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Serving 500+ biopharmaceutical companies globally:

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Generated: September 25, 2017

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Title: Method of lowering the blood pressure
Abstract:A method of potentiating the effects of blood pressure reducing agents in warm-blooded animals, said method comprising administering to said warm-blooded animals of an effective amount of a blood pressure reducing agent and a 2,2'-iminobisethanol derivative.
Inventor(s): Xhonneux; Raymond Mathieu (Vlimmeren, BE), Van Lommen; Guy Rosalia Eugene (Berlaar, BE)
Assignee: Janssen Pharmaceutica N.V. (BE)
Application Number:07/825,488
Patent Claims: 1. A composition consisting of the compound [2R,.alpha.S,2'S,.alpha.'S]-.alpha.,.alpha.'-[iminobismethylene]bis[6-fluo ro-3,4-dihydro-2H-1-benzopyran-2-methanol] having the formula: ##STR4##

or a pharmaceutically acceptable acid addition salt thereof.

2. A pharmaceutical composition consisting of a pharmaceutically acceptable carrier and, as active ingredients: (a) the blood pressure reducing compound [2S,.alpha.R, 2'R,.alpha.'R]-.alpha.,.alpha.'-[iminobismethylene]bis[6-fluoro-3,4-dihydr o-2H-1-benzopyran-2-methanol] having the formula: ##STR5##

or a pharmaceutically acceptable acid addition salt thereof; and (b) the compound [2R,.alpha.S,2'S,.alpha.'S]-.alpha.,.alpha.'-[iminobismethylene]bis[6-fluo ro-3,4-dihydro-2H-1-benzopyran-2-methanol] having the formula: ##STR6##

or a pharmaceutically acceptable acid addition salt thereof.

3. A composition according to claim 2 wherein compound (b) is present in an amount capable of potentiating the activity of the blood pressure reducing compound (a).

4. A composition according to claim 3 wherein the molar ratio of the compounds (a) and (b) is about 1:1.

5. A method of treating hypertension in warm blooded animals in need of such treatment which comprises administering to said warm blooded animals an effective amount of the pharmaceutical composition of claim 2.

6. A method of treating hypertension in warm blooded animals in need of such treatment which comprises administering to said warm blooded animals an effective amount of the pharmaceutical composition of claim 4.
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Serving 500+ biopharmaceutical companies globally:

Daiichi Sankyo
Fish and Richardson
Teva
Johnson and Johnson
Fuji
McKinsey
Merck
AstraZeneca
Citi
Express Scripts

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

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