.

Pharmaceutical Business Intelligence

  • Anticipate P&T budget requirements
  • Evaluate market entry opportunities
  • Find generic sources and suppliers
  • Predict branded drug patent expiration

► Plans and Pricing

Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

DrugPatentWatch Database Preview

Claims for Patent: 6,596,746

« Back to Dashboard

Claims for Patent: 6,596,746

Title: Cyclic protein tyrosine kinase inhibitors
Abstract:Novel cyclic compounds and salts thereof, pharmaceutical compositions containing such compounds, and methods of using such compounds in the treatment of protein tyrosine kinase-associated disorders such as immunologic and oncologic disorders.
Inventor(s): Das; Jagabandhu (Mercerville, NJ), Padmanabha; Ramesh (Hamden, CT), Chen; Ping (Belle Mead, NJ), Norris; Derek J. (Trenton, NJ), Doweyko; Arthur M. P. (Long Valley, NJ), Barrish; Joel C. (Holland, PA), Wityak; John (Robbinsville, NJ)
Assignee: Bristol-Myers Squibb Company (Princeton, NJ)
Application Number:09/548,929
Patent Claims: 1. A compound of formula I or a salt thereof ##STR622##

where Q is thiazole; Z is a single bond; X.sub.1 and X.sub.2 together form .dbd.O; R.sub.1 is (1) hydrogen or R.sub.6, where R.sub.6 is alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, cycloalkenyl, cycloalkenylalkyl, aryl, aralkyl, heterocyclo, or heterocycloalkyl, each of which is unsubstituted or substituted with Z.sub.1, Z.sub.2 and one or more groups Z.sub.3 ; (2) --OH or --OR.sub.6 ; (3) --SH or --SR.sub.6 ; (4) --C(O).sub.2 H, --C(O).sub.q R.sub.6, or --O--C(O).sub.q R.sub.6, where q is 1 or 2; (5) --SO.sub.3 H or --S(O).sub.q R.sub.6 ; (6) halo; (7) cyano; (8) nitro; (9) --Z.sub.4 --NR.sub.7 R.sub.8 ; (10) --Z.sub.4 --N(R.sub.9)--Z.sub.5 --NR.sub.10 R.sub.11 ; (11) --Z.sub.4 --N(R.sub.12)--Z.sub.5 --R.sub.6 ; (12) --P(O)(OR.sub.6).sub.2 ; R.sub.2 is hydrogen, R.sub.6, --Z.sub.4 --R.sub.6, or --Z.sub.13 --NR.sub.7 R.sub.8 ; R.sub.3 is --Z.sub.4 --R.sub.6 wherein Z.sub.4 is a single bond and wherein R.sub.6 is aryl substituted with at least one group Z.sub.3 where Z.sub.3 is --Z.sub.4 --NZ.sub.7 Z.sub.8 where Z.sub.4 is a bond Z.sub.7 is hydrogen or alkyl and Z.sub.8 is heterocyclo-substituted alkyl; R.sub.4 and R.sub.5 are each independently (1) hydrogen or R.sub.6 ; (2) --Z.sub.4 --N(R.sub.9)--Z.sub.5 --NR.sub.10 R.sub.11 ; (3) --N(R.sub.9)Z.sub.4 R.sub.6 ; or (4) together with the nitrogen atom to which they are attached complete a 3- to 8-membered saturated or unsaturated heterocyclic ring which is unsubstituted or substituted with Z.sub.1, Z.sub.2 and Z.sub.3, which heterocyclic ring may optionally have fused to it a benzene ring itself unsubstituted or substituted with Z.sub.1, Z.sub.2 and Z.sub.3 ; R.sub.7, R.sub.8, R.sub.9, R.sub.10, R.sub.11 and R.sub.12 (1) are each independently hydrogen or R.sub.6 ; (2) R.sub.7 and R.sub.8 may together be alkylene, alkenylene or heteroalkyl, completing a 3- to 8-membered saturated or unsaturated ring with the nitrogen atom to which they are attached, which ring is unsubstituted or substituted with Z.sub.1, Z.sub.2 and Z.sub.3 ; or (3) any two of R.sub.9, R.sub.10 and R.sub.11 may together be alkylene or alkenylene completing a 3- to 8-membered saturated or unsaturated ring together with the nitrogen atoms to which they are attached, which ring is unsubstituted or substituted with Z.sub.1, Z.sub.2 and Z.sub.3 ; R.sub.13 is (1) cyano; (2) nitro; (3) --NH.sub.2 ; (4) --NHOalkyl; (5) --OH; (6) --NHOaryl; (7) --NHCOOalkyl; (8) --NHCOOaryl; (9) --NHSO.sub.2 alkyl; (10) --NHSO.sub.2 aryl; (11) aryl; (12) heteroaryl; (13) --Oalkyl; or (14) --Oaryl; R.sub.14 is (1) --NO.sub.2 ; (2) --COOalkyl; or (3) --COOaryl; R.sub.15 is (1) hydrogen; (2) alkyl; (3) aryl; (4) arylalkyl; or (5) cycloalkyl; Z.sub.1, Z.sub.2 and Z.sub.3 are each independently (1) hydrogen or Z.sub.6, where Z.sub.6 is (i) alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, cycloalkenyl, cycloalkenylalkyl, aryl, aralkyl, alkylaryl, cycloalkylaryl, heterocyclo, or heterocycloalkyl; (ii) a group (i) which is itself substituted by one or more of the same or different groups (i); or (iii) a group (i) or (ii) which is substituted by one or more of the following groups (2) to (16) of the definition of Z.sub.1, Z.sub.2 and Z.sub.3 ; (2) --OH or --OZ.sub.6 ; (3) --SH or --SZ.sub.6 ; (4) --C(O).sub.q H, --C(O).sub.q Z.sub.6, or --O--C(O).sub.q Z.sub.6 ; (5) --SO.sub.3 H, --S(O).sub.q Z.sub.6 ; or S(O).sub.q N(Z.sub.9)Z.sub.6 ; (6) halo; (7) cyano; (8) nitro; (9) --Z.sub.4 --NZ.sub.7 Z.sub.8 ; (10) --Z.sub.4 --N(Z.sub.9)--Z.sub.5 --NZ.sub.7 Z.sub.8 ; (11) --Z.sub.4 --N(Z.sub.10)--Z.sub.5 Z.sub.6 ; (12) --Z.sub.4 --N(Z.sub.10)--Z.sub.5 --H; (13) oxo; (14) --O--C(O)--Z.sub.6 ; (15) any two of Z.sub.1, Z.sub.2, and Z.sub.3 may together be alkylene or alkenylene completing a 3- to 8-membered saturated or unsaturated ring together with the atoms to which they are attached; or (16) any two of Z.sub.1, Z.sub.2, and Z.sub.3 may together be --O--(CH.sub.2).sub.r --O--, where r is 1 to 5, completing a 4- to 8-membered ring together with the atoms to which they are attached; Z.sub.4 and Z.sub.5 are each independently (1) a single bond; (2) --Z.sub.11 --S(O).sub.q --Z.sub.12 --; (3) --Z.sub.11 --C(O)--Z.sub.12 --; (4) --Z.sub.11 --C(S)--Z.sub.12 --; (5) --Z.sub.11 --O--Z.sub.12 --; (6) --Z.sub.11 --S--Z.sub.12 --; (7) --Z.sub.11 --O--C(O)--Z.sub.12 --; or (8) --Z.sub.11 --C(O)--O--Z.sub.12 --; Z.sub.7, Z.sub.8, Z.sub.9 and Z.sub.10 (1) are each independently hydrogen or Z.sub.6 ; (2) Z.sub.7 and Z.sub.8, or Z.sub.6 and Z.sub.10, may together be alkylene or alkenylene, completing a 3- to 8-membered saturated or unsaturated ring together with the atoms to which they are attached, which ring is unsubstituted or substituted with Z.sub.1, Z.sub.2 and Z.sub.3 ; or (3) Z.sub.7 or Z.sub.8, together with Z.sub.9, may be alkylene or alkenylene completing a 3- to 8-membered saturated or unsaturated ring together with the nitrogen atoms to which they are attached, which ring is unsubstituted or substituted with Z.sub.1, Z.sub.2 and Z.sub.3 ; Z.sub.11 and Z.sub.12 are each independently (1) a single bond; (2) alkylene; (3) alkenylene; or (4) alkynylene; and Z.sub.13 is (1) a single bond; (2) --Z.sub.11 --S(O).sub.q --Z.sub.12 --; (3) --Z.sub.11 --C(O)--Z.sub.12 --; (4) --Z.sub.11 --C(S)--Z.sub.12 --; (5) --Z.sub.11 --O--Z.sub.12 --; (6) --Z.sub.11 --S--Z.sub.12 --; (7) --Z.sub.11 --O--C(O)--Z.sub.12 --; (8) --Z.sub.11 --C(O)--O--Z.sub.12 --; (9) --C(NR.sub.13)--; (10) --C(CHR.sub.14)--; or (11) --C(C(R.sub.14).sub.2)--.

2. A compound of claim 1 wherein R.sub.1 is hydrogen or alkyl, R.sub.2 and R.sub.4 are independently hydrogen or alkyl, and R.sub.5 is aryl which is unsubstituted or substituted with Z.sub.1, Z.sub.2 and one or more groups Z.sub.3.

3. A compound of formula I or a salt thereof ##STR623##

where Q is thiazole; Z is a single bond; X.sub.1 and X.sub.2 together form .dbd.O; R.sub.1 is (1) hydrogen or R.sub.6, where R.sub.6 is alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, cycloalkenyl, cycloalkenylalkyl, aryl, aralkyl, heterocyclo, or heterocycloalkyl, each of which is unsubstituted or substituted with Z.sub.1, Z.sub.2 and one or more groups Z.sub.3 ; (2) --OH or --OR.sub.6 ; (3) --SH or --SR.sub.6 ; (4) --C(O).sub.2 H, --C(O).sub.q R.sub.6, or --O--C(O).sub.q R.sub.6, where q is 1 or 2; (5) --SO.sub.3 H or --S(O).sub.q R.sub.6 ; (6) halo; (7) cyano; (8) nitro; (9) --Z.sub.4 --NR.sub.7 R.sub.8 ; (10) --Z.sub.4 --N(R.sub.9)--Z.sub.5 --NR.sub.10 R.sub.11 ; (11) --Z.sub.4 --N(R.sub.12)--Z.sub.5 --R.sub.6 ; (12) --P(O)(OR.sub.6).sub.2 ; R.sub.2 is hydrogen, R.sub.6, --Z.sub.4 --R.sub.6, or --Z.sub.13 --NR.sub.7 R.sub.8 ; R.sub.3 is --Z.sub.4 --R.sub.6 wherein Z.sub.4 is a single bond and wherein R.sub.6 is heteroaryl substituted with at least one group Z.sub.3 where Z.sub.3 is --Z.sub.4 --NZ.sub.7 Z.sub.8 where Z.sub.4 is a bond Z.sub.7 is hydrogen or alkyl and Z.sub.8 is heterocyclo-substituted alkyl; R.sub.4 and R.sub.5 are each independently (1) hydrogen or R.sub.6 ; (2) --Z.sub.4 --N(R.sub.9)--Z.sub.5 --NR.sub.10 R.sub.11 ; (3) --N(R.sub.9)Z.sub.4 R.sub.6 ; or (4) together with the nitrogen atom to which they are attached complete a 3- to 8-membered saturated or unsaturated heterocyclic ring which is unsubstituted or substituted with Z.sub.1, Z.sub.2 and Z.sub.3, which heterocyclic ring may optionally have fused to it a benzene ring itself unsubstituted or substituted with Z.sub.1, Z.sub.2 and Z.sub.3 ; R.sub.7, R.sub.8, R.sub.9, R.sub.10, R.sub.11 and R.sub.12 (1) are each independently hydrogen or R.sub.6 ; (2) R.sub.7 and R.sub.8 may together be alkylene, alkenylene or heteroalkyl, completing a 3- to 8-membered saturated or unsaturated ring with the nitrogen atom to which they are attached, which ring is unsubstituted or substituted with Z.sub.1, Z.sub.2 and Z.sub.3 ; or (3) any two of R.sub.9, R.sub.10 and R.sub.11 may together be alkylene or alkenylene completing a 3- to 8-membered saturated or unsaturated ring together with the nitrogen atoms to which they are attached, which ring is unsubstituted or substituted with Z.sub.1, Z.sub.2 and Z.sub.3 ; R.sub.13 is (1) cyano; (2) nitro; (3) --NH.sub.2 ; (4) --NHOalkyl; (5) --OH; (6) --NHOaryl; (7) --NHCOOalkyl; (8) --NHCOOaryl; (9) --NHSO.sub.2 alkyl; (10) --NHSO.sub.2 aryl; (11) aryl; (12) heteroaryl; (13) --Oalkyl; or (14) --Oaryl; R.sub.14 is (1) --NO.sub.2 ; (2) --COOalkyl; or (3) --COOaryl; R.sub.15 is (1) hydrogen; (2) alkyl; (3) aryl; (4) arylalkyl; or (5) cycloalkyl; Z.sub.1, Z.sub.2 and Z.sub.3 are each independently (1) hydrogen or Z.sub.6, where Z.sub.6 is (i) alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, cycloalkenyl, cycloalkenylalkyl, aryl, aralkyl, alkylaryl, cycloalkylaryl, heterocyclo, or heterocycloalkyl; (ii) a group (i) which is itself substituted by one or more of the same or different groups (i); or (iii) a group (i) or (ii) which is substituted by one or more of the following groups (2) to (16) of the definition of Z.sub.1, Z.sub.2 and Z.sub.3 ; (2) --OH or --OZ.sub.6 ; (3) --SH or --SZ.sub.6 ; (4) --C(O).sub.q H, --C(O).sub.q Z.sub.6, or --O--C(O).sub.q Z.sub.6 ; (5) --SO.sub.3 H, --S(O).sub.q Z.sub.6 ; or S(O).sub.q N(Z.sub.9)Z.sub.6 ; (6) halo; (7) cyano; (8) nitro; (9) --Z.sub.4 --NZ.sub.7 Z.sub.8 ; (10) --Z.sub.4 --N(Z.sub.9)--Z.sub.5 --NZ.sub.7 Z.sub.8 ; (11) --Z.sub.4 --N(Z.sub.10)--Z.sub.5 --Z.sub.6 ; (12) --Z.sub.4 --N(Z.sub.10)--Z.sub.5 --H; (13) oxo; (14) --O--C(O)--Z.sub.6 ; (15) any two of Z.sub.1, Z.sub.2, and Z.sub.3 may together be alkylene or alkenylene completing a 3- to 8-membered saturated or unsaturated ring together with the atoms to which they are attached; or (16) any two of Z.sub.1, Z.sub.2, and Z.sub.3 may together be --O--(CH.sub.2).sub.r --O--, where r is 1 to 5, completing a 4- to 8-membered ring together with the atoms to which they are attached; Z.sub.4 and Z.sub.5 are each independently (1) a single bond; (2) --Z.sub.11 --S(O).sub.q --Z.sub.12 --; (3) --Z.sub.11 --C(O)--Z.sub.12 --; (4) --Z.sub.11 --C(S)--Z.sub.12 --; (5) --Z.sub.11 --O--Z.sub.12 --; (6) --Z.sub.11 --S--Z.sub.12 --; (7) --Z.sub.11 --O--C(O)--Z.sub.12 --; or (8) --Z.sub.11 --C(O)--O--Z.sub.12 --; Z.sub.7, Z.sub.8, Z.sub.9 and Z.sub.10 (1) are each independently hydrogen or Z.sub.6 ; (2) Z.sub.7 and Z.sub.8, or Z.sub.6 and Z.sub.10, may together be alkylene or alkenylene, completing a 3- to 8-membered saturated or unsaturated ring together with the atoms to which they are attached, which ring is unsubstituted or substituted with Z.sub.1, Z.sub.2 and Z.sub.3 ; or (3) Z.sub.7 or Z.sub.8, together with Z.sub.9, may be alkylene or alkenylene completing a 3- to 8-membered saturated or unsaturated ring together with the nitrogen atoms to which they are attached, which ring is unsubstituted or substituted with Z.sub.1, Z.sub.2 and Z.sub.3 ; Z.sub.11 and Z.sub.12 are each independently (1) a single bond; (2) alkylene; (3) alkenylene; or (4) alkynylene; and Z.sub.13 is (1) a single bond; (2) --Z.sub.11 --S(O).sub.q --Z.sub.12 --; (3) --Z.sub.11 --C(O)--Z.sub.12 --; (4) --Z.sub.11 --C(S)--Z.sub.12 --; (5) --Z.sub.11 --O--Z.sub.12 --; (6) --Z.sub.11 --S--Z--.sub.12 --; (7) --Z.sub.11 --O--C(O)--Z.sub.12 --; (8) --Z.sub.11 --C(O)--O--Z.sub.12 --; (9) --C(NR.sub.13)--; (10) --C(CHR.sub.14)--; or (11) --C(C(R.sub.14).sub.2)--.

4. A compound of formula I or a salt thereof ##STR624##

where Q is thiazole; Z is a single bond; X.sub.1 and X.sub.2 together form .dbd.O; R.sub.1 is (1) hydrogen or R.sub.6, where R.sub.6 is alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, cycloalkenyl, cycloalkenylalkyl, aryl, aralkyl, heterocyclo, or heterocycloalkyl, each of which is unsubstituted or substituted with Z.sub.1, Z.sub.2 and one or more groups Z.sub.3 ; (2) --OH or --OR.sub.6 ; (3) --SH or --SR.sub.6 ; (4) --C(O).sub.2 H, --C(O).sub.q R.sub.6, or --O--C(O).sub.q R.sub.6, where q is 1 or 2; (5) --SO.sub.3 H or --S(O).sub.q R.sub.6 ; (6) halo; (7) cyano; (8) nitro; (9) --Z.sub.4 --NR.sub.7 R.sub.8 ; (10) --Z.sub.4 --N(R.sub.9)--Z.sub.5 --NR.sub.10 R.sub.11 ; (11) --Z.sub.4 --N(R.sub.12)--Z.sub.5 --R.sub.6 ; (12) --P(O)(OR.sub.6).sub.2 ; R.sub.2 is hydrogen, R.sub.6, --Z.sub.4 --R.sub.6, or --Z.sub.13 --NR.sub.7 R.sub.8 ; R.sub.3 is --Z.sub.4 --R.sub.6 wherein Z.sub.4 is a single bond and wherein R.sub.6 is heteroaryl substituted with at least one group Z.sub.3 where Z.sub.3 is alkyl; R.sub.4 and R.sub.5 are each independently (1) hydrogen or R.sub.6 ; (2) --Z.sub.4 --N(R.sub.9)--Z.sub.5 --NR.sub.10 R.sub.11 ; (3) --N(R.sub.9)Z.sub.4 R.sub.6 ; or (4) together with the nitrogen atom to which they are attached complete a 3- to 8-membered saturated or unsaturated heterocyclic ring which is unsubstituted or substituted with Z.sub.1, Z.sub.2 and Z.sub.3, which heterocyclic ring may optionally have fused to it a benzene ring itself unsubstituted or substituted with Z.sub.1, Z.sub.2 and Z.sub.3 ; R.sub.7, R.sub.8, R.sub.9, R.sub.10, R.sub.11 and R.sub.12 (1) are each independently hydrogen or R.sub.6 ; (2) R.sub.7 and R.sub.8 may together be alkylene, alkenylene or heteroalkyl, completing a 3- to 8-membered saturated or unsaturated ring with the nitrogen atom to which they are attached, which ring is unsubstituted or substituted with Z.sub.1, Z.sub.2 and Z.sub.3 ; or (3) any two of R.sub.9, R.sub.10 and R.sub.11 may together be alkylene or alkenylene completing a 3- to 8-membered saturated or unsaturated ring together with the nitrogen atoms to which they are attached, which ring is unsubstituted or substituted with Z.sub.1, Z.sub.2 and Z.sub.3 ; R.sub.13 is (1) cyano; (2) nitro; (3) --NH.sub.2 ; (4) --NHOalkyl; (5) --OH; (6) --NHOaryl; (7) --NHCOOalkyl; (8) --NHCOOaryl; (9) --NHSO.sub.2 alkyl; (10) --NHSO.sub.2 aryl; (11) aryl; (12) heteroaryl; (13) --Oalkyl; or (14) --Oaryl; R.sub.14 is (1) --NO.sub.2 ; (2) --COOalkyl; or (3) --COOaryl; R.sub.15 is (1) hydrogen; (2) alkyl; (3) aryl; (4) arylalkyl; or (5) cycloalkyl; Z.sub.1, Z.sub.2 and Z.sub.3 are each independently (1) hydrogen or Z.sub.6, where Z.sub.6 is (i) alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, cycloalkenyl, cycloalkenylalkyl, aryl, aralkyl, alkylaryl, cycloalkylaryl, heterocyclo, or heterocycloalkyl; (ii) a group (i) which is itself substituted by one or more of the same or different groups (i); or (iii) a group (i) or (ii) which is substituted by one or more of the following groups (2) to (16) of the definition of Z.sub.1, Z.sub.2 and Z.sub.3 ; (2) --OH or --OZ.sub.6 ; (3) --SH or --SZ.sub.6 ; (4) --C(O).sub.q H, --C(O).sub.q Z.sub.6, or --O--C(O).sub.q Z.sub.6 ; (5) --SO.sub.3 H, --S(O).sub.q Z.sub.6 ; or S(O).sub.q N(Z.sub.9)Z.sub.6 ; (6) halo; (7) cyano; (8) nitro; (9) --Z.sub.4 --NZ.sub.7 Z.sub.8 ; (10) --Z.sub.4 --N(Z.sub.9)--Z.sub.5 --NZ.sub.7 Z.sub.8 ; (11) --Z.sub.4 --N(Z.sub.10)--Z.sub.5 --Z.sub.6 ; (12) --Z.sub.4 --N(Z.sub.10)--Z.sub.5 --H; (13) oxo; (14) --O--C(O)--Z.sub.6 ; (15) any two of Z.sub.1, Z.sub.2, and Z.sub.3 may together be alkylene or alkenylene completing a 3- to 8-membered saturated or unsaturated ring together with the atoms to which they are attached; or (16) any two of Z.sub.1, Z.sub.2, and Z.sub.3 may together be --O--(CH.sub.2).sub.r --O--, where r is 1 to 5, completing a 4- to 8-membered ring together with the atoms to which they are attached; Z.sub.4 and Z.sub.5 are each independently (1) a single bond; (2) --Z.sub.11 --S(O).sub.q --Z.sub.12 --; (3) --Z.sub.11 --C(O)--Z.sub.12 --; (4) --Z.sub.11 --C(S)--Z.sub.12 --; (5) --Z.sub.11 --O--Z.sub.12 --; (6) --Z.sub.11 --S--Z.sub.12 --; (7) --Z.sub.11 --O--C(O)--Z.sub.12 --; or (8) --Z.sub.11 --C(O)--O--Z.sub.12 --; Z.sub.7, Z.sub.8, Z.sub.9 and Z.sub.10 (1) are each independently hydrogen or Z.sub.6 ; (2) Z.sub.7 and Z.sub.8, or Z.sub.6 and Z.sub.10, may together be alkylene or alkenylene, completing a 3- to 8-membered saturated or unsaturated ring together with the atoms to which they are attached, which ring is unsubstituted or substituted with Z.sub.1, Z.sub.2 and Z.sub.3 ; or (3) Z.sub.7 or Z.sub.8, together with Z.sub.9, may be alkylene or alkenylene completing a 3- to 8-membered saturated or unsaturated ring together with the nitrogen atoms to which they are attached, which ring is unsubstituted or substituted with Z.sub.1, Z.sub.2 and Z.sub.3 ; Z.sub.11 and Z.sub.12 are each independently (1) a single bond; (2) alkylene; (3) alkenylene; or (4) alkynylene; and Z.sub.13 is (1) a single bond; (2) --Z.sub.11 --S(O).sub.q --Z.sub.12 --; (3) --Z.sub.11 --C(O)--Z.sub.12 --; (4) --Z.sub.11 --C(S)--Z.sub.12 --; (5) --Z.sub.11 --O--Z.sub.12 --; (6) --Z.sub.11 --S--Z.sub.12 --; (7) --Z.sub.11 --O--C(O)--Z.sub.12 --; (8) --Z.sub.11 --C(O)--O--Z.sub.12 --; (9) --C(NR.sub.13)--; (10) --C(CHR.sub.14)--; or (11) --C(C(R.sub.14).sub.2)--.

5. A compound of claim 4 wherein R.sub.1 is hydrogen or alkyl, R.sub.2 and R.sub.4 are independently hydrogen or alkyl, and R.sub.5 is aryl which is unsubstituted or substituted with Z.sub.1, Z.sub.2 and one or more groups Z.sub.3.

6. A compound or salt thereof selected from the group consisting of: [5-[[(2,4,6-Trimethylphenyl)amino]carbonyl]-4-methyl-2-thiazolyl]carbamic acid, 1,1-dimethylethyl ester; [5-[[(2,4,6-Trimethylphenyl)amino]carbonyl]-4-trifluoromethyl-2-thiazolyl]c arbamic acid, 1,1-dimethylethyl ester; 2-Amino-N-(2,4,6-trimethylphenyl)-4-trifluoromethyl-5-thiazolecarboxamide, trifluoroacetate (1:1); [5-[[(2,4,6-Trimethylphenyl)amino]carbonyl]-4-phenyl-2-thiazolyl]carbamic acid, 1,1-dimethylethyl ester; 2-Amino-N-(2,4,6-trimethylphenyl)-4-phenyl-5-thiazolecarboxamide, trifluoroacetate (1:1); [5-[[phenylamino]carbonyl]-4-methyl-2-thiazolyl]carbamic acid, 1,1-dimethylethyl ester; [5-[[(2,4-Dichlorophenyl)amino]carbonyl]-4-methyl-2-thiazolyl]carbamic acid, 1,1-dimethylethyl ester; 5-[[(2,4,6-Trimethylphenyl)amino]carbonyl]-2-thiazolyl]carbamic acid, 1,1-dimethylethyl ester; 2-Amino-N-(2,4,6-trimethylphenyl)-4-phenyl-5-thiazolecarboxamide, trifluoroacetate (1:1); [5-[[(2-Methoxy-6-methylphenyl)amino]carbonyl]-4-methyl-2-thiazolyl]carbami c acid 1,1-dimethylethyl ester; [4-Methyl-5-[[[3-methyl-4-(1-methylethyl)phenyl]amino]carbonyl]-2-thiazolyl ]carbamic acid 1,1-dimethylethyl ester; [5-[[(4-Bromo-2,6-dimethylphenyl)amino]carbonyl]-4-methyl-2-thiazolyl]carba mic acid 1,1-dimethylethyl ester; [4-Methyl-5-[[[2-methyl-6-(1-methylethyl)phenyl]amino]carbonyl]-2-thiazolyl ]carbamic acid 1,1-dimethylethyl ester; [5-[[(2,4-Dimethylphenyl)amino]carbonyl]-4-methyl-2-thiazolyl]carbamic acid 1,1-dimethylethyl ester; [4-Methyl-5-[[(2-methylphenyl)amino]carbonyl]-2-thiazolyl]carbamic acid 1,1-dimethylethyl ester; [5-[[(2-Chloro-6-methylphenyl)amino]carbonyl]-4-methyl-2-thiazolyl]carbamic acid 1,1-dimethylethyl ester; [5-[[[2-(1,1-Dimethylethyl)-4-methylphenyl]amino]carbonyl]-4-methyl-2-thiaz olyl]carbamic acid 1,1-dimethylethyl ester; [5-[[(2-Furanylmethyl)amino]carbonyl]-4-methyl-2-thiazolyl]carbamic acid 1,1-dimethylethyl ester; [5-[[[3-Methoxy-5-(trifluoromethyl)phenyl]amino]carbonyl]-4-methyl-2-thiazo lyl]carbamic acid 1,1-dimethylethyl ester; [5-[[(4-Cyclohexylphenyl)amino]carbonyl]-4-methyl-2-thiazolyl]carbamic acid 1,1-dimethylethyl ester; [5-[[(Cyclohexylmethyl)amino]carbonyl]-4-methyl-2-thiazolyl]carbamic acid 1,1-dimethylethyl ester; [5-[[(2,3-Dihydro-1H-indenyl)amino]carbonyl]-4-methyl-2-thiazolyl]carbamic acid 1,1-dimethylethyl ester; [5-[(2,5-Dihydro-1H-pyrrol-1-yl)carbonyl]-4-methyl-2-thiazolyl]carbamic acid 1,1-dimethylethyl ester; [5-[(2,5-Dihydro-2,5-dimethyl-1H-pyrrol-1-yl)carbonyl]-4-methyl-2-thiazolyl ]carbamic acid 1,1-dimethylethyl ester; 1-[[2-[[(1,1-Dimethylethoxy)carbonyl]amino]-4-methyl-5-thiazolyl]carbonyl]- L-prolinamide; [5-[(4-Formyl-1-piperazinyl)carbonyl]-4-methyl-2-thiazolyl]carbamic acid 1,1-dimethylethyl ester; [5-(1,4-Dioxa-8-azaspiro[4,5]decan-8-ylcarbonyl)-4-methyl-2-thiazolyl]carba mic acid 1,1-dimethylethyl ester; [5-[[3-[(Diethylamino)carbonyl]-1-piperidinyl]carbonyl]-4-methyl-2-thiazoly l]carbamic acid 1,1-dimethylethyl ester; [4-Methyl-5-[(octahydro-1-quinolinyl)carbonyl]-2-thiazolyl]carbamic acid 1,1-dimethylethyl ester; 2-[[(1,1-Dimethylethoxy)carbonyl]amino]-4-methyl-5-thiazolecarboxylic acid 2-[(1,1-dimethylethoxy)carbonyl]hydrazide; [5-[[(4-Methoxyphenyl)amino]carbonyl]-4-methyl-2-thiazolyl]carbamic acid 1,1-dimethylethyl ester; [4-Methyl-5-[[(4-methylphenyl)amino]carbonyl]-2-thiazolyl]carbamic acid 1,1-dimethylethyl ester; [5-[[(1,2-Dimethylpropyl)amino]carbonyl]-4-methyl-2-thiazolyl]carbamic acid 1,1-dimethylethyl ester; [5-[[(2,2-Dimethylpropyl)amino]carbonyl]-4-methyl-2-thiazolyl]carbamic acid 1,1-dimethylethyl ester; [4-Methyl-5-[(2-propynylamino)carbonyl]-2-thiazolyl]carbamic acid 1,1-dimethylethyl ester; [4-Methyl-5-[(2-propenylamino)carbonyl]-2-thiazolyl]carbamic acid 1,1-dimethylethyl ester; [4-Methyl-5-[(methylphenylamino)carbonyl]-2-thiazolyl]carbamic acid 1,1-dimethylethyl ester; [4-Methyl-5-[[(3,4,5-trimethoxyphenyl)amino]carbonyl]-2-thiazolyl]carbamic acid 1,1-dimethylethyl ester; [5-[[[2,6-Bis(1-methylethyl)phenyl]amino]carbonyl]-4-methyl-2-thiazolyl]car bamic acid 1,1-dimethylethyl ester; [5-[[[3-(1H-Imidazol-1-yl)propyl]amino]carbonyl]-4-methyl-2-thiazolyl]carba mic acid 1,1-dimethylethyl ester; [5-[[[(3,4-Difluorophenyl)methyl]amino]carbonyl]-4-methyl-2-thiazolyl]carba mic acid 1,1-dimethylethyl ester; N-[[2-[[(1,1-Dimethylethoxy)carbonyl]amino]-4-methyl-5-thiazolyl]carbonyl]- L-leucine methyl ester; 5-[[[2-[[(1,1-Dimethylethoxy)carbonyl]amino]-4-methyl-5-thiazolyl]carbonyl] amino]-4-oxopentanoic acid methyl ester; [5-[[[2-(Ethylthio)ethyl]amino]carbonyl]-4-methyl-2-thiazolyl]carbamic acid 1,1-dimethylethyl ester; [5-[[Bis(3-methylbutyl)amino]carbonyl]-4-methyl-2-thiazolyl]carbamic acid 1,1-dimethylethyl ester; [5-[[Ethyl(1-methylethyl)amino]carbonyl]-4-methyl-2-thiazolyl]carbamic acid 1,1-dimethylethyl ester; 2-[[(1,1-Dimethylethoxy)carbonyl]amino]-4-methyl-5-thiazolecarboxylic acid 2-[[(3,5-dichlorophenyl)amino]thioxomethyl]hydrazide; [5-[[Bis(2-ethoxyethyl)amino]carbonyl]-4-methyl-2-thiazolyl]carbamic acid 1,1-dimethylethyl ester; [4-Methyl-5-[[3-[(trifluoroacetyl)amino]-1-pyrrolidinyl]carbonyl]-2-thiazol yl]carbamic acid 1,1-dimethylethyl ester; [5-[[(2,6-Dimethylphenyl)amino]carbonyl]-4-methyl-2-thiazolyl]carbamic acid 1,1-dimethylethyl ester; 2-[[(2,2-Dichloro-1-methylcyclopropyl)carbonyl]amino]-4-methyl-N-(2,4,6-tri methylphenyl)-5-thiazolecarboxamide; 2-[(Cyclohexylacetyl)amino]-4-methyl-N-(2,4,6-trimethylphenyl)-5-thiazoleca rboxamide; 2-[(2,5-Difluorobenzoyl)amino]-4-methyl-N-(2,4,6-trimethylphenyl)-5-thiazol ecarboxamide; 2-[(5-Bromo-2-chlorobenzoyl)amino]-4-methyl-N-(2,4,6-trimethylphenyl)-5-thi azolecarboxamide; 2-[(3-Cyanobenzoyl)amino]-4-methyl-N-(2,4,6-trimethylphenyl)-5-thiazolecarb oxamide; 2-[[4-(Acetylamino)benzoyl]amino]-4-methyl-N-(2,4,6-trimethylphenyl)-5-thia zolecarboxamide; 4-Methyl-2-[[3-(trifluoromethyl)benzoyl]amino]-N-(2,4,6-trimethylphenyl)-5- thiazolecarboxamide; 4-Methyl-2-[[2-(2-phenylethyl)benzoyl]amino]-N-(2,4,6-trimethylphenyl)-5-th iazolecarboxamide; 2-[(3,5-Dimethylbenzoyl)amino]-4-methyl-N-(2,4,6-trimethylphenyl)-5-thiazol ecarboxamide; 2-[(4-Ethenylbenzoyl)amino]-4-methyl-N-(2,4,6-trimethylphenyl)-5-thiazoleca rboxamide; 2-[(4-Butylbenzoyl)amino]-4-methyl-N-(2,4,6-trimethylphenyl)-5-thiazolecarb oxamide; 4-Methyl-2-[(4-pentylbenzoyl)amino]-N-(2,4,6-trimethylphenyl)-5-thiazolecar boxamide; 4-Methyl-2-[(1-oxo-3-phenoxypropyl)amino]-N-(2,4,6-trimethylphenyl)-5-thiaz olecarboxamide; 4-Methyl-2-[(1-oxo-3-phenylpropyl)amino]-N-(2,4,6-trimethylphenyl)-5-thiazo lecarboxamide; 2-[[3-(2-Methoxyphenyl)-1-oxopropyl]amino]-4-methyl-N-(2,4,6-trimethylpheny l)-5-thiazolecarboxamide; 4-Methyl-2-[(2-naphthalenylacetyl)amino]-N-(2,4,6-trimethylphenyl)-5-thiazo lecarboxamide; 2-[(Diphenylacetyl)amino]-4-methyl-N-(2,4,6-trimethylphenyl)-5-thiazolecarb oxamide; 2-[[(2-Chloro-6-fluorophenyl)acetyl]amino]-4-methyl-N-(2,4,6-trimethylpheny l)-5-thiazolecarboxamide; 4-Methyl-2-[[(2-methylphenyl)acetyl]amino]-N-(2,4,6-trimethylphenyl)-5-thia zolecarboxamide; 2-[[(3-Methoxyphenyl)acetyl]amino]-4-methyl-N-(2,4,6-trimethylphenyl)-5-thi azolecarboxamide; 2-[[(3,4-Dimethoxyphenyl)acetyl]amino]-4-methyl-N-(2,4,6-trimethylphenyl)-5 -thiazolecarboxamide; 2-[[(4-Chlorophenyl)acetyl]amino]-4-methyl-N-(2,4,6-trimethylphenyl)-5-thia zolecarboxamide; 2-[([1,1'-Biphenyl]-4-ylacetyl)amino]-4-methyl-N-(2,4,6-trimethylphenyl)-5- thiazolecarboxamide; 4-Methyl-2-[(1-oxo-4-phenylbutyl)amino]-N-(2,4,6-trimethylphenyl)-5-thiazol ecarboxamide; 2-[(2-Hydroxy-2-phenyl-1-oxopropyl)amino]-4-methyl-N-(2,4,6-trimethylphenyl )-5-thiazolecarboxamide; 2-[(2-Hydroxy-1-oxohexyl)amino]-4-methyl-N-(2,4,6-trimethylphenyl)-5-thiazo lecarboxamide; 4-Methyl-2-[[1-oxo-4-(2-thienyl)butyl]amino]-N-(2,4,6-trimethylphenyl)-5-th iazolecarboxamide; 4-Methyl-2-[(3-thienylcarbonyl)amino]-N-(2,4,6-trimethylphenyl)-5-thiazolec arboxamide; 2-[(2-Benzofuranylcarbonyl)amino]-4-methyl-N-(2,4,6-trimethylphenyl)-5-thia zolecarboxamide; N-[4-Methyl-5-[[(2,4,6-trimethylphenyl)amino]carbonyl]-2-thiazolyl]-4-pyrid inecarboxamide, N-oxide; 6-Chloro-N-[4-methyl-5-[[(2,4,6-trimethylphenyl)amino]carbonyl]-2-thiazolyl ]-3-pyridinecarboxamide; N-[4-Methyl-5-[[(2,4,6-trimethylphenyl)amino]carbonyl]-2-thiazolyl]-3-pyrid inecarboxamide; N-[4-Methyl-5-[[(2,4,6-trimethylphenyl)amino]carbonyl]-2-thiazolyl]-3-quino linecarboxamide; 4-Methyl-2-[[(4-nitrophenyl)acetyl]amino]-N-(2,4,6-trimethylphenyl)-5-thiaz olecarboxamide; 4-Methyl-2-[(2,4,6-trichlorobenzoyl)amino]-N-(2,4,6-trimethylphenyl)-5-thia zolecarboxamide; 4-Methyl-2-[[2-[[3-(trifluoromethyl)phenyl]amino]benzoyl]amino]-N-(2,4,6-tr imethylphenyl)-5-thiazolecarboxamide; 4-Methyl-2-[[4-(4-nitrophenyl)-1-oxobutyl]amino]-N-(2,4,6-trimethylphenyl)- 5-thiazolecarboxamide; 4-Methyl-2-[[4-(methylsulfonyl)benzoyl]amino]-N-(2,4,6-timethylphenyl)-5-th iazolecarboxamide; 2-[(4-Heptylbenzoyl)amino]-4-methyl-N-(2,4,6-trimethylphenyl)-5-thiazolecar boxamide; 2-[[(2,4-Difluorophenyl)acetyl]amino]-4-methyl-N-(2,4,6-trimethylphenyl)-5- thiazolecarboxamide; (S)-2-[[2-(Dipropylamino)-1-oxopropyl]amino]-4-methyl-N-(2,4,6-trimethylphe nyl)-5-thiazolecarboxamide; 2-[(2-Biphenylenecarbonyl)amino]-4-methyl-N-(2,4,6-trimethylphenyl)-5-thiaz olecarboxamide; 2-[[3-(3-Methoxyphenyl)-1-oxopropyl]amino]-4-methyl-N-(2,4,6-trimethylpheny l)-5-thiazolecarboxamide; 4-Methyl-N-(2,4,6-trimethylphenyl)-2-[[(2,4,6-trimethylphenyl)acetyl]amino] -5-thiazolecarboxamide; 4-Methyl-2-[(1-oxo-6-heptenyl)amino]-N-(2,4,6-trimethylphenyl)-5-thiazoleca rboxamide; 2-[[(1,3-Benzodioxol-5-yl)acetyl]amino]-4-methyl-N-(2,4,6-trimethylphenyl)- 5-thiazolecarboxamide; 4-Methyl-2-[[[2-(phenylmethoxy)phenyl]acetyl]amino]-N-(2,4,6-trimethylpheny l)-5-thiazolecarboxamide; 4-Methyl-2-[[(3-phenoxyphenyl)acetyl]amino]-N-(2,4,6-trimethylphenyl)-5-thi azolecarboxamide; 2-[(3,5-Dimethoxyphenyl)acetyl]amino]-4-methyl-N-(2,4,6-trimethylphenyl)-5- thiazolecarboxamide; 2-[[4-[4-[Bis(2-chloroethyl)amino]phenyl]-1-oxobutyl]amino]-4-methyl-N-(2,4 ,6-trimethylphenyl)-5-thiazolecarboxamide; 4-[[4-[[[4-methyl-5-[[(2,4,6-trimethylphenyl)amino]carbonyl]-2-thiazolyl]am ino]carbonyl]phenyl]amino]-4-oxobutanoic acid methyl ester; 4-Methyl-2-[[(phenysulfonyl)acetyl]amino]-N-(2,4,6-trimethylphenyl)-5-thiaz olecarboxamide; 2-[[2-(Acetylamino)-1-oxohexyl]amino]-4-methyl-N-(2,4,6-trimethylphenyl)-5- thiazolecarboxamide; 2-[[4-[(Dipropylamino)sulfonyl]benzoyl]amino]-4-methyl-N-(2,4,6-trimethylph enyl)-5-thiazolecarboxamide; 2-[(4-Cyclohexylbenzoyl)amino]-4-methyl-N-(2,4,6-trimethylphenyl)-5-thiazol ecarboxamide; 2-[(4-Bromo-3-methylbenzoyl)amino]-4-methyl-N-(2,4,6-trimethylphenyl)-5-thi azolecarboxamide; 2-[[(2,3-Difluorophenyl)acetyl]amino]-4-methyl-N-(2,4,6-trimethylphenyl)-5- thiazolecarboxamide; 4-Methyl-2-[[[4-(1-methylethyl)phenyl]acetyl]amino]-N-(2,4,6-trimethylpheny l)-5-thiazolecarboxamide; 2-[[[4-(1,1-Dimethylethyl)cyclohexyl]carbonyl]amino]-4-methyl-N-(2,4,6-trim ethylphenyl)-5-thiazolecarboxamide; N,N-Dimethyl-N'-[4-methyl-5-[[(2,4,6-trimethylphenyl)amino]carbonyl]-2-thia zolyl]butanediamide; 2-[(1,6-Dioxohexyl)amino]-4-methyl-N-(2,4,6-trimethylphenyl)-5-thiazolecarb oxamide; 2-[(Benzo[b]thiophen-2-ylcarbonyl)amino]-4-methyl-N-(2,4,6-trimethylphenyl) -5-thiazolecarboxamide; 2-[(1-Adamantylcarbonyl)amino]-4-methyl-N-(2,4,6-trimethylphenyl)-5-thiazol ecarboxamide; 4-Methyl-2-[[(4-methylcyclohexyl)carbonyl]amino]-N-(2,4,6-trimethylphenyl)- 5-thiazolecarboxamide; 2-[(1,7-Dioxooctyl)amino]-4-methyl-N-(2,4,6-trimethylphenyl)-5-thiazolecarb oxamide; 2-[[2-(Acetylamino)-4-(ethylthio)-1-oxobutyl]amino]-4-methyl-N-(2,4,6-trime thylphenyl)-5-thiazolecarboxamide; 1,5-Dimethyl-N-[4-methyl-5-[[(2,4,6-trimethylphenyl)amino]carbonyl]-2-thiaz olyl]-1H-pyrazole-3-carboxamide; 2-[[[4-methyl-5-[[(2,4,6-trimethylphenyl)amino]carbonyl]-2-thiazolyl]amino] carbonyl]benzoic acid; N-[4-Methyl-5-[[(2,4,6-trimethylphenyl)amino]carbonyl]-2-thiazolyl]-6-benzo thiazolecarboxamide; 1-Ethyl-4-methyl-N-[4-methyl-5-[[(2,4,6-trimethylphenyl)amino]carbonyl]-2-t hiazolyl]-1H-pyrazole-3-carboxamide; 4-Methyl-2-[[3-[(3H-1,2,3-triazolo[4,5-b]pyridin-3-yloxy)methyl]benzoyl]ami no]-N-(2,4,6-trimethylphenyl)-5-thiazolecarboxamide; 2-[(2-Furanylcarbonyl)amino]-4-methyl-N-(2,4,6-trimethylphenyl)-5-thiazolec arboxamide; 2-[(4-Chlorobenzoyl)amino]-4-methyl-N-(2,4,6-trimethylphenyl)-5-thiazolecar boxamide; [4-Methyl-5[[(2-nitrophenyl)amino]carbonyl]-2-thiazolyl]carbamic acid, 1,1-dimethylethyl ester; [4-Methyl-5[[(2,4,6-trimethylphenyl)amino]carbonyl]-2-thiazolyl]carbamic acid, phenyl methyl ester;

Methyl [4-methyl-5-[[(2,4,6-trimethylphenyl)amino]carbonyl]-2-thiazolyl]carbamic acid, 1,1-dimethylethyl ester; [4-Methyl-5-[[methyl(2,4,6-trimethylphenyl)amino]carbonyl]-2-thiazolyl]carb amic acid, 1,1-dimethylethyl ester; [4-Methyl-5[[(2,4,6-trimethylphenyl)amino]carbonyl]-2-thiazolyl]carbamic acid, methyl ester; [4-Ethyl-5[[(2,4,6-trimethylphenyl)amino]carbonyl]-2-thiazolyl]carbamic acid, 1,1-dimethylethyl ester; [5-[[(2,6-Dichlorophenyl)amino]carbonyl]-4-methyl-2-thiazolyl]carbamic acid, 1,1-dimethylethyl ester; 2-Amino-N-(2-methyl-6-isopropylphenyl)-4-methyl-5-thiazolecarboxamide, trifluoroacetate (1:1); 2-(Benzoylamino)-4-methyl-N-(2,4,6-trimethylphenyl)-5-thiazolecarboxamide; 4-Methyl-2-[(phenylcetyl)amino]-N-(2,4,6-trimethylphenyl)-5-thiazolecarboxa mide; 2-[[(Acetylamino)acetyl]amino]-4-methyl-N-(2,4,6-trimethylphenyl)-6-thiazol ecarboxamide; 2-Amino-4-methyl-N-(2,4,6-trimethylphenyl)-5-thiazolecarbothioamide; 2-[(4-Bromobenzoyl)amino]-4-methyl-N-(2,4,6-trimethylphenyl)-5-thiazolecarb oxamide; 4-Methyl-2-[(4-nitrobenzoyl)amino]-N-(2,4,6-trimethylphenyl)-5-thiazolecarb oxamide; 2-[(4-Cyanobenzoyl)amino]-4-methyl-N-(2,4,6-trimethylphenyl)-5-thiazolecarb oxamide; 4-Methyl-2-[[(5-nitro-2-furanyl)carbonyl]amino]-N-(2,4,6-trimethylphenyl)-5 -thiazolecarboxamide; 4-Methyl-2-[(2-thienylcarbonyl)amino]-N-(2,4,6-trimethylphenyl)-5-thiazolec arboxamide; 4-[[[4-Methyl-5-[[(2,4,6-trimethylphenyl)amino]carbonyl]-2-thiazolyl]amino] carbonyl]benzoic acid methyl ester; 2-[(5-Isoxazolylcarbonyl)amino]-4-methyl-N-(2,4,6-trimethylphenyl)-5-thiazo lecarboxamide; 2-[(3-Furanylcarbonyl)amino]-4-methyl-N-(2,4,6-trimethylphenyl)-5-thiazolec arboxamide; 2-[[(2,4-Dimethyl-5-thiazolyl)carbonyl]amino]-4-methyl-N-(2,4,6-trimethylph enyl)-5-thiazolecarboxamide; 2-[[(4-Methoxy-3-thienyl)carbonyl]amino]-4-methyl-N-(2,4,6-trimethylphenyl) -5-thiazolecarboxamide; 4-Methyl-2-[[(5-nitro-3-thienyl)carbonyl]amino]-N-(2,4,6-trimethylphenyl)-5 -thiazolecarboxamide; 2-[[[4-[(4-Chlorophenyl)thio]-3-thienyl]carbonyl]amino]-4-methyl-N-(2,4,6-t rimethylphenyl)-5-thiazolecarboxamide; 2-[[(5-Chloro-4-methoxy-3-thienyl)carbonyl]amino]-4-methyl-N-(2,4,6-trimeth ylphenyl)-5-thiazolecarboxamide; 2-[[[2-(4,5-Dihydro-4,4-dimethyl-2-oxazolyl)-3-thienyl]carbonyl]amino]-4-me thyl-N-(2,4,6-trimethylphenyl)-5-thiazolecarboxamide; 2-[[(2-Acetyl-3-thienyl)carbonyl]amino]-4-methyl-N-(2,4,6-trimethylphenyl)- 5-thiazolecarboxamide; 4-Methyl-2-[[(methylamino)carbonyl]amino]-N-(2,4,6-trimethylphenyl)-5-thiaz olecarboxamide; 4-Methyl-2-[[(phenylamino)carbonyl]amino]-N-(2,4,6-trimethylphenyl)-5-thiaz olecarboxamide; 4-Methyl-2-[[[(4-methylphenyl)amino]carbonyl]amino]-N-(2,4,6-trimethylpheny l)-5-thiazolecarboxamide; 4-Methyl-2-[[[(phenylmethyl)amino]carbonyl]amino]-N-(2,4,6-trimethylphenyl) -5-thiazolecarboxamide; 2-[[(Butylamino)carbonyl]amino]-4-methyl-N-(2,4,6-trimethylphenyl)-5-thiazo lecarboxamide; 4-Methyl-2-[[(propylamino)carbonyl]amino]-N-(2,4,6-trimethylphenyl)-5-thiaz olecarboxamide; 2-[[(Cyclohexylamino)carbonyl]amino]-4-methyl-N-(2,4,6-trimethylphenyl)-5-t hiazolecarboxamide; 2-[[[(2-Chlorophenyl)amino]carbonyl]amino]-4-methyl-N-(2,4,6-trimethylpheny l)-5-thiazolecarboxamide; 2-[[[(3-Fluorophenyl)amino]carbonyl]amino]-4-methyl-N-(2,4,6-trimethylpheny l)-5-thiazolecarboxamide; 2-[[[(2,6-Dimethylphenyl)amino]carbonyl]amino]-4-methyl-N-(2,4,6-trimethyl phenyl)-5-thiazolecarboxamide; [5-[[(2,4,6-Trimethylphenyl)amino]carbonyl]-4-methyl-2-thiazolyl]carbamic acid, phenyl ester; 4-Methyl-2-[[[(2-phenylethyl)amino]carbonyl]amino]-N-(2,4,6-trimethylphenyl )-5-thiazolecarboxamide 2-[[(Hexylamino)carbonyl]amino]-4-methyl-N-(2,4,6-trimethylphenyl)-5-thiazo lecarboxamide; 2-[[[(1,1-Dimethylethyl)amino]carbonyl]amino]-4-methyl-N-(2,4,6-trimethylph enyl)-5-thiazolecarboxamide; 2-[[[(3-Fluoro-4-methylphenyl)amino]carbonyl]amino]-4-methyl-N-(2,4,6-trime thylphenyl)-5-thiazolecarboxamide; 2-[[[(4-Methoxyphenyl)amino]carbonyl]amino]-4-methyl-N-(2,4,6-trimethylphen yl)-5-thiazolecarboxamide; 2-[[(Diethylamino)carbonyl]amino]-4-methyl-N-(2,4,6-trimethylphenyl)-5-thia zolecarboxamide; 2-[[[Bis(1-methylethyl)amino]carbonyl]amino]-4-methyl-N-(2,4,6-trimethylphe nyl)-5-thiazolecarboxamide; 4-Methyl-2-[[[methyl(phenylmethyl)amino]carbonyl]amino]-N-(2,4,6-trimethylp henyl)-5-thiazolecarboxamide; 4-Methyl-2-[[(methylphenylamino)carbonyl]amino]-N-(2,4,6-trimethylphenyl)-5 -thiazolecarboxamide; 2-[[(Cyclohexylmethylamino)carbonyl]amino]-4-methyl-N-(2,4,6-trimethylpheny l)-5-thiazolecarboxamide; 4-Methyl-2-[[[(1-phenylethyl)amino]carbonyl]amino]-N-(2,4,6-trimethylphenyl )-5-thiazolecarboxamide; 2-[[[(Cyclopropylmethyl)propylamino]carbonyl]amino]-4-methyl-N-(2,4,6-trime thylphenyl)-5-thiazolecarboxamide; 4-Methyl-2-[[[(2-methylcyclohexyl)amino]carbonyl]amino]-N-(2,4,6-trimethylp henyl)-5-thiazolecarboxamide; 4-Methyl-2-[[[(4-methylcyclohexyl)amino]carbonyl]amino]-N-(2,4,6-trimethylp henyl)-5-thiazolecarboxamide; 2-[[[(Cyclohexylmethyl)amino]carbonyl]amino]-4-methyl-N-(2,4,6-trimethylphe nyl)-5-thiazolecarboxamide; 2-[[[(2,3-Dihydro-1H-inden-1-yl)amino]carbonyl]amino]-4-methyl-N-(2,4,6-tri methylphenyl)-5-thiazolecarboxamide; 4-Methyl-2-[[[(1-naphthalenylmethyl)amino]carbonyl]amino]-N-(2,4,6-trimethy lphenyl)-5-thiazolecarboxamide 2-[[[Bis(phenylmethyl)amino]carbonyl]amino]-4-methyl-N-(2,4,6-trimethylphen yl)-5-thiazolecarboxamide; 2,6-Dimethyl-N-[4-methyl-5-[[(2,4,6-trimethylphenyl)amino]carbonyl]-2-thiaz olyl]-4-morpholinecarboxamide; 2-Ethyl-N-[4-methyl-5-[[(2,4,6-trimethylphenyl)amino]carbonyl]-2-thiazolyl] -1-piperidinecarboxamide; 1-[[[4-Methyl-5-[[(2,4,6-trimethylphenyl)amino]carbonyl]-2-thiazolyl]amino] carbonyl]-3-piperidinecarboxylic acid ethyl ester; 3,3-Dimethyl-N-[4-methyl-5-[[(2,4,6-trimethylphenyl)amino]carbonyl]-2-thiaz olyl]-1-piperidinecarboxamide 1-[[[4-Methyl-5-[[(2,4,6-trimethylphenyl)amino]carbonyl]-2-thiazolyl]amino] carbonyl]-4-piperidinecarboxylic acid ethyl ester; 4-Methyl-2-[[[(3-methyl-2-pyridinyl)amino]carbonyl]amino]-N-(2,4,6-trimethy lphenyl)-5-thiazolecarboxamide 4-Methyl-2-[[[1-(phenylmethyl)-4-piperidinyl]amino]carbonyl]amino]-N-(2,4,6 -trimethylphenyl)-5-thiazolecarboxamide; Octahydro-N-[4-methyl-5-[[(2,4,6-trimethylphenyl)amino]carbonyl]-2-thiazoly l]-1(2H)-quinolinecarboxamide; 3,4-Dihydro-N-[4-methyl-5-[[(2,4,6-trimethylphenyl)amino]carbonyl]-2-thiazo lyl]-2(1H)-isoquinolinecarboxamide; 2-[[[(1,5-Dimethylhexyl)amino]carbonyl]amino]-4-methyl-N-(2,4,6-trimethylph enyl)-5-thiazolecarboxamide; 4-Methyl-2-[[[(1-methylheptyl)amino]carbonyl]amino]-N-(2,4,6-trimethylpheny l)-5-thiazolecarboxamide; 2-[[[[(2-Fluorophenyl)methyl]amino]carbonyl]amino]-4-methyl-N-(2,4,6-trimet hylphenyl)-5-thiazolecarboxamide; 2-[[[[(2-Methoxyphenyl)methyl]amino]carbonyl]amino]-4-methyl-N-(2,4,6-trime thylphenyl)-5-thiazolecarboxamide; 2-[[[[(2-Ethoxyphenyl)methyl]amino]carbonyl]amino]-4-methyl-N-(2,4,6-trimet hylphenyl)-5-thiazolecarboxamide; 2-[[[[(3-Methoxyphenyl)methyl]amino]carbonyl]amino]-4-methyl-N-(2,4,6-trime thylphenyl)-5-thiazolecarboxamide; 2-[[[[(4-Chlorophenyl)methyl]amino]carbonyl]amino]-4-methyl-N-(2,4,6-trimet hylphenyl)-5-thiazolecarboxamide; 2-[[[[(4-Methoxyphenyl)methyl]amino]carbonyl]amino]-4-methyl-N-(2,4,6-trime thylphenyl)-5-thiazolecarboxamide; 2-[[[(2,2-Diphenylethyl)amino]carbonyl]amino]-4-methyl-N-(2,4,6-trimethylph enyl)-5-thiazolecarboxamide 2-[[[(2-Aminoethyl)phenylamino]carbonyl]amino]-4-methyl-N-(2,4,6-trimethylp henyl)-5-thiazolecarboxamide; 2-[[[[2-(3-Methoxyphenyl)ethyl]amino]carbonyl]amino]-4-methyl-N-(2,4,6-trim ethylphenyl)-5-thiazolecarboxamide; 2-[[[[2-(3,4-Dimethoxyphenyl)ethyl]amino]carbonyl]amino]-4-methyl-N-(2,4,6- trimethylphenyl)-5-thiazolecarboxamide; 2-[[[[2-(4-Methoxyphenyl)ethyl]amino]carbonyl]amino]-4-methyl-N-(2,4,6-trim ethylphenyl)-5-thiazolecarboxamide; 4-Methyl-2-[[[(3-phenylpropyl)amino]carbonyl]amino]-N-(2,4,6-trimethylpheny l)-5-thiazolecarboxamide; 2-[[[[2-(Cyclohex-1-en-1-yl)ethyl]amino]carbonyl]amino]-4-methyl-N-(2,4,6-t rimethylphenyl)-5-thiazolecarboxamide; 2-[[[[4-(1,1-Dimethylethyl)cyclohexyl]amino]carbonyl]amino]-4-methyl-N-(2,4 ,6-trimethylphenyl)-5-thiazolecarboxamide; 2-[[[(3-Butoxypropyl)amino]carbonyl]amino]-4-methyl-N-(2,4,6-trimethylpheny l)-5-thiazolecarboxamide; 2-[[[[2-(2-Methoxyphenyl)ethyl]amino]carbonyl]amino]-4-methyl-N-(2,4,6-trim ethylphenyl)-5-thiazolecarboxamide; 2-[[[[(2-Chloro-4-fluorophenyl)methyl]amino]carbonyl]amino]-4-methyl-N-(2,4 ,6-trimethylphenyl)-5-thiazolecarboxamide; 2-[[(Hexylmethylamino)carbonyl]amino]-4-methyl-N-(2,4,6-trimethylphenyl)-5- thiazolecarboxamide; 2-[[[[1-(4-Chlorophenyl)ethyl]amino]carbonyl]amino]-4-methyl-N-(2,4,6-trime thylphenyl)-5-thiazolecarboxamide; 2-[[[[2-(3-Chlorophenyl)ethyl]amino]carbonyl]amino]-4-methyl-(2,4,6-trimeth ylphenyl)-5-thiazolecarboxamide; 4-Methyl-2-[[[[2-(2-thienyl)ethyl]amino]carbonyl]amino]-N-(2,4,6-trimethylp henyl)-5-thiazolecarboxamide; 2-[[[[2-(2-Fluorophenyl)ethyl]amino]carbonyl]amino]-4-methyl-N-(2,4,6-trime thylphenyl)-5-thiazolecarboxamide; 4-Methyl-2-[[[[2-(2-pyridinyloxy)ethyl]amino]carbonyl]amino]-N-(2,4,6-trime thylphenyl)-5-thiazolecarboxamide; 2-[[[[(2-Bromo-4,5-dimethoxyphenyl)methyl]methylamino]carbonyl]amino]-4-met hyl-N-(2,4,6-trimethylphenyl)-5-thiazolecarboxamide; (E)-2-[[[(3,7-Dimethyl-2,6-octadienyl)amino]carbonyl]amino]-4-methyl-N-(2,4 ,6-trimethylphenyl)-5-thiazolecarboxamide; 2-[[[[(2,3-Dihydro-1,4-benzodioxin-2-yl)methyl]amino]carbonyl]amino]-4-meth yl-N-(2,4,6-trimethylphenyl)-5-thiazolecarboxamide; 2-[[[[3-Methoxy-5-(trifluoromethyl)phenyl]amino]carbonyl]amino]-4-methyl-N- (2,4,6-trimethylphenyl)-5-thiazolecarboxamide; 2-[[[(4-Cyclohexylphenyl)amino]carbonyl]amino]-4-methyl-N-(2,4,6-trimethylp henyl)-5-thiazolecarboxamide; 4-Methyl-2-[[[(5,6,7,8-tetrahydro-1-naphthalenyl)amino]carbonyl]amino]-N-(2 ,4,6-trimethylphenyl)-5-thiazolecarboxamide; 2-[[(1-Anthracenylamino)carbonyl]amino]-4-methyl-N-(2,4,6-trimethylphenyl)- 5-thiazolecarboxamide; 2-[[[(4-Chloro-1-naphthalenyl)amino]carbonyl]amino]-4-methyl-N-(2,4,6-trime thylphenyl)-5-thiazolecarboxamide; 4-Methyl-2-[[(2-naphthalenylamino)carbonyl]amino]-N-(2,4,6-trimethylphenyl) -5-thiazolecarboxamide; 2-[[(1H-Indol-5-ylamino)carbonyl]amino]-4-methyl-N-(2,4,6-trimethylphenyl)- 5-thiazolecarboxamide; 2-[[(1,3-Benzodioxol-5-ylamino)carbonyl]amino]-4-methyl-N-(2,4,6-trimethylp henyl)-5-thiazolecarboxamide 4-Methyl-2-[[(2-pyrazinylamino)carbonyl]amino]-N-(2,4,6-trimethylphenyl)-5- thiazolecarboxamide; 2-[[[(5-Chloro-2-pyridinyl)amino]carbonyl]amino]-4-methyl-N-(2,4,6-trimethy lphenyl)-5-thiazolecarboxamide; 4-Methyl-2-[[[(6-methyl-2-pyridinyl)amino]carbonyl]amino]-N-(2,4,6-trimethy lphenyl)-5-thiazolecarboxamide; 4-Methyl-2-[[[(2-methyl-4-quinolinyl)amino]carbonyl]amino]-N-(2,4,6-trimeth ylphenyl)-5-thiazolecarboxamide; 2-[[[(2,3-Dihydro-1,4-benzodioxin-6-yl)amino]carbonyl]amino]-4-methyl-N-(2, 4,6-trimethylphenyl)-5-thiazolecarboxamide; 2-[[([1,1'-Biphenyl]-2-ylamino)carbonyl]amino]-4-methyl-N-(2,4,6-trimethylp henyl)-5-thiazolecarboxamide; 2-[[[(4-Methoxy-2-methylphenyl)amino]carbonyl]amino]-4-methyl-N-(2,4,6-trim ethylphenyl)-5-thiazolecarboxamide 4-Methyl-N-(2,4,6-trimethylphenyl)-2-[[[(2,4,6-trimethylphenyl)amino]carbon yl]amino]-5-thiazolecarboxamide; 2-[[[[2-(2-Hydroxyethyl)phenyl]amino]carbonyl]amino]-4-methyl-N-(2,4,6-trim ethylphenyl)-5-thiazolecarboxamide; 2-[[[(3-Methoxyphenyl)amino]carbonyl]amino]-4-methyl-N-(2,4,6-trimethylphen yl)-5-thiazolecarboxamide; 2-[[[(4-Methoxy[1,1'-biphenyl]-3-yl)amino]carbonyl]amino]-4-methyl-N-(2,4,6 -trimethylphenyl)-5-thiazolecarboxamide; 2-[[[(3-Acetylphenyl)amino]carbonyl]amino]-4-methyl-N-(2,4,6-trimethylpheny l)-5-thiazolecarboxamide; 2-[[[(4-Cyanophenyl)amino]carbonyl]amino]-4-methyl-N-(2,4,6-trimethylphenyl )-5-thiazolecarboxamide; 2-[[[[4-Fluoro-2-(trifluoromethyl)phenyl]amino]carbonyl]amino]-4-methyl-N-( 2,4,6-trimethylphenyl)-5-thiazolecarboxamide 2-[[[(4-Hexyloxyphenyl)amino]carbonyl]amino]-4-methyl-N-(2,4,6-trimethylphe nyl)-5-thiazolecarboxamide; 4-[[[[4-Methyl-5-[[(2,4,6-trimethylphenyl)amino]carbonyl]-2-thiazolyl]amino ]carbonyl]amino]benzoic acid ethyl ester; 2-[[[(4-Decylphenyl)amino]carbonyl]amino]-4-methyl-N-(2,4,6-trimethylphenyl )-5-thiazolecarboxamide; 4-Methyl-2-[[[(4-propylphenyl)amino]carbonyl]amino]-N-(2,4,6-trimethylpheny l)-5-thiazolecarboxamide 4-Methyl-2-[[[(3,4,5-trimethoxyphenyl)amino]carbonyl]amino]-N-(2,4,6-trimet hylphenyl)-5-thiazolecarboxamide; 4-Methyl-2-[[[[4-[[(5-methyl-3-isoxazolyl)amino]sulfonyl]phenyl]amino]carbo nyl]amino]-N-(2,4,6-trimethylphenyl)-5-thiazolecarboxamide; 4-[[[[4-Methyl-5-[[(2,4,6-trimethylphenyl)amino]carbonyl]-2-thiazolyl]amino ]carbonyl]amino]benzoic acid butyl ester; 2-[[(1-Isoquinolinylamino)carbonyl]amino]-4-methyl-N-(2,4,6-trimethylphenyl )-5-thiazolecarboxamide; 4-Methyl-2-[[[[2-[(phenylmethyl)thio]phenyl]amino]carbonyl]amino]-N-(2,4,6- trimethylphenyl)-5-thiazolecarboxamide; 4-Methyl-2-[[[[4-[(5-phenoxypentyl)oxy]phenyl]amino]carbonyl]amino]-N-(2,4, 6-trimethylphenyl)-5-thiazolecarboxamide; 2-[[[[5-(1,1-Dimethylpropyl)-2-methoxyphenyl]amino]carbonyl]amino]-4-methyl -N-(2,4,6-trimethylphenyl)-5-thiazolecarboxamide; 2-[[[(1,2-Dihydro-5-acenaphthylenyl)amino]carbonyl]amino]-4-methyl-N-(2,4,6 -trimethylphenyl)-5-thiazolecarboxamide; 4-Methyl-2-[[[(3-phenoxyphenyl)amino]carbonyl]amino]-N-(2,4,6-trimethylphen yl)-5-thiazolecarboxamide

4-Methyl-2-[[[[2-(4-morpholinyl)phenyl]amino]carbonyl]amino]-N-(2,4,6-trime thylphenyl)-5-thiazolecarboxamide; 4-Methyl-2-[[[[2-(1-piperidinyl)phenyl]amino]carbonyl]amino]-N-(2,4,6-trime thylphenyl)-5-thiazolecarboxamide; 2-[[[(1-Acetyl-2,3-dihydro-1H-indol-6-yl)amino]carbonyl]amino]-4-methyl-N-( 2,4,6-trimethylphenyl)-5-thiazolecarboxamide; 2-[[[(2-Bromo-5-methoxyphenyl)amino]carbonyl]amino]-4-methyl-N-(2,4,6-trime thylphenyl)-5-thiazolecarboxamide; 2-[[[(2,3-Dimethyl-1H-indol-5-yl)amino]carbonyl]amino]-4-methyl-N-(2,4,6-tr imethylphenyl)-5-thiazolecarboxamide; 4-Methyl-2-[[[[2-[[(1-methylethyl)amino]carbonyl]phenyl]amino]carbonyl]amin o]-N-(2,4,6-trimethylphenyl)-5-thiazolecarboxamide; 2-[[[(3-Bromo-2-methylphenyl)amino]carbonyl]amino]-4-methyl-N-(2,4,6-trimet hylphenyl)-5-thiazolecarboxamide; 2-[[[(4-Methoxybutyl)amino]carbonyl]amino]-4-methyl-N-(2,4,6-trimethylpheny l)-5-thiazolecarboxamide 2-[[[(3,3-Dimethylbutyl)amino]carbonyl]amino]-4-methyl-N-(2,4,6-trimethylph enyl)-5-thiazolecarboxamide; 4-Methyl-2-[[[(2-methylbutyl)amino]carbonyl]amino]-N-(2,4,6-trimethylphenyl )-5-thiazolecarboxamide; 4-Methyl-2-[[[(3-methylbutyl)amino]carbonyl]amino]-N-(2,4,6-trimethylphenyl )-5-thiazolecarboxamide; 2-[[[(2-Methoxyethyl)amino]carbonyl]amino]-4-methyl-N-(2,4,6-trimethylpheny l)-5-thiazolecarboxamide; 2-[[[[2-(Dimethylamino)ethyl]amino]carbonyl]amino]-4-methyl-N-(2,4,6-trimet hylphenyl)-5-thiazolecarboxamide; 4-Methyl-2-[[[[2-(methylthio)ethyl]amino]carbonyl]amino]-N-(2,4,6-trimethyl phenyl)-5-thiazolecarboxamide; 2-[[(Butylamino)carbonyl]amino]-N-(2,3-dihydro-1H-inden-5-yl)-4-methyl-5-th iazolecarboxamide; 2-[[(Butylamino)carbonyl]amino]-N-2-naphthalenyl-4-methyl-5-thiazolecarboxa mide; 2-[[(Butylamino)carbonyl]amino]-N-(3-hydroxy-2-naphthalenyl)-4-methyl-5-thi azolecarboxamide; 2-[[(Butylamino)carbonyl]amino]-N-(2-fluoro-5-methylphenyl)-4-methyl-5-thia zolecarboxamide; 2-[[(Butylamino)carbonyl]amino]-N-(2,6-dimethylphenyl)-4-methyl-5-thiazolec arboxamide; N-(3-Bromo-2,4,6-trimethylphenyl)-2-[[(butylamino)carbonyl]amino]-4-methyl- 5-thiazolecarboxamide; 2-[[(Butylamino)carbonyl]amino]-N-[2,6-dimethyl-3-(1-methylethyl)phenyl]-4- methyl-5-thiazolecarboxamide N-(2-Bromo-4,6-dimethylphenyl)-2-[[(butylamino)carbonyl]amino]-4-methyl-5-t hiazolecarboxamide; 3-[[[2-[[(Butylamino)carbonyl]amino]-4-methyl-5-thiazolyl]carbonyl]amino]-4 -methyl-2-thiophenecarboxylic acid methyl ester; 2-[[(Butylamino)carbonyl]amino]-4-methyl-N-(2-methyl-6-quinolinyl)-5-thiazo lecarboxamide; 2-[[(Butylamino)carbonyl]amino]-N-(2,6-dimethoxyphenyl)-4-methyl-5-thiazole carboxamide; 2-[[(Butylamino)carbonyl]amino]-N-(4-methoxy-2-naphthalenyl)-4-methyl-5-thi azolecarboxamide; 2-[[(Butylamino)carbonyl]amino]-N-(2-methyl-1-naphthalenyl)-4-methyl-5-thia zolecarboxamide; 2-[[(Butylamino)carbonyl]amino]-N-[4-(dimethylamino)-2,3,5,6-tetramethylphe nyl]-4-methyl-5-thiazolecarboxamide; 2-[[(Butylamino)carbonyl]amino]-N-(6-methyl-5-quinolinyl)-4-methyl-5-thiazo lecarboxamide; 2-[[(Butylamino)carbonyl]amino]-N-[2-(2-hydroxyethyl)-6-methylphenyl]-4-met hyl-5-thiazolecarboxamide; 2-[[(Butylamino)carbonyl]amino]-N-(2,6-dimethyl-3-nitrophenyl)-4-methyl-5-t hiazolecarboxamide; N-(2-Bromo-3,4,6-trimethylphenyl)-2-[[(butylamino)carbonyl]amino]-4-methyl- 5-thiazolecarboxamide; N-(2-Acetyl-6-hydroxyphenyl)-2-[[(butylamino)carbonyl]amino]-4-methyl-5-thi azolecarboxamide; [4-[[[2-[[(Butylamino)carbonyl]amino]-4-methyl-5-thiazolyl]carbonyl]amino]- 2,3,5,6-tetramethylphenyl]carbamic acid 1,1-dimethylethyl ester; 2-[[(Butylamino)carbonyl]amino]-N-(2,6-dichlorophenyl)-4-methyl-5-thiazolec arboxamide; N-(4-Amino-2,3,5,6-tetramethylphenyl)-2-[[(butylamino)carbonyl]amino]-4-met hyl-5-thiazolecarboxamide; N-[5-(Acetylamino)-2,4-dimethylphenyl]-2-[[(butylamino)carbonyl]amino]-4-me thyl-5-thiazolecarboxamide; N-(4-Bromo-2,6-dimethylphenyl)-2-[[(butylamino)carbonyl]amino]-4-methyl-5-t hiazolecarboxamide 2-[[(Butylamino)carbonyl]amino]-N-(2-chloro-6-methylphenyl)-4-methyl-5-thia zolecarboxamide; 4-Methyl-2-[(methylsulfonyl)amino]-N-(2,4,6-trimethylphenyl)-5-thiazolecarb oxamide; 4-Methyl-2-[[(phenylamino)thiocarbonyl]amino]-N-(2,4,6-trimethylphenyl)-5-t hiazolecarboxamide; 2-[[(Ethylamino)carbonyl]amino]-4-methyl-N-(2,4,6-trimethylphenyl)-5-thiazo lecarboxamide; N-(2-Chloro-6-methylphenyl)-2-[(cyclopropylcarbonyl)amino]-5-thiazolecarbox amide; 2-[[[(1,1-Dimethylethyl)amino]carbonyl]amino]-N-(2-chloro-6-methylphenyl)-5 -thiazolecarboxamide; 2-[[(1,1-Dimethylethoxy)carbonyl]amino]-4-methyl-N-(2,4,6-trimethylphenyl)- 5-thiazoleacetamide; 2-Amino-4-methyl-N-(2,4,6-trimethylphenyl)-5-thiazoleacetamide; N-(2-Chloro-6-methylphenyl)-2-[(4,6-dimethyl-2-pyridinyl)amino]-5-thiazolec arboxamide; N-(2-Chloro-6-methylphenyl)-2-[(4-ethyl-2-pyridinyl)amino]-5-thiazolecarbox amide; N-(2-Chloro-6-methylphenyl)-2-[(2,6-dimethyl-4-pyrimdinyl)amino]-5-thiazole carboxamide; N-(2-Chloro-6-methylphenyl)-2-(3-pyridazinylamino)-5-thiazolecarboxamide; N-(2-Chloro-6-methylphenyl)-4-methyl-2-[(2-thienylcarbonyl)amino]-5-thiazol ecarboxamide; N-(2-Chloro-6-methylphenyl)-2-[(cyclopropylcarbonyl)amino]-4-methyl-5-thiaz olecarboxamide; N-(2-Chloro-6-methylphenyl)-4-methyl-2-[(2-furanylcarbonyl)amino]-5-thiazol ecarboxamide; N-(2-Chloro-6-methylphenyl)-4-methyl-2-[(3-thienylcarbonyl)amino]-5-thiazol ecarboxamide; N-(2-Chloro-6-methylphenyl)-4-methyl-2-[(3-furanylcarbonyl)amino]-5-thiazol ecarboxamide; trans-N(-Chloro-6-methylphenyl)-4-methyl-2-[[(2-phenylcyclopropyl)carbonyl] amino]-5-thiazolecarboxamide; N-(2-Chloro-6-methylphenyl)-4-methyl-2-[[(2-methylcyclopropyl)carbonyl]amin o]-5-thiazolecarboxamide; N-(2-Chloro-6-methylphenyl)-2-[(cyclobutylcarbonyl)amino]-4-methyl-5-thiazo lecarboxamide; N-(2-Chloro-6-methylphenyl)-2-[(cyclopentylcarbonyl)amino]-4-methyl-5-thiaz olecarboxamide; 2-(Benzoylamino)-N-(2-chloro-6-methylphenyl)-4-methyl-5-thiazolecarboxamide ; N-(2-Chloro-6-methylphenyl)-2-[(1-oxopropyl)amino]-5-thiazolecarboxamide; N-(2-Chloro-6-methylphenyl)-2-[(1-oxobutyl)amino]-5-thiazolecarboxamide; N-(2-Chloro-6-methylphenyl)-2-[(2-ethyl-1-oxobutyl)amino]-5-thiazolecarboxa mide; N-(2-Chloro-6-methylphenyl)-2-[[(1-phenylcyclopropyl)carbonyl]amino]-5-thia zolecarboxamide; N-(2-Chloro-6-methylphenyl)-2-[[(1-methylcyclopropyl)carbonyl]amino]-5-thia zolecarboxamide; N-(2-Chloro-6-methylphenyl)-2-[[(2,2-dichloro-1-methylcyclopropyl)carbonyl] amino]-5-thiazolecarboxamide; N-(2-Chloro-6-methylphenyl)-2-[[(2-methylcyclopropyl)carbonyl]amino]-5-thia zolecarboxamide; N-(2-Chloro-6-methylphenyl)-2-[[(1-hydroxycyclopropyl)carbonyl]amino]-5-thi azolecarboxamide; N-(2-Chloro-6-methylphenyl)-2-[[(2,2,3,3-tetramethylcyclopropyl)carbonyl]am ino]-5-thiazolecarboxamide; N-(2-Chloro-6-methylphenyl)-2-[[(1-cyanocyclopropyl)carbonyl]amino]-5-thiaz olecarboxamide; N-(2-Chloro-6-methylphenyl)-2-[(cyclobutylcarbonyl)amino]-5-thiazolecarboxa mide; N-(2-Chloro-6-methylphenyl)-2-[(cyclopentylcarbonyl)amino]-5-thiazolecarbox amide; N-(2-Chloro-6-methylphenyl)-2-[(cyclohexylcarbonyl)amino]-5-thiazolecarboxa mide; N-(2-Chloro-6-methylphenyl)-2-[(phenylacetyl)amino]-5-thiazolecarboxamide; N-(2-Chloro-6-methylphenyl)-2-[(cyclohexylacetyl)amino]-5-thiazolecarboxami de; N-(2-Chloro-6-methylphenyl)-2-[(4-pyridinylacetyl)amino]-5-thiazolecarboxam ide; N-(2-Chloro-6-methylphenyl)-2-[[(2,5-dimethyl-1H-pyrrol-3-yl)carbonyl]amino ]-5-thiazolecarboxamide; N-(2-Chloro-6-methylphenyl)-2-[(2-pyridinylcarbonyl)amino]-5-thiazolecarbox amide; N-(2-Chloro-6-methylphenyl)-2-[(3-pyridinylcarbonyl)amino]-5-thiazolecarbox amide; N-(2-Chloro-6-methylphenyl)-2-[(4-pyridinylcarbonyl)amino]-5-thiazolecarbox amide; N-(2-Chloro-6-methylphenyl)-2-[(3-thienylcarbonyl)amino]-5-thiazolecarboxam ide; N-(2-Chloro-6-methylphenyl)-2-[(2-thienylcarbonyl)amino]-5-thiazolecarboxam ide; N-(2-Chloro-6-methylphenyl)-2-[(2-furanylcarbonyl)amino]-5-thiazolecarboxam ide; N-(2-Chloro-6-methylphenyl)-2-[(3-furanylcarbonyl)amino]-5-thiazolecarboxam ide; trans-N-(2-Chloro-6-methylphenyl)-2-[[(2-phenylcyclopropyl)carbonyl]amino]- 5-thiazolecarboxamide; N-(2-Chloro-6-methylphenyl)-2-[(2-methyl-1-oxopentyl)amino]-5-thiazolecarbo xamide; 2-(Benzoylamino)-N-(2-chloro-6-methylphenyl)-5-thiazolecarboxamide; 2-[(Cyclopropylcarbonyl)amino]-N-(2,6-dimethylphenyl)-5-thiazolecarboxamide ; 2-[(Cyclopropylcarbonyl)amino]-N-(2,4,6-trimethylphenyl)-5-thiazolecarboxam ide; N-(2-Chloro-4,6-dimethylphenyl)-2-[(cyclopropylcarbonyl)amino]-5-thiazoleca rboxamide; [4-[2-Oxo-2-[(2,4,6-trimethylphenyl)amino]ethyl]-2-thiazolyl]carbamic acid 1,1-dimethylethyl ester; 2-Amino-N-(2,4,6-trimethylphenyl)-4-thiazoleacetamide; 5-Amino-2-methyl-N-(2,4,6-trimethylphenyl)benzamide; 2-Amino-5-chloro-N-(2,4,6-trimethylphenyl)-4-pyrimidinecarboxamide; [4-Methyl-5-[[(2,4,6-trimethylphenyl)amino]carbonyl]-2-oxazolyl]carbamic acid 1,1-dimethylethyl ester; 2-Amino-4-(methyl)-N-(2,4,6-trimethylphenyl)-5-oxazolecarboxamide, trifluoroacetate (1:1); 2-Amino-N-(2,4,6-trimethylphenyl)-5-pyridinecarboxamide; 3-Amino-N-(2,4,6-trimethylphenyl)-4-pyridinecarboxamide; N-(2-Chloro-6-methylphenyl)-2-[(4-methyl-2-pyridinyl)amino]-5-thiazolecarbo xamide; 2-[(6-Amino-2-pyridinyl)amino]-N-(2-chloro-6-methylphenyl)-5-thiazolecarbox amide; N-(2-Chloro-6-methylphenyl)-2-[(6-propyl-2-pyridinyl)amino]-5-thiazolecarbo xamide; N-(2-Chloro-6-methylphenyl)-2-[(6-ethyl-4-pyrimidinyl)amino]-5-thiazolecarb oxamide; 'N-(2-Chloro-6-methylphenyl)-2-(2-pyridinylamino)-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[(6-methyl-2-pyridinyl)amino]-5-thiazolecarb oxamide; 'N-(2-Chloro-6-methylphenyl)-2-[(5-methyl-2-pyridinyl)amino]-5-thiazolecarb oxamide; 'N-(2-Chloro-6-methylphenyl)-2-[(4-methyl-2-pyridinyl)amino]-5-thiazolecarb oxamide; 'N-(2-Chloro-6-methylphenyl)-2-[(3-methyl-2-pyridinyl)amino]-5-thiazolecarb oxamide; '2-[(5-Bromo-3-methyl-2-pyridinyl)amino]-N-(2-chloro-6-methylphenyl)-5-thia zolecarboxamide; '2-[(6-Amino-2-pyridinyl)amino]-N-(2-chloro-6-methylphenyl)-5-thiazolecarbo xamide; '2-[(5-Bromo-2-pyridinyl)amino]-N-(2-chloro-6-methylphenyl)-5-thiazolecarbo xamide; 'N-(2-Chloro-6-methylphenyl)-2-[[3-(phenylmethoxy)-2-pyridinyl]amino]-5-thi azolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[(5-chloro-2-pyridinyl)amino]-5-thiazolecarb oxamide; 'N-(2-Chloro-6-methylphenyl)-2-[(6-ethyl-2-pyridinyl)amino]-5-thiazolecarbo xamide; 'N-(2-Chloro-6-methylphenyl)-2-[(6-propyl-2-pyridinyl)amino]-5-thiazolecarb oxamide; '2-[(3-Bromo-5-methyl-2-pyridinyl)amino]-N-(2-chloro-6-methylphenyl)-5-thia zolecarboxamide; '2-[(2-Amino-3-pyridinyl)amino]-N-(2-chloro-6-methylphenyl)-5-thiazolecarbo xamide; '2-[(3-Amino-2-pyridinyl)amino]-N-(2-chloro-6-methylphenyl)-5-thiazolecarbo xamide; 'N-(2-Chloro-6-methylphenyl)-2-(4-pyridinylamino)-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-(3-pyridinylamino)-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-3-pyridinyl)amino]-5-thiazolecarb oxamide; 'N-(2-Chloro-6-methylphenyl)-2-[(2-chloro-3-pyridinyl)amino]-5-thiazolecarb oxamide; 'N-(2-Chloro-6-methylphenyl)-2-[(6-methoxy-3-pyridinyl)amino]-5-thiazolecar boxamide; 'N-(2-Chloro-6-methylphenyl)-2-[(3,5-dimethyl-2-pyrazinyl)amino]-5-thiazole carboxamide; 'N-(2-Chloro-6-methylphenyl)-2-(phenylamino)-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[(3-ethylphenyl)amino]-5-thiazolecarboxamide ; 'N-(2-Chloro-6-methylphenyl)-2-[(3,5-dimethylphenyl)amino]-5-thiazolecarbox amide; 'N-(2-Chloro-6-methylphenyl)-2-[(4,6-dimethyl-2-pyrimidinyl)amino]-5-thiazo lecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[(6-ethyl-4-pyrimidinyl)amino]-5-thiazolecar boxamide; 'N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-pyrazinyl)amino]-5-thiazolecarb oxamide; '2-[(3-Aminophenyl)amino]-N-(2-chloro-6-methylphenyl)-5-thiazolecarboxamide ; 'N-(2-Chloro-6-methylphenyl)-2-[(3-hydroxyphenyl)amino]-5-thiazolecarboxami de; '2-[(3-Bromophenyl)amino]-N-(2-chloro-6-methylphenyl)-5-thiazolecarboxamide ; 'N-(2,6-Dimethylphenyl)-2-(phenylamino)-5-thiazolecarboxamide; 'N-(2,6-Dimethylphenyl)-2-(methylphenylamino)-5-thiazolecarboxamide;

'N-(2,6-Dimethylphenyl)-2-(2-pyridinylamino)-5-thiazolecarboxamide; 'N-(2,6-Dimethylphenyl)-2-[(6-methyl-2-pyridinyl)amino]-5-thiazolecarboxami de; 'N-(2,6-Dimethylphenyl)-2-[(4-methyl-2-pyridinyl)amino]-5-thiazolecarboxami de; 'N-(2,6-Dimethylphenyl)-2-[(4-ethyl-2-pyridinyl)amino]-5-thiazolecarboxamid e; 'N-(2,6-Dimethylphenyl)-2-[(4,6-dimethyl-2-pyridinyl)amino]-5-thiazolecarbo xamide; '2-[(6-Amino-2-pyridinyl)amino]-N-(2,6-dimethylphenyl)-5-thiazolecarboxamid e; 'N-(2,6-Dimethylphenyl)-2-[(6-ethyl-2-pyridinyl)amino]-5-thiazolecarboxamid e; 'N-(2,6-Dimethylphenyl)-2-[(6-propyl-2-pyridinyl)amino]-5-thiazolecarboxami de; '2-[(2-Amino-3-pyridinyl)amino]-N-(2,6-dimethylphenyl)-5-thiazolecarboxamid e; '2-[(3-Amino-2-pyridinyl)amino]-N-(2,6-dimethylphenyl)-5-thiazolecarboxamid e; '2-[(6-Amino-2-methyl-4-pyrimidinyl)amino]-N-(2,6-dimethylphenyl)-5-thiazol ecarboxamide; 'N-(2,6-Dimethylphenyl)-2-[[6-(4-morpholinyl)-3-pyridazinyl]amino]-5-thiazo lecarboxamide; '2-[(6-Chloro-3-pyridazinyl)amino]-N-(2,6-dimethylphenyl)-5-thiazolecarboxa mide; 'N-(2,6-Dimethylphenyl)-2-(3-pyridazinylamino)-5-thiazolecarboxamide; '2-[(3-Aminophenyl)amino]-N-(2,6-dimethylphenyl)-5-thiazolecarboxamide; '2-[(3-Bromophenyl)amino]-N-(2,6-dimethylphenyl)-5-thiazolecarboxamide; '2-(2-Pyridinylamino)-N-(2,4,6-trimethylphenyl)-5-thiazolecarboxamide; '2-[(6-Methyl-2-pyridinyl)amino]-N-(2,4,6-trimethylphenyl)-5-thiazolecarbox amide; '2-[(5-Methyl-2-pyridinyl)amino]-N-(2,4,6-trimethylphenyl)-5-thialzolecarbo xamide; '2-[(4-Methyl-2-pyridinyl)amino]-N-(2,4,6-trimethylphenyl)-5-thiazolecarbox amide; '2-[(3-Methyl-2-pyridinyl)amino]-N-(2,4,6-trimethylphenyl)-5-thiazolecarbox amide; '2-[(5-Bromo-2-pyridinyl)amino]-N-(2,4,6-trimethylphenyl)-5-thiazolecarboxa mide; '2-[(5-Chloro-2-pyridinyl)amino]-N-(2,4,6-trimethylphenyl)-5-thiazolecarbox amide; '2-[(6-Methoxy-3-pyridinyl)amino]-N-(2,4,6-trimethylphenyl)-5-thiazolecarbo xamide; '2-[(4-Ethyl-2-pyridinyl)amino]-N-(2,4,6-trimethylphenyl)-5-thiazolecarboxa mide; '2-[(6-Ethyl-2-pyridinyl)amino]-N-(2,4,6-trimethylphenyl)-5-thiazolecarboxa mide; '2-[(6-Chloro-3-pyridinyl)amino]-N-(2,4,6-trimethylphenyl)-5-thiazolecarbox amide; '2-[(2,6-Dimethyl-4-pyrimidinyl)amino]-N-(2,4,6-trimethylphenyl)-5-thiazole carboxamide; '2-[(4-Methyl-2-pyrimidinyl)amino]-N-(2,4,6-trimethylphenyl)-5-thiazolecarb oxamide; '2-(2-Pyrazinylamino)-N-(2,4,6-trimethylphenyl)-5-thiazolecarboxamide '2-[(6-Chloro-2-pyrazinyl)amino]-N-(2,4,6-trimethylphenyl)-5-thiazolecarbox amide; '2-[(3,5-Dimethyl-2-pyrazinyl)amino]-N-(2,4,6-trimethylphenyl)-5-thiazoleca rboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[2-methyl-6-[[2-(4-morpholinyl)ethyl]amino] -4-pyrimidinyl]amino]-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[2-methyl-6-[[3-(4-morpholinyl)propyl]amino ]-4-pyrimidinyl]amino]-5-thiazolecarboxamide; 'N-(2-Chloro-6-methyl phenyl)-2-[[2-methyl-6-[methyl[3-(methylamino)propyl]amino]-4-pyrimidinyl] amino]-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[2-methyl-6-[[2-(tetrahydro-2-oxo-1H-imidaz ol-1-yl)ethyl]amino]-4-pyrimidinyl]amino]-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[2-methyl-6-[(2-1H-imidazol-4-ylethyl)amino ]-4-pyrimidinyl]amino]-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[2-methyl-6-(4-morpholinyl)-4-pyrimidinyl]a mino]-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[6-[[[(2R)-1-ethyl-2-pyrrolidinyl]methyl]am ino]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[6-[[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]am ino]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide; '2-[[6-[(2S)-2-(Aminocarbonyl)-1-pyrrolidinyl]-2-methyl-4-pyrimidinyl]amino ]-N-(2-chloro-6-methylphenyl)-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[6-[(2-hydroxyethyl)amino]-2-methyl-4-pyrim idinyl]amino]-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(hydroxymethyl)-1-piperidinyl]-2-meth yl-4-pyrimidinyl]amino]-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-met hyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide; '1-[6-[[5-[[(2-Chloro-6-methylphenyl)amino]carbonyl]-2-thiazolyl]amino]-2-m ethyl-4-pyrimidinyl]-4-piperidinecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[2-methyl-6-[(3S)-3-methyl-1-piperazinyl]-4 -pyrimidinyl]amino]-5-thiazolecarboxamide; '2-[[6-[3-(Acetylamino)-1-pyrrolidinyl]-2-methyl-4-pyrimidinyl]amino]-N-(2- chloro-6-methylphenyl)-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[6-[[2-(1-methyl-2-pyrrolidinyl)ethyl]amino ]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[2-methyl-6-[[(5-methyl-2-pyrazinyl)methyl] amino]-4-pyrimidinyl]amino]-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[2-methyl-6-[[2-(1H-1,2,3-triazol-1-yl)ethy l]amino]-4-pyrimidinyl]amino]-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[6-[[2-(4-morpholinyl)ethyl]amino]-4-pyrimi dinyl]amino]-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[6-[[2-(dimethylamino)ethyl]amino]-4-pyrimi dinyl]amino]-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-7-[[6-[[2-(tetrahydro-2-oxo-1H-imidazol-1-yl)e thyl]amino]-4-pyrimidinyl]amino]-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[6-[methyl[2-(methylamino)ethyl]amino]-4-py rimidinyl]amino]-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[6-[[2-(1-methyl-2-pyrrolidinyl)ethyl]amino ]-4-pyrimidinyl]amino]-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[6-[[2-(1-pyrrolidinyl)ethyl]amino]-4-pyrim idinyl]amino]-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[6-[[(1-ethyl-2-pyrrolidinyl)methyl]amino]- 4-pyrimidinyl]amino]-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[6-[(4-piperidinylmethyl)amino]-4-pyrimidin yl]amino]-5-thiazolecarboxamide; '2-[[6-[[2-(Acetylamino)ethyl]amino]-4-pyrimidinyl]amino]-N-(2-chloro-6-met hylphenyl)-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[6-[[2-(1H-1,2,3-triazol-1-yl)ethyl]amino]- 4-pyrimidinyl]amino]-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[6-(4-morpholinyl)-4-pyrimidinyl]amino]-5-t hiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[6-[[2-(4-morpholinyl)ethyl]amino]-2-pyridi nyl]amino]-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[6-[[3-(4-morpholinyl)propyl]amino]-2-pyrid inyl]amino]-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[6-[methyl [3-(methylamino)propyl]amino]-2-pyridinyl]amino]-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[6-[(3S)-3-methyl-1-piperazinyl]-2-pyridiny l]amino]-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[6-[(3-1H-imidazol-1-ylpropyl)amino]-2-pyri dinyl]amino]-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[6-[(2-hydroxyethyl)amino]-2-pyridinyl]amin o]-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[6-[(2-1H-imidazol-1-ylethyl)amino]-2-pyrid inyl]amino]-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[6-(4-morpholinyl)-2-pyridinyl]amino]-5-thi azolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[6-[[2-(4-morpholinyl)ethyl]amino]-2-pyrazi nyl]amino]-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[6-[[3-(4-morpholinyl)propyl]amino]-2-pyraz inyl]amino]-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[6-(4-morpholinyl)-2-pyrazinyl]amino]-5-thi azolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[6-[(3S)-3-methyl-1-piperazinyl]-2-pyraziny l]amino]-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[6-(3-hydroxy-1-pyrrolidinyl)-2-pyrazinyl]a mino]-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[6-(1H-imidazol-1-yl)-2-pyrazinyl]amino]-5- thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[6-(3-hydroxy-1-pyyrolidinyl)-3-pryidazinyl ]amino]-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[6-(1H-imidazol-1-yl)-3-pyridazinyl]amino]- 5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[3-(methylamino)-2-pyrazinyl]amino]-5-thiaz olecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[3-(3-hydroxy-1-pyrrolidinyl)-2-pyrazinyl]a mino]-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[3-(cyclopropylamino)-2-pyrazinyl]amino]-5- thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[3-(4-morpholinyl)-2-pyrazinyl]amino]-5-thi azolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[3-[[2-(4-morpholinyl)ethyl]amino]-2-pyrazi nyl]amino]-5-thiazolecarboxamide; '2-[[3-[[2-(Acetylamino)ethyl]amino]-2-pyrazinyl]amino]-N-(2-chloro-6-methy lphenyl)-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-(cyclohexylamino)-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-(methylamino)-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-(cyclopropylamino)-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[(phenylmethyl)amino]-5-thiazolecarboxamide; '2-[[2-(Acetylamino)ethyl]amino]-N-(2-chloro-6-methylphenyl)-5-thiazolecarb oxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[(1R)-1-(hydroxymethyl)-3-methylbutyl]amino ]-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[6-(methoxymethyl)-4-pyrimidinyl]amino]-5-t hiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[6-hydroxymethyl)-4-pyrimidinyl]amino]-5-th iazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[6-(4-morpholinylmethyl)-4-pyrimidinyl]amin o]-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[6-[[[2-(dimethylamino)-ethyl]amino]methyl] -4-pyrimidinyl]amino]-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[6-[[[2-(4-morpholinyl)ethyl]amino]methyl]- 4-pyrimidinyl]amino]-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[6-[[[3-(4-morpholinyl)propyl]-amino]methyl ]-4-pyrimidinyl]amino]-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[6-[[[3-(2-oxo-1-pyrrolidinyl)propyl]amino] methyl]-4-pyrimidinyl]amino]-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[6-[[(2-1H-imidazol-4-ylethyl)amino]methyl] -4-pyrimidinyl]amino]-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[6-[[(3-1H-imidazol-1-ylpropyl)amino]methyl ]-4-pyrimidinyl]amino]-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[6-[[[2-(2-pyridinyl)ethyl]amino]methyl]-4- pyrimidinyl]amino]-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[6-[[[2-(3-pyridinyl)ethyl]amino]methyl]-4- pyrimidinyl]amino]-5-thiazolecarboxamide; '1-[[6-[[5-[[(2-Chloro-6-methylphenyl)amino]carbonyl]-2-thiazolyl]amino]-4- pyrimidinyl]methyl]-4-piperidinecarboxamide; '2-[[6-[[[2-(Acetylamino)ethyl]amino]methyl]-4-pyrimidinyl]amino]-N-(2-chlo ro-6-methylphenyl)-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-(2-naphthalenylamino)-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-(2-quinolinylamino)-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-(3-isoquinolinylamino)-5-thiazolecarboxamide ; 'N-(2-Chloro-6-methylphenyl)-2-(2-quinoxalinylamino)-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-4-methyl-2-[[2-methyl-6-(4-morpholinyl)-4-pyri midinyl]amino]-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-4-methyl-2-[[2-methyl-6-[[2-(4-morpholinyl)eth yl]amino]-4-pyrimidinyl]amino]-5-thiazolecarboxamide; '2-[(2,6-Dimethyl-4-pyrimidinyl)amino]-N-phenyl-5-thiazolecarboxamide; '2-[(2,6-Dimethyl-4-pyrimidinyl)methylamino]-N-(2-methylphenyl)-5-thiazolec arboxamide; '2-[(2,6-Dimethyl-4-pyrimidinyl)amino]-N-(2-methylphenyl)-5-thiazolecarboxa mide; 'N-(3,5-Dimethoxyphenyl)-2-[(2,6-dimethyl-4-pyrimidinyl)amino]-5-thiazoleca rboxamide; 'N-[2,6-Bis(1-methylethyl)phenyl]-2-[(2,6-dimethyl-4-pyrimidinyl)amino]-5-t hiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[2,6-dimethyl-4-pyrimidinyl)methylamino]-5-t hiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[(2,6-dimethyl-4-pyrimidinyl)amino]-N-methyl -5-thiazolecarboxamide; N-,N-(2-Chloro-6-methylphenyl)-(4-methoxybenzyl)-2-[(6-bromo-2-pyridinyl)am ino]-5-thiazolecarboxamide; N-(2-Chloro-6-methylphenyl)-2-[(6-bromo-2-pyridinyl)amino-5-thiazolecarboxa mide; 'N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-furanylcarbonyl)-1-piperazinyl]-2- pyridinyl]amino]-5-thiazolecarboxamide; '2-[[6-[[3-(1H-Benzimidazol-1-yl)propyl]amino]-2-pyridinyl]amino]-N-(2-chlo ro-6-methylphenyl)-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[6-[[4-(1H-imidazol-1-yl)butyl]amino]-2-pyr idinyl]amino]-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[6-[[5-(1H-imidazol-1-yl)pentyl]amino]-2-py ridinyl]amino]-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[6-[[3-(4-methyl-1-piperazinyl)propyl]amino ]-2-pyridinyl]amino]-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[6-[[4-(1H-imidazol-1-yl)phenyl]amino]-2-py ridinyl]amino]-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[6-[[6-(1H-imidazol-1-yl)hexyl]amino]-2-pyr idinyl]amino]-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[6-[(3-1H-imidazol-1-ylpropyl)amino]-2-pyri dinyl]amino]-5-thiazolecarboxamide; '2-[[6-[[3-(1H-Imidazol-1-yl)propyl]amino]-2-pyridinyl]amino]-N-(4-methoxyp henyl)-5-thiazolecarboxamide; '2-[[6-[[3-(1H-Imidazol-1-yl)propyl]amino]-2-pyridinyl]amino]-N-(4-phenoxyp henyl)-5-thiazolecarboxamide; 'N-(4-Chlorophenyl)-2-[[6-[[3-(1H-imidazol-1-yl)propyl]amino]-2-pyridinyl]a mino]-5-thiazolecarboxamide; '2-[[6-[[3-(1H-Imidazol-1-yl)propyl]amino]-2-pyridinyl]amino]-N-[1-(phenylm ethyl)-1H-indazol-5-yl]-5-thiazolecarboxamide; 'N-(2-Ethylphenyl)-2-[[6-[[3-(1H-imidazol-1-yl)propyl]amino]-2-pyridinyl]am ino]-5-thiazolecarboxamide; 'N-(2,6-Dimethoxyphenyl)-2-[[6-[[3-(1H-imidazol-1-yl)propyl]amino]-2-pyridi nyl]amino]-5-thiazolecarboxamide; 'N-(2,4-Dimethoxyphenyl)-2-[[6-[[3-(1H-imidazol-1-yl)propyl]amino]-2-pyridi nyl]amino]-5-thiazolecarboxamide;

'2-[[6-[[3-(1H-Imidazol-1-yl)propyl]amino]-2-pyridinyl]amino]-N-phenyl-5-th iazolecarboxamide; '2-[[6-[[3-(1H-Imidazol-1-yl)propyl]amino]-2-pyridinyl]amino]-N-(2-methylph enyl)-5-thiazolecarboxamide; 'N-(2-Chlorophenyl)-2-[[6-[[3-(1H-imidazol-1-yl)propyl]amino]-2-pyridinyl]a mino]-5-thiazolecarboxamide; 'N-(2,6-Diethylphenyl)-2-[[6-[[3-(1H-imidazol-1-yl)propyl]amino]-2-pyridiny l]amino]-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[6-[[3-(1H-imidazol-1-yl)propyl]amino]-2-py ridinyl]amino]4-methyl-5-thiazolecarboxamide; '2-[[6-[[3-(1H-Imidazol-1-yl)propyl]amino]-2-pyridinyl]amino]-4-methyl-N-[1 -(phenylmethyl)-1H-indazol-5-yl]-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[3-[[3-(1H-imidazol-1-yl)propyl]amino]pheny l]amino]-5-thiazolecarboxamide; 'N-(2-Chloro-6-methylphenyl)-2-[[5-[[3-(1H-imidazol-1-yl)propyl]amino]-2-ni trophenyl]amino]-5-thiazolecarboxamide; N-(2-Chloro-6-methylphenyl)-2-[(3,4,5-trimethoxy-phenyl)amino]-5-thiazoleca rboxamide; N-(2-Chloro-6-methyl-phenyl)-2-[(4-methoxy-phenyl)amino]-5-thiazolecarboxam ide; N-(2-Chloro-6-methyl-phenyl)-2-[(3-methoxy-phenyl)amino]-5-thiazolecarboxam ide; N-(2-Chloro-6-methyl-phenyl)-2-[(2-methoxy-phenyl)amino]-5-thiazolecarboxam ide; N-(2-Chloro-6-methyl-phenyl)-2-[(3,5-dimethoxyphenyl)amino]-5-thiazolecarbo xamide; N-(2-Chloro-6-methyl-phenyl)-2-[[4-(dimethylamino)-phenyl]amino]-5-thiazole carboxamide; N-(2-Chloro-6-methylphenyl)-2-[[4-(4-morpholinyl)phenyl]amino]-5-thiazoleca rboxamide; N-(2-Chloro-6-methylphenyl)-2-[[3-(carboxymethyl)-phenyl]amino]-5-thiazolec arboxamide; N-(2-Chloro-6-methylphenyl)-2-[[3-(3-carboxypropyl)-phenyl]amino]-5-thiazol ecarboxamide; N-(2-Chloro-6-methylphenyl)-2-[[4-(carboxymethyl)phenyl]amino]-5-thiazoleca rboxamide; N-(2-Chloro-6-methylphenyl)-2-[(2-methyl-1H-benzimidazol-5-yl)amino]-5-thia zolecarboxamide; N-(2-Chloro-6-methylphenyl)-2-[[1-[3-(1H-imidazol-1-yl)propyl]-1H-benzimida zol-4-yl]amino]-5-thiazolecarboxamide; N-(2-Chloro-6-methylphenyl)-2-[[1-[2-(1H-imidazol-1-yl)ethyl]-1H-indazol-6- yl]amino]-5-thiazolecarboxamide; N-(2-Chloro-6-methylphenyl)-2-[[2-[2-(1H-imidazol-1-yl)ethyl]-2H-indazol-6- yl]amino]-5-thiazolecarboxamide; N-(2-Chloro-6-methylphenyl)-2-[(1-methyl-1H-benzimidazol-6-yl)amino]-5-thia zolecarboxamide; N-(2-Chloro-6-methylphenyl)-2-[(1-methyl-1H-benzimidazol-5-yl)amino]-5-thia zolecarboxamide; N-(2-Chloro-6-methylphenyl)-2-[[2-[3-(1H-imidazol-1-yl)propyl]amino]-1H-ben zimidazol-5-yl]amino]-5-thiazolecarboxamide; N-(2-Chloro-6-methylphenyl)-2-[[2-(4-morpholinylmethyl)-1H-benzimidazol-5-y l]amino]-5-thiazolecarboxamide; N-(2-Chloro-6-methylphenyl)-2-[[2-(1H-imidazol-1-ylmethyl)-1H-benzimidazol- 5-yl]amino]-5-thiazolecarboxamide; N-(2-Chloro-6-methylphenyl)-2-[[3-[[5-(1H-imidazol-1-yl)-2-pyridinyl]amino] phenyl]amino]-5-thiazolecarboxamide; N-(2-Chloro-6-methylphenyl)-2-[[3-[3-(1H-imidazol-1-yl)propoxy]phenyl]amino ]-5-thiazolecarboxamide; N-(2-Chloro-6-methylphenyl)-2-[[4-[3-(1H-imidazol-1-yl)propoxy]phenyl]amino ]-5-thiazolecarboxamide; N-(2-Chloro-6-methylphenyl)-2-[[3-[[[3-(1H-imidazol-1-yl)propyl]amino]sulfo nyl]phenyl]amino]-5-thiazolecarboxamide; and N-(2-Chloro-6-methylphenyl)-2-[[4-[[[3-(1H-imidazol-1-yl)propyl]amino]sulfo nyl]phenyl]amino]-5-thiazolecarboxamide.

7. A method for the treatment of a protein tyrosine kinase-associated disorder, comprising the step of administering to a subject in need thereof an amount effective therefor of at least one compound of formula III or a salt thereof: ##STR625##

where Q is thiazole optionally substituted with R.sub.1 ; Z is a single bond X.sub.3 is oxygen; R.sub.1 is (1) hydrogen or R.sub.6, where R.sub.6 is alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, cycloalkenyl, cycloalkenylalkyl, aryl, aralkyl, heterocyclo, or heterocycloalkyl, each of which is unsubstituted or substituted with Z.sub.1, Z.sub.2 and one or more groups Z.sub.3 ; (2) --OH or --OR.sub.6 ; (3) --SH or --SR.sub.6 ; (4) --C(O).sub.2 H, --C(O).sub.q R.sub.6, or --O--C(O).sub.q R.sub.6, where q is 1 or 2; (5) --SO.sub.3 H or S(O).sub.q R.sub.6 ; (6) halo; (7) cyano; (8) nitro; (9) --Z.sub.4 --NR.sub.7 R.sub.8 ; (10) --Z.sub.4 --N(R.sub.9)--Z.sub.5 --NR.sub.10 R.sub.11 ; (11) --Z.sub.4 --N(R.sub.12)--Z.sub.5 --R.sub.6 ; (12) --P(O)(OR.sub.6).sub.2 ; R.sub.2 and R.sub.3 are each independently (1) hydrogen or R.sub.6 ; (2) --Z.sub.4 --R.sub.6 ; or (3) --Z.sub.13 --NR.sub.7 R.sub.8 ; R.sub.4 and R.sub.5 (1) are each independently hydrogen or R.sub.6 ; (2) --Z.sub.4 --N(R.sub.9)--Z.sub.5 --NR.sub.10 R.sub.11 ; (3) --N(R.sub.9)Z.sub.4 R.sub.6 ; or (4) together with the nitrogen atom to which they are attached complete a 3- to 8-membered saturated or unsaturated heterocyclic ring which is unsubstituted or substituted with Z.sub.1, Z.sub.2 and Z.sub.3, which heterocyclic ring may optionally have fused to it a benzene ring itself unsubstituted or substituted with Z.sub.1, Z.sub.2 and Z.sub.3 ; R.sub.7, R.sub.8, R.sub.9, R.sub.10, R.sub.11 and R.sub.12 (1) are each independently hydrogen or R.sub.6 ; (2) R.sub.7 and R.sub.8 may together be alkylene, alkenylene or heteroalkyl, completing a 3- to 8-membered saturated or unsaturated ring with the nitrogen atom to which they are attached, which ring is unsubstituted or substituted with Z.sub.1, Z.sub.2 and Z.sub.3 ; or (3) any two of R.sub.9, R.sub.10 and R.sub.11 may together be alkylene or alkenylene completing a 3- to 8-membered saturated or unsaturated ring together with the nitrogen atoms to which they are attached, which ring is unsubstituted or substituted with Z.sub.1, Z.sub.2 and Z.sub.3 ; R.sub.13 is (1) cyano; (2) nitro; (3) --NH.sub.2 ; (4) --NHOalkyl; (5) --OH; (6) --NHOaryl; (7) --NHCOOalkyl; (8) --NHCOOaryl; (9) --NHSO.sub.2 alkyl; (10) --NHSO.sub.2 aryl; (11) aryl; (12) heteroaryl; (13) --Oalkyl; or (14) --Oaryl; R.sub.14 is (1) --NO.sub.2 ; (2) --COOalkyl; or (3) --COOaryl; R.sub.15 is (1) hydrogen; (2) alkyl; (3) aryl; (4) arylalkyl; or (5) cycloalkyl; Z.sub.1, Z.sub.2 and Z.sub.3 are each independently (1) hydrogen or Z.sub.6, where Z.sub.6 is (i) alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, cycloalkenyl, cycloalkenylalkyl, aryl, aralkyl, alkylaryl, cycloalkylaryl, heterocyclo, or heterocycloalkyl; (ii) a group (i) which is itself substituted by one or more of the same or different groups (i); or (iii) a group (i) or (ii) which is substituted by one or more of the following groups (2) to (16) of the definition of Z.sub.1, Z.sub.2 and Z.sub.3 ; (2) --OH or --OZ.sub.6 ; (3) --SH or --SZ.sub.6 ; (4) C(O).sub.q H, --C(O).sub.q Z.sub.6, or --O--C(O).sub.q Z.sub.6 ; (5) --SO.sub.3 H, --S(O).sub.q Z.sub.6 ; or S(O).sub.q N(Z.sub.9)Z.sub.6 ; (6) halo; (7) cyano; (8) nitro; (9) --Z.sub.4 --NZ.sub.7 Z.sub.8 ; (10) --Z.sub.4 --N(Z.sub.9)--Z.sub.5 --NZ.sub.7 Z.sub.8 ; (11) --Z.sub.4 --N(Z.sub.10)--Z.sub.5 --Z.sub.6 ; (12) --Z.sub.4 --N(Z.sub.10)--Z.sub.5 --H; (13) oxo; (14) --O--C(O)--Z.sub.6 ; (15) any two of Z.sub.1, Z.sub.2, and Z.sub.3 may together be alkylene or alkenylene completing a 3- to 8-membered saturated or unsaturated ring together with the atoms to which they are attached; or (16) any two of Z.sub.1, Z.sub.2, and Z.sub.3 may together be --O--(CH.sub.2).sub.r --O--, where r is 1 to 5, completing a 4- to 8-membered ring together with the atoms to which they are attached; Z.sub.4 and Z.sub.5 are each independently (1) a single bond; (2) --Z.sub.11 --S(O).sub.q --Z.sub.12 --; (3) --Z.sub.11 --C(O)--Z.sub.12 --; (4) --Z.sub.11 --C(S)--Z.sub.12 --; (5) --Z.sub.11 --O--Z.sub.12 --; (6) --Z.sub.11 --Z.sub.12 --; (7) --Z.sub.11 --O--C(O)--Z.sub.12 --; or (8) --Z.sub.11 --C(O)--O--Z.sub.12 --; Z.sub.7, Z.sub.8, Z.sub.9 and Z.sub.10 (1) are each independently hydrogen or Z.sub.6 ; (2) Z.sub.7 and Z.sub.8, or Z.sub.6 and Z.sub.10, may together be alkylene or alkenylene, completing a 3- to 8-membered saturated or unsaturated ring together with the atoms to which they are attached, which ring is unsubstituted or substituted with Z.sub.1, Z.sub.2 and Z.sub.3 ; or (3) Z.sub.7 or Z.sub.8, together with Z.sub.9, may be alkylene or alkenylene completing a 3- to 8-membered saturated or unsaturated ring together with the nitrogen atoms to which they are attached, which ring is unsubstituted or substituted with Z.sub.1, Z.sub.2 and Z.sub.3 ; Z.sub.11 and Z.sub.12 are each independently (1) a single bond; (2) alkylene; (3) alkenylene; or (4) alkynylene; and Z.sub.13 is (1) a single bond; (2) --Z.sub.11 --S(O).sub.q --Z.sub.12 --; (3) --Z.sub.11 --C(O)--Z.sub.12 --; (4) --Z.sub.11 --C(S)--Z.sub.12 --; (5) --Z.sub.11 --O--Z.sub.12 --; (6) --Z.sub.11 --S--Z.sub.12 --; (7) --Z.sub.11 --C(O)--Z.sub.12 --; (8) --Z.sub.11 --C(O)--O--Z.sub.12 --; (9) --C(NR.sub.13)--; (10) --C(CHR.sub.14)--; or (11) --C(C(R.sub.14).sub.2)--providing that said compound is other than (a) a compound of formula (i) ##STR626## where R.sub.1a is alkyl or --C(O)NHNH.sub.2 ; R.sub.2a and R.sub.3a are independently hydrogen, alkyl, --C(O)-(alk); and R.sub.4a is hydrogen and R.sub.5a is aryl, alkyl-substituted aryl, halo-substituted aryl, aralkyl, cycloalkyl or amino; Or R.sub.4a is alkyl and R.sub.5a is alkyl or aryl; Or R.sub.4a and R.sub.5a together with the nitrogen atom to which they are bonded together from morpholino; or (b) a compound of formula (vi) ##STR627## where R.sub.4d and R.sub.5d are independently hydrogen, alkyl, alkenyl, or phenyl; R.sub.27 is hydrogen or alkyl.

8. The method of claim 7, wherein said protein tyrosine kinase-associated disorder is transplant rejection.

9. The method of claim 7, wherein said protein tyrosine kinase-associated disorder is rheumatoid arthritis.

10. The method of claim 7, wherein said protein tyrosine kinase-associated disorder is multiple sclerosis.

11. The method of claim 7, wherein said protein tyrosine kinase-associated disorder is inflammatory bowel disease.

12. The method of claim 7, wherein said protein tyrosine kinase-associated disorder is lupus.

13. The method of claim 7 wherein said protein tyrosine kinase-associated disorder is graft vs. host disease.

14. The method of claim 7, wherein said protein tyrosine kinase-associated disorder is a T-cell mediated hypersensitivity disease.

15. The method of claim 7, wherein said protein tyrosine kinase-associated disorder is psoriasis.

16. The method of claim 7, wherein said protein tyrosine kinase-associated disorder is Hashimoto's thyroiditis.

17. The method of claim 7, wherein said protein tyrosine kinase-associated disorder is Guillain-Barre syndrome.

18. The method of claim 7, wherein said protein tyrosine kinase-associated disorder is a cancer.

19. The method of claim 7, wherein said protein tyrosine kinase-associated disorder is contact dermatitis.

20. The method of claim 7, wherein said protein tyrosine kinase-associated disorder is an allergic disease.

21. The method of claim 7, wherein said protein tyrosine kinase-associated disorder is asthma.

22. The method of claim 7, wherein said protein tyrosine kinase-associated disorder is ischemic or reperfusion injury.

23. The method of claim 7, wherein said protein tyrosine kinase-associated disorder is atopic dermatitis.

24. The method of claim 7, wherein said protein tyrosine kinase-associated disorder is allergic rhinitis.

25. The method of claim 7, wherein said protein tyrosine kinase-associated disorder is chronic obstructive pulmonary disease.

26. The method of claim 7, wherein said protein tyrosine kinase-associated disorder is diabetic retinopathy.

27. The method of claim 7, wherein said protein tyrosine kinase is Lck.

28. The method of claim 7, wherein said protein tyrosine kinase is Fyn.

29. The method of claim 7, wherein said protein tyrosine kinase is Lyn.

30. The method of claim 7, wherein said protein tyrosine kinase is Hck.

31. The method of claim 7, wherein said protein tyrosine kinase is Fgr.

32. The method of claim 7, wherein said protein tyrosine kinase is Src.

33. The method of claim 7, wherein said protein tyrosine kinase is Yes.

34. The method of claim 7, wherein said protein tyrosine kinase is Blk.

35. The method of claim 7, wherein said protein tyrosine kinase is HER1.

36. The method of claim 7, wherein said protein tyrosine kinase is HER2.

37. The method of claim 7, wherein R.sub.2 is other than heteroaryl and R.sub.3 is aryl which is unsubstituted or substituted with Z.sub.1, Z.sub.2 and one or more groups Z.sub.3.

38. The method of claim 7, wherein said compound of the formula III or salt thereof is administered, simultaneously or sequentially, with an antiinflammatory, antiproliferative, chemotherapeutic agent, immunosuppressant, anti-cancer, cytotoxic agent or PTK inhibitor other than a compound of the formula III or salt thereof.

39. The method of claim 38, wherein said compound of the formula III or salt thereof is administered with one or more of: another PTK inhibitor; cyclosporin A; CTLA4-Ig; antibodies selected from anti-ICAM-3, anti-IL-2 receptor (Anti-Tac), anti-CD45RB, anti-CD2, anti-CD3 (OKT-3), anti-CD4, anti-CD80, anti-CD86, and monoclonal antibody OKT3; agents blocking the interaction between CD40 and gp39; fusion proteins constructed from CD40 and gp39; inhibitors of NF-kappa B function; non-steroidal antiinflammatory drugs (NSAIDs); steroids; gold compounds; antiproliferative agents; FK506 (tacrolimus, Prograf); mycophenolate mofetil; cytotoxic drugs; TNF-.alpha. inhibitors; anti-TNF antibodies or soluble TNF receptor; rapamycin (sirolimus or Rapamune); leflunimide; cyclooxygenase-2 inhibitors; paclitaxel, cisplatin, carboplatin, doxorubicin, carminomycin, daunorubicin, aminopterin, methotrexate, methopterin, mitomycin C, ecteinascidin 743, porfiromycin, 5-fluorouracil, 6-mercaptopurine, gemcitabine, cytosine arabinoside, podophyllotoxin, etoposide, etoposide phosphate, teniposide, melphalan, vinblastine, vincristine, leurosidine, epothilone, vindesine, leurosine, or derivatives thereof.

40. A method for the treatment of a T cell mediated disorder, comprising the step of administering to a subject in need thereof an amount effective therefor of at least one compound of claim 7.

41. The method of claim 40, wherein T cell activation is inhibited.

42. A pharmaceutical composition for the treatment of a protein tyrosine kinase-associated disorder, comprising a pharmaceutically acceptable vehicle or diluent and at least one compound of claim 6.

43. The compound ##STR628##

including salts thereof.

44. A method for the treatment of cancer, comprising the step of administering to a subject in need thereof an amount effective therefor of the compound of claim 43.

45. A method of claim 44 where the claimed compound is used to treat solid tumors.

46. A pharmaceutical composition comprising the compound of claim 43 and a pharmaceutically acceptable vehicle or carrier thereof.

47. A method for the treatment of a protein tyrosine kinase-associated disorder, comprising the step of administering to a subject in need thereof an effective amount of the compound of claim 43.

48. A method of claim 47 wherein the compound of claim 43 administered with at least one additional therapeutic agent selected from cyclosporin A; CTLA4-Ig; antibodies selected from anti-ICAM-3, anti-IL-2 receptor (Anti-Tac), anti-CD45RB, anti-CD2, anti-CD3 (OKT-3), anti-CD4, anti-CD80, anti-CD86, and monoclonal antibody OKT3; agents blocking the interaction between CD40 and gp39; fusion proteins constructed from CD40 and gp39; inhibitors of NF-kappa B function; non-steroidal antiinflammatory drugs; steroids; gold compounds; antiproliferative agents; FK506; mycophenolate mofetil; cytotoxic drugs; TNF-.quadrature. inhibitors; anti-TNF antibodies or soluble TNF receptor; rapamycin; leflunimide; cyclooxygenase-2 inhibitors; paclitaxel, cisplatin, carboplatin, doxorubicin, carminomycin, daunorubicin, aminopterin, methotrexate, methopterin, mitomycin C, ecteinascidin 743, porfiromycin, 5-fluorouracil, 6-mercaptopurine, gemcitabine, cytosine arabinoside, podophyllotoxin, etoposide, etoposide phosphate, teniposide, melphalan, vinblastine, vincristine, leurosidine, epothilone, vindesine, or leurosine.

49. A method of claim 47 wherein the portein tyrosine kinase-associated disorder is transplant rejection, rheumatoid arthritis, multiple sclerosis, inflammatory bowel disease, lupus, graft vs. host disease, T-cell mediated hypersensitivity disease, psoriasis, Hashimoto's thyroiditis, Guillian-Barre syndrome, contact dermatitis, allergic disease, asthma, ischemic or reperfusion injury, atopic dermatitis, allergic rhinitis, chronic obstructive pulmonary disease, or diabetic retinopathy.
« Back to Dashboard

For more information try a trial or see the database preview and plans and pricing

How are People Using DrugPatentWatch?

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

`abc