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Claims for Patent: 6,573,378

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Claims for Patent: 6,573,378

Title: Antiviral guanine derivatives
Abstract:A compound of formula (I) ##STR1## or a salt or acyl derivative thereof, in which X represents chlorine, C.sub.1-6 alkoxy, phenoxy, phenyl C.sub.1-6 alkoxy, NH.sub.2, --OH or --SH, is useful in treating viral infections.
Inventor(s): Jarvest; Richard Lewis (Surbiton, GB), Harnden; Michael Raymond (Horsham, GB)
Assignee: Novartis International Pharmaceutical Ltd. (Hamilton, BM)
Application Number:08/357,363
Patent Claims: 1. 9-(4-hydroxy-3-hydroxymethylbut-1-yl)guanine having a purity of greater than 95% by weight.

2. 9-(4-hydroxy-3-hydroxymethylbut-1-yl)guanine having an .sup.1 H-NMR spectrum of d.sub.H [(CD.sub.3).sub.2 SO] 1.3-1.5 (3H, m, CHCH.sub.2 CH.sub.2), 3.42 (4H, d, J 5 Hz, 2.times.CH.sub.2 O), 3.99 (2H, t, J 7 Hz, CH.sub.2 N), 4.41 (2H, br, D.sub.2 O exchangeable, 2.times.OH), 6.44 (2H, s, D.sub.2 O exchangeable, 2-NH.sub.2), 7.71 (1H, s, 8-H), and 10.55 (1H, br, D.sub.2 O exchangeable, 1-H), and having substantially no detectable signal in the .delta. 7.1-7.4 region of the .sup.1 H-NMR spectrum.

3. 9-(4-hydroxy-3-hydroxymethylbut-1-yl)guanine in substantially pure form.

4. The sodium salt of 9-(4-hydroxy-3-hydroxymethylbut-1-yl)guanine, said salt being in substantially pure form.

5. 9-(4-hydroxy-3-hydroxymethylbut-1-yl)guanine having a purity of greater than 90% by weight.

6. The compound 9-(4-hydroxy-3-hydroxymethylbut-1-yl)guanine, sodium salt, having a purity of greater than 90% by weight.

7. The compound according to claim 6 which has a purity of greater than 95% by weight.

8. A pharmaceutically acceptable salt of 9-(4-hydroxy-3-hydroxymethylbut-1-yl)guanine, having a purity of at least 90% by weight.

9. A pharmaceutically acceptable salt of 9-(4-hydroxy-3-hydroxymethylbut-1-yl)guanine, having a purity of at least 95% by weight.

10. 9-(4-hydroxy-3-hydroxymethylbut-1-yl)guanine, in crystalline form, having a purity of greater than 90% by weight.

11. 9-(4-hydroxy-3-hydroxymethylbut-1-yl)guanine, in crystalline form, having a purity of greater than 95% by weight.

12. A pharmaceutically acceptable salt of 9-(4-hydroxy-3-hydroxymethylbut-1-yl)guanine.
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