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|Title:||Copolymer-1 improvements in compositions of copolymers|
|Abstract:||The present invention relates to an improved composition of copolymer-1 comprising copolymer-1 substantially free of species having a molecular weight of over 40 kilodaltons.|
|Inventor(s):||Konfino; Eliezer (Ramat Gan, IL), Sela; Michael (Rehovot, IL), Teitelbaum; Dvora (Rehovot, IL), Arnon; Ruth (Rehovot, IL)|
|Assignee:||Yeda Research & Development Company Limited (Rehovot, IL)|
1. A method for treating multiple sclerosis, comprising administering to a subject in need thereof, a pharmaceutically effective amount of a copolymer-1 fraction wherein said
fraction contains less than 5% of species of copolymer-1 having a molecular weight of over 40 kilodaltons; and wherein over 75% of said copolymer-1 in said fraction is within a molecular weight range of about 2 kilodaltons to about 20 kilodaltons,
wherein said copolymer-1 fraction is prepared by a process comprising the steps of:
reacting protected copolymer-1 with hydrobromic acid to form trifluoroacetyl copolymer-1 having over 75% of its molar fraction within the molecular weight range from about 2 kDa to about 20 kDa, wherein said reaction takes place for a time and at a temperature predetermined by test reaction, and
treating said trifluoroacetyl copolymer-1 having over 75% of its molar fraction within the molecular weight range from about 2 kDa to about 20 kDa with aqueous piperidine solution to form copolymer-1 having over 75% of its molar fraction within the molecular weight range from about 2 kDa to about 20 kDa.
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