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Last Updated: April 24, 2024

Claims for Patent: 6,534,070

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Summary for Patent: 6,534,070

Title:	Composition with azelaic acid
Abstract:	The invention relates to a pharmaceutical composition having the following constituents: azelaic acid, polyacrylic acid, triacylglyceride, propylene glycol, polysorbate, soya lecithin, water and salts. The composition is a hydrogel which is suited for the treatment of rosacea, presbyderma, melasma or skin irritations.
Inventor(s):	Franke; Patrick (Berlin, DE), Gunther; Clemens (Berlin, DE), Riedl; Jutta (Inzlingen, DE)
Assignee:	Schering Aktiengesellschaft (Berlin, DE)
Application Number:	09/554,738
Patent Litigation and PTAB cases:	See patent lawsuits and PTAB cases for patent 6,534,070
Patent Claims:	1. A composition that comprises: (i) azelaic acid as a therapeutically active ingredient in a concentration of 5 to 20% by weight, (iii) at least one triacylglyceride in a concentration of 0.5 to 5% by weight, (iv) propylene glycol, and (v) at least one polysorbate, in an aqueous phase that further comprises water and salts, and the composition further comprises (ii) at least one polyacrylic acid, and (vi) lecithin, wherein the composition is in the form of a hydrogel. 2. A composition according to claim 1, wherein the composition is in a form for topical administration. 3. A composition according to claim 1, wherein the lecithin is soybean lecithin. 4. A composition according to claim 1, wherein the lecithin is present at a concentration within the range of greater than 0% to 1% by weight. 5. A composition according to claim 1, wherein the individual components, independently of one another, have the following concentrations; (ii) at least one polyacrylic acid at a concentration of 0.5 to 2% by weight, (iii) at least one triacylglyceride at a concentration of 0.5 to 5% by weight, (iv) propylene glycol at a concentration of 5 to 15% by weight, and (v) at least one polysorbate at a concentration of 0.5 to 3% by weight. 6. A composition according to claim 1, wherein the individual components, independently of one another, have the following concentrations: (ii) at least one polyacrylic acid at a concentration of 1.+-.0.25% by weight, (iii) at least one triacylglyceride at a concentration of 2.+-.1% by weight, (iv) propylene glycol at a concentration of 10.+-.2-% by weight, and (v) at least one polysorbate at a concentration of 2.+-.0.5% by weight. 7. A composition according to claim 1, wherein the composition further comprises at least one physiologically compatible, pharmacological adjuvant or vehicle. 8. A method for treating rosacea, presbyderma, melasma, acne and/or skin irritations in a patient, comprising administering to the patient in need thereof a therapeutically effective amount of the composition according to claim 1. 9. The method of claim 8, wherein the composition is administered topically. 10. A composition according to claim 1, wherein the azelaic acid is present at a concentration of 10 to 18% by weight. 11. A composition according to claim 1, wherein the lecithin is present at a concentration within the range of greater than 0% to 3% by weight. 12. A composition according to claim 1, further comprising benzoic acid.

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