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Claims for Patent: 6,723,303

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Claims for Patent: 6,723,303

Title: Ultrasound contrast agents including protein stabilized microspheres of perfluoropropane, perfluorobutane or perfluoropentane
Abstract:Agents for use in ultrasound contrast include protein microspheres in which a gas such as perfluoropropane, perfluorobutane or perfluoropentane is contained.
Inventor(s): Quay; Steven C (Pacific Palisades, CA)
Assignee: Amersham Health, AS (Oslo, NO)
Application Number:08/466,104
Patent Claims: 1. Biocompatible ultrasound contrast media comprising a solution in which microbubbles of a gas are stabilized by human protein, the gas comprising perfluoropropane.

2. Biocompatible ultrasound contrast media as in claim 1 wherein said human protein is denatured by heat or chemical treatment.

3. Biocompatible ultrasound contrast media as in claim 1 wherein said microbubbles are formed by sonication.

4. Biocompatible ultrasound contrast media comprising a solution in which microbubbles of a gas are stabilized by human protein, the gas comprising perfluorobutane.

5. Biocompatible ultrasound contrast media as in claim 4 wherein said human protein is denatured by heat or chemical treatment.

6. Biocompatible ultrasound contrast media as in claim 4 wherein said microbubbles are formed by sonication.

7. Biocompatible ultrasound contrast media comprising a solution in which microbubbles of a gas are stabilized by human protein, the gas comprising perfluoropentane.

8. Biocompatible ultrasound contrast media as in claim 7 wherein said human protein is denatured by heat or chemical treatment.

9. Biocompatible ultrasound contrast media as in claim 7 wherein said microbubbles are formed by sonication.
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