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Serving hundreds of leading biopharmaceutical companies globally:

Argus Health
QuintilesIMS
Fish and Richardson
US Department of Justice
Boehringer Ingelheim
Queensland Health
UBS
Colorcon
McKinsey

Generated: April 25, 2018

DrugPatentWatch Database Preview

Claims for Patent: 6,362,161

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Summary for Patent: 6,362,161
Title: Copolymer-1 improvements on compositions of copolymers
Abstract:The present invention relates to an improved composition of copolymer-1 comprising copolymer-1 substantially free of species having a molecular weight of over 40 kilodaltons.
Inventor(s): Konfino; Eliezer (Ramat Gan, IL), Sela; Michael (Rehovot, IL), Teitelbaum; Dvora (Rehovot, IL), Arnon; Ruth (Rehovot, IL)
Assignee: Yeda Research & Development Company Limited (Rehovot, IL)
Application Number:09/510,466
Patent Claims: 1. A composition for the treatment of multiple sclerosis comprising a pharmaceutically effective amount of a copolymer-1 fraction, wherein said fraction contains less than 5% of species of copolymer-1 having a molecular weight of over 40 kilodaltons; and wherein over 75% of said copolymer-1 in said fraction is within a molecular weight range of about 2 kilodaltons to about 20 kilodaltons, wherein said copolymer-1 fraction is prepared by a process comprising the steps of: reacting protected copolymer-1 with hydrobromic acid to form trifluoroacetyl copolymer-1 having over 75% of its molar fraction within the molecular weight range from about 2 kDa to about 20 kDa, wherein said reaction takes place for a time and at a temperature predetermined by test reaction, and treating said trifluoroacetyl copolymer-1 having over 75% of its molar fraction within the molecular weight range from about 2 kDa to about 20 kDa with aqueous piperidine solution to form copolymer-1 having over 75% of its molar fraction within the molecular weight range from about 2 kDa to about 20 kDa.

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Serving hundreds of leading biopharmaceutical companies globally:

UBS
Argus Health
Fuji
QuintilesIMS
Julphar
Colorcon
Express Scripts
Cerilliant
Medtronic

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