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Claims for Patent: 6,685,958

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Claims for Patent: 6,685,958

Title: Quinolone carboxylic acid compositions and related methods of treatment
Abstract:The present invention relates to the use of quinolone carboxylic acid formulations in the treatment of ocular and periocular infections. The present invention also relates to sustained release compositions comprising specific quinolone carboxylic acid compounds. The invention also relates to quinolone carboxylic acid compositions and methods of preparing the same.
Inventor(s): Roy; Samir (San Ramon, CA), Chandrasekaran; Santosh Kumar (Moraga, CA), Imamori; Katsumi (Chiba, JP), Asaoka; Takemitsu (Chiba, JP), Shibata; Akihiro (Chiba, JP), Takahashi; Masami (Tokyo, JP), Bowman; Lyle M. (Pleasanton, CA)
Assignee: InSite Vision Incorporated (Alameda, CA) SSP Co., Ltd. (Tokyo, JP)
Application Number:09/840,871
Patent Claims: 1. A topical ophthalmic broad spectrum antibiotic composition comprising: from about 0.005% to about 10% by weight, based upon the total weight of the composition, of a quinolone carboxylic acid derivative of formula (I), ##STR5##

wherein R.sup.1 is a hydrogen atom, an alkyl group, an aralkyl group, an ester residual group which can be hydrolyzed in vivo, R.sup.2 is a hydrogen atom or an amino group which may be substituted by one or two lower alkyl groups, X is a hydrogen atom or a halogen atom, Y is CH.sub.2, O, S, SO, SO.sub.2, or N--R.sup.3, wherein R.sup.3 is a hydrogen atom or a lower alkyl group, and Z is an oxygen atom or two hydrogen atoms; and a carboxy containing polymer; wherein said topical ophthalmic broad spectrum antibiotic composition is nonirritating to ocular tissue.

2. The composition of claim 1, wherein said broad spectrum antibiotic composition provides sustained release of said quinolone carboxylic acid derivative.

3. The composition of claim 1, consisting essentially of a quinolone carboxylic acid derivative of formula (I), wherein R.sup.1 is a hydrogen atom, an alkyl group, an aralkyl group, an ester residual group which can be hydrolyzed in vivo, R.sup.2 is a hydrogen atom or an amino group which may be substituted by one or two lower alkyl groups, X is a hydrogen atom or a halogen atom, Y is CH.sub.2, O, S, SO, SO.sub.2, or N--R.sup.3, wherein R.sup.3 is a hydrogen atom or a lower alkyl group, and Z is an oxygen atom or two hydrogen atoms; and a carboxy containing polymer.

4. The composition of claim 1, wherein said carboxy containing polymer comprises from about 0.1% to about 6.5% by weight of said composition, based on the total weight of said composition.

5. The composition of claim 4, wherein said polymer contains up to about 40% by weight of non-carboxyl containing monoethylenically unsaturated monomers.

6. The composition of claim 1, wherein said quinolone carboxylic acid derivative of formula (I) is present from about 0.02%-0.25% by weight based upon the total weight of the composition.

7. The composition as in claim 1, further comprising one or more excipients.

8. The composition as in claim 1, in which said quinolone carboxylic acid derivative of formula (I) is a pro-drug form of said quinolone carboxylic acid derivative.

9. The composition as in claim 1, wherein said quinolone carboxylic acid derivative of formula (I) is the free acid (R)-(+)-7-(3-amino-2,3,4,5,6,7-hexahydro-1H-azepin-1-yl)-8-chloro-1-cyclop ropyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid, a salt thereof, or hydrochloride thereof.

10. The composition as in claim 1, wherein said quinolone carboxylic acid derivative of formula (I) is the free acid 8-chloro-1-cyclopropyl-6-fluoro-7-(2,3,4,5,6,7-hexahydro-5-oxo-1H-1,4-diaz epin-1-yl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid, a salt thereof, or hydrochloride thereof.

11. The composition of claim 1, further comprising a solubilizer.

12. The composition of claim 11, wherein said solubilizer is hydroxypropyl-.beta.-cyclodextrin.

13. The composition of claim 12, wherein said hydroxypropyl-.beta.-cyclodextrin is about 5.0% to about 20.0% by weight of said composition, based on the total weight of said composition.

14. The composition of claim 1, further comprising a cross-linked carboxy containing polymer.

15. The composition of claim 14, wherein said cross-linked carboxy containing polymer comprises from about 0.1% to about 6.5% by weight of said composition, based on the total weight of said composition.

16. The composition of claim 15, wherein said cross-linked carboxy containing polymer comprises from about 0.5% to about 1.0% by weight of said composition, based on the total weight of said composition.

17. A method of treating or preventing a bacterial infection in the ocular or periocular region comprising: delivering to the ocular or periocular region a topical ophthalmic broad spectrum antibiotic composition comprising from about 0.005% to about 10% by weight, based upon the total weight of the composition, of a quinolone carboxylic acid derivative of formula (I), ##STR6##

wherein R.sup.1 is a hydrogen atom, an alkyl group, an aralkyl group, an ester residual group which can be hydrolyzed in vivo, R.sup.2 is a hydrogen atom or an amino group which may be substituted by one or two lower alkyl groups, X is a hydrogen atom or a halogen atom, Y is CH.sub.2, O, S, SO, SO.sub.2, or N--R.sup.3, wherein R.sup.3 is a hydrogen atom or a lower alkyl group, and Z is an oxygen atom or two hydrogen atoms;

wherein said topical ophthalmic broad spectrum antibiotic composition is nonirritating to ocular tissue.

18. The method of claim 17, wherein said broad spectrum antibiotic composition provides sustained release of said quinolone carboxylic acid derivative.

19. The method of claim 17, wherein said broad spectrum antibiotic composition further comprises a carboxy containing polymer.

20. The method of claim 19, wherein said carboxy containing polymer comprises from about 0.1% to about 6.5% by weight of said composition, based on the total weight of said composition.

21. The method of claim 20, wherein said polymer contains up to about 40% by weight of non-carboxyl containing monoethylenically unsaturated monomers.

22. The method of claim 17, wherein said quinolone carboxylic acid derivative of formula (I) is present from about 0.02%-2.5% by weight based upon the total weight of the composition.

23. The method of claim 17, wherein said broad spectrum antibiotic composition further comprises one or more excipients.

24. The method as in claim 17, in which said quinolone carboxylic acid derivative of formula (I) is a pro-drag form of said quinolone carboxylic acid derivative.

25. The method as in claim 17, wherein said quinolone carboxylic acid derivative of formula (I) is the free acid (R)-(+)-7-(3-amino-2,3,4,5,6,7-hexahydro-1H-azepin-1-yl)-8-chloro-1-cyclop ropyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid, a salt thereof, or hydrochloride thereof.

26. The method as in claim 17, wherein said quinolone carboxylic acid derivative of formula (I) is the free acid 8-chloro-1-cyclopropyl-6-fluoro-7-(2,3,4,5,6,7-hexahydro-5-oxo-1H-1-1,4-di azepin-1-yl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid, a salt thereof, or hydrochloride thereof.

27. The method of claim 17, wherein said broad spectrum antibiotic composition further comprises a solubilizer.

28. The method of claim 27, wherein said solubilizer is hydroxypropyl-.beta.-cyclodextrin.

29. The method of claim 28, wherein said hydroxypropyl-.beta.-cyclodextrin is about 5.0% to about 20.0% by weight of said composition, based on the total weight of said composition.

30. The method of claim 17, wherein said broad spectrum antibiotic composition further comprises a cross-linked carboxy containing polymer.

31. The method of claim 30, wherein said cross-linked carboxy containing polymer comprises from about 0.1% to about 6.5% by weight of said composition, based on the total weight of said composition.

32. The method of claim 30, wherein said cross-linked carboxy containing polymer comprises from about 0.5% to about 1.0% by weight of said composition, based on the total weight of said composition.

33. The method as in claim 17, wherein said broad spectrum antibiotic composition is a solution, composition, ointment, or instillant.

34. The method as in claim 17, wherein said infection is an infection of Gram positive bacteria, Gram negative bacteria, or a mixed infection of Gram positive and Gram negative bacteria.

35. The method as in claim 34, wherein said infection is an infection of a bacteria selected from the group consisting of Escherichia coli, Salmonella typhi, Shigella flexneri, Klebsiellia pneumonia, Proteus vulgaris, Proteus rettgeri, Haemophilus influenzae, Pseudomonas aeruginosia, Serratia marcescens, Moraxella morganii, Moraxella lacunata, Moraxella catarrhalis, Bacillus subtilis, Staphylococcus aureus, Staphylococcus epidermidis, Staphylococcus haemolyticus, Staphylococcus hominis, Staphylococcus pyogenes, Streptococcus pneumoniae, Enterococcus faecalis, Micrococcus lysodeikticus, and combinations thereof.

36. The method of claim 32, wherein the infection is a mixed infection of Gram negative bacteria and Gram positive bacteria.

37. A method of preparing a sustained release topical ophthalmic delivery system, comprising: preparing a topical ophthalmic broad spectrum antibiotic composition comprising from about 0.005% to about 10% by weight, based upon the total weight of the composition, of a quinolone carboxylic acid derivative of formula (I), ##STR7##

wherein R.sup.1 is a hydrogen atom, an alkyl group, an aralkyl group, an ester residual group which can be hydrolyzed in vivo, R.sup.2 is a hydrogen atom or an amino group which may be substituted by one or two lower alkyl groups, X is a hydrogen atom or a halogen atom, Y is CH.sub.2, O, S, SO, SO.sub.2, or N--R.sup.3, wherein R.sup.3 is a hydrogen atom or a lower alkyl group, and Z is an oxygen atom or two hydrogen atoms; and, packaging said composition for administration to the eye;

wherein said topical ophthalmic broad spectrum antibiotic composition is nonirritating to ocular tissue.
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