.

Pharmaceutical Business Intelligence

  • Anticipate P&T budget requirements
  • Evaluate market entry opportunities
  • Find generic sources and suppliers
  • Predict branded drug patent expiration

► Plans and Pricing

Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

DrugPatentWatch Database Preview

Claims for Patent: 6,352,998

« Back to Dashboard

Claims for Patent: 6,352,998

Title: Pharmaceutical compositions
Abstract:This invention provides a topical composition, in the form of an emulsion, that comprises a compound of the FK506 class; a physiologically acceptable alkanediol, ether diol or diether alcohol containing up to 8 carbon atoms as solvent for the compound of the FK506 class; an unsaturated fatty alcohol and water. In another aspect, this invention provides a topical pharmaceutical composition that comprises a macrolide in suspension. In a further aspect, this invention provides the use of an unsaturated fatty alcohol to stabilize a macrolide in a pharmaceutical composition.
Inventor(s): Jackman; Martin (Allschwil, CH), Popp; Xue-Ping (Basel, CH), Richter; Friedrich (Grenzach-Wyhlen, DE), Schmook; Fritz (Vienna, AT)
Assignee: Novartis AG (Basel, CH)
Application Number:09/767,656
Patent Claims: 1. A topical composition, in the form of an emulsion, consisting essentially of an immunosupressant effective amount of 33-epi-chloro-33-desoxyascomycin, an alkanediol, ether diol, or diether alcohol containing up to 8 carbon atoms as solvent for the 33-epi-chloro-33-desoxyascomycin, a C.sub.8 -C.sub.22 unsaturated fatty alcohol, water, a liquid oil, a thickening agent, an emulsifier and a preservative.

2. A topical composition according to claim 1 in which the solvent is hexylene glycol or propylene glycol.

3. A topical composition according to claim 1 wherein the unsaturated fatty alcohol is oleyl alcohol or elaidic alcohol.

4. A topical composition according to claim 1 wherein the unsaturated fatty alcohol contains one, two or three double bonds.

5. A topical composition according to claim 1 wherein the unsaturated fatty alcohol contains one double bond.

6. A topical composition according to claim 1 wherein the double bond has a cis configuration.

7. A topical composition, in the form of an emulsion, consisting essentially of 33-epi-chloro-33-desoxyascomycin; an alkanediol, ether diol, or diether alcohol containing up to 8 carbon atoms as solvent for the 33-epi-chloro-33-desoxyascomycin; a C.sub.8 -C.sub.22 unsaturated fatty alcohol; water; a liquid oil; a thickening agent; an emulsifier; and a preservative, wherein the 33-epi-chloro-33-desoxyascomycin is present in the emulsion in an amount of about 0.01 to about 10% w/w.

8. A topical composition according to claim 7 wherein the 33-epi-chloro-33-desoxyascomycin is present in the emulsion in an amount of about 0.1 to about 1% w/w.

9. A topical composition according to claim 1 wherein the alkanediol solvent is selected from propylene glycol, butylene glycol, 2-ethyl-1,3-hexanediol and 2-methyl-2,4-pentanediol.

10. A topical composition according to claim 1 wherein the ether diol is selected from dipropylene glycol and diethylene glycol.

11. A topical composition according to claim 1 wherein the diether alcohol is diethylene glycol monoethyl ether.

12. A topical composition according to claim 1 wherein the unsaturated fatty alcohol is a lanolin alcohol or a C.sub.16 -C.sub.18 fatty alcohol.

13. A topical composition according to claim 1 wherein the unsaturated fatty alcohol is oleyl alcohol.
« Back to Dashboard

For more information try a trial or see the database preview and plans and pricing

How are People Using DrugPatentWatch?

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

`abc