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Claims for Patent: 6,531,141

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Claims for Patent: 6,531,141

Title: Oil-in-water emulsion containing tretinoin
Abstract:The present invention relates to an oil-in-water emulsion containing tretinoin and the use thereof in mitigating skin disorders such as acne, photodamaged skin, wrinkles, mottled hyperpigmentation, tactile roughness, and yellowing of facial skin.
Inventor(s): Marvel; John (East Brunswick, NJ)
Assignee: Ortho-McNeil Pharmaceutical, Inc. (Raritan, NJ)
Application Number:09/521,445
Patent Claims: 1. An oil-in-water emulsion comprising: (i) about 0.001% to about 1%, by weight, of tretinoin; (ii) about 5% to about 20%, by weight, of caprylic/capric triglyceride; (iii) about 1% to about 10%, by weight, of a C.sub.30 -C.sub.100 polyethylene glycol ether of a C.sub.10 -C.sub.30 fatty alcohol; (iv) about 0.1% to about 5%, by weight, of a C.sub.4 -C.sub.30 polyethylene glycol ether of a C.sub.10 -C.sub.30 fatty alcohol; (v) about 0% to about 10%, by weight, of a C.sub.10 -C.sub.30 fatty acid; (vi) about 1% to about 10%, by weight, of a first C.sub.10 -C.sub.30 fatty alcohol; (vii) about 0% to about 10%, by weight, of a second C.sub.10 -C.sub.30 fatty alcohol; and (viii) about 50% to about 90%, by weight, of water.

2. An oil-in-water emulsion of claim 1 further comprising: (ix) about 0.1% to about 1%, by weight, of xanthan gum; (x) about 0.001% to about 1%, by weight, of a preservative; (xi) about 0.001% to about 1%, by weight, of an antioxidant; (xii) about 0.001% to about 1%, by weight, of a chelating agent; and (xiii) about 0% to about 1%, by weight, of a fragrance.

3. An oil-in-water emulsion of claim 2, said emulsion comprising: (i) about 0.001% to about 1%, by weight, of tretinoin; (ii) about 5% to about 20%, by weight, of caprylic/capric triglyceride; (iii) about 1% to about 10%, by weight, of steareth-20; (iv) about 0.1% to about 5%, by weight, of steareth-2; (v) about 0% to about 10%, by weight, of stearic acid; (vi) about 1% to about 10%, by weight, of cetyl alcohol; (vii) about 1% to about 10%, by weight, of stearyl alcohol; (viii) about 50% to about 90%, by weight, of water; (ix) about 0.1% to about 1%, by weight, of xanthan gum; (x) about 0.001% to about 1%, by weight, of a mixture of propylparaben and methylparaben and about 0.1% to about 5%, by weight, of benzyl alcohol; (xi) about 0.001% to about 1%, by weight, of butylene hydroxytoluene; (xii) about 0.001% to about 1%, by weight, of edetate disodium; and (xiii) about 0% to about 1%, by weight, of Chemoderm 6401B.

4. An oil-in-water emulsion of claim 1, wherein said emulsion comprises: (i) about 0.01% to about 1%, by weight, of tretinoin; (ii) about 10%, by weight, of caprylic/capric triglyceride; (iii) about 4%, by weight, of steareth-20; (iv) about 0.8%, by weight, of steareth-2; (v) about 0% to about 4%, by weight, of stearic acid; (vi) about 4% to about 6%, by weight, of cetyl alcohol; (vii) about 3% to about 6%, by weight, of stearyl alcohol; and (viii) about 72%, by weight, of water.

5. An oil-in-water emulsion of claim 4 further comprising: (ix) about 0.3% of xanthan gum; (x) about 0.1%, by weight, of propylparaben, about 0.2%, by weight, of methylparaben; and about 1%, by weight, of benzyl alcohol; (xi) about 0.1%, by weight, of butylated hydroxytoluene; (xii) about 0.05%, by weight, of edetate disodium; and (xiii) about 0% to about 0.01%, by weight, of Chemoderm 6401B.

6. An oil-in-water emulsion of consisting essentially of: (i) about 0.01% to about 1%, by weight, of tretinoin; (ii) about 10%, by weight, of caprylic/capric triglyceride; (iii) about 4%, by weight, of steareth-20; (iv) about 0.8%, by weight, of steareth-2; (v) about 0% to about 4%, by weight, of stearic acid; (vi) about 4% to about 6%, by weight, of cetyl alcohol; (vii) about 3% to about 6%, by weight, of stearyl alcohol; (viii) about 72%, by weight, of water; (ix) about 0.3% of xanthan gum; (x) about 0.1%, by weight, of propylparaben, about 0.2%, by weight, of methylparaben, and about 1%, by weight, of benzyl alcohol; (xi) about 0.1%, by weight, of butylated hydroxytoluene; (xii) about 0.05%, by weight, of edetate disodium; and (xiii) about 0% to about 0.01%, by weight, of Chemoderm 6401B.

7. An oil-in-water emulsion of consisting of: (i) about 0.01% to about 1%, by weight, of tretinoin; (ii) about 10%, by weight, of caprylic/capric triglyceride; (iii) about 4%, by weight, of steareth-20; (iv) about 0.8%, by weight, of steareth-2; (v) about 4%, by weight, of stearic acid; (vi) about 4%, by weight, of cetyl alcohol; (vii) about 3%, by weight, of stearyl alcohol; (viii) about 72%, by weight, of water; (ix) about 0.3% of xanthan gum; (x) about 0.1%, by weight, of propylparaben, about 0.2%, by weight, of methylparaben, and about 1%, by weight, of benzyl alcohol; (xi) about 0.1%, by weight, of butylated hydroxytoluene; (xii) about 0.05%, by weight, of edetate disodium; and (xiii) about 0.01%, by weight, of Chemoderm 6401B.

8. An oil-in-water emulsion of consisting of: (i) about 0.01% to about 1%, by weight, of tretinoin; (ii) about 10%, by weight, of caprylic/capric triglyceride; (iii) about 4%, by weight, of steareth-20; (iv) about 0.8%, by weight, of steareth-2; (v) about 5%, by weight, of cetyl alcohol; (vi) about 5%, by weight, of stearyl alcohol; (vii) about 72%, by weight, of water; (viii) about 0.3% of xanthan gum; (ix) about 0.1%, by weight, of propylparaben, about 0.2%, by weight, of methylparaben, and about 1%, by weight, of benzyl alcohol; (x) about 0.1%, by weight, of butylated hydroxytoluene; and (xi) about 0.05%, by weight, of edetate disodium.

9. An oil-in-water emulsion of claim 1, wherein said emulsion comprises about 0.02%, by weight, of tretinoin.

10. An oil-in-water emulsion of claim 7, wherein said emulsion comprises about 0.02%, by weight, of tretinoin.

11. An oil-in-water emulsion of claim 8, wherein said emulsion consists of about 0.02%, by weight, of tretinoin.

12. An oil-in-water emulsion of claim 1, wherein said emulsion comprises about 0.05%, by weight, of tretinoin.

13. An oil-in-water emulsion of claim 7, wherein said emulsion comprises about 0.05%, by weight, of tretinoin.

14. An oil-in-water emulsion of claim 8, wherein said emulsion consists of about 0.05%, by weight, of tretinoin.

15. A method of mitigating a skin condition in a human selected from the group consisting of acne, photodamaged skin, wrinkles, mottled hyperpigmentation, tactile roughness, and yellowing of facial skin, said method comprising topically administering to the skin of said human an oil-in-water emulsion comprising: (i) about 0.001% to about 1%, by weight, of tretinoin; (ii) about 5% to about 20%, by weight, of caprylic/capric triglyceride; (iii) about 1% to about 10%, by weight, of a C.sub.30 -C.sub.100 polyethylene glycol ether of a C.sub.10 -C.sub.30 fatty alcohol; (iv) about 1% to about 10%, by weight, of a C.sub.4 -C.sub.30 polyethylene glycol ether of a C.sub.10 -C.sub.30 fatty alcohol; (v) about 0% to about 10%, by weight, of a C.sub.10 -C.sub.30 fatty acid; (vi) about 1% to about 10%, by weight, of a first C.sub.10 -C.sub.30 fatty alcohol; (vii) about 0% to about 10%, by weight, of a second C.sub.10 -C.sub.30 fatty alcohol; and (viii) about 50% to about 90%, by weight, of water.

16. A method of mitigating a skin condition in a human selected from the group consisting of acne, photodamaged skin, wrinkles, mottled hyperpigmentation, tactile roughness, and yellowing of facial skin, said method comprising topically administering to the skin of said human an oil-in-water emulsion consisting of: (i) about 0.01% to about 1%, by weight, of tretinoin; (ii) about 10%, by weight, of caprylic/capric triglyceride; (iii) about 4%, by weight, of steareth-20; (iv) about 0.8%, by weight, of steareth-2; (v) about 4%, by weight, of stearic acid; (vi) about 4%, by weight, of cetyl alcohol; (vii) about 3%, by weight, of stearyl alcohol; (viii) about 72%, by weight, of water; (ix) about 0.3% of xanthan gum; (x) about 0.1%, by weight, of propylparaben, about 0.2%, by weight, of methylparaben, and about 1%, by weight, of benzyl alcohol; (xi) about 0.1%, by weight, of butylated hydroxytoluene; (xii) about 0.05%, by weight, of edetate disodium; and (xiii) about 0.01%, by weight, of Chemoderm 6401B.

17. A method of mitigating a skin condition in a human selected from the group consisting of acne, photodamaged skin, wrinkles, mottled hyperpigmentation, tactile roughness, and yellowing of facial skin, said method comprising topically administering to the skin of said human an oil-in-water emulsion consisting of: (i) about 0.01% to about 1%, by weight, of tretinoin; (ii) about 10%, by weight, of caprylic/capric triglyceride; (iii) about 4%, by weight, of steareth-20; (iv) about 0.8%, by weight, of steareth-2; (v) about 5%, by weight, of cetyl alcohol; (vi) about 5%, by weight, of stearyl alcohol; (vii) about 72%, by weight, of water; (viii) about 0.3% of xanthan gum; (ix) about 0.1%, by weight, of propylparaben, about 0.2%, by weight, of methylparaben, and about 1%, by weight, of benzyl alcohol; (x) about 0.1%, by weight, of butylated hydroxytoluene; and (xi) about 0.05%, by weight, of edetate disodium.

18. A method of claim 15, wherein said method comprises a method of mitigating fine wrinkles in a human.

19. A method of claim 16, wherein said method comprises a method of mitigating fine wrinkles in a human.

20. A method of claim 17, wherein said method comprises a method of mitigating fine wrinkles in a human.

21. A method of claim 18, wherein said emulsion comprises about 0.02%, by weight, of tretinoin.

22. A method of claim 19, wherein said emulsion consists of about 0.02%, by weight, of tretinoin.

23. A method of claim 20, wherein said emulsion consists of about 0.02%, by weight, of tretinoin.

24. A method of claim 18, wherein said emulsion consists of about 0.05%, by weight, of tretinoin.

25. A method of claim 19, wherein said emulsion consists of about 0.05%, by weight, of tretinoin.

26. A method of claim 20, wherein said emulsion consists of about 0.05%, by weight, of tretinoin.
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