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Claims for Patent: 6,319,192

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Claims for Patent: 6,319,192

Title: Method for the treatment of fertility disorders
Abstract:An improvement to the method of intrauterine insemination by the administration of luteinizing hormone-releasing hormone antagonists (LHRH antagonists).
Inventor(s): Engel; Jurgen (Alzenau, DE), Riethmuller-Winzen; Hilde (Frankfurt, DE), Reissmann; Thomas (Frankfurt, DE)
Assignee: Zentaris AG (Frankfurt am Main, DE)
Application Number:09/296,610
Patent Claims: 1. In the method of therapeutic management of infertility by intrauterine insemination, the improvement consisting of

a) the dose-dependent suppression of endogenous gonadotropins, especially LH, with an LH-RH antagonist allowing the maintenance of physiological oestrogen levels

b) exogenous stimulation of the ovarian follicle growth

c) ovulation induction with HCG, native LHRH, LHRH agonists or recombinant LH

d) intrauterine insemination by sperm injection.

2. The method of therapeutic management of infertility by intrauterine insemination according to claim 1 in which the LHRH antagonist is cetrorelix.

3. The method of therapeutic management of infertility by intrauterine insemination according to claim 1 in which he LHRH antagonist is antarelix.

4. The method of therapeutic management of infertility by intrauterine insemination according to claim 1 in which ovarian follicle stimulation is performed by administration of urinary or recombinant FSH or HMG, with or without recombinant LH.

5. The method of therapeutic management of infertility by intrauterine insemination according to claim 1 in which ovarian follicle stimulation is achieved with antioestrogens.

6. The method of therapeutic management of infertility by intrauterine insemination according to claim 1 in which ovarian follicle stimulation is achieved with the combination of antioestrogens with gonadotropins.
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