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Generated: April 26, 2018

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Claims for Patent: 6,551,616

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Summary for Patent: 6,551,616
Title: Extended release formulations of erythromycin derivatives
Abstract:Disclosed is a pharmaceutical composition for extended release of an erythromycin derivative in the gastrointestinal environment. The composition comprises an erythromycin derivative and a pharmaceutically acceptable polymer so that, when ingested orally, the composition induces statistically significantly lower C.sub.max in the plasma than an immediate release composition of the erythromycin derivative while maintaining bioavailability and minimum concentration substantially equivalent to that of the immediate release composition of the erythromycin derivative upon multiple dosing. The compositions of the invention have an improved taste profile and reduced gastrointestinal side effects as compared to those for the immediate release composition.
Inventor(s): Notario; Gerard F. (Chicago, IL), Palmer; Robert N. (Gurnee, IL), Hom; Richard C. (Wilmette, IL), Zhang; Jie (Basking Ridge, NJ), Devcich; Karen J. (Grayslake, IL), Semla; Susan J. (Evanston, IL)
Assignee: Abbott Laboratories (Abbott Park, IL)
Application Number:09/416,916
Patent Claims: 1. A method of reducing gastrointestinal adverse side effects comprising administering an effective amount of an extended release pharmaceutical composition comprising an erythromycin derivative and a pharmaceutically acceptable polymer.

2. The method according to claim 1, wherein the erythromycin derivative is clarithromycin.

3. The method according to claim 2, wherein the composition comprises about 50% by weight of clarithromycin.

4. The method according to claim 3, wherein the composition comprises from about 10 to about 30% by weight of hydroxypropylmethylcellulose having a viscosity of about 100 cps.

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