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Claims for Patent: 6,579,981

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Claims for Patent: 6,579,981

Title: Antiviral guanine derivatives
Abstract:A compound of formula (I) ##STR1## or a salt or acyl derivative thereof, in which X represents chlorine, C.sub.1-6 alkoxy, phenoxy, phenyl C.sub.1-6 alkoxy, NH.sub.2, --OH or --SH, is useful in treating viral infections.
Inventor(s): Jarvest; Richard Lewis (Surbiton, GB), Harnden; Michael Raymond (Horsham, GB)
Assignee: Novartis International Pharmaceutical Ltd. (Hamilton, BM)
Application Number:08/311,291
Patent Claims: 1. A pharmaceutical composition comprising a compound of formula A: ##STR25##

or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier or excipient.

2. A pharmaceutical composition as recited in claim 1 wherein said salt of said compound is the sodium salt.

3. A method of treating herpesvirus infections in a human in need thereof, which method comprises administering to said human an effective, non-toxic dose of a pharmaceutical composition as recited in claim 1.

4. A method of treating herpesvirus infections in a human in need thereof, which method comprises administering to said human an effective, non-toxic dose of a pharmaceutical composition as recited in claim 2.

5. A method of treating a herpesvirus infection wherein said infection is a herpes simplex type 1 (HSV-1) virus infection in a human or animal in need thereof, which method comprises administering to said human or animal an effective, non-toxic dose of a pharmaceutical composition as recited in claim 1.

6. A pharmaceutical composition as recited in claim 1 which is suitable for topical application.

7. A pharmaceutical composition as recited in claim 6 suitable for application to the skin.

8. A method of treating herpesvirus infections in an animal in need thereof, which method comprises administering to said animal an effective amount of a pharmaceutical composition as recited in claim 1.

9. A method as recited in claim 8 wherein the compound is administered by injection.

10. A method as recited in claim 8 wherein the compound is administered topically.

11. A method as recited in claim 10 wherein the compound administered to the eyes.

12. A method as recited in claim 10 wherein the compound administered to the skin.

13. A method as recited in claim 12 wherein the compound is in a cream formulation.

14. A method of treating herpesvirus infections in an animal in need thereof, which method comprises administering to said animal an effective amount of a pharmaceutical composition as recited in claim 2.

15. A method as recited in claim 14 wherein the compound is administered by injection.

16. A method as recited in claim 14 wherein the compound is administered topically.

17. A method as recited in claim 16 wherein the compound is administered to the eyes.

18. A method as recited in claim 16 wherein the compound is administered to the skin.

19. A method as recited in claim 18 wherein the compound is in a cream formulation.

20. A method of treating a herpesvirus infection, wherein said infection is a herpes simplex type 1 (HSV-1) virus infection, in a human or animal in need thereof, which method comprises administering to said human or animal an effective, non-toxic dose of a compound of the formula ##STR26##

or a pharmaceutically acceptable salt thereof.

21. A method of treating a herpesvirus infection, wherein said infection is a herpes simplex type 2 (HSV-2) virus infection, in a human or animal in need thereof, which method comprises administering to said human or animal an effective, non-toxic dose of a compound of the formula ##STR27##

or a pharmaceutically acceptable salt thereof.

22. A method of treating a herpesvirus infection, wherein said infection is a varciella zoster (VZV) virus infection, in a human or animal in need thereof, which method comprises administering to said human or animal an effective, non-toxic dose of a compound of the formula ##STR28##

or a pharmaceutically acceptable salt thereof.

23. A method as recited in claim 3 wherein the compound is administered by injection.

24. A method as recited in claim 3 wherein the compound is administered topically.

25. A method as recited in claim 24 wherein the compound is administered to the eyes.

26. A method as recited in claim 24 wherein the compound is administered to the skin.

27. A pharmaceutical composition comprising a sodium salt of a compound of the formula ##STR29##

and a pharmaceutically acceptable carrier or excipient, said compound having a purity of greater than 90% by weight.

28. A method as recited in claim 4 wherein the compound is administered by injection.

29. A method as recited in claim 4 wherein the compound is administered topically.

30. A method as recited in claim 4 wherein the compound is administered to the eyes.

31. A method as recited in claim 29, wherein the compound is administered to the skin.

32. A method as recited in claim 31 wherein the compound is in a cream formulation.

33. A method as recited in claim 5 wherein the compound is administered by injection.

34. A method as recited in claim 5 wherein the compound is administered topically.

35. A method as recited in claim 5 wherein the compound is administered to the eyes.

36. A method as recited in claim 34 wherein the compound is administered to the skin.

37. A method as recited in claim 36 wherein the compound is in a cream formulation.

38. A pharmaceutical composition as recited in claim 27 which is suitable for topical application.

39. A pharmaceutical composition as recited in claim 2 which is suitable for injection.

40. A pharmaceutical composition as recited in claim 7 formulated as a cream.

41. A method of treating a herpesvirus infection wherein said infection is a herpes simplex type 2 (HSV-2) virus infection in a human or animal in need thereof, which method comprises administering to said human or animal an effective, non-toxic dose of a pharmaceutical composition as recited in claim 1.

42. A method of treating a herpesvirus infection wherein said infection is a varicella zoster virus (VZV) virus infection in a human or animal in need thereof, which method comprises administering to said human or animal an effective, non-toxic dose of a pharmaceutical composition as recited in claim 1.

43. A method of treating herpesvirus infections in a human or animal in need thereof, which method comprises administering to said human or animal an effective, non-toxic dose of a compound of the formula ##STR30##

or a pharmaceutically acceptable salt thereof.

44. A method as recited in claim 43 wherein said pharmaceutically acceptable salt is the sodium salt.

45. A method as recited in claim 26 wherein the compound is in a cream formulation.

46. A pharmaceutical composition as recited in claim 27 which is suitable for injection.

47. A pharmaceutical composition as recited in claim 38 suitable for application to the eyes.

48. A pharmaceutical composition as recited in claim 38 suitable for application to the skin.

49. A pharmaceutical composition as recited in claim 48 in the form of a cream.

50. A pharmaceutical composition as recited in claim 42 suitable for application to the eyes.
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