BioPharmaceutical Business Intelligence

  • Identify first generic entrants
  • Uncover prior art in expired and abandoned patents
  • Drug patents in 130+ countries
➤ Start Trial

or, See Plans & Pricing

Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

Serving leading biopharmaceutical companies globally:

Boehringer Ingelheim
Harvard Business School
Colorcon
Julphar
Cerilliant
McKinsey
Baxter
McKesson
Cipla
Medtronic

Generated: January 18, 2018

DrugPatentWatch Database Preview

Claims for Patent: 6,294,548

« Back to Dashboard

Summary for Patent: 6,294,548
Title: Multidose vial formulations for administering endo-N-(9-methyl-9-azabicyclo[3.3. 1]non-3-yl)-1-methyl-1H-indazole-3-carboxamide hydrochloride
Abstract:Invented are improved multidose aqueous formulations of endo-N-(9-methyl-9-azabicyclo[3.3.1. ]non-3-yl)-1-methyl-1H-indazole-3-carboxamide hydrochloride.
Inventor(s): James; Susan (Haverhill, GB)
Assignee: Hoffmann-La Roche Inc. (Nutley, NJ)
Application Number:09/548,838
Patent Claims: 1. A multidose aqueous formulation comprising endo-N-(9-methyl-9-azabicyclo[3.3. 1]non-3-yl)-1-methyl-1H-indazole-3-carboxamide hydrochloride and as a preservative, benzyl alcohol.

2. A multidose aqueous formulation as disclosed in claim 1, further comprising citric acid.

3. A multidose aqueous formulation as disclosed in claim 1 wherein benzyl alcohol is present in an amount from about 0.85% to about 1.15% w/w.

4. A multidose aqueous formulation as disclosed in claim 2 wherein benzyl alcohol is present in an amount from about 0.85% to about 1.15% w/w and citric acid, as citric acid monohydrate, is present in an amount from about 0.15% to about 0.25% w/w.

5. A multidose aqueous formulation as disclosed in claim 3 wherein benzyl alcohol is present in an amount of about 1.0% w/w.

6. A multidose aqueous formulation as disclosed in claim 4 wherein benzyl alcohol is present in an amount of about 1.0% w/w and citric acid, as citric acid monohydrate, is present in an amount of about 0.2% w/w.

7. A 4 mL multidose aqueous formulation as disclosed in claim 4 wherein each 1 mL contains 1.12 mg endo-N-(9-methyl-9-azabicyclo[3.3. 1]non-3-yl)-1-methyl-1H-indazole-3-carboxamide hydrochloride, and wherein benzyl alcohol is present in an amount from about 0.85% to about 1.15% w/w and citric acid, as citric acid monohydrate, is present in an amount from 0.15% to 0.25% w/w.

8. A multidose aqueous formulation as disclosed in claim 7 wherein benzyl alcohol is present in an amount of about 10 mg and citric acid is present in an amount of about 2 mg.

9. A multidose aqueous formulation as disclosed in claim 7 wherein the product is stable with regards to bacteria, mold and yeast contamination for a period of at least 35 days from the first aliquot extraction.

10. A multidose aqueous formulation as disclosed in claim 8 wherein the product is stable with regards to bacteria, mold and yeast contamination for a period of at least 35 days from the first aliquot extraction.

For more information try a trial or see the plans and pricing

Serving leading biopharmaceutical companies globally:

Healthtrust
Covington
Chinese Patent Office
Federal Trade Commission
McKinsey
Boehringer Ingelheim
Cipla
UBS
Dow

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

botpot