.

Pharmaceutical Business Intelligence

  • Anticipate P&T budget requirements
  • Evaluate market entry opportunities
  • Find generic sources and suppliers
  • Predict branded drug patent expiration

► Plans and Pricing

Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

DrugPatentWatch Database Preview

Claims for Patent: 6,492,365

« Back to Dashboard

Claims for Patent: 6,492,365

Title: Microsomal triglyceride transfer protein
Abstract:Nucleic acid sequences, particularly DNA sequences, coding for all or part of the high molecular weight subunit of microsomal triglyceride transfer protein, expression vectors containing the DNA sequences, host cells containing the expression vectors, and methods utilizing these materials. The invention also concerns polypeptide molecules comprising all or part of the high molecular weight subunit of microsomal triglyceride transfer protein, and methods for producing these polypeptide molecules. The invention additionally concerns novel methods for preventing, stabilizing or causing regression of atherosclerosis and therapeutic agents having such activity. The invention concerns further novel methods for lowering serum liquid levels and therapeutic agents having such activity.
Inventor(s): Wetterau, II; John R. (Langhorne, PA), Sharp; Daru Young (Perrineville, NJ), Gregg; Richard E. (Pennington, NJ)
Assignee: Bristol-Myers Squibb Company (New York, NY)
Application Number:08/486,929
Patent Claims: 1. A method for treating atherosclerosis in a mammalian species comprising administration of a therapeutically effective amount of an agent which decreases the amount or activity of microsomal triglyceride transfer protein, wherein said agent is not a polynucleotide compound.

2. A method for decreasing serum lipid levels in a mammalian species, which comprises administration of a therapeutically effective amount of an agent which decreases the amount or activity of microsomal triglyceride transfer protein, wherein said agent is not a polynucleotide compound.

3. The method of claim 1 or 2, wherein the agent is a compound of the formula ##STR180##

or a compound of the formula ##STR181##

or a compound of the formula ##STR182##

wherein: R.sup.1 is alkyl, alkenyl, alkynyl, aryl, heteroaryl, arylalkyl, heteroarylalkyl, cycloalkyl, cycloalkylalkyl (all optionally substituted through available carbon atoms with 1, 2, or 3 groups selected from halo, alkyl, alkenyl, alkoxy, aryloxy, aryl, arylalkyl, alkylmercapto, arylmercapto, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl); R.sup.2, R.sup.3, R.sup.4 are independently hydrogen, halo, alkyl, alkenyl, alkoxy, aryloxy, aryl, arylalkyl, alkylmercapto, arylmercapto, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl; R.sup.5 and R.sup.6 are independently hydrogen, alkyl, alkenyl, aryl, heteroaryl, arylalkyl, heteroarylalkyl, cycloalkyl, cycloalkylalkyl (all optionally substituted through available carbon atoms with 1, 2, or 3 groups selected from halo, alkyl, alkenyl, alkoxy, aryloxy, aryl, arylalkyl, alkylmercapto, arylmercapto, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl; with the proviso that when R.sup.5 is CH.sub.3, R.sup.6 is not hydrogen, R.sup.7 is alkyl (optionally substituted with oxo), aryl, or arylalkyl (wherein the alkyl portion is optionally substituted with oxo).

4. The method of claim 3, wherein the agent is a compound of the formula ##STR183##

or a compound of the formula ##STR184##

wherein: R.sup.1 is --R.sup.v --R.sup.w or ##STR185## R.sup.v and R.sup.x are each independently alkylene or cis-alkenylene of up to 6 carbon atoms; R.sup.w is aryl or heteroaryl; and R.sup.y and R.sup.z are each independently alkyl, alkenyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl, or cycloalkylalkyl.

5. The method of claim 4, wherein R.sup.y and R.sup.z are each independently aryl, arylalkyl, heteroaryl, or heteroarylalkyl.

6. A method for treating hyperglycemia in a mammalian species comprising administration of a therapeutically effective amount of an agent which decreases the amount or activity of microsomal triglyceride transfer protein, wherein said agent is not a polynucleotide compound.

7. A method for treating hypertriglyceridemia in a mammalian species comprising administration of a therapeutically effective amount of an agent which decreases the amount or activity of microsomal triglyceride transfer protein, wherein said agent is not a polynucleotide compound.

8. A method for treating hypercholesterolemia in a mammalian species comprising administration of a therapeutically effective amount of an agent which decreases the amount or activity of microsomal triglyceride transfer protein, wherein said agent is not a polynucleotide compound.

9. A method for treating hypertriglyceridemia and hypercholesterolemia in a mammalin species comprising administration of a therapeutically effective amount of an agent which decreases the amount or activity of microsomal triglyceride protein, wherein said agent is not a polynucleotide compound.

10. A method of reducing gastrointestinal triglyceride, fatty acid cholesterol absorption in a mammalian species comprising administration of a therapeutically effective amount of an agent which decreases the amount or activity of microsomal triglyceride transfer protein, wherein said agent is not a polynucleotide compound.
« Back to Dashboard

For more information try a trial or see the database preview and plans and pricing

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

`abc