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Claims for Patent: 6,510,969

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Claims for Patent: 6,510,969

Title: Valve for aerosol container
Abstract:Valve for an aerosol container for dispensing a suspension of a substance in a liquid propellant contained therein. The valve comprises a valve body (1) having at least one orifice (16) to allow a quantity of the suspension to pass from the container into the valve. The valve further comprises a ring (18) disposed around the valve body (1), the ring being positioned below the at least one orifice to reduce the volume of suspension that can be accommodated within the container below the at least one orifice when the container is orientated with the valve at the bottom, the ring having at least one portion of reduced axial thickness to provide a trough (19) around the valve body below the at least one orifice.
Inventor(s): Di Giovanni; Patrick (Le Vaudrueil, FR), Rogerson; Cheryl Vanessa (Essex, GB)
Assignee: SmithKline Beecham Corporation (Philadelphia, PA)
Application Number:09/957,916
Patent Claims: 1. A drug product comprising: an aerosol container containing a suspension of drug particles in a liquid propellant in communication with a metering valve comprising: a valve body; a metering chamber; a valve stem; one or more stem seals; and, at least one orifice in the valve body; and, a ring having a trough disposed around the valve body, wherein the ring further includes an annular wall interrupted with a plurality of slots forming a plurality of vanes, wherein, upon shaking of the valve, the suspension flows around the plurality of vanes assisting in dispersion of drug particles in the suspension; wherein the metering valve is suitable for dispensing the suspension of drug particles in the liquid propellant, and, wherein the drug is a member selected from the group consisting of salmeterol, salbutamol, formoterol, ipratropium, fluticasone, beclomethasone, budesonide, terbutaline, salts, esters and solvates thereof, and combinations thereof.

2. The drug product of claim 1 including an upper stem seal and a lower stem seal.

3. The drug product of claim 1 wherein the at least one orifice is at least one slot extending substantially axially.

4. The drug product of claim 1 further including a sampling chamber, wherein the at least one slot extends substantially the axial length of the sampling chamber.

5. The drug product of claim 1 including more than two slots.

6. The drug product of claim 2 wherein the ring further includes a seat adapted to accommodate a gasket to seal the container.

7. The drug product of claim 1 including more than 2 slots and more than 2 vanes.

8. The drug product of claim 1 comprising 6 slots and 6 vanes.

9. The drug product of claim 1 wherein the drug is fluticasone propionate.

10. The drug product of claim 1 wherein the ring is further capable of reducing the volume of suspension accompanied within the aerosol container below the at least one orifice when the container is oriented with the valve at the bottom, and wherein the trough is circumferential around the valve body.

11. The drug product of claim 1 wherein the drug is a combination of a salt, ester or solvate of salmeterol and fluticasone.

12. The drug product of claim 1 wherein the drug is salmeterol xinafoate.

13. The drug product of claim 1 wherein the drug is salbutamol sulfate.

14. The drug product of claim 1 wherein the drug is beclomethasone dipropionate.

15. The drug product of claim 1 wherein the drug is a combination of a salt, ester or solvate of ipratropium and salmeterol.

16. The drug product of claim 1 wherein the drug is a combination of ipratropium bromide and salmeterol xinafoate.

17. The drug product of claim 1 wherein the ring is constructed from a nylon.

18. The drug product of claim 1 wherein the ring is adapted to be friction fitted with the valve body.

19. The drug product of claim 18 wherein the ring includes an inner annular contacting rim adapted to friction fit to the valve body.

20. The drug product of claim 1 wherein the propellant is 1,1,1,2-tetrafluoroethane.

21. A drug product comprising: a means for containing a suspension of drug particles in a liquid propellant in communication with a means for metering the suspension; and, a means for assisting in dispersion of the suspension; wherein the metering means is suitable for dispensing the suspension of drug particles in the liquid propellant, and, wherein the drug is a member selected from the group consisting of salmeterol, salbutamol, formoterol, ipratropium, fluticasone, beclomethasone, budesonide, terbutaline, salts, esters and solvates thereof, and combinations thereof.

22. A drug product comprising: an aerosol container containing a suspension of drug particles in a liquid propellant in communication with a metering valve comprising: a valve body; at least one orifice, a sampling chamber having an axial length, a metering chamber, a transfer passage between the sampling chamber and the metering chamber, a valve stem, one or more stem seals; and, a dispensing passage within the valve stem, and, a ring having a trough and an annular wall interrupted with a plurality of slots and a plurality of vanes, the ring disposed around the valve body, wherein the valve stem is slideably moveable within the valve body such that in a first position the dispensing passage is isolated from the metering chamber and the metering chamber is in communication with the sampling chamber via the transfer passage, wherein the valve stem is slideably moveable within the valve body such that in a second position the dispensing passage is in communication with the metering chamber and the transfer passage is isolated from the metering chamber, wherein the metering valve is suitable for dispensing the suspension of drug particles in the liquid propellant, and wherein the drug is a member selected from the group consisting of salmeterol, salbutamol, formoterol, ipratropium, fluticasone, beclomethasone, budesonide, terbutaline, salts, esters and solvates thereof, and combinations thereof.
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