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Claims for Patent: 6,713,485

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Claims for Patent: 6,713,485

Title: Heterocyclic compounds
Abstract:The present invention relates to substituted heteroaromatic compounds, methods for their preparation, pharmaceutical compositions containing them and their use in medicine. Specifically, the invention relates to quinazoline derivatives useful in treating disorders mediated by protein tyrosine kinase activity, in particular erbB-2 and/or EGFR activity.
Inventor(s): Carter; Malcolm Clive (Ware, GB), Cockerill; George Stuart (Bedford, GB), Guntrip; Stephen Barry (Hertford, GB), Lackey; Karen Elizabeth (Hillsborough, NC), Smith; Kathryn Jane (Hertfordshire, GB)
Assignee: SmithKline Beecham Corporation (Philadelphia, PA)
Application Number:10/071,358
Patent Claims: 1. A compound of the formula: ##STR54##

and salts or solvates thereof.

2. A pharmaceutical formulation, comprising: the compound of claim 1 or a pharmaceutically acceptable salt or solvate thereof together with one or more pharmaceutically acceptable carriers, diluents, or excipients.

3. A method of treating a susceptible cancer in a human or animal subject mammal, comprising administering to said subject an effective amount of a compound as claimed in claim 1, wherein said cancer is breast cancer, gastric cancer or head and neck cancer.

4. A method as claimed in claim 3, wherein the susceptible cancer is breast cancer.

5. A method as claimed in claim 3, wherein the susceptible cancer is gastric cancer.

6. A method as claimed in claim 3, wherein the susceptible cancer is head and neck cancer.

7. A compound of the formula: ##STR55##

and salts or solvates thereof.

8. A pharmaceutical formulation, comprising: the compound of claim 7 or a pharmaceutically acceptable salt or solvate thereof together with one or more pharmaceutically acceptable carriers, diluents, or excipients.

9. A method of treating a susceptible cancer in a human or animal subject mammal, comprising administering to said subject an effective amount of a compound as claimed in claim 7, wherein said cancer is breast cancer, gastric cancer or head and neck cancer.

10. A method as claimed in claim 9, wherein the susceptible cancer is breast cancer.

11. A method as claimed in claim 9, wherein the susceptible cancer is gastric cancer.

12. A method as claimed in claim 9, wherein the susceptible cancer is head and neck cancer.

13. A compound of the formula: ##STR56##

and salts or solvates thereof.

14. A pharmaceutical formulation, comprising: the compound of claim 13 or a pharmaceutically acceptable salt or solvate thereof together with one or more pharmaceutically acceptable carriers, diluents, or excipients.

15. A method of treating a susceptible cancer in a human or animal subject mammal, comprising administering to said subject an effective amount of a compound as claimed in claim 13, wherein said cancer is breast cancer, gastric cancer or head and neck cancer.

16. A method as claimed in claim 15, wherein the susceptible cancer is breast cancer.

17. A method as claimed in claim 15, wherein the susceptible cancer is gastric cancer.

18. A method as claimed in claim 15, wherein the susceptible cancer is head and neck cancer.
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