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Claims for Patent: 6,342,515

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Claims for Patent: 6,342,515

Title: Remedy for neurodegenerative diseases
Abstract:The present invention provides a medicament for neurodegenerative diseases comprising zonisamide or an alkali metal salt thereof as an active ingredient. The present medicament can be used in the prevention and treatment of neurodegenerative diseases such as Parkinson's disease, Huntington's disease, choreic syndrome and dystonic syndrome in mammals (including human).
Inventor(s): Masuda; Yoshinobu (Katano, JP), Ochi; Yoshiaki (Sanda, JP)
Assignee: Dainippon Pharmaceutical Co., Ltd. (Osaka-fu, JP)
Application Number:09/582,433
Patent Claims: 1. A method for the prevention and/or treatment of neurodegenerative diseases in a mammal which comprises administering an effective amount of zonisamide or an alkali metal salt thereof to said mammal in need of such prevention and/or treatment.

2. The method for the prevention and/or treatment according to claim 1, wherein the neurodegenerative disease is Parkinson's disease.

3. The method for the prevention and/or treatment according to claim 1, wherein the daily dosage is in the range of 1 to 50 mg per kg of body weight of a mammal.

4. The method for the prevention and/or treatment according to claim 3, wherein the daily dosage is in the range of 2 to 20 mg per kg of body weight of a mammal.

5. The method for the prevention and/or treatment according to claim 2, wherein the daily dosage is in the range of 1 to 5 mg per kg of body weight of a mammal.

6. A The method for the prevention and/or treatment according to claim 5, wherein the daily dosage is in the range of 2 to 20 mg per kg of body weight of a mammal.

7. The method for the prevention and/or treatment according to claim 1, wherein the mammal is human.

8. The method for the prevention and/or treatment according to claim 2, wherein the mammal is human.

9. The method for the prevention and/or treatment according to claim 3, wherein the mammal is human.

10. The method for the prevention and/or treatment according to claim 4, wherein the mammal is human.

11. The method for the prevention and/or treatment according to claim 5, wherein the mammal is human.

12. The method for the prevention and/or treatment according to claim 6, wherein the mammal is human.

13. A method for the prevention and/or treatment of neurodegenerative diseases in a mammal which comprises administering an effective amount of zonisamide to said mammal in need of such prevention and/or treatment.

14. The method for the prevention and/or treatment according to claim 13, wherein the neurodegenerative disease is Parkinson's disease.

15. The method for the prevention and/or treatment according to claim 13, wherein the daily dosage is in the range of 1 to 50 mg per kg of body weight of a mammal.

16. The method for the prevention and/or treatment according to claim 15, wherein the daily dosage is in the range of 2 to 20 mg per kg of body weight of a mammal.

17. The method for the prevention and/or treatment according to claims 14, wherein the daily dosage is in the range of 1 to 50 mg per kg of body weight of a mammal.

18. The method for the prevention and/or treatment according to claim 17, wherein the daily dosage is in the range of 2 to 20 mg per kg of body weight of a mammal.

19. The method for the prevention and/or treatment according to claim 13, wherein the mammal is human.

20. The method for the prevention and/or treatment according to claim 14, wherein the mammal is human.

21. The method for the prevention and/or treatment according to claim 15, wherein the mammal is human.

22. The method for the prevention and/or treatment according to claim 16, wherein the mammal is human.

23. The method for the prevention and/or treatment according to claim 17, wherein the mammal is human.

24. The method for the prevention and/or treatment according to claim 18, wherein the mammal is human.
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