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Harvard Business School
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Generated: December 17, 2017

DrugPatentWatch Database Preview

Claims for Patent: 6,589,959

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Claims for Patent: 6,589,959

Title: Crystalline bis[(e)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]p yrimidin-5-yl](3R,5S)-3,5-dihydroxyhept-6-enoic acid]calcium salt
Abstract:The present invention relates to a crystalline form of the compound bis[(E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]p yrimidin-5-yl](3R,5S)-3,5-dihydroxyhept-6-enoic acid]calcium salt, as well as processes for its manufacture and pharmaceutical compositions comprising the crystalline form, which is useful as an agent for treating hyperlipidemia, hypercholesterolemia and atherosclerosis.
Inventor(s): Taylor; Nigel P (Macclesfield, GB)
Assignee: Astrazeneca AB (Sodertalje, SE)
Application Number:09/869,462
Patent Claims: 1. A crystalline form of the compound bis[(E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]p yrimidin-5-yl](3R,5S)-3,5-dihydroxyhept-6-enoic acid]calcium salt of the formula I ##STR2##

in hydrated form having an X-ray powder diffraction pattern with specific peaks at 2-theta (2.theta.)=4.92, 11.50, 6.93, 9.35, 23.12 and 18.76.degree..

2. A pharmaceutical composition comprising the crystalline form of compound as claimed in claim 1, together with a pharmaceutically acceptable carrier.
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Serving leading biopharmaceutical companies globally:

Chubb
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Boehringer Ingelheim
McKesson
Daiichi Sankyo
Healthtrust
Medtronic
Cantor Fitzgerald
Merck
Teva

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