Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

Serving hundreds of leading biopharmaceutical companies globally:

Deloitte
Chinese Patent Office
Harvard Business School
Healthtrust
Medtronic
Farmers Insurance
Moodys
AstraZeneca
Chubb

Generated: May 27, 2018

DrugPatentWatch Database Preview

Claims for Patent: 6,399,101

« Back to Dashboard

Summary for Patent: 6,399,101
Title: Stable thyroid hormone preparations and method of making same
Abstract:Provided is a pharmaceutical preparation of thyroid hormone and a process of making a tablet formulation of the pharmaceutical preparation using direct compression. In a preferred embodiment, the pharmaceutical preparation comprises levothyroxine sodium and silicified microcrystalline cellulose.
Inventor(s): Frontanes; Ramon A. (Caguas, PR), Bruno; Maria S. (Guaynabo, PR), Garcia; Hector L. (Cidra, PR), Simamora; Pahala (Cardova, TN), Perez; Maria A. (Aguas Buenas, PR)
Assignee: Mova Pharmaceutical Corp. (Caguas, PR)
Application Number:09/538,461
Patent Claims: 1. A stabilized pharmaceutical preparation comprising a therapeutically effective amount of levothyroxine sodium and silicified microcrystalline cellulose.

2. The preparation of claim 1, further comprising a disintegrant and a lubricant.

3. The preparation of claim 2, wherein the disintegrant is sodium starch glycolate.

4. The preparation of claim 2, wherein the lubricant is magnesium stearate.

5. A stabilized pharmaceutical preparation comprising a stabilizing matrix consisting essentially of silicified microcrystalline cellulose and a therapeutically effective amount of levothyroxine sodium particles, which particles are captured and protected within the stabilizing matrix.

6. The preparation of claim 5, further comprising a disintegrant, a lubricant and a coloring agent.

7. The preparation of claim 6, wherein the disintegrant is sodium starch glycolate, pregelatinized starch or cellulose.

8. The preparation of claim 6, wherein the lubricant is magnesium stearate, calcium stearate, talc or stearic acid.

9. The preparation of claim 6, wherein the disintegrant is sodium starch glycolate and the lubricant is magnesium stearate.

10. The preparation of claim 1, wherein the stabilized pharmaceutical preparation is in the form of a tablet.

11. A stabilized pharmaceutical preparation comprising a therapeutically effective amount of a thyroid hormone and silicified microcrystalline cellulose.

12. A method for the manufacture of a pharmaceutical tablet preparation comprising the steps of:

(a) forming an active blend by blending in intimate admixture silicified microcrystalline cellulose and a therapeutic agent comprising one or more thyroid hormone or hormones;

(b) forming a color blend by blending in intimate admixture one or more pharmaceutically acceptable dyes and silicified microcrystalline cellulose;

(c) combining the active blend, the color blend and a disintegrate in a preblend;

(d) adding a lubricant to the preblend to form a final blend; and

(e) compressing the final blend to form a stabilized pharmaceutical tablet preparation.

13. The method of claim 12, wherein the thyroid hormone is levothyroxine sodium.

14. The method of claim 13, wherein the disintegrant is sodium starch glycolate.

15. The method of claim 13, wherein the lubricant is magnesium stearate.

For more information try a trial or see the plans and pricing

Serving hundreds of leading biopharmaceutical companies globally:

Deloitte
Cantor Fitzgerald
Federal Trade Commission
AstraZeneca
Dow
Chubb
Fish and Richardson
Daiichi Sankyo
Citi

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.