoyl, carbamoylalkyl, hydroxy, alkoxy, hydroxyalkyl, trifluoromethyl, acyl, carbamoyloxy, nitro, acyloxy, aryl, aryloxy, alkylthio or alkylsulfinyl, R.sup.2 is hydrogen, alkyl, acyl, carboalkoxy, carbamoyl, alkylcarbamoyl, dialkylcarbamoyl, alkylcarbonylmethyl, alkoxycarbonylmethyl or alkylsulfonyl, R.sup.3 and R.sup.5 are the same or different and each is hydrogen, alkyl, alkoxy or alkoxyalkoxy, R.sup.4 is hydrogen, alkyl, alkoxy which may optionally be fluorinated, or alkoxyalkoxy, and m is an integer of 0 through 4, and a basic inorganic salt stabilizing agent, is physically stable. Magnesium and calcium basic inorganic salt stabilizing agents are particularly useful.
Inventor(s): Makino; Tadashi (Osaka, JP), Tabata; Tetsuro (Osaka, JP), Hirai; Shin-Ichiro (Kyoto, JP)
Assignee: Takeda Chemical Industries, Ltd. (Osaka, JP)
Application Number:10/335,421
Patent Claims: 1. A stabilized pharmaceutical composition for the inhibition of gastric acid secretion, comprising an effective amount of a benzimidazole compound of the formula (I) ##STR8## wherein R.sup.1 is hydrogen, alkyl, halogen, cyano, carboxy, carboalkoxy, carboalkoxyalkyl, carbamoyl, carbamoylalkyl, hydroxy, alkoxy hydroxyalkyl, trifluoromethyl, acyl carbamoyloxy, nitro, acyloxy, aryl, aryloxy, alkylthio or alkylsulfinyl; R.sup.2 is hydrogen, alkyl, acyl, carboalkoxy, carbamoyl, alkylcarbamoyl, dialkylcarbamoyl, alkylcarbonylmethyl, alkoxycarbonylmethyl or alkylsulfonyl; R.sup.3 and R.sup.5 are the same or different and each is hydrogen, alkyl, alkoxy or alkoxyalkoxy; R.sup.4 is hydrogen, alkyl, alkoxy which may optionally be fluorinated, or alkoxyalkoxy; and m is an integer from 0 to 4,

or a derivative thereof or salt thereof having a gastric acid secretion inhibitory property, and a basic inorganic salt stabilizing agent, wherein the stabilizing agent is a basic inorganic salt of at least one selected from the group consisting of magnesium, calcium, potassium, and sodium and the stabilizing agent is homogenously admixed with the compound of the formula (I) in an effective amount to provide stability to the compound of the formula (I).

2. A composition of claim 1, wherein the basic inorganic salt stabilizing agent is a basic inorganic salt of magnesium or calcium.

3. A composition of claim 1, wherein the basic inorganic salt stabilizing agent is a basic inorganic salt of sodium.

4. A composition of claim 1, wherein the basic inorganic salt stabilizing agent is a basic inorganic salt of potassium.
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Serving 500+ biopharmaceutical companies globally:

Citi
Healthtrust
Cantor Fitzgerald
Argus Health
Covington
Daiichi Sankyo
McKesson
Mallinckrodt
Teva
Chinese Patent Office

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