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Claims for Patent: 6,479,535

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Claims for Patent: 6,479,535

Title: 2-phenyl-1-[4-(2-aminoethoxy)-benzyl]-indole and estrogen formulations
Abstract:The present invention relates to new formulations containing one or more estrogens and 2-Phenyl-1-[4-(2-Aminoethoxy)-Benzyl]-Indole compounds which are useful as estrogenic agents, as well as pharmaceutical compositions and methods of treatment utilizing these compounds, which have the general structures below: ##STR1##
Inventor(s): Pickar; James Harrison (Springfield, PA), Komm; Barry Samuel (Havertown, PA)
Assignee: Wyeth (Madison, NJ)
Application Number:09/306,073
Patent Claims: 1. A pharmaceutical composition comprising a pharmaceutically effective amount of 1-[4-(2-Azepan-1-yl-ethoxy)-benzyl]-2-(4-hydroxy-phenyl)-3-methyl-1H-indol -5-ol, or a pharmaceutically acceptable salt thereof, and a pharmaceutically effective amount of conjugated estrogens.

2. A method of treating vasomotor symptoms in a postmenopausal or estrogen deficient woman in need thereof, which comprises administering to said woman an effective amount of a combination of 1-[4-(2-azepan-1-yl-ethoxy)-benzyl]-2-(4-hydroxyphenyl)-3-methyl-1H-indol- 5-ol and conjugated estrogens.

3. The method according to claim 2, wherein the vasomotor symptom is hot flushes.

4. A method of inhibiting or retarding bone demineralization or treating or inhibiting osteoporosis in a postmenopausal or estrogen deficient woman in need thereof, which comprises administering to said woman an effective amount of a combination of 1-[4-(2-azepan-1-yl-ethoxy)-benzyl]-2-(4-hydroxy-phenyl)-3-methyl-1H-indol -5-ol and conjugated estrogens.

5. A method of treating or inhibiting menopausal or postmenopausal disorders in a postmenopausal or estrogen deficient woman in need thereof, which comprises administering to said woman an effective amount of a combination of 1-[4-(2-azepan-1-yl-ethoxy)-benzyl]-2-(4-hydroxy-phenyl)-3-methyl-1H-indol -5-ol and conjugated estrogens.
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