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Claims for Patent: 6,545,040

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Claims for Patent: 6,545,040

Title: Method of lowering the blood pressure
Abstract:A method of potentiating the effects of blood pressure reducing agents in warm-blooded animals, said method comprising administering to said warm-blooded animals of an effective amount of a blood pressure reducing agent and a 2,2'-iminobisethanol derivative.
Inventor(s): Xhonneux; Raymond Mathieu (Vlimmeren, BE), Van Lommen; Guy Rosalia Eugene (Berlaar, BE)
Assignee: Janssen Pharmaceutica N.V. (BE)
Application Number:07/825,488
Patent Claims: 1. A composition consisting of the compound [2R,.alpha.S,2'S,.alpha.'S]-.alpha.,.alpha.'-[iminobismethylene]bis[6-fluo ro-3,4-dihydro-2H-1-benzopyran-2-methanol] having the formula: ##STR4##

or a pharmaceutically acceptable acid addition salt thereof.

2. A pharmaceutical composition consisting of a pharmaceutically acceptable carrier and, as active ingredients: (a) the blood pressure reducing compound [2S,.alpha.R, 2'R,.alpha.'R]-.alpha.,.alpha.'-[iminobismethylene]bis[6-fluoro-3,4-dihydr o-2H-1-benzopyran-2-methanol] having the formula: ##STR5##

or a pharmaceutically acceptable acid addition salt thereof; and (b) the compound [2R,.alpha.S,2'S,.alpha.'S]-.alpha.,.alpha.'-[iminobismethylene]bis[6-fluo ro-3,4-dihydro-2H-1-benzopyran-2-methanol] having the formula: ##STR6##

or a pharmaceutically acceptable acid addition salt thereof.

3. A composition according to claim 2 wherein compound (b) is present in an amount capable of potentiating the activity of the blood pressure reducing compound (a).

4. A composition according to claim 3 wherein the molar ratio of the compounds (a) and (b) is about 1:1.

5. A method of treating hypertension in warm blooded animals in need of such treatment which comprises administering to said warm blooded animals an effective amount of the pharmaceutical composition of claim 2.

6. A method of treating hypertension in warm blooded animals in need of such treatment which comprises administering to said warm blooded animals an effective amount of the pharmaceutical composition of claim 4.
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