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Generated: August 20, 2017

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Title: Stabilized composition comprising antidementia medicament
Abstract:The present invention provides a stable composition of an antidementia medicament. Specifically, it is a stabilized composition of an antidementia medicament comprising an antidementia medicament and an organic acid. As the organic acid, tosyllic acid, mesyllic acid, benzoic acid, salicylic acid, tartaric acid, citric acid and the like are particularly preferable.
Inventor(s): Kato; Akira (Ibaraki, JP), Harada; Tsutomu (Aichi, JP), Murahashi; Naokazu (Aichi, JP), Sugaya; Yukiko (Ibaraki, JP), Ando; Hidenobu (Gunma, JP)
Assignee: Eisai Co., Ltd. (Tokyo, JP)
Application Number:09/700,342
Patent Claims: 1. An antidementia medicament composition, comprising:

an antidementia medicament and

an organic acid,

wherein the antidementia medicament is donepezil and the organic acid is selected from the group consisting of tosyllic acid, mesyllic acid, benzoic acid, salicylic acid, tartaric acid, citric acid and combinations thereof, wherein the organic acid is not added to form a salt.

2. The composition as claimed in claim 1, which is stabilized to light and/or heat.

3. A method for stabilizing an antidementia medicament, which comprises the step of:

adding an organic acid to an antidementia medicament,

wherein the antidementia medicament is donepezil and the organic acid is selected from the group consisting of tosyllic acid, mesyllic acid, benzoic acid, salicylic acid, tartaric acid, citric acid and combinations thereof, wherein the organic acid is not added to form a salt.

4. The method as claimed in claim 3, which comprises the step of stabilizing to light and/or heat.

5. The method as claimed in claim 3, wherein the organic acid is added in an amount of 0.1 to 10 parts by weight to 1 part of the antidementia medicament.

6. The antidementia medicament composition according to claim 1, wherein the amount of organic acid is 0.1 to 10 parts by weight to 1 part by weight of donepezil.

7. The antidementia medicament composition according to claim 1, wherein the amount of organic acid is 0.2 to 5 parts by weight to 1 part by weight of donepezil.

8. The antidementia medicament composition according to claim 1, wherein the amount of organic acid is 0.2 to 2 parts by weight to 1 part by weight of donepezil.

9. The method for stabilizing an antidementia medicament according to claim 3, wherein the amount added of organic acid is 0.2 to 5 parts by weight to 1 part by weight of donepezil.

10. The method for stabilizing an antidementia medicament according to claim 3, wherein the amount added of organic acid is 0.2 to 2 parts by weight to 1 part by weight of donepezil.
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