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Last Updated: April 24, 2024

Claims for Patent: 6,723,303

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Summary for Patent: 6,723,303

Title:	Ultrasound contrast agents including protein stabilized microspheres of perfluoropropane, perfluorobutane or perfluoropentane
Abstract:	Agents for use in ultrasound contrast include protein microspheres in which a gas such as perfluoropropane, perfluorobutane or perfluoropentane is contained.
Inventor(s):	Quay; Steven C (Pacific Palisades, CA)
Assignee:	Amersham Health, AS (Oslo, NO)
Application Number:	08/466,104
Patent Claims:	1. Biocompatible ultrasound contrast media comprising a solution in which microbubbles of a gas are stabilized by human protein, the gas comprising perfluoropropane. 2. Biocompatible ultrasound contrast media as in claim 1 wherein said human protein is denatured by heat or chemical treatment. 3. Biocompatible ultrasound contrast media as in claim 1 wherein said microbubbles are formed by sonication. 4. Biocompatible ultrasound contrast media comprising a solution in which microbubbles of a gas are stabilized by human protein, the gas comprising perfluorobutane. 5. Biocompatible ultrasound contrast media as in claim 4 wherein said human protein is denatured by heat or chemical treatment. 6. Biocompatible ultrasound contrast media as in claim 4 wherein said microbubbles are formed by sonication. 7. Biocompatible ultrasound contrast media comprising a solution in which microbubbles of a gas are stabilized by human protein, the gas comprising perfluoropentane. 8. Biocompatible ultrasound contrast media as in claim 7 wherein said human protein is denatured by heat or chemical treatment. 9. Biocompatible ultrasound contrast media as in claim 7 wherein said microbubbles are formed by sonication.

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