Generated: May 26, 2017
|Title:||Copolymer-1 improvements in compositions of copolymers|
|Abstract:||The present invention relates to an improved composition of copolymer-1 comprising copolymer-1 substantially free of species having a molecular weight of over 40 kilodaltons.|
|Inventor(s):||Konfino; Eliezer (Ramat Gan, IL), Sela; Michael (Rehovot, IL), Teitelbaum; Dvora (Rehovot, IL), Arnon; Ruth (Rehovot, IL)|
|Assignee:||Yeda Research and Development Co., Ltd. (Rehovot, IL)|
1. Copolymer-1 having a molecular weight of about 4 to about 9 kilodaltons, made by a process comprising: treating trifluoroacetyl copolymer-1 with aqueous piperidine to form
a solution of copolymer-1; and purifying copolymer-1, thereby producing copolymer-1 having a molecular weight of about 4 to about 9 kilodaltons.
2. Copolymer-1 made by the process of claim 1, wherein the process further comprises reacting protected copolymer-1 with hydrobromic acid to form trifluoroacetyl copolymer-1.
3. Copoloymer-1 made by the process of claim 2, wherein the hydrobromic acid comprises about 33% hydrogen bromide in acetic acid.
4. Copolymer-1 made by the process of claim 2, wherein the process further comprises polymerizing N-carboxyanhydride derivatives to form protected copolymer-1.
5. Copolymer-1 made by the process of claim 4, wherein the polymerizing step comprises providing a diethylamine initiator.
6. Copoloymer-1 made by the process of claim 1, wherein the process further comprises adding acetic acid subsequent to the treating step.
7. Copoloymer-1 made by the process of claim 1, wherein the purfying step comprises filtration.
8. A method of manufacturing trifluoroacetyl copolymer-1 having a predetermined molecular weight profile, comprising the steps of: selecting a predetermined molecular weight profile, and then reacting protected copolymer-1 with hydrobromic acid at about 26.degree. C. for a time predetermined by test reaction to provide trifluoroacetyl copolymer-1 having the predetermined molecular weight profile.
9. The method of claim 7, further comprising a step of treating the trifluoroacetyl copoloymer-1 having the predetermined molecular weight profile with aqueous peperidine solution to form copolymer-1 having the predetermined molecular weight profile.
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