.

Pharmaceutical Business Intelligence

  • Anticipate P&T budget requirements
  • Evaluate market entry opportunities
  • Find generic sources and suppliers
  • Predict branded drug patent expiration

► Plans and Pricing

Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

DrugPatentWatch Database Preview

Claims for Patent: 6,413,549

« Back to Dashboard

Claims for Patent: 6,413,549

Title: Fast-Dispersing solid oral dosage form containing coarse particles
Abstract:This invention is directed to an oral solid, rapidly disintegrating, freeze-dried dosage form containing coarse particles of a pharmaceutically active material which are uncoated or coated with a polymer or lipid material. Preferably, the oral dosage form comprises coarse particles having a size in the range of 50 micron to 400 micron. The oral solid rapidly disintegrating dosage form according to the present invention preferably disintegrates in the oral cavity in less than 10 seconds.
Inventor(s): Green; Richard (Wiltshire, GB), Kearney; Patrick (Swindon, GB)
Assignee: R. P. Scherer Corporation (Basking Ridge, NJ)
Application Number:09/335,177
Patent Claims: 1. A freeze-dried oral solid rapidly disintegrating dosage form comprising coarse particles consisting of a pharmaceutically active material, said coarse particles having a size within the range of 50 .mu.m to 400 .mu.m, which are coated with a polymer or lipid material in a matrix comprising a carrier material and a structure forming agent, wherein said carrier material is selected from the group consisting of water soluble and water-dispersible carrier materials, wherein said dosage form disintegrates in water in less than 10 seconds.

2. A freeze-dried oral solid rapidly disintegrating dosage form according to claim 1, wherein said carrier material is gelatin and said structure-forming agent is a polyhydric alcohol.

3. A freeze-dried oral solid rapidly disintegrating dosage form according to claim 2, wherein said polyhydric alcohol is selected from mannitol and sorbitol.

4. A freeze-dried oral solid rapidly disintegrating dosage form according to claim 1, wherein said coarse particles are coated with a coating which delays release of the pharmaceutically active substance beyond the point of disintegration of said form on the tongue.

5. A freeze-dried oral solid rapidly disintegrating dosage form according to claim 4, wherein said coating is selected from the group consisting of a polymeric materials and a lipid material.

6. A freeze-dried oral solid rapidly disintegrating dosage form according to claim 5, wherein said polymeric material is selected from the group consisting of cellulose, a cellulose derivative, an acrylic derivative, polyglycolic-polylactic acid, polyvinyl alcohol, gelatin, collagen and polyethylene glycol.

7. A freeze-dried oral solid rapidly disintegrating dosage form according to claim 6, wherein said cellulose derivative is selected from the group consisting of ethylcellulose, hydroxyethylcellulose, hydroxypropylmethylcellulose, hydroxypropylcellulose, methylcellulose, cellulose acetate, cellulose acetate phthalate and hydroxypropylmethylcellulosephthalate, and said acrylic derivative is a polymethacrylate.

8. A freeze-dried oral solid rapidly disintegrating dosage form according to claim 5, wherein said coating is selected from the group consisting of a wax, lanolin, stearic acid, a stearic acid derivative, a phospholipid and a glycolipid.

9. A freeze-dried oral solid rapidly disintegrating dosage form according to claim 8, wherein stearic acid derivative is selected from the group consisting of a glycerol ester, a fixed oil and a fat.

10. A freeze-dried oral solid rapidly disintegrating dosage form according to claim 1, wherein said structure-forming agent is present in the amount of 1 to 5% by weight.

11. A freeze-dried oral solid rapidly disintegrating dosage form according to claim 1, wherein said coarse particles have a size in the range of 100 .mu.m to 400 .mu.m.

12. A freeze-dried oral solid rapidly disintegrating dosage form comprising coarse particles consisting of a pharmaceutically active material which are coated with a polymer or lipid material in a matrix comprising a carrier material and a structure forming agent, wherein said carrier material is selected from the group consisting of water soluble and water-dispersible carrier materials, wherein said coarse particles have a size of at least 100 .mu.m.
« Back to Dashboard

For more information try a trial or see the database preview and plans and pricing

How are People Using DrugPatentWatch?

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

`abc